Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	257218
Gene name	SNF2 histone linker PHD RING helicase
Gene symbol	SHPRH
Synonyms (NCBI Gene)	RAD5bA545I5.2
Chromosome	6
Chromosome location	6q24.3
Summary	SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM

Show/Hide all (82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049497	hsa-miR-92a-3p	CLASH	23622248
MIRT1347683	hsa-miR-1225-5p	CLIP-seq
MIRT1347684	hsa-miR-1256	CLIP-seq
MIRT1347685	hsa-miR-200b	CLIP-seq
MIRT1347686	hsa-miR-200c	CLIP-seq
MIRT1347687	hsa-miR-2117	CLIP-seq
MIRT1347688	hsa-miR-3074-3p	CLIP-seq
MIRT1347689	hsa-miR-3147	CLIP-seq
MIRT1347690	hsa-miR-3153	CLIP-seq
MIRT1347691	hsa-miR-3201	CLIP-seq
MIRT1347692	hsa-miR-34c-3p	CLIP-seq
MIRT1347693	hsa-miR-3615	CLIP-seq
MIRT1347694	hsa-miR-374c	CLIP-seq
MIRT1347695	hsa-miR-3917	CLIP-seq
MIRT1347696	hsa-miR-3941	CLIP-seq
MIRT1347697	hsa-miR-3942-3p	CLIP-seq
MIRT1347698	hsa-miR-3974	CLIP-seq
MIRT1347699	hsa-miR-429	CLIP-seq
MIRT1347700	hsa-miR-4328	CLIP-seq
MIRT1347701	hsa-miR-4425	CLIP-seq
MIRT1347702	hsa-miR-4432	CLIP-seq
MIRT1347703	hsa-miR-4445	CLIP-seq
MIRT1347704	hsa-miR-4452	CLIP-seq
MIRT1347705	hsa-miR-4457	CLIP-seq
MIRT1347706	hsa-miR-450b-3p	CLIP-seq
MIRT1347707	hsa-miR-4636	CLIP-seq
MIRT1347708	hsa-miR-466	CLIP-seq
MIRT1347709	hsa-miR-4668-5p	CLIP-seq
MIRT1347710	hsa-miR-4672	CLIP-seq
MIRT1347711	hsa-miR-4684-5p	CLIP-seq
MIRT1347712	hsa-miR-4699-3p	CLIP-seq
MIRT1347713	hsa-miR-4713-3p	CLIP-seq
MIRT1347714	hsa-miR-4724-5p	CLIP-seq
MIRT1347715	hsa-miR-4731-3p	CLIP-seq
MIRT1347716	hsa-miR-4753-3p	CLIP-seq
MIRT1347717	hsa-miR-4791	CLIP-seq
MIRT1347718	hsa-miR-4794	CLIP-seq
MIRT1347719	hsa-miR-4801	CLIP-seq
MIRT1347720	hsa-miR-499-3p	CLIP-seq
MIRT1347721	hsa-miR-499a-3p	CLIP-seq
MIRT1347722	hsa-miR-513b	CLIP-seq
MIRT1347723	hsa-miR-548ac	CLIP-seq
MIRT1347724	hsa-miR-548ae	CLIP-seq
MIRT1347725	hsa-miR-548aj	CLIP-seq
MIRT1347726	hsa-miR-548am	CLIP-seq
MIRT1347727	hsa-miR-548d-3p	CLIP-seq
MIRT1347728	hsa-miR-548u	CLIP-seq
MIRT1347729	hsa-miR-548x	CLIP-seq
MIRT1347730	hsa-miR-548z	CLIP-seq
MIRT1347731	hsa-miR-555	CLIP-seq
MIRT1347732	hsa-miR-600	CLIP-seq
MIRT1347733	hsa-miR-618	CLIP-seq
MIRT1347734	hsa-miR-638	CLIP-seq
MIRT1347735	hsa-miR-655	CLIP-seq
MIRT1347736	hsa-miR-769-3p	CLIP-seq
MIRT1347737	hsa-miR-892b	CLIP-seq
MIRT1347738	hsa-miR-944	CLIP-seq
MIRT1347690	hsa-miR-3153	CLIP-seq
MIRT1347696	hsa-miR-3941	CLIP-seq
MIRT1347708	hsa-miR-466	CLIP-seq
MIRT1347709	hsa-miR-4668-5p	CLIP-seq
MIRT1347710	hsa-miR-4672	CLIP-seq
MIRT1347715	hsa-miR-4731-3p	CLIP-seq
MIRT1347719	hsa-miR-4801	CLIP-seq
MIRT1347690	hsa-miR-3153	CLIP-seq
MIRT2327285	hsa-miR-3185	CLIP-seq
MIRT1347692	hsa-miR-34c-3p	CLIP-seq
MIRT1347694	hsa-miR-374c	CLIP-seq
MIRT1347696	hsa-miR-3941	CLIP-seq
MIRT2327286	hsa-miR-411	CLIP-seq
MIRT1347700	hsa-miR-4328	CLIP-seq
MIRT2327287	hsa-miR-4464	CLIP-seq
MIRT1347708	hsa-miR-466	CLIP-seq
MIRT1347709	hsa-miR-4668-5p	CLIP-seq
MIRT1347710	hsa-miR-4672	CLIP-seq
MIRT1347712	hsa-miR-4699-3p	CLIP-seq
MIRT1347715	hsa-miR-4731-3p	CLIP-seq
MIRT2327288	hsa-miR-4748	CLIP-seq
MIRT1347719	hsa-miR-4801	CLIP-seq
MIRT1347720	hsa-miR-499-3p	CLIP-seq
MIRT1347721	hsa-miR-499a-3p	CLIP-seq
MIRT1347735	hsa-miR-655	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0000209	Process	Protein polyubiquitination	IDA	17108083
GO:0000786	Component	Nucleosome	IEA
GO:0003677	Function	DNA binding	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	17108083
GO:0005515	Function	Protein binding	IPI	17108083, 25416956
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006281	Process	DNA repair	IEA
GO:0006334	Process	Nucleosome assembly	IEA
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IDA	25023518
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IDA	25023518
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	EXP	17108083, 17130289, 18719106
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
608048	19336	ENSG00000146414

Q149N8

Protein name

E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)

Protein function

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non

PDB

2M85 , 4QN1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00176	SNF2_N	307 → 987	SNF2 family N-terminal domain	Family
PF00538	Linker_histone	439 → 511	linker histone H1 and H5 family	Domain
PF00271	Helicase_C	1510 → 1622	Helicase conserved C-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Broadly expressed. {ECO:0000269|PubMed:12837266}.

Sequence

MSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDS
LKEEVAHRDKKRCSKVVSFSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELT
LQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPMSICDKGILVESS
FSGEMLEDLGWLQKKRRIKLYQKPEGNHIIKVGIYLLEAGLAKLDFLSDANSRMKKFNQL
MKKVMEKLHNSIIPDVLEEDEDDPESEPEGQDIDELYHFVKQTHQQETQSIQVDVQHPAL
IPVLRPYQREAVNWMLQQECFRSSPATESALHFLWREIVTSEGLKLYYNPYTGCIIREYP
NSGPQLLGGILADEMGLGKTVEVLALILTHTRQDVKQDALTLPEGKVVNYFIPSHYFGGK
LKKTEIQNIEFEPKEKVQCPPTRVMILTAVKEMNGKKGVSILSIYKYVSSIYRYDVQRNR
SLLKRMLKCLIFEGLVKQIKGHGFSGTFTLGKNYKEEDICDKTKKQAVGSPRKIQKETRK
SGNKDTDSEYLPSDTSDDDDDPYYYYYKSRRNRSKLRKKLVPSTKKGKSQPFINPDSQGH
CPATSDSGITDVAMSKSTCISEFNQEHETEDCAESLNHADSDVPPSNTMSPFNTSDYRFE
CICGELDQIDRKPRVQCLKCHLWQHAKCVNYDEKNLKIKPFYCPHCLVAMEPVSTRATLI
ISPSSICHQWVDEINRHVRSSSLRVLVYQGVKKDGFLQPHFLAEQDIVIITYDVLRSELN
YVDIPHSNSEDGRRLRNQKRYMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSG
INRWCISGTPVQRGLEDLFGLVVFLGIEPYCVKHWWVRLLYRPYCKKNPQHLYSFIAKIL
WRSAKKDVIDQIQIPPQTEEIHWLHFSPVERHFYHRQHEVCCQDVVVKLRKISDWALKLS
SLDRRTVTSILYPLLRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCGTECEEAH
RQLVCALNGLAGIHIIKGEYALAAELYREVLRSSEEHKGKLKTDSLQRLHATHNLMELLI
ARHPGIPPTLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALYPVQQTIHELQRKIHSNSP
WWLNVIHRAIEFTIDEELVQRVRNEITSNYKQQTGKLSMSEKFRDCRGLQFLLTTQMEEL
NKCQKLVREAVKNLEGPPSRNVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFSN
TVKGQTAIFEEMIEDEEGLVDDRAPTTTRGLWAISETERSMKAILSFAKSHRFDVEFVDE
GSTSMDLFEAWKKEYKLLHEYWMALRNRVSAVDELAMATERLRVRDPREPKPNPPVLHII
EPHEVEQNRIKLLNDKAVATSQLQKKLGQLLYLTNLEKSQDKTSGGVNPEPCPICARQLG
KQWAVLTCGHCFCNECISIIIEQYSVGSHRSSIKCAICRQTTSHKEISYVFTSEKANQEE
DIPVKGSHSTKVEAVVRTLMKIQLRDPGAKALVFSTWQDVLDIISKALTDNNMEFAQISR
VKTFQENLSAFKRDPQINILLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVHR
IGQTKPTIVHRFLIKATIEERMQAMLKTAERSHTNSSAKHSEASVLTVADLADLFTKETE
ELE

Sequence length

1683

Interactions

View interactions

	Reactome
			E3 ubiquitin ligases ubiquitinate target proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Gastric cancer	Benign	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
GASTRIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31137016	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29343848, 29706655		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29343848, 29706655		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29343848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37086071	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31137016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31689751		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29343848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	38282862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SHPRH (SNF2 histone linker PHD RING helicase)