SCML4 (Scm polycomb group protein like 4)

Gene

• Entrez ID: 256380
• Gene name: Scm polycomb group protein like 4
• Gene symbol: SCML4
• Synonyms (NCBI Gene): dJ47M23.1
• Chromosome: 6
• Chromosome location: 6q21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT445948	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445947	hsa-miR-4476	PAR-CLIP	22100165
MIRT445946	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT445945	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT445944	hsa-miR-8065	PAR-CLIP	22100165
MIRT445943	hsa-miR-2052	PAR-CLIP	22100165
MIRT445942	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT445948	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445947	hsa-miR-4476	PAR-CLIP	22100165
MIRT445946	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT445945	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT445944	hsa-miR-8065	PAR-CLIP	22100165
MIRT445943	hsa-miR-2052	PAR-CLIP	22100165
MIRT445942	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT445948	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445947	hsa-miR-4476	PAR-CLIP	22100165
MIRT445946	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT445945	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT445944	hsa-miR-8065	PAR-CLIP	22100165
MIRT445943	hsa-miR-2052	PAR-CLIP	22100165
MIRT445942	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT445948	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT445947	hsa-miR-4476	PAR-CLIP	22100165
MIRT445946	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT445945	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT445944	hsa-miR-8065	PAR-CLIP	22100165
MIRT445943	hsa-miR-2052	PAR-CLIP	22100165
MIRT445942	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT1329611	hsa-let-7a	CLIP-seq
MIRT1329612	hsa-let-7b	CLIP-seq
MIRT1329613	hsa-let-7c	CLIP-seq
MIRT1329614	hsa-let-7d	CLIP-seq
MIRT1329615	hsa-let-7e	CLIP-seq
MIRT1329616	hsa-let-7f	CLIP-seq
MIRT1329617	hsa-let-7g	CLIP-seq
MIRT1329618	hsa-let-7i	CLIP-seq
MIRT1329619	hsa-miR-105	CLIP-seq
MIRT1329620	hsa-miR-1226	CLIP-seq
MIRT1329621	hsa-miR-1237	CLIP-seq
MIRT1329622	hsa-miR-1243	CLIP-seq
MIRT1329623	hsa-miR-1255a	CLIP-seq
MIRT1329624	hsa-miR-1255b	CLIP-seq
MIRT1329625	hsa-miR-1283	CLIP-seq
MIRT1329626	hsa-miR-130a	CLIP-seq
MIRT1329627	hsa-miR-130b	CLIP-seq
MIRT1329628	hsa-miR-1324	CLIP-seq
MIRT1329629	hsa-miR-148a	CLIP-seq
MIRT1329630	hsa-miR-148b	CLIP-seq
MIRT1329631	hsa-miR-152	CLIP-seq
MIRT1329632	hsa-miR-181a	CLIP-seq
MIRT1329633	hsa-miR-181b	CLIP-seq
MIRT1329634	hsa-miR-181c	CLIP-seq
MIRT1329635	hsa-miR-181d	CLIP-seq
MIRT1329636	hsa-miR-1913	CLIP-seq
MIRT1329637	hsa-miR-194	CLIP-seq
MIRT1329638	hsa-miR-202	CLIP-seq
MIRT1329639	hsa-miR-224	CLIP-seq
MIRT1329640	hsa-miR-2355-5p	CLIP-seq
MIRT1329641	hsa-miR-2964a-5p	CLIP-seq
MIRT1329642	hsa-miR-299-5p	CLIP-seq
MIRT1329643	hsa-miR-301a	CLIP-seq
MIRT1329644	hsa-miR-301b	CLIP-seq
MIRT1329645	hsa-miR-3065-3p	CLIP-seq
MIRT1329646	hsa-miR-3123	CLIP-seq
MIRT1329647	hsa-miR-3180-5p	CLIP-seq
MIRT1329648	hsa-miR-324-3p	CLIP-seq
MIRT1329649	hsa-miR-346	CLIP-seq
MIRT1329650	hsa-miR-3654	CLIP-seq
MIRT1329651	hsa-miR-3666	CLIP-seq
MIRT1329652	hsa-miR-3667-3p	CLIP-seq
MIRT1329653	hsa-miR-3919	CLIP-seq
MIRT1329654	hsa-miR-421	CLIP-seq
MIRT1329655	hsa-miR-4262	CLIP-seq
MIRT1329656	hsa-miR-4274	CLIP-seq
MIRT1329657	hsa-miR-4276	CLIP-seq
MIRT1329658	hsa-miR-4279	CLIP-seq
MIRT1329659	hsa-miR-4284	CLIP-seq
MIRT1329660	hsa-miR-4290	CLIP-seq
MIRT1329661	hsa-miR-4295	CLIP-seq
MIRT1329662	hsa-miR-4304	CLIP-seq
MIRT1329663	hsa-miR-4311	CLIP-seq
MIRT1329664	hsa-miR-4458	CLIP-seq
MIRT1329665	hsa-miR-4459	CLIP-seq
MIRT1329666	hsa-miR-4477b	CLIP-seq
MIRT1329667	hsa-miR-4500	CLIP-seq
MIRT1329668	hsa-miR-4519	CLIP-seq
MIRT1329669	hsa-miR-4524	CLIP-seq
MIRT1329670	hsa-miR-454	CLIP-seq
MIRT1329671	hsa-miR-4659a-5p	CLIP-seq
MIRT1329672	hsa-miR-4659b-5p	CLIP-seq
MIRT1329673	hsa-miR-4670-3p	CLIP-seq
MIRT1329674	hsa-miR-4708-3p	CLIP-seq
MIRT1329675	hsa-miR-4717-3p	CLIP-seq
MIRT1329676	hsa-miR-4726-3p	CLIP-seq
MIRT1329677	hsa-miR-4733-3p	CLIP-seq
MIRT1329678	hsa-miR-4761-5p	CLIP-seq
MIRT1329679	hsa-miR-4802-3p	CLIP-seq
MIRT1329680	hsa-miR-486-5p	CLIP-seq
MIRT1329681	hsa-miR-490-5p	CLIP-seq
MIRT1329682	hsa-miR-495	CLIP-seq
MIRT1329683	hsa-miR-513a-3p	CLIP-seq
MIRT1329684	hsa-miR-520a-5p	CLIP-seq
MIRT1329685	hsa-miR-520d-5p	CLIP-seq
MIRT1329686	hsa-miR-524-5p	CLIP-seq
MIRT1329687	hsa-miR-525-5p	CLIP-seq
MIRT1329688	hsa-miR-548ad	CLIP-seq
MIRT1329689	hsa-miR-548u	CLIP-seq
MIRT1329690	hsa-miR-622	CLIP-seq
MIRT1329691	hsa-miR-873	CLIP-seq
MIRT1329692	hsa-miR-98	CLIP-seq
MIRT1329622	hsa-miR-1243	CLIP-seq
MIRT1329639	hsa-miR-224	CLIP-seq
MIRT1329650	hsa-miR-3654	CLIP-seq
MIRT1329622	hsa-miR-1243	CLIP-seq
MIRT1329639	hsa-miR-224	CLIP-seq
MIRT1329650	hsa-miR-3654	CLIP-seq
MIRT1921713	hsa-miR-3127-3p	CLIP-seq
MIRT1329658	hsa-miR-4279	CLIP-seq
MIRT1921714	hsa-miR-4727-5p	CLIP-seq
MIRT1921715	hsa-miR-4769-3p	CLIP-seq
MIRT1921716	hsa-miR-942	CLIP-seq
MIRT2097730	hsa-miR-101	CLIP-seq
MIRT2097731	hsa-miR-2681	CLIP-seq
MIRT1329645	hsa-miR-3065-3p	CLIP-seq
MIRT2097732	hsa-miR-3615	CLIP-seq
MIRT2097733	hsa-miR-3942-3p	CLIP-seq
MIRT1329665	hsa-miR-4459	CLIP-seq
MIRT2097734	hsa-miR-491-3p	CLIP-seq
MIRT2097735	hsa-miR-711	CLIP-seq
MIRT2322012	hsa-miR-1251	CLIP-seq
MIRT2322013	hsa-miR-1252	CLIP-seq
MIRT1329623	hsa-miR-1255a	CLIP-seq
MIRT1329624	hsa-miR-1255b	CLIP-seq
MIRT1329636	hsa-miR-1913	CLIP-seq
MIRT1329645	hsa-miR-3065-3p	CLIP-seq
MIRT1329648	hsa-miR-324-3p	CLIP-seq
MIRT1329649	hsa-miR-346	CLIP-seq
MIRT1329652	hsa-miR-3667-3p	CLIP-seq
MIRT1329660	hsa-miR-4290	CLIP-seq
MIRT2322014	hsa-miR-4303	CLIP-seq
MIRT1329665	hsa-miR-4459	CLIP-seq
MIRT2322015	hsa-miR-4533	CLIP-seq
MIRT1329671	hsa-miR-4659a-5p	CLIP-seq
MIRT1329672	hsa-miR-4659b-5p	CLIP-seq
MIRT1329673	hsa-miR-4670-3p	CLIP-seq
MIRT2322016	hsa-miR-4682	CLIP-seq
MIRT2322017	hsa-miR-513a-5p	CLIP-seq
MIRT1329691	hsa-miR-873	CLIP-seq
MIRT1329611	hsa-let-7a	CLIP-seq
MIRT1329612	hsa-let-7b	CLIP-seq
MIRT1329613	hsa-let-7c	CLIP-seq
MIRT1329614	hsa-let-7d	CLIP-seq
MIRT1329615	hsa-let-7e	CLIP-seq
MIRT1329616	hsa-let-7f	CLIP-seq
MIRT1329617	hsa-let-7g	CLIP-seq
MIRT1329618	hsa-let-7i	CLIP-seq
MIRT1329622	hsa-miR-1243	CLIP-seq
MIRT2322013	hsa-miR-1252	CLIP-seq
MIRT2394082	hsa-miR-1299	CLIP-seq
MIRT1329638	hsa-miR-202	CLIP-seq
MIRT1329639	hsa-miR-224	CLIP-seq
MIRT1329645	hsa-miR-3065-3p	CLIP-seq
MIRT1329650	hsa-miR-3654	CLIP-seq
MIRT1329664	hsa-miR-4458	CLIP-seq
MIRT1329665	hsa-miR-4459	CLIP-seq
MIRT1329667	hsa-miR-4500	CLIP-seq
MIRT2394083	hsa-miR-4639-3p	CLIP-seq
MIRT2394084	hsa-miR-4695-3p	CLIP-seq
MIRT1329692	hsa-miR-98	CLIP-seq
MIRT2458915	hsa-miR-570	CLIP-seq
MIRT2458916	hsa-miR-606	CLIP-seq
MIRT2458917	hsa-miR-888	CLIP-seq
MIRT1329619	hsa-miR-105	CLIP-seq
MIRT2618473	hsa-miR-1587	CLIP-seq
MIRT1329642	hsa-miR-299-5p	CLIP-seq
MIRT2618474	hsa-miR-378g	CLIP-seq
MIRT2618475	hsa-miR-4492	CLIP-seq
MIRT2618476	hsa-miR-4498	CLIP-seq
MIRT2618477	hsa-miR-4656	CLIP-seq
MIRT1329671	hsa-miR-4659a-5p	CLIP-seq
MIRT1329672	hsa-miR-4659b-5p	CLIP-seq
MIRT2618478	hsa-miR-4675	CLIP-seq
MIRT2618479	hsa-miR-4741	CLIP-seq
MIRT2618480	hsa-miR-4786-5p	CLIP-seq
MIRT1329685	hsa-miR-520d-5p	CLIP-seq
MIRT1329686	hsa-miR-524-5p	CLIP-seq
MIRT2618481	hsa-miR-762	CLIP-seq
MIRT2618482	hsa-miR-769-5p	CLIP-seq
MIRT2618473	hsa-miR-1587	CLIP-seq
MIRT2618474	hsa-miR-378g	CLIP-seq
MIRT2618475	hsa-miR-4492	CLIP-seq
MIRT2618476	hsa-miR-4498	CLIP-seq
MIRT2618477	hsa-miR-4656	CLIP-seq
MIRT2618478	hsa-miR-4675	CLIP-seq
MIRT2618479	hsa-miR-4741	CLIP-seq
MIRT2618481	hsa-miR-762	CLIP-seq
MIRT2618482	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0042393	Function	Histone binding	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N228
• Protein name: Sex comb on midleg-like protein 4
• Protein function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17208	RBR	1 → 60	RNA binding Region	Family
  PF12140	SLED	95 → 205	SLED domain	Domain
  PF00536	SAM_1	344 → 410	SAM domain (Sterile alpha motif)	Domain

• Sequence:

  MQSQRIPGRKRGRPSLHSTPMKMAVHNLYSASAGSLPAVKIPKKRGRKPGYKIKSRVLMT
  PLALSPPRSTPEPDLSSIPQDAATVPSLAAPQALTVCLYINKQANAGPYLERKKVQQLPE
  HFGPERPSAVLQQAVQACIDCAHQQKLVFSLVKQGYGGEMVSVSASFDGKQHLRSLPVVN
  SIGYVLRFLAKLCRSLLCDDLFSHQPFPRGCSASEKVQEKEEGRMESVKTVTTEEYLVNP
  VGMNRYSVDTSASTFNHRGSLHPSSSLYCKRQNSGDSHLGGGPAATAGGPRTSPMSSGGP
  SAPGLRPPASSPKRNTTSLEGNRCASSPSQDAQDARRPRSRNPSAWTVEDVVWFVKDADP
  QALGPHVELFRKHEIDGNALLLLKSDMVMKYLGLKLGPALKLCYHIDKLKQAKF

• Sequence length: 414

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISORDER OF EAR	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Coronary Artery Disease	Coronary artery disease	BEFREE	29472232		★★☆☆☆ Found in Text Mining + Unknown/Other Associations