SLC41A1 (solute carrier family 41 member 1)

Gene

• Entrez ID: 254428
• Gene name: Solute carrier family 41 member 1
• Gene symbol: SLC41A1
• Synonyms (NCBI Gene): MgtE, NPHPL2
• Chromosome: 1
• Chromosome location: 1q32.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT653521	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT061952	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653520	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653519	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT653518	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653517	hsa-miR-5696	HITS-CLIP	23824327
MIRT653516	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT653515	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT653514	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT653513	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT653512	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT439596	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT439596	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT653521	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT061952	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653520	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653519	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT653518	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653517	hsa-miR-5696	HITS-CLIP	23824327
MIRT653516	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT653515	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT653514	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT653513	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT653512	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1363979	hsa-miR-1	CLIP-seq
MIRT1363980	hsa-miR-101	CLIP-seq
MIRT1363981	hsa-miR-1251	CLIP-seq
MIRT1363982	hsa-miR-1254	CLIP-seq
MIRT1363983	hsa-miR-1262	CLIP-seq
MIRT1363984	hsa-miR-1263	CLIP-seq
MIRT1363985	hsa-miR-1292	CLIP-seq
MIRT1363986	hsa-miR-1294	CLIP-seq
MIRT1363987	hsa-miR-129-5p	CLIP-seq
MIRT1363988	hsa-miR-1299	CLIP-seq
MIRT1363989	hsa-miR-1304	CLIP-seq
MIRT1363990	hsa-miR-183	CLIP-seq
MIRT1363991	hsa-miR-198	CLIP-seq
MIRT1363992	hsa-miR-200b	CLIP-seq
MIRT1363993	hsa-miR-200c	CLIP-seq
MIRT1363994	hsa-miR-204	CLIP-seq
MIRT1363995	hsa-miR-2052	CLIP-seq
MIRT1363996	hsa-miR-206	CLIP-seq
MIRT1363997	hsa-miR-211	CLIP-seq
MIRT1363998	hsa-miR-2467-3p	CLIP-seq
MIRT1363999	hsa-miR-2909	CLIP-seq
MIRT1364000	hsa-miR-3065-3p	CLIP-seq
MIRT1364001	hsa-miR-31	CLIP-seq
MIRT1364002	hsa-miR-3116	CLIP-seq
MIRT1364003	hsa-miR-3125	CLIP-seq
MIRT1364004	hsa-miR-3162-5p	CLIP-seq
MIRT1364005	hsa-miR-3173-3p	CLIP-seq
MIRT1364006	hsa-miR-3180	CLIP-seq
MIRT1364007	hsa-miR-3180-3p	CLIP-seq
MIRT1364008	hsa-miR-3180-5p	CLIP-seq
MIRT1364009	hsa-miR-3196	CLIP-seq
MIRT1364010	hsa-miR-3202	CLIP-seq
MIRT1364011	hsa-miR-361-5p	CLIP-seq
MIRT1364012	hsa-miR-3616-3p	CLIP-seq
MIRT1364013	hsa-miR-3622a-5p	CLIP-seq
MIRT1364014	hsa-miR-3622b-5p	CLIP-seq
MIRT1364015	hsa-miR-3664-3p	CLIP-seq
MIRT1364016	hsa-miR-3689d	CLIP-seq
MIRT1364017	hsa-miR-382	CLIP-seq
MIRT1364018	hsa-miR-3909	CLIP-seq
MIRT1364019	hsa-miR-3915	CLIP-seq
MIRT1364020	hsa-miR-3916	CLIP-seq
MIRT1364021	hsa-miR-3925-5p	CLIP-seq
MIRT1364022	hsa-miR-3928	CLIP-seq
MIRT1364023	hsa-miR-3978	CLIP-seq
MIRT1364024	hsa-miR-4254	CLIP-seq
MIRT1364025	hsa-miR-4278	CLIP-seq
MIRT1364026	hsa-miR-429	CLIP-seq
MIRT1364027	hsa-miR-4316	CLIP-seq
MIRT1364028	hsa-miR-4423-3p	CLIP-seq
MIRT1364029	hsa-miR-4428	CLIP-seq
MIRT1364030	hsa-miR-4433	CLIP-seq
MIRT1364031	hsa-miR-4434	CLIP-seq
MIRT1364032	hsa-miR-4459	CLIP-seq
MIRT1364033	hsa-miR-4471	CLIP-seq
MIRT1364034	hsa-miR-4476	CLIP-seq
MIRT1364035	hsa-miR-4481	CLIP-seq
MIRT1364036	hsa-miR-4496	CLIP-seq
MIRT1364037	hsa-miR-450b-3p	CLIP-seq
MIRT1364038	hsa-miR-4516	CLIP-seq
MIRT1364039	hsa-miR-4531	CLIP-seq
MIRT1364040	hsa-miR-4668-5p	CLIP-seq
MIRT1364041	hsa-miR-4688	CLIP-seq
MIRT1364042	hsa-miR-4695-5p	CLIP-seq
MIRT1364043	hsa-miR-4701-3p	CLIP-seq
MIRT1364044	hsa-miR-4710	CLIP-seq
MIRT1364045	hsa-miR-4713-3p	CLIP-seq
MIRT1364046	hsa-miR-4719	CLIP-seq
MIRT1364047	hsa-miR-4727-5p	CLIP-seq
MIRT1364048	hsa-miR-4745-5p	CLIP-seq
MIRT1364049	hsa-miR-4747-5p	CLIP-seq
MIRT1364050	hsa-miR-4761-5p	CLIP-seq
MIRT1364051	hsa-miR-4768-3p	CLIP-seq
MIRT1364052	hsa-miR-4768-5p	CLIP-seq
MIRT1364053	hsa-miR-4769-3p	CLIP-seq
MIRT1364054	hsa-miR-4773	CLIP-seq
MIRT1364055	hsa-miR-4775	CLIP-seq
MIRT1364056	hsa-miR-4786-3p	CLIP-seq
MIRT1364057	hsa-miR-4789-3p	CLIP-seq
MIRT1364058	hsa-miR-4797-5p	CLIP-seq
MIRT1364059	hsa-miR-486-3p	CLIP-seq
MIRT1364060	hsa-miR-486-5p	CLIP-seq
MIRT1364061	hsa-miR-490-3p	CLIP-seq
MIRT1364062	hsa-miR-513a-5p	CLIP-seq
MIRT1364063	hsa-miR-520a-5p	CLIP-seq
MIRT1364064	hsa-miR-525-5p	CLIP-seq
MIRT1364065	hsa-miR-542-5p	CLIP-seq
MIRT1364066	hsa-miR-548a-3p	CLIP-seq
MIRT1364067	hsa-miR-548e	CLIP-seq
MIRT1364068	hsa-miR-548f	CLIP-seq
MIRT1364069	hsa-miR-563	CLIP-seq
MIRT1364070	hsa-miR-571	CLIP-seq
MIRT1364071	hsa-miR-583	CLIP-seq
MIRT1364072	hsa-miR-590-3p	CLIP-seq
MIRT1364073	hsa-miR-613	CLIP-seq
MIRT1364074	hsa-miR-619	CLIP-seq
MIRT1364075	hsa-miR-623	CLIP-seq
MIRT1364076	hsa-miR-636	CLIP-seq
MIRT1364077	hsa-miR-638	CLIP-seq
MIRT1364078	hsa-miR-649	CLIP-seq
MIRT1364079	hsa-miR-651	CLIP-seq
MIRT1364080	hsa-miR-760	CLIP-seq
MIRT1364081	hsa-miR-765	CLIP-seq
MIRT1364082	hsa-miR-769-3p	CLIP-seq
MIRT1364083	hsa-miR-875-3p	CLIP-seq
MIRT1364084	hsa-miR-892b	CLIP-seq
MIRT1364085	hsa-miR-935	CLIP-seq
MIRT1364024	hsa-miR-4254	CLIP-seq
MIRT1363980	hsa-miR-101	CLIP-seq
MIRT2108039	hsa-miR-1178	CLIP-seq
MIRT2108040	hsa-miR-1184	CLIP-seq
MIRT2108041	hsa-miR-1205	CLIP-seq
MIRT2108042	hsa-miR-1231	CLIP-seq
MIRT2108043	hsa-miR-1266	CLIP-seq
MIRT2108044	hsa-miR-1273g	CLIP-seq
MIRT2108045	hsa-miR-1286	CLIP-seq
MIRT1363988	hsa-miR-1299	CLIP-seq
MIRT2108046	hsa-miR-1321	CLIP-seq
MIRT2108047	hsa-miR-134	CLIP-seq
MIRT2108048	hsa-miR-137	CLIP-seq
MIRT2108049	hsa-miR-143	CLIP-seq
MIRT2108050	hsa-miR-186	CLIP-seq
MIRT2108051	hsa-miR-18a	CLIP-seq
MIRT2108052	hsa-miR-18b	CLIP-seq
MIRT2108053	hsa-miR-2355-3p	CLIP-seq
MIRT1363998	hsa-miR-2467-3p	CLIP-seq
MIRT2108054	hsa-miR-296-5p	CLIP-seq
MIRT2108055	hsa-miR-3118	CLIP-seq
MIRT2108056	hsa-miR-3127-5p	CLIP-seq
MIRT2108057	hsa-miR-3135b	CLIP-seq
MIRT2108058	hsa-miR-3158-5p	CLIP-seq
MIRT2108059	hsa-miR-3179	CLIP-seq
MIRT1364008	hsa-miR-3180-5p	CLIP-seq
MIRT1364010	hsa-miR-3202	CLIP-seq
MIRT2108060	hsa-miR-323b-5p	CLIP-seq
MIRT2108061	hsa-miR-346	CLIP-seq
MIRT1364013	hsa-miR-3622a-5p	CLIP-seq
MIRT2108062	hsa-miR-3646	CLIP-seq
MIRT2108063	hsa-miR-3652	CLIP-seq
MIRT2108064	hsa-miR-3670	CLIP-seq
MIRT1364016	hsa-miR-3689d	CLIP-seq
MIRT2108065	hsa-miR-3908	CLIP-seq
MIRT1364018	hsa-miR-3909	CLIP-seq
MIRT1364019	hsa-miR-3915	CLIP-seq
MIRT2108066	hsa-miR-3918	CLIP-seq
MIRT2108067	hsa-miR-3926	CLIP-seq
MIRT1364022	hsa-miR-3928	CLIP-seq
MIRT2108068	hsa-miR-3942-3p	CLIP-seq
MIRT1364023	hsa-miR-3978	CLIP-seq
MIRT2108069	hsa-miR-4288	CLIP-seq
MIRT2108070	hsa-miR-4419a	CLIP-seq
MIRT1364028	hsa-miR-4423-3p	CLIP-seq
MIRT1364029	hsa-miR-4428	CLIP-seq
MIRT2108071	hsa-miR-4430	CLIP-seq
MIRT1364034	hsa-miR-4476	CLIP-seq
MIRT2108072	hsa-miR-4505	CLIP-seq
MIRT2108073	hsa-miR-4510	CLIP-seq
MIRT2108074	hsa-miR-4518	CLIP-seq
MIRT2108075	hsa-miR-4639-5p	CLIP-seq
MIRT2108076	hsa-miR-4649-5p	CLIP-seq
MIRT2108077	hsa-miR-4650-3p	CLIP-seq
MIRT2108078	hsa-miR-4651	CLIP-seq
MIRT2108079	hsa-miR-4714-3p	CLIP-seq
MIRT2108080	hsa-miR-4722-5p	CLIP-seq
MIRT2108081	hsa-miR-4735-3p	CLIP-seq
MIRT2108082	hsa-miR-4739	CLIP-seq
MIRT2108083	hsa-miR-4754	CLIP-seq
MIRT2108084	hsa-miR-4756-3p	CLIP-seq
MIRT2108085	hsa-miR-4756-5p	CLIP-seq
MIRT1364051	hsa-miR-4768-3p	CLIP-seq
MIRT2108086	hsa-miR-4770	CLIP-seq
MIRT1364057	hsa-miR-4789-3p	CLIP-seq
MIRT2108087	hsa-miR-485-5p	CLIP-seq
MIRT1364059	hsa-miR-486-3p	CLIP-seq
MIRT2108088	hsa-miR-510	CLIP-seq
MIRT1364063	hsa-miR-520a-5p	CLIP-seq
MIRT1364064	hsa-miR-525-5p	CLIP-seq
MIRT2108089	hsa-miR-548s	CLIP-seq
MIRT2108090	hsa-miR-579	CLIP-seq
MIRT1364071	hsa-miR-583	CLIP-seq
MIRT2108091	hsa-miR-591	CLIP-seq
MIRT2108092	hsa-miR-608	CLIP-seq
MIRT2108093	hsa-miR-632	CLIP-seq
MIRT2108094	hsa-miR-676	CLIP-seq
MIRT1364081	hsa-miR-765	CLIP-seq
MIRT1364083	hsa-miR-875-3p	CLIP-seq
MIRT1363980	hsa-miR-101	CLIP-seq
MIRT2108039	hsa-miR-1178	CLIP-seq
MIRT2331852	hsa-miR-139-5p	CLIP-seq
MIRT2331853	hsa-miR-1910	CLIP-seq
MIRT1364013	hsa-miR-3622a-5p	CLIP-seq
MIRT1364028	hsa-miR-4423-3p	CLIP-seq
MIRT2331854	hsa-miR-455-3p	CLIP-seq
MIRT2108078	hsa-miR-4651	CLIP-seq
MIRT1364057	hsa-miR-4789-3p	CLIP-seq
MIRT2108088	hsa-miR-510	CLIP-seq
MIRT2108092	hsa-miR-608	CLIP-seq
MIRT2331855	hsa-miR-661	CLIP-seq
MIRT1364081	hsa-miR-765	CLIP-seq
MIRT2331856	hsa-miR-767-3p	CLIP-seq
MIRT1364013	hsa-miR-3622a-5p	CLIP-seq
MIRT1364024	hsa-miR-4254	CLIP-seq
MIRT1364028	hsa-miR-4423-3p	CLIP-seq
MIRT1364057	hsa-miR-4789-3p	CLIP-seq
MIRT1363980	hsa-miR-101	CLIP-seq
MIRT2108039	hsa-miR-1178	CLIP-seq
MIRT2108040	hsa-miR-1184	CLIP-seq
MIRT2108041	hsa-miR-1205	CLIP-seq
MIRT2108042	hsa-miR-1231	CLIP-seq
MIRT2626328	hsa-miR-1273f	CLIP-seq
MIRT2108045	hsa-miR-1286	CLIP-seq
MIRT2626329	hsa-miR-1303	CLIP-seq
MIRT2626330	hsa-miR-1323	CLIP-seq
MIRT2108048	hsa-miR-137	CLIP-seq
MIRT2108049	hsa-miR-143	CLIP-seq
MIRT2108050	hsa-miR-186	CLIP-seq
MIRT2626331	hsa-miR-196a	CLIP-seq
MIRT2626332	hsa-miR-196b	CLIP-seq
MIRT2626333	hsa-miR-2110	CLIP-seq
MIRT2626334	hsa-miR-216a	CLIP-seq
MIRT2626335	hsa-miR-216b	CLIP-seq
MIRT1364001	hsa-miR-31	CLIP-seq
MIRT2626336	hsa-miR-3128	CLIP-seq
MIRT2108058	hsa-miR-3158-5p	CLIP-seq
MIRT2626337	hsa-miR-326	CLIP-seq
MIRT2626338	hsa-miR-330-5p	CLIP-seq
MIRT2108061	hsa-miR-346	CLIP-seq
MIRT1364013	hsa-miR-3622a-5p	CLIP-seq
MIRT2108062	hsa-miR-3646	CLIP-seq
MIRT2108064	hsa-miR-3670	CLIP-seq
MIRT2626339	hsa-miR-371-5p	CLIP-seq
MIRT2626340	hsa-miR-371b-5p	CLIP-seq
MIRT2108068	hsa-miR-3942-3p	CLIP-seq
MIRT1364024	hsa-miR-4254	CLIP-seq
MIRT2626341	hsa-miR-4271	CLIP-seq
MIRT2108069	hsa-miR-4288	CLIP-seq
MIRT1364028	hsa-miR-4423-3p	CLIP-seq
MIRT2626342	hsa-miR-4473	CLIP-seq
MIRT2626343	hsa-miR-448	CLIP-seq
MIRT1364036	hsa-miR-4496	CLIP-seq
MIRT2108075	hsa-miR-4639-5p	CLIP-seq
MIRT2626344	hsa-miR-4667-5p	CLIP-seq
MIRT1364041	hsa-miR-4688	CLIP-seq
MIRT2626345	hsa-miR-4700-5p	CLIP-seq
MIRT2626346	hsa-miR-4708-5p	CLIP-seq
MIRT2626347	hsa-miR-4717-3p	CLIP-seq
MIRT2108080	hsa-miR-4722-5p	CLIP-seq
MIRT2626348	hsa-miR-4725-3p	CLIP-seq
MIRT2626349	hsa-miR-4725-5p	CLIP-seq
MIRT1364047	hsa-miR-4727-5p	CLIP-seq
MIRT1364049	hsa-miR-4747-5p	CLIP-seq
MIRT2108083	hsa-miR-4754	CLIP-seq
MIRT1364051	hsa-miR-4768-3p	CLIP-seq
MIRT1364052	hsa-miR-4768-5p	CLIP-seq
MIRT1364053	hsa-miR-4769-3p	CLIP-seq
MIRT2108086	hsa-miR-4770	CLIP-seq
MIRT1364057	hsa-miR-4789-3p	CLIP-seq
MIRT2108087	hsa-miR-485-5p	CLIP-seq
MIRT1364061	hsa-miR-490-3p	CLIP-seq
MIRT2626350	hsa-miR-504	CLIP-seq
MIRT2626351	hsa-miR-512-3p	CLIP-seq
MIRT2626352	hsa-miR-520f	CLIP-seq
MIRT2626353	hsa-miR-548o	CLIP-seq
MIRT2108091	hsa-miR-591	CLIP-seq
MIRT2108093	hsa-miR-632	CLIP-seq
MIRT2626354	hsa-miR-637	CLIP-seq
MIRT2626355	hsa-miR-658	CLIP-seq
MIRT1363980	hsa-miR-101	CLIP-seq
MIRT2108039	hsa-miR-1178	CLIP-seq
MIRT2108040	hsa-miR-1184	CLIP-seq
MIRT2108041	hsa-miR-1205	CLIP-seq
MIRT2108042	hsa-miR-1231	CLIP-seq
MIRT2108045	hsa-miR-1286	CLIP-seq
MIRT2626329	hsa-miR-1303	CLIP-seq
MIRT2626330	hsa-miR-1323	CLIP-seq
MIRT2108048	hsa-miR-137	CLIP-seq
MIRT2108050	hsa-miR-186	CLIP-seq
MIRT2626331	hsa-miR-196a	CLIP-seq
MIRT2626332	hsa-miR-196b	CLIP-seq
MIRT2626333	hsa-miR-2110	CLIP-seq
MIRT2626334	hsa-miR-216a	CLIP-seq
MIRT2626335	hsa-miR-216b	CLIP-seq
MIRT1364001	hsa-miR-31	CLIP-seq
MIRT2626336	hsa-miR-3128	CLIP-seq
MIRT2108058	hsa-miR-3158-5p	CLIP-seq
MIRT2626337	hsa-miR-326	CLIP-seq
MIRT2626338	hsa-miR-330-5p	CLIP-seq
MIRT2108061	hsa-miR-346	CLIP-seq
MIRT1364013	hsa-miR-3622a-5p	CLIP-seq
MIRT2108062	hsa-miR-3646	CLIP-seq
MIRT2108064	hsa-miR-3670	CLIP-seq
MIRT2626339	hsa-miR-371-5p	CLIP-seq
MIRT2626340	hsa-miR-371b-5p	CLIP-seq
MIRT2108068	hsa-miR-3942-3p	CLIP-seq
MIRT1364024	hsa-miR-4254	CLIP-seq
MIRT2626341	hsa-miR-4271	CLIP-seq
MIRT2108069	hsa-miR-4288	CLIP-seq
MIRT1364028	hsa-miR-4423-3p	CLIP-seq
MIRT2626342	hsa-miR-4473	CLIP-seq
MIRT2626343	hsa-miR-448	CLIP-seq
MIRT1364036	hsa-miR-4496	CLIP-seq
MIRT2108075	hsa-miR-4639-5p	CLIP-seq
MIRT2626344	hsa-miR-4667-5p	CLIP-seq
MIRT2626345	hsa-miR-4700-5p	CLIP-seq
MIRT2108080	hsa-miR-4722-5p	CLIP-seq
MIRT2626348	hsa-miR-4725-3p	CLIP-seq
MIRT2626349	hsa-miR-4725-5p	CLIP-seq
MIRT1364047	hsa-miR-4727-5p	CLIP-seq
MIRT1364049	hsa-miR-4747-5p	CLIP-seq
MIRT2108083	hsa-miR-4754	CLIP-seq
MIRT1364051	hsa-miR-4768-3p	CLIP-seq
MIRT1364052	hsa-miR-4768-5p	CLIP-seq
MIRT1364053	hsa-miR-4769-3p	CLIP-seq
MIRT1364057	hsa-miR-4789-3p	CLIP-seq
MIRT2108087	hsa-miR-485-5p	CLIP-seq
MIRT1364061	hsa-miR-490-3p	CLIP-seq
MIRT2626350	hsa-miR-504	CLIP-seq
MIRT2626351	hsa-miR-512-3p	CLIP-seq
MIRT2626352	hsa-miR-520f	CLIP-seq
MIRT2626353	hsa-miR-548o	CLIP-seq
MIRT2108091	hsa-miR-591	CLIP-seq
MIRT2108093	hsa-miR-632	CLIP-seq
MIRT2626354	hsa-miR-637	CLIP-seq
MIRT2626355	hsa-miR-658	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18367447, 22031603, 23976986
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0008324	Function	Monoatomic cation transmembrane transporter activity	IEA
GO:0010961	Process	Intracellular magnesium ion homeostasis	IMP	22031603
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IDA	18367447
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IEA
GO:0015095	Function	Magnesium ion transmembrane transporter activity	TAS
GO:0015693	Process	Magnesium ion transport	IDA	18367447, 23661805, 23976986
GO:0015693	Process	Magnesium ion transport	IMP	22031603
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	23661805
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IDA	23661805, 23976986
GO:0022857	Function	Transmembrane transporter activity	IMP	22031603
GO:0022890	Function	Inorganic cation transmembrane transporter activity	IEA
GO:0022890	Function	Inorganic cation transmembrane transporter activity	ISS
GO:0030001	Process	Metal ion transport	IEA
GO:0030001	Process	Metal ion transport	ISS
GO:0032991	Component	Protein-containing complex	IDA	18367447
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0061768	Function	Magnesium:sodium antiporter activity	IMP	22031603, 23661805, 23976986
GO:0071286	Process	Cellular response to magnesium ion	IEA
GO:0071286	Process	Cellular response to magnesium ion	IGI	21696366
GO:0071286	Process	Cellular response to magnesium ion	ISS
GO:1903830	Process	Magnesium ion transmembrane transport	IDA	18367447
GO:1903830	Process	Magnesium ion transmembrane transport	IEA
GO:1903830	Process	Magnesium ion transmembrane transport	ISS

Other IDs

• MIM: 610801
• HGNC: 19429
• e!Ensembl: ENSG00000133065

Protein

• UniProt ID: Q8IVJ1
• Protein name: Solute carrier family 41 member 1
• Protein function: Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01769	MgtE	139 → 273	Divalent cation transporter	Family
  PF01769	MgtE	353 → 497	Divalent cation transporter	Family

• Tissue specificity: TISSUE SPECIFICITY: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen. In the kidney, it is expressed
• Sequence:

  MSSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDGAGVEVVIESRANAKGV
  REEDALLENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVL
  DIVQHWEVFQKVTEVFILVPALLGLKGNLEMTLASRLSTAANIGHMDTPKELWRMITGNM
  ALIQVQATVVGFLASIAAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVI
  IGSRKIGINPDNVATPIAASLGDLITLALLSGISWGLYLELNHWRYIYPLVCAFFVALLP
  VWVVLARRSPATREVLYSGWEPVIIAMAISSVGGLILDKTVSDPNFAGMAVFTPVINGVG
  GNLVAVQASRISTFLHMNGMPGENSEQAPRRCPSPCTTFFSPDVNSRSARVLFLLVVPGH
  LVFLYTISCMQGGHTTLTLIFIIFYMTAALLQVLILLYIADWMVHWMWGRGLDPDNFSIP
  YLTALGDLLGTGLLALSFHVLWLIGDRDTDVGD

• Sequence length: 513

Pathways

Reactome:

Metal ion SLC transporters

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Nephronophthisis-like nephropathy 2	Pathogenic	rs2102504055	RCV001554331	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
KIDNEY DISEASES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY DISORDER	—	ClinGen, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHRONOPHTHISIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	35163527	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	39628683	Stimulate	★☆☆☆☆ Found in Text Mining only
Ciliopathies	Ciliopathies	BEFREE	23661805		★☆☆☆☆ Found in Text Mining only
Cystic kidney	Cystic Kidney Disease	BEFREE	23661805		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	25733456	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	25733456		★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	22031603	Associate	★☆☆☆☆ Found in Text Mining only
Magnesium Deficiency	Magnesium Deficiency	BEFREE	15713785		★☆☆☆☆ Found in Text Mining only
Magnesium Deficiency	Magnesium Deficiency	LHGDN	15713785		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31076559		★☆☆☆☆ Found in Text Mining only
Nephronophthisis	Nephronophthisis	BEFREE	23661805		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nephronophthisis	Nephronophthisis	GENOMICS_ENGLAND_DG	23661805		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	35163527	Associate	★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	28222767		★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	31076559		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	20683486, 21812739, 22232350, 23976986, 24661466, 26308152, 27612022, 28749816		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	Pubtator	20683486, 23976986, 27612022, 35163527	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	GWASCAT_DG	21738487		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	GWASDB_DG	21738487, 22438815		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE, LATE-ONSET	Parkinson disease	BEFREE	21812739		★☆☆☆☆ Found in Text Mining only