Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	254394
Gene name	Minichromosome maintenance 9 homologous recombination repair factor
Gene symbol	MCM9
Synonyms (NCBI Gene)	C6orf61MCMDC1ODG4dJ329L24.1dJ329L24.3
Chromosome	6
Chromosome location	6q22.31
Summary	The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recr

Show/Hide all (3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs587777871	A>G	Pathogenic	Genic downstream transcript variant, intron variant, splice donor variant
rs587777872	G>A	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1060505058	C>A	Pathogenic	Stop gained, genic downstream transcript variant, non coding transcript variant, coding sequence variant

116

Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024400	hsa-miR-215-5p	Microarray	19074876
MIRT024400	hsa-miR-215-5p	Microarray	19074876
MIRT026373	hsa-miR-192-5p	Microarray	19074876
MIRT633754	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT633753	hsa-miR-7160-3p	HITS-CLIP	23824327
MIRT633752	hsa-miR-4512	HITS-CLIP	23824327
MIRT633751	hsa-miR-5693	HITS-CLIP	23824327
MIRT633750	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT633749	hsa-miR-4284	HITS-CLIP	23824327
MIRT633748	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633747	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633746	hsa-miR-1296-5p	HITS-CLIP	23824327
MIRT633745	hsa-miR-2909	HITS-CLIP	23824327
MIRT446902	hsa-miR-6750-3p	PAR-CLIP	22100165
MIRT446901	hsa-miR-888-5p	PAR-CLIP	22100165
MIRT446900	hsa-miR-4453	PAR-CLIP	22100165
MIRT446899	hsa-miR-4538	PAR-CLIP	22100165
MIRT446898	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT446897	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT446896	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT446895	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT446894	hsa-miR-5579-3p	PAR-CLIP	22100165
MIRT446893	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT633754	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT633753	hsa-miR-7160-3p	HITS-CLIP	23824327
MIRT633752	hsa-miR-4512	HITS-CLIP	23824327
MIRT633751	hsa-miR-5693	HITS-CLIP	23824327
MIRT633750	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT633749	hsa-miR-4284	HITS-CLIP	23824327
MIRT633748	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633747	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633746	hsa-miR-1296-5p	HITS-CLIP	23824327
MIRT633745	hsa-miR-2909	HITS-CLIP	23824327
MIRT446902	hsa-miR-6750-3p	PAR-CLIP	22100165
MIRT446901	hsa-miR-888-5p	PAR-CLIP	22100165
MIRT446900	hsa-miR-4453	PAR-CLIP	22100165
MIRT446899	hsa-miR-4538	PAR-CLIP	22100165
MIRT446898	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT446897	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT446896	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT446895	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT446894	hsa-miR-5579-3p	PAR-CLIP	22100165
MIRT446893	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT1137845	hsa-miR-1207-3p	CLIP-seq
MIRT1137846	hsa-miR-138	CLIP-seq
MIRT1137847	hsa-miR-224	CLIP-seq
MIRT1137848	hsa-miR-3652	CLIP-seq
MIRT1137849	hsa-miR-3664-5p	CLIP-seq
MIRT1137850	hsa-miR-4282	CLIP-seq
MIRT1137851	hsa-miR-4430	CLIP-seq
MIRT1137852	hsa-miR-4503	CLIP-seq
MIRT1137853	hsa-miR-4699-5p	CLIP-seq
MIRT1137854	hsa-miR-4760-3p	CLIP-seq
MIRT1137855	hsa-miR-4774-5p	CLIP-seq
MIRT1137856	hsa-miR-4803	CLIP-seq
MIRT1137857	hsa-miR-490-3p	CLIP-seq
MIRT1137858	hsa-miR-649	CLIP-seq
MIRT1137859	hsa-miR-3123	CLIP-seq
MIRT1137860	hsa-miR-3159	CLIP-seq
MIRT1137861	hsa-miR-34b	CLIP-seq
MIRT1137862	hsa-miR-34c-3p	CLIP-seq
MIRT1137863	hsa-miR-3647-3p	CLIP-seq
MIRT1137864	hsa-miR-374a	CLIP-seq
MIRT1137865	hsa-miR-374b	CLIP-seq
MIRT1137866	hsa-miR-3925-5p	CLIP-seq
MIRT1137867	hsa-miR-4445	CLIP-seq
MIRT1137868	hsa-miR-4762-5p	CLIP-seq
MIRT1137869	hsa-miR-489	CLIP-seq
MIRT1137870	hsa-miR-539	CLIP-seq
MIRT1137845	hsa-miR-1207-3p	CLIP-seq
MIRT2039124	hsa-miR-140-3p	CLIP-seq
MIRT2039125	hsa-miR-2052	CLIP-seq
MIRT2039126	hsa-miR-3650	CLIP-seq
MIRT1137848	hsa-miR-3652	CLIP-seq
MIRT1137851	hsa-miR-4430	CLIP-seq
MIRT2039127	hsa-miR-496	CLIP-seq
MIRT2039128	hsa-miR-630	CLIP-seq
MIRT2269183	hsa-miR-23a	CLIP-seq
MIRT2269184	hsa-miR-23b	CLIP-seq
MIRT2269185	hsa-miR-23c	CLIP-seq
MIRT2039126	hsa-miR-3650	CLIP-seq
MIRT1137848	hsa-miR-3652	CLIP-seq
MIRT1137849	hsa-miR-3664-5p	CLIP-seq
MIRT1137851	hsa-miR-4430	CLIP-seq
MIRT2269186	hsa-miR-4639-3p	CLIP-seq
MIRT2269187	hsa-miR-4719	CLIP-seq
MIRT1137857	hsa-miR-490-3p	CLIP-seq
MIRT2269188	hsa-miR-587	CLIP-seq
MIRT2269189	hsa-miR-640	CLIP-seq
MIRT1137858	hsa-miR-649	CLIP-seq
MIRT2390737	hsa-miR-1208	CLIP-seq
MIRT2039126	hsa-miR-3650	CLIP-seq
MIRT1137845	hsa-miR-1207-3p	CLIP-seq
MIRT2039124	hsa-miR-140-3p	CLIP-seq
MIRT2269183	hsa-miR-23a	CLIP-seq
MIRT2269184	hsa-miR-23b	CLIP-seq
MIRT2269185	hsa-miR-23c	CLIP-seq
MIRT2039126	hsa-miR-3650	CLIP-seq
MIRT1137848	hsa-miR-3652	CLIP-seq
MIRT2568425	hsa-miR-3672	CLIP-seq
MIRT1137851	hsa-miR-4430	CLIP-seq
MIRT2269188	hsa-miR-587	CLIP-seq
MIRT2390737	hsa-miR-1208	CLIP-seq
MIRT2684739	hsa-miR-1236	CLIP-seq
MIRT2039124	hsa-miR-140-3p	CLIP-seq
MIRT2039126	hsa-miR-3650	CLIP-seq
MIRT1137848	hsa-miR-3652	CLIP-seq
MIRT1137849	hsa-miR-3664-5p	CLIP-seq
MIRT2568425	hsa-miR-3672	CLIP-seq
MIRT1137851	hsa-miR-4430	CLIP-seq
MIRT2684740	hsa-miR-4474-5p	CLIP-seq
MIRT2269186	hsa-miR-4639-3p	CLIP-seq
MIRT2684741	hsa-miR-4695-3p	CLIP-seq
MIRT2684742	hsa-miR-4729	CLIP-seq
MIRT2684743	hsa-miR-4778-3p	CLIP-seq
MIRT2684744	hsa-miR-579	CLIP-seq

Show/Hide all (42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000724	Process	Double-strand break repair via homologous recombination	IDA	22771115
GO:0000724	Process	Double-strand break repair via homologous recombination	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IMP	23401855
GO:0000724	Process	Double-strand break repair via homologous recombination	NAS	22771115
GO:0003677	Function	DNA binding	IEA
GO:0003678	Function	DNA helicase activity	IMP	26300262
GO:0003682	Function	Chromatin binding	IDA	23401855, 26300262
GO:0003682	Function	Chromatin binding	IEA
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	23401855, 26215093, 26300262, 32296183, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23401855, 26300262
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0006260	Process	DNA replication	IGI	23401855
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	22771115
GO:0006974	Process	DNA damage response	IEA
GO:0007276	Process	Gamete generation	IEA
GO:0007292	Process	Female gamete generation	IEA
GO:0007292	Process	Female gamete generation	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017116	Function	Single-stranded DNA helicase activity	IBA
GO:0019899	Function	Enzyme binding	IPI	23401855, 26300262
GO:0032406	Function	MutLbeta complex binding	IDA	26300262
GO:0032407	Function	MutSalpha complex binding	IDA	26300262
GO:0032408	Function	MutSbeta complex binding	IDA	26300262
GO:0036298	Process	Recombinational interstrand cross-link repair	IEA
GO:0036298	Process	Recombinational interstrand cross-link repair	IMP	23401855
GO:0042555	Component	MCM complex	IBA
GO:0044877	Function	Protein-containing complex binding	IDA	26215093
GO:0070716	Process	Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	IMP	26300262
GO:0070716	Process	Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	NAS	26300262
GO:0071168	Process	Protein localization to chromatin	IMP	23401855
GO:0097362	Component	MCM8-MCM9 complex	IDA	22771115, 23401855, 26215093, 26300262
GO:0097362	Component	MCM8-MCM9 complex	IEA
GO:0097362	Component	MCM8-MCM9 complex	IPI	26300262

MIM	HGNC	e!Ensembl
610098	21484	ENSG00000111877

Q9NXL9

Protein name

DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9)

Protein function

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NB

PDB

7DPD , 7WI7 , 7YOX , 8S91 , 8S92 , 8S94

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17207	MCM_OB	114 → 247	MCM OB domain	Domain
PF00493	MCM	294 → 509	MCM P-loop domain	Domain
PF17855	MCM_lid	522 → 604	MCM AAA-lid domain	Domain

Sequence

MNSDQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNAMTLFETNMEIGEYFNM
FPSEVLTIFDSALRRSALTILQSLSQPEAVSMKQNLHARISGLPVCPELVREHIPKTKDV
GHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYYTFCRPSSCPSLESCDS
SKFTCLSGLSSSPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTI
YGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFWEYYKSDPF
AGRNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQ
FLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLK
EHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLL
SRFDLILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSD
VGNQVLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVM
ESSMQGGALLGGVNALHTSFPENPGEQYQRQCELILEKLELQSLLSEELRRLERLQNQSV
HQSQPRVLEVETTPGSLRNGPGEESNFRTSSQQEINYSTHIFSPGGSPEGSPVLDPPPHL
EPNRSTSRKHSAQHKNNRDDSLDWFDFMATHQSEPKNTVVVSPHPKTSGENMASKISNST
SQGKEKSEPGQRSKVDIGLLPSPGETGVPWRADNVESNKKKRLALDSEAAVSADKPDSVL
THHVPRNLQKLCKERAQKLCRNSTRVPAQCTVPSHPQSTPVHSPDRMLDSPKRKRPKSLA
QVEEPAIENVKPPGSPVAKLAKFTFKQKSKLIHSFEDHSHVSPGATKIAVHSPKISQRRT
RRDAALPVKRPGKLTSTPGNQISSQPQGETKEVSQQPPEKHGPREKVMCAPEKRIIQPEL
ELGNETGCAHLTCEGDKKEEVSGSNKSGKVHACTLARLANFCFTPPSESKSKSPPPERKN
RGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKLIVSKESLFTLPELGDEAFDCDWDEEMR
KKS

Sequence length

1143

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
46,XX ovarian dysgenesis-short stature syndrome	Pathogenic; Likely pathogenic	rs587777871, rs587777872, rs1380220881, rs772472098, rs774660544, rs1060505058	RCV000149815 RCV000149816 RCV002289161 RCV004594995 RCV004594996 RCV000477968 View all (1 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Non-obstructive azoospermia	Likely pathogenic; Pathogenic	rs587777872	RCV001640177	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Premature ovarian failure 1	Pathogenic; Likely pathogenic	rs587777871, rs587777872	RCV000144731 RCV000144732	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY	—	Disgenet, GenCC Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MCM9-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN DYSGENESIS 4	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Premature ovarian failure	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREMATURE OVARIAN FAILURE 10	—	Disgenet, GenCC Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Premature ovarian insufficiency	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TESTICULAR AZOOSPERMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
46,XX ovarian dysgenesis-short stature syndrome	46, XX ovarian dysgenesis-short stature syndrome	Orphanet			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	36445337	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromosomal Instability	Chromosomal instability	Pubtator	25480036	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26806154		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	39596218	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	33750944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	BEFREE	25480036, 26771056		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Gonadal Dysgenesis 46 XX	46, xx gonadal dysgenesis	Pubtator	39529088	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	25480036	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypogonadism	Hypogonadism	Pubtator	25480036	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intestinal Polyposis	Intestinal polyposis	Pubtator	34704405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35360518	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	30219690		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	34432380	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30648820, 31509747		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Dysgenesis 2	Ovarian dysgenesis	Pubtator	25480036	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
OVARIAN DYSGENESIS 4	Ovarian Dysgenesis	ORPHANET_DG	25480036		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN DYSGENESIS 4	Ovarian Dysgenesis	GENOMICS_ENGLAND_DG	2771120		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN DYSGENESIS 4	Ovarian Dysgenesis	CTD_human_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN DYSGENESIS 4	Ovarian Dysgenesis	CLINVAR_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian Failure, Premature	Ovarian Failure	BEFREE	26771056, 26806154, 27802094		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	27695057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	26771056, 27802094		★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature Ovarian Failure 1	Premature Ovarian Failure	CLINVAR_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Primary hypogonadism	Hypogonadism	BEFREE	25480036		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary hypogonadism	Hypogonadism	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary physiologic amenorrhea	Physiologic Amenorrhea	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Tremor	Tremor	Pubtator	35063306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Turcot syndrome (disorder)	Turcot syndrome	BEFREE	26300262		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	32066835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MCM9 (minichromosome maintenance 9 homologous recombination repair factor)