TCP11L2 (t-complex 11 like 2)

Gene

• Entrez ID: 255394
• Gene name: T-complex 11 like 2
• Gene symbol: TCP11L2
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019114	hsa-miR-335-5p	Microarray	18185580
MIRT439476	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439476	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1416711	hsa-miR-3173-3p	CLIP-seq
MIRT1416712	hsa-miR-3613-5p	CLIP-seq
MIRT1416713	hsa-miR-4428	CLIP-seq
MIRT1416714	hsa-miR-4477b	CLIP-seq
MIRT1416715	hsa-miR-548ac	CLIP-seq
MIRT1416716	hsa-miR-548ae	CLIP-seq
MIRT1416717	hsa-miR-548aj	CLIP-seq
MIRT1416718	hsa-miR-548am	CLIP-seq
MIRT1416719	hsa-miR-548d-3p	CLIP-seq
MIRT1416720	hsa-miR-548x	CLIP-seq
MIRT1416721	hsa-miR-548z	CLIP-seq
MIRT2124960	hsa-miR-1290	CLIP-seq
MIRT2124961	hsa-miR-3167	CLIP-seq
MIRT2124962	hsa-miR-876-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0014812	Process	Muscle cell migration	ISS

Other IDs

• MIM: 619889
• HGNC: 28627
• e!Ensembl: ENSG00000166046

Protein

• UniProt ID: Q8N4U5
• Protein name: T-complex protein 11-like protein 2
• Protein function: Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05794	Tcp11	77 → 500	T-complex protein 11	Family

• Sequence:

  MPFNGEKQCVGEDQPSDSDSSRFSESMASLSDYECSRQSFASDSSSKSSSPASTSPPRVV
  TFDEVMATARNLSNLTLAHEIAVNENFQLKQEALPEKSLAGRVKHIVHQAFWDVLDSELN
  ADPPEFEHAIKLFEEIREILLSFLTPGGNRLRNQICEVLDTDLIRQQAEHSAVDIQGLAN
  YVISTMGKLCAPVRDNDIRELKATGNIVEVLRQIFHVLDLMQMDMANFTIMSLRPHLQRQ
  LVEYERTKFQEILEETPSALDQTTEWIKESVNEELFSLSESALTPGAENTSKPSLSPTLV
  LNNSYLKLLQWDYQKKELPETLMTDGARLQELTEKLNQLKIIACLSLITNNMVGAITGGL
  PELASRLTRISAVLLEGMNKETFNLKEVLNSIGIQTCVEVNKTLMERGLPTLNAEIQANL
  IGQFSSIEEEDNPIWSLIDKRIKLYMRRLLCLPSPQKCMPPMPGGLAVIQQELEALGSQY
  ANIVNLNKQVYGPFYANILRKLLFNEEAMGKVDASPPTN

• Sequence length: 519

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations