Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	254827
Gene name	N-acetylated alpha-linked acidic dipeptidase like 2
Gene symbol	NAALADL2
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3q26.31

127

Show/Hide all (127)

miRTarBase ID	miRNA	Experiments
MIRT1172342	hsa-miR-1	CLIP-seq
MIRT1172343	hsa-miR-206	CLIP-seq
MIRT1172344	hsa-miR-3119	CLIP-seq
MIRT1172345	hsa-miR-3125	CLIP-seq
MIRT1172346	hsa-miR-3152-3p	CLIP-seq
MIRT1172347	hsa-miR-3161	CLIP-seq
MIRT1172348	hsa-miR-34b	CLIP-seq
MIRT1172349	hsa-miR-3653	CLIP-seq
MIRT1172350	hsa-miR-3658	CLIP-seq
MIRT1172351	hsa-miR-3673	CLIP-seq
MIRT1172352	hsa-miR-3682-3p	CLIP-seq
MIRT1172353	hsa-miR-375	CLIP-seq
MIRT1172354	hsa-miR-3916	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT1172356	hsa-miR-3936	CLIP-seq
MIRT1172357	hsa-miR-4273	CLIP-seq
MIRT1172358	hsa-miR-4477a	CLIP-seq
MIRT1172359	hsa-miR-4502	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT1172361	hsa-miR-4677-5p	CLIP-seq
MIRT1172362	hsa-miR-4695-3p	CLIP-seq
MIRT1172363	hsa-miR-4709-3p	CLIP-seq
MIRT1172364	hsa-miR-4714-3p	CLIP-seq
MIRT1172365	hsa-miR-4762-3p	CLIP-seq
MIRT1172366	hsa-miR-4799-5p	CLIP-seq
MIRT1172367	hsa-miR-582-3p	CLIP-seq
MIRT1172368	hsa-miR-613	CLIP-seq
MIRT2049825	hsa-miR-1275	CLIP-seq
MIRT2049826	hsa-miR-196a	CLIP-seq
MIRT2049827	hsa-miR-196b	CLIP-seq
MIRT2049828	hsa-miR-2909	CLIP-seq
MIRT2049829	hsa-miR-296-3p	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT2049830	hsa-miR-3927	CLIP-seq
MIRT2049831	hsa-miR-4260	CLIP-seq
MIRT2049832	hsa-miR-4525	CLIP-seq
MIRT2049833	hsa-miR-4650-3p	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT2049834	hsa-miR-4665-5p	CLIP-seq
MIRT2049835	hsa-miR-4723-5p	CLIP-seq
MIRT2049836	hsa-miR-590-3p	CLIP-seq
MIRT2049837	hsa-miR-607	CLIP-seq
MIRT2049838	hsa-miR-625	CLIP-seq
MIRT1172342	hsa-miR-1	CLIP-seq
MIRT2049825	hsa-miR-1275	CLIP-seq
MIRT2278783	hsa-miR-1284	CLIP-seq
MIRT2278784	hsa-miR-1305	CLIP-seq
MIRT2278785	hsa-miR-139-5p	CLIP-seq
MIRT2278786	hsa-miR-190	CLIP-seq
MIRT2278787	hsa-miR-190b	CLIP-seq
MIRT2049826	hsa-miR-196a	CLIP-seq
MIRT2049827	hsa-miR-196b	CLIP-seq
MIRT2278788	hsa-miR-1976	CLIP-seq
MIRT1172343	hsa-miR-206	CLIP-seq
MIRT2278789	hsa-miR-2110	CLIP-seq
MIRT2278790	hsa-miR-2116	CLIP-seq
MIRT2278791	hsa-miR-2467-5p	CLIP-seq
MIRT2278792	hsa-miR-2681	CLIP-seq
MIRT2049828	hsa-miR-2909	CLIP-seq
MIRT2049829	hsa-miR-296-3p	CLIP-seq
MIRT2278793	hsa-miR-3120-3p	CLIP-seq
MIRT2278794	hsa-miR-3124-3p	CLIP-seq
MIRT2278795	hsa-miR-3150a-3p	CLIP-seq
MIRT2278796	hsa-miR-3175	CLIP-seq
MIRT2278797	hsa-miR-3188	CLIP-seq
MIRT2278798	hsa-miR-329	CLIP-seq
MIRT2278799	hsa-miR-337-3p	CLIP-seq
MIRT1172348	hsa-miR-34b	CLIP-seq
MIRT2278800	hsa-miR-3613-3p	CLIP-seq
MIRT2278801	hsa-miR-3614-3p	CLIP-seq
MIRT2278802	hsa-miR-362-3p	CLIP-seq
MIRT2278803	hsa-miR-3664-5p	CLIP-seq
MIRT2278804	hsa-miR-3671	CLIP-seq
MIRT1172351	hsa-miR-3673	CLIP-seq
MIRT2278805	hsa-miR-3684	CLIP-seq
MIRT2278806	hsa-miR-3685	CLIP-seq
MIRT2278807	hsa-miR-3690	CLIP-seq
MIRT2278808	hsa-miR-384	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT2049830	hsa-miR-3927	CLIP-seq
MIRT2278809	hsa-miR-3941	CLIP-seq
MIRT2278810	hsa-miR-3975	CLIP-seq
MIRT2278811	hsa-miR-421	CLIP-seq
MIRT2278812	hsa-miR-4254	CLIP-seq
MIRT2049831	hsa-miR-4260	CLIP-seq
MIRT2278813	hsa-miR-4264	CLIP-seq
MIRT2278814	hsa-miR-4271	CLIP-seq
MIRT2278815	hsa-miR-4279	CLIP-seq
MIRT2278816	hsa-miR-4307	CLIP-seq
MIRT2278817	hsa-miR-4328	CLIP-seq
MIRT2278818	hsa-miR-4452	CLIP-seq
MIRT2278819	hsa-miR-4470	CLIP-seq
MIRT2278820	hsa-miR-4639-3p	CLIP-seq
MIRT2278821	hsa-miR-4649-3p	CLIP-seq
MIRT2049833	hsa-miR-4650-3p	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT2049834	hsa-miR-4665-5p	CLIP-seq
MIRT2278822	hsa-miR-4668-5p	CLIP-seq
MIRT1172361	hsa-miR-4677-5p	CLIP-seq
MIRT2278823	hsa-miR-4704-3p	CLIP-seq
MIRT2278824	hsa-miR-4705	CLIP-seq
MIRT2278825	hsa-miR-4714-5p	CLIP-seq
MIRT2278826	hsa-miR-4725-3p	CLIP-seq
MIRT2278827	hsa-miR-4780	CLIP-seq
MIRT2278828	hsa-miR-4789-5p	CLIP-seq
MIRT2278829	hsa-miR-485-5p	CLIP-seq
MIRT2278830	hsa-miR-548p	CLIP-seq
MIRT2278831	hsa-miR-579	CLIP-seq
MIRT2278832	hsa-miR-582-5p	CLIP-seq
MIRT2049836	hsa-miR-590-3p	CLIP-seq
MIRT2278833	hsa-miR-603	CLIP-seq
MIRT2049837	hsa-miR-607	CLIP-seq
MIRT1172368	hsa-miR-613	CLIP-seq
MIRT2278834	hsa-miR-623	CLIP-seq
MIRT2278835	hsa-miR-668	CLIP-seq
MIRT2278836	hsa-miR-939	CLIP-seq
MIRT2278811	hsa-miR-421	CLIP-seq
MIRT2278819	hsa-miR-4470	CLIP-seq
MIRT2431465	hsa-miR-450b-5p	CLIP-seq
MIRT2431466	hsa-miR-518a-5p	CLIP-seq
MIRT2431467	hsa-miR-527	CLIP-seq
MIRT2454811	hsa-miR-1279	CLIP-seq
MIRT2454812	hsa-miR-203	CLIP-seq
MIRT2454813	hsa-miR-3612	CLIP-seq
MIRT2454814	hsa-miR-4443	CLIP-seq
MIRT2278818	hsa-miR-4452	CLIP-seq
MIRT2454815	hsa-miR-650	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005654	Component	Nucleoplasm	IDA
GO:0009617	Process	Response to bacterium	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
608806	23219	ENSG00000177694

Q58DX5

Protein name

Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2)

Protein function

May be catalytically inactive.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04389	Peptidase_M28	431 → 622	Peptidase family M28	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.

Sequence

MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESG
FDQFQLDGAENQNLGHSETIDLNLDSIQPATSPKGRFQRLQEESDYITHYTRSAPKSNRC
NFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCF
HPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQI
ALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQV
QTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSK
VKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLE
GPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQN
NLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFL
VKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYF
KAGLDVFKSVLDGKN

Sequence length

795

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (33)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental cataract	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MUCOCUTANEOUS LYMPH NODE SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NAALADL2-related disorder	Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROLIFERATIVE DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	26398136	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Behcet Syndrome	Behcet Syndrome	BEFREE	28045058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	28045058	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28145423	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	28145423		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cornelia De Lange Syndrome	Cornelia De Lange Syndrome	BEFREE	15168106, 16160854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	GWASCAT_DG	28333195		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Impaired cognition	Impaired Cognition	GWASCAT_DG	31201950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	GWASCAT_DG	30796134		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	28145423		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24240687		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24240687		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	GWASCAT_DG	19132087		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	GWASDB_DG	19132087		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	Pubtator	19132087	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ovarian neoplasm	Ovarian neoplasm	BEFREE	28145423		★★★★★ ★☆☆☆☆ Found in Text Mining only
Proliferative diabetic retinopathy	Proliferative Diabetic Retinopathy	GWASCAT_DG	30487263		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	BEFREE	24240687		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	GWASCAT_DG	25939597		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	24240687		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25939597, 27409348, 32796921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	37232821	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	25939597	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2)