Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2570
Gene name	Gamma-aminobutyric acid type A receptor subunit rho2
Gene symbol	GABRR2
Synonyms (NCBI Gene)	-
Chromosome	6
Chromosome location	6q15
Summary	Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a compo

146

Show/Hide all (146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT453919	hsa-miR-302f	PAR-CLIP	21572407
MIRT453918	hsa-miR-1910-3p	PAR-CLIP	21572407
MIRT453917	hsa-miR-6511a-5p	PAR-CLIP	21572407
MIRT453913	hsa-miR-4257	PAR-CLIP	21572407
MIRT453912	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT453911	hsa-miR-1247-3p	PAR-CLIP	21572407
MIRT453909	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT453908	hsa-miR-1827	PAR-CLIP	21572407
MIRT453907	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT453906	hsa-miR-6086	PAR-CLIP	21572407
MIRT453905	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT453904	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT453903	hsa-miR-3612	PAR-CLIP	21572407
MIRT453902	hsa-miR-650	PAR-CLIP	21572407
MIRT453901	hsa-miR-4792	PAR-CLIP	21572407
MIRT453900	hsa-miR-4710	PAR-CLIP	21572407
MIRT453899	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT453898	hsa-miR-1273e	PAR-CLIP	21572407
MIRT453897	hsa-miR-7855-5p	PAR-CLIP	21572407
MIRT453919	hsa-miR-302f	PAR-CLIP	23592263
MIRT453918	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT453917	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT453916	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT453915	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT453914	hsa-miR-940	PAR-CLIP	23592263
MIRT453913	hsa-miR-4257	PAR-CLIP	23592263
MIRT453912	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT453911	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT453910	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT453909	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT453908	hsa-miR-1827	PAR-CLIP	23592263
MIRT453907	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT453906	hsa-miR-6086	PAR-CLIP	23592263
MIRT453905	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT453904	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT453903	hsa-miR-3612	PAR-CLIP	23592263
MIRT453902	hsa-miR-650	PAR-CLIP	23592263
MIRT453901	hsa-miR-4792	PAR-CLIP	23592263
MIRT453900	hsa-miR-4710	PAR-CLIP	23592263
MIRT453899	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT453898	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453897	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT453911	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT453911	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT453911	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT453898	hsa-miR-1273e	PAR-CLIP	26701625
MIRT453898	hsa-miR-1273e	PAR-CLIP	26701625
MIRT453898	hsa-miR-1273e	PAR-CLIP	26701625
MIRT453908	hsa-miR-1827	PAR-CLIP	26701625
MIRT453908	hsa-miR-1827	PAR-CLIP	26701625
MIRT453908	hsa-miR-1827	PAR-CLIP	26701625
MIRT453918	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT453918	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT453918	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT453909	hsa-miR-219b-3p	PAR-CLIP	26701625
MIRT453909	hsa-miR-219b-3p	PAR-CLIP	26701625
MIRT453909	hsa-miR-219b-3p	PAR-CLIP	26701625
MIRT453905	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT453905	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT453905	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT453919	hsa-miR-302f	PAR-CLIP	26701625
MIRT453919	hsa-miR-302f	PAR-CLIP	26701625
MIRT453919	hsa-miR-302f	PAR-CLIP	26701625
MIRT453903	hsa-miR-3612	PAR-CLIP	26701625
MIRT453907	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT453907	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT453907	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT453913	hsa-miR-4257	PAR-CLIP	26701625
MIRT453913	hsa-miR-4257	PAR-CLIP	26701625
MIRT453913	hsa-miR-4257	PAR-CLIP	26701625
MIRT453900	hsa-miR-4710	PAR-CLIP	26701625
MIRT453900	hsa-miR-4710	PAR-CLIP	26701625
MIRT453900	hsa-miR-4710	PAR-CLIP	26701625
MIRT453904	hsa-miR-4722-5p	PAR-CLIP	26701625
MIRT453904	hsa-miR-4722-5p	PAR-CLIP	26701625
MIRT453904	hsa-miR-4722-5p	PAR-CLIP	26701625
MIRT453912	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT453912	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT453912	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT453901	hsa-miR-4792	PAR-CLIP	26701625
MIRT453901	hsa-miR-4792	PAR-CLIP	26701625
MIRT453901	hsa-miR-4792	PAR-CLIP	26701625
MIRT453906	hsa-miR-6086	PAR-CLIP	26701625
MIRT453906	hsa-miR-6086	PAR-CLIP	26701625
MIRT453906	hsa-miR-6086	PAR-CLIP	26701625
MIRT453902	hsa-miR-650	PAR-CLIP	26701625
MIRT453917	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT453917	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT453917	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT453899	hsa-miR-6807-5p	PAR-CLIP	26701625
MIRT453899	hsa-miR-6807-5p	PAR-CLIP	26701625
MIRT453899	hsa-miR-6807-5p	PAR-CLIP	26701625
MIRT453916	hsa-miR-6808-5p	PAR-CLIP	26701625
MIRT453916	hsa-miR-6808-5p	PAR-CLIP	26701625
MIRT453916	hsa-miR-6808-5p	PAR-CLIP	26701625
MIRT453915	hsa-miR-6893-5p	PAR-CLIP	26701625
MIRT453915	hsa-miR-6893-5p	PAR-CLIP	26701625
MIRT453915	hsa-miR-6893-5p	PAR-CLIP	26701625
MIRT453897	hsa-miR-7855-5p	PAR-CLIP	26701625
MIRT453897	hsa-miR-7855-5p	PAR-CLIP	26701625
MIRT453897	hsa-miR-7855-5p	PAR-CLIP	26701625
MIRT453914	hsa-miR-940	PAR-CLIP	26701625
MIRT453914	hsa-miR-940	PAR-CLIP	26701625
MIRT453914	hsa-miR-940	PAR-CLIP	26701625
MIRT453919	hsa-miR-302f	PAR-CLIP	21572407
MIRT453918	hsa-miR-1910-3p	PAR-CLIP	21572407
MIRT453917	hsa-miR-6511a-5p	PAR-CLIP	21572407
MIRT453913	hsa-miR-4257	PAR-CLIP	21572407
MIRT453912	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT453911	hsa-miR-1247-3p	PAR-CLIP	21572407
MIRT453909	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT453908	hsa-miR-1827	PAR-CLIP	21572407
MIRT453907	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT453906	hsa-miR-6086	PAR-CLIP	21572407
MIRT453905	hsa-miR-2467-3p	PAR-CLIP	21572407
MIRT453904	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT453903	hsa-miR-3612	PAR-CLIP	21572407
MIRT453902	hsa-miR-650	PAR-CLIP	21572407
MIRT453901	hsa-miR-4792	PAR-CLIP	21572407
MIRT453900	hsa-miR-4710	PAR-CLIP	21572407
MIRT453899	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT453898	hsa-miR-1273e	PAR-CLIP	21572407
MIRT453897	hsa-miR-7855-5p	PAR-CLIP	21572407
MIRT453919	hsa-miR-302f	PAR-CLIP	23592263
MIRT453918	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT453917	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT453916	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT453915	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT453914	hsa-miR-940	PAR-CLIP	23592263
MIRT453913	hsa-miR-4257	PAR-CLIP	23592263
MIRT453912	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT453911	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT453910	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT453909	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT453908	hsa-miR-1827	PAR-CLIP	23592263
MIRT453907	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT453906	hsa-miR-6086	PAR-CLIP	23592263
MIRT453905	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT453904	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT453903	hsa-miR-3612	PAR-CLIP	23592263
MIRT453902	hsa-miR-650	PAR-CLIP	23592263
MIRT453901	hsa-miR-4792	PAR-CLIP	23592263
MIRT453900	hsa-miR-4710	PAR-CLIP	23592263
MIRT453899	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT453898	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453897	hsa-miR-7855-5p	PAR-CLIP	23592263

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004890	Function	GABA-A receptor activity	IBA
GO:0004890	Function	GABA-A receptor activity	IEA
GO:0004890	Function	GABA-A receptor activity	ISS
GO:0004890	Function	GABA-A receptor activity	TAS	1315307
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005230	Function	Extracellular ligand-gated monoatomic ion channel activity	IEA
GO:0005254	Function	Chloride channel activity	IBA
GO:0005254	Function	Chloride channel activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1315307
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0007165	Process	Signal transduction	TAS	1315307
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	1315307
GO:0007601	Process	Visual perception	IEA
GO:0016020	Component	Membrane	IEA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0022851	Function	GABA-gated chloride ion channel activity	IEA
GO:0022851	Function	GABA-gated chloride ion channel activity	ISS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051932	Process	Synaptic transmission, GABAergic	IBA
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0097708	Component	Intracellular vesicle	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:1902476	Process	Chloride transmembrane transport	IBA
GO:1902711	Component	GABA-A receptor complex	IBA
GO:1904315	Function	Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA

MIM	HGNC	e!Ensembl
137162	4091	ENSG00000111886

P28476

Protein name

Gamma-aminobutyric acid receptor subunit rho-2 (GABA(A) receptor subunit rho-2) (GABAAR subunit rho-2) (GABA(C) receptor)

Protein function

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02931	Neur_chan_LBD	55 → 261	Neurotransmitter-gated ion-channel ligand binding domain	Family
PF02932	Neur_chan_memb	268 → 409	Neurotransmitter-gated ion-channel transmembrane region	Family

Sequence

MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLR
VDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASN
KSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNM
DFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLA
FYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITT
VLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLR
EKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA
RKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS

Sequence length

465

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse Morphine addiction Nicotine addiction		GABA receptor activation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISTIC DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Progressive sensorineural hearing impairment	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autistic Disorder	Autism	Pubtator	16080114	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	20889312		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cognition Disorders	Cognition disorder	Pubtator	26922432	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	21420396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Tremor	Tremor	BEFREE	20820800		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	BEFREE	28699326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Restless Legs Syndrome	Restless Legs Syndrome	BEFREE	29720720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis pigmentosa	Pubtator	9585594	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2)