PLA2G4F (phospholipase A2 group IVF)

Gene

• Entrez ID: 255189
• Gene name: Phospholipase A2 group IVF
• Gene symbol: PLA2G4F
• Synonyms (NCBI Gene): PLA2G4FZ
• Chromosome: 15
• Chromosome location: 15q15.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048985	hsa-miR-92a-3p	CLASH	23622248
MIRT047586	hsa-miR-10a-5p	CLASH	23622248
MIRT047465	hsa-miR-10b-5p	CLASH	23622248
MIRT046020	hsa-miR-125b-5p	CLASH	23622248
MIRT045727	hsa-miR-125a-5p	CLASH	23622248
MIRT044179	hsa-miR-99b-5p	CLASH	23622248
MIRT043622	hsa-miR-326	CLASH	23622248
MIRT043457	hsa-miR-331-3p	CLASH	23622248
MIRT052654	hsa-miR-2116-3p	CLASH	23622248
MIRT1238789	hsa-miR-1207-5p	CLIP-seq
MIRT1238790	hsa-miR-1224-5p	CLIP-seq
MIRT1238791	hsa-miR-296-5p	CLIP-seq
MIRT1238792	hsa-miR-3921	CLIP-seq
MIRT1238793	hsa-miR-3939	CLIP-seq
MIRT1238794	hsa-miR-4270	CLIP-seq
MIRT1238795	hsa-miR-4441	CLIP-seq
MIRT1238796	hsa-miR-4649-3p	CLIP-seq
MIRT1238797	hsa-miR-4653-5p	CLIP-seq
MIRT1238798	hsa-miR-4736	CLIP-seq
MIRT1238799	hsa-miR-4751	CLIP-seq
MIRT1238800	hsa-miR-4763-3p	CLIP-seq
MIRT1238801	hsa-miR-555	CLIP-seq
MIRT1238802	hsa-miR-582-3p	CLIP-seq
MIRT1238803	hsa-miR-635	CLIP-seq
MIRT1238790	hsa-miR-1224-5p	CLIP-seq
MIRT1238791	hsa-miR-296-5p	CLIP-seq
MIRT1238792	hsa-miR-3921	CLIP-seq
MIRT1238796	hsa-miR-4649-3p	CLIP-seq
MIRT1238797	hsa-miR-4653-5p	CLIP-seq
MIRT1238799	hsa-miR-4751	CLIP-seq
MIRT1238803	hsa-miR-635	CLIP-seq
MIRT1238796	hsa-miR-4649-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001516	Process	Prostaglandin biosynthetic process	IEA
GO:0004620	Function	Phospholipase activity	IEA
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IEA
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006650	Process	Glycerophospholipid metabolic process	IEA
GO:0008970	Function	Phospholipase A1 activity	IEA
GO:0008970	Function	Phospholipase A1 activity	TAS
GO:0009395	Process	Phospholipid catabolic process	IEA
GO:0015908	Process	Fatty acid transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031982	Component	Vesicle	IBA
GO:0031982	Component	Vesicle	IEA
GO:0032587	Component	Ruffle membrane	IBA
GO:0032587	Component	Ruffle membrane	IEA
GO:0036148	Process	Phosphatidylglycerol acyl-chain remodeling	TAS
GO:0046475	Process	Glycerophospholipid catabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IBA
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IEA
GO:0050482	Process	Arachidonate secretion	IEA
GO:0071236	Process	Cellular response to antibiotic	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q68DD2
• Protein name: Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF)
• Protein function: Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attac
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	44 → 147	C2 domain	Domain
  PF18695	cPLA2_C2	182 → 304	Cytosolic phospholipases A2 C2-domain	Domain
  PF01735	PLA2_B	357 → 588	Lysophospholipase catalytic domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in myocardium (at protein level). {ECO:0000269|PubMed:29158256}.
• Sequence:

  MLWALWPRWLADKMLPLLGAVLLQKREKRGPLWRHWRRETYPYYDLQVKVLRATNIRGTD
  LLSKADCYVQLWLPTASPSPAQTRIVANCSDPEWNETFHYQIHGAVKNVLELTLYDKDIL
  GSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFVLEKSQVPASEVITNGVLVAH
  PCLRIQGTLRGDGTAPREEYGSRQLQLAVPGAYEKPQLLPLQPPTEPGLPPTFTFHVNPV
  LSSRLHVELMELLAAVQSGPSAELEAQTSKLGEGGILLSSLPLGQEEQCSVALGEGQEVA
  LSMKVEMSSGDLDLRLGFDLSDGEQEFLDRRKQVVSKALQQVLGLSEALDSGQVPVVAVL
  GSGGGTRAMSSLYGSLAGLQELGLLDTVTYLSGVSGSTWCISTLYRDPAWSQVALQGPIE
  RAQVHVCSSKMGALSTERLQYYTQELGVRERSGHSVSLIDLWGLLVEYLLYQEENPAKLS
  DQQEAVRQGQNPYPIYTSVNVRTNLSGEDFAEWCEFTPYEVGFPKYGAYVPTELFGSELF
  MGRLLQLQPEPRICYLQGMWGSAFATSLDEIFLKTAGSGLSFLEWYRGSVNITDDCQKPQ
  LHNPSRLRTRLLTPQGPFSQAVLDIFTSRFTSAQSFNFTRGLCLHKDYVAGREFVAWKDT
  HPDAFPNQLTPMRDCLYLVDGGFAINSPFPLALLPQRAVDLILSFDYSLEAPFEVLKMTE
  KYCLDRGIPFPSIEVGPEDMEEARECYLFAKAEDPRSPIVLHFPLVNRTFRTHLAPGVER
  QTAEEKAFGDFVINRPDTPYGMMNFTYEPQDFYRLVALSRYNVLNNVETLKCALQLALDR
  HQARERAGA

• Sequence length: 849

Pathways

KEGG:

Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
MAPK signaling pathway
Ras signaling pathway
Phospholipase D signaling pathway
Necroptosis
Vascular smooth muscle contraction
VEGF signaling pathway
Platelet activation
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
Serotonergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Ovarian steroidogenesis
Oxytocin signaling pathway
Choline metabolism in cancer

Reactome:

Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHAGAS CARDIOMYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Degenerative polyarthritis	Arthritis	BEFREE	29968759		★☆☆☆☆ Found in Text Mining only
Synovitis	Synovitis	Pubtator	29968759	Associate	★☆☆☆☆ Found in Text Mining only