Gene Gene information from NCBI Gene database.
Entrez ID 256356
Gene name Glycerol kinase 5
Gene symbol GK5
Synonyms (NCBI Gene)
-
Chromosome 3
Chromosome location 3q23
miRNA miRNA information provided by mirtarbase database.
1791
miRTarBase ID miRNA Experiments Reference
MIRT019547 hsa-miR-340-5p Sequencing 20371350
MIRT022437 hsa-miR-124-3p Microarray 18668037
MIRT708139 hsa-miR-548c-3p HITS-CLIP 21572407
MIRT708138 hsa-miR-548aa HITS-CLIP 21572407
MIRT708137 hsa-miR-548ap-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004370 Function Glycerol kinase activity IBA
GO:0004370 Function Glycerol kinase activity IEA
GO:0004370 Function Glycerol kinase activity ISS
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620801 28635 ENSG00000175066
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZS86
Protein name Glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5)
Protein function Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00370 FGGY_N 20 282 FGGY family of carbohydrate kinases, N-terminal domain Domain
PF02782 FGGY_C 291 480 FGGY family of carbohydrate kinases, C-terminal domain Domain
Sequence
Sequence length 529
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
EBV-positive nodal T- and NK-cell lymphoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ROLANDIC EPILEPSY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 30791926
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30791926
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 30791926
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 29131260 Associate
★☆☆☆☆
Found in Text Mining only
Essential Tremor Tremor BEFREE 29326290
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma BEFREE 25936394
★☆☆☆☆
Found in Text Mining only
Glioblastoma Multiforme Glioblastoma BEFREE 25936394
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 30791926
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple Sclerosis BEFREE 29326290
★☆☆☆☆
Found in Text Mining only
Non-Small Cell Lung Carcinoma Lung carcinoma BEFREE 30791926
★☆☆☆☆
Found in Text Mining only