Gene Gene information from NCBI Gene database.
Entrez ID 257194
Gene name Neuronal growth regulator 1
Gene symbol NEGR1
Synonyms (NCBI Gene)
DMML2433IGLON4KILONNtra
Chromosome 1
Chromosome location 1p31.1
miRNA miRNA information provided by mirtarbase database.
595
miRTarBase ID miRNA Experiments Reference
MIRT722855 hsa-miR-6819-3p HITS-CLIP 19536157
MIRT722854 hsa-miR-6877-3p HITS-CLIP 19536157
MIRT722853 hsa-miR-4528 HITS-CLIP 19536157
MIRT722852 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT722851 hsa-miR-2114-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21982860, 27940359, 37207277
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
GO:0007155 Process Cell adhesion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613173 17302 ENSG00000172260
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z3B1
Protein name Neuronal growth regulator 1 (IgLON family member 4)
Protein function May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
PDB 6DLD , 6U6T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 43 135 Immunoglobulin I-set domain Domain
PF13927 Ig_3 138 207 Domain
PF13927 Ig_3 224 301 Domain
Sequence
Sequence length 354
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules   Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
22
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anorexia Nervosa Anorexia nervosa Pubtator 35703085 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma BEFREE 20816195
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 20816195 Associate
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorders Autism Spectrum Disorder BEFREE 30059965
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 30059965, 30932003
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 24648515, 26544852 Associate
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Ischemic stroke Pubtator 33000228 Associate
★☆☆☆☆
Found in Text Mining only
Child Development Disorders, Pervasive Development Disorder GWASCAT_DG 30804558
★☆☆☆☆
Found in Text Mining only
Depressive disorder Mental Depression BEFREE 30651602
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Major depressive disorder Pubtator 36634823 Associate
★☆☆☆☆
Found in Text Mining only