Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	256130
Gene name	Transmembrane protein 196
Gene symbol	TMEM196
Synonyms (NCBI Gene)	-
Chromosome	7
Chromosome location	7p21.1

144

Show/Hide all (144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT716806	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT716805	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT716804	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT716803	hsa-miR-630	HITS-CLIP	19536157
MIRT716802	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT716801	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT716800	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT527264	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT527263	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT527262	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT527261	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT527260	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT527259	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT527258	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT527257	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT527256	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT527255	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT527254	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT527253	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT527252	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT527251	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT527250	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT444889	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT444888	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT444887	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT444886	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444885	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444884	hsa-miR-6086	PAR-CLIP	22100165
MIRT444883	hsa-miR-4753-3p	PAR-CLIP	22100165
MIRT444882	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444881	hsa-miR-491-3p	PAR-CLIP	22100165
MIRT449357	hsa-miR-3662	PAR-CLIP	22100165
MIRT449355	hsa-miR-6750-3p	PAR-CLIP	22100165
MIRT444889	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT444888	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT444887	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT444886	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444885	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444884	hsa-miR-6086	PAR-CLIP	22100165
MIRT444883	hsa-miR-4753-3p	PAR-CLIP	22100165
MIRT444882	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444881	hsa-miR-491-3p	PAR-CLIP	22100165
MIRT716806	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT716805	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT716804	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT716803	hsa-miR-630	HITS-CLIP	19536157
MIRT716802	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT716801	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT716800	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT527264	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT527263	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT527262	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT527261	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT527260	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT527259	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT527258	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT527257	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT527256	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT527255	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT527254	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT527253	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT527252	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT527251	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT527250	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT444889	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT444888	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT444887	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT444886	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444885	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444884	hsa-miR-6086	PAR-CLIP	22100165
MIRT444883	hsa-miR-4753-3p	PAR-CLIP	22100165
MIRT444882	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444881	hsa-miR-491-3p	PAR-CLIP	22100165
MIRT449357	hsa-miR-3662	PAR-CLIP	22100165
MIRT449355	hsa-miR-6750-3p	PAR-CLIP	22100165
MIRT444889	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT444888	hsa-miR-329-5p	PAR-CLIP	22100165
MIRT444887	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT444886	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT444885	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT444884	hsa-miR-6086	PAR-CLIP	22100165
MIRT444883	hsa-miR-4753-3p	PAR-CLIP	22100165
MIRT444882	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444881	hsa-miR-491-3p	PAR-CLIP	22100165
MIRT1434898	hsa-miR-145	CLIP-seq
MIRT1434899	hsa-miR-181a	CLIP-seq
MIRT1434900	hsa-miR-181b	CLIP-seq
MIRT1434901	hsa-miR-181c	CLIP-seq
MIRT1434902	hsa-miR-181d	CLIP-seq
MIRT1434903	hsa-miR-19a	CLIP-seq
MIRT1434904	hsa-miR-19b	CLIP-seq
MIRT1434905	hsa-miR-2113	CLIP-seq
MIRT1434906	hsa-miR-3143	CLIP-seq
MIRT1434907	hsa-miR-329	CLIP-seq
MIRT1434908	hsa-miR-362-3p	CLIP-seq
MIRT1434909	hsa-miR-377	CLIP-seq
MIRT1434910	hsa-miR-3941	CLIP-seq
MIRT1434911	hsa-miR-4255	CLIP-seq
MIRT1434912	hsa-miR-4262	CLIP-seq
MIRT1434913	hsa-miR-433	CLIP-seq
MIRT1434914	hsa-miR-4639-3p	CLIP-seq
MIRT1434915	hsa-miR-4775	CLIP-seq
MIRT1434916	hsa-miR-4789-3p	CLIP-seq
MIRT1434917	hsa-miR-5096	CLIP-seq
MIRT1434918	hsa-miR-543	CLIP-seq
MIRT1434919	hsa-miR-548t	CLIP-seq
MIRT1434920	hsa-miR-580	CLIP-seq
MIRT1434921	hsa-miR-590-3p	CLIP-seq
MIRT1434922	hsa-miR-603	CLIP-seq
MIRT1434923	hsa-miR-885-5p	CLIP-seq
MIRT2130328	hsa-miR-3120-5p	CLIP-seq
MIRT2130329	hsa-miR-330-3p	CLIP-seq
MIRT2130330	hsa-miR-3942-3p	CLIP-seq
MIRT2130331	hsa-miR-4697-3p	CLIP-seq
MIRT2130332	hsa-miR-4795-3p	CLIP-seq
MIRT1434917	hsa-miR-5096	CLIP-seq
MIRT2130333	hsa-miR-511	CLIP-seq
MIRT2130334	hsa-miR-607	CLIP-seq
MIRT2351680	hsa-miR-144	CLIP-seq
MIRT2351681	hsa-miR-3171	CLIP-seq
MIRT2351682	hsa-miR-3174	CLIP-seq
MIRT2351683	hsa-miR-338-5p	CLIP-seq
MIRT2351684	hsa-miR-380	CLIP-seq
MIRT2351685	hsa-miR-3924	CLIP-seq
MIRT1434913	hsa-miR-433	CLIP-seq
MIRT2351686	hsa-miR-4659a-3p	CLIP-seq
MIRT2351687	hsa-miR-4659b-3p	CLIP-seq
MIRT2351688	hsa-miR-4693-3p	CLIP-seq
MIRT2351689	hsa-miR-4719	CLIP-seq
MIRT2351690	hsa-miR-4760-5p	CLIP-seq
MIRT2351691	hsa-miR-520d-5p	CLIP-seq
MIRT2351692	hsa-miR-524-5p	CLIP-seq
MIRT2351693	hsa-miR-616	CLIP-seq
MIRT2351694	hsa-miR-921	CLIP-seq
MIRT1434903	hsa-miR-19a	CLIP-seq
MIRT1434904	hsa-miR-19b	CLIP-seq
MIRT1434905	hsa-miR-2113	CLIP-seq
MIRT1434914	hsa-miR-4639-3p	CLIP-seq
MIRT2693466	hsa-miR-1279	CLIP-seq
MIRT2693467	hsa-miR-196a	CLIP-seq
MIRT2693468	hsa-miR-196b	CLIP-seq
MIRT2693469	hsa-miR-3927	CLIP-seq
MIRT2693470	hsa-miR-4650-3p	CLIP-seq
MIRT2693471	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IDA	36355209
GO:0005737	Component	Cytoplasm	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	26056045
GO:0016020	Component	Membrane	IEA
GO:0030308	Process	Negative regulation of cell growth	IDA	26056045
GO:0030336	Process	Negative regulation of cell migration	IDA	26056045, 36355209
GO:0043065	Process	Positive regulation of apoptotic process	IDA	26056045
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	ISS

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q5HYL7

Protein name

Transmembrane protein 196

Protein function

Acts as a tumor suppressor in lung cancer (PubMed:26056045, PubMed:36355209). Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis (PubMed:26056045, PubMed:36355209). Inhibits metastasis of lung

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expression is significantly decreased in lung cancer cells compared to normal lung tissue (at protein level). {ECO:0000269|PubMed:36355209}.

Sequence

MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHKPQLGDSSPVWSGVCFLLCG
ICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIG
IGGCTLSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEITDNMSNGGPQLIFNGRV

Sequence length

178

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	BEFREE	30694883	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	30694883	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26056045, 30536447	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	26056045	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26056045, 30536447	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30536447	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26056045, 30536447	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiration Disorders	Respiration Disorders	BEFREE	30694883	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Tract Diseases	Respiratory Tract Diseases	BEFREE	30694883	★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM196 (transmembrane protein 196)