SNX32 (sorting nexin 32)

Gene

• Entrez ID: 254122
• Gene name: Sorting nexin 32
• Gene symbol: SNX32
• Synonyms (NCBI Gene): SNX6B
• Chromosome: 11
• Chromosome location: 11q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018071	hsa-miR-335-5p	Microarray	18185580
MIRT1378095	hsa-miR-3132	CLIP-seq
MIRT1378096	hsa-miR-4326	CLIP-seq
MIRT1378097	hsa-miR-4451	CLIP-seq
MIRT1378098	hsa-miR-4687-3p	CLIP-seq
MIRT1378099	hsa-miR-485-5p	CLIP-seq
MIRT2629827	hsa-miR-1265	CLIP-seq
MIRT2629828	hsa-miR-299-3p	CLIP-seq
MIRT2629829	hsa-miR-3151	CLIP-seq
MIRT2629830	hsa-miR-3605-5p	CLIP-seq
MIRT2629831	hsa-miR-4324	CLIP-seq
MIRT2629832	hsa-miR-4447	CLIP-seq
MIRT2629833	hsa-miR-4472	CLIP-seq
MIRT2629834	hsa-miR-4764-5p	CLIP-seq
MIRT2629835	hsa-miR-486-3p	CLIP-seq
MIRT2629836	hsa-miR-491-5p	CLIP-seq
MIRT2629837	hsa-miR-759	CLIP-seq
MIRT2629827	hsa-miR-1265	CLIP-seq
MIRT2629828	hsa-miR-299-3p	CLIP-seq
MIRT2629829	hsa-miR-3151	CLIP-seq
MIRT2629830	hsa-miR-3605-5p	CLIP-seq
MIRT2629831	hsa-miR-4324	CLIP-seq
MIRT2629832	hsa-miR-4447	CLIP-seq
MIRT2629833	hsa-miR-4472	CLIP-seq
MIRT2629834	hsa-miR-4764-5p	CLIP-seq
MIRT2629835	hsa-miR-486-3p	CLIP-seq
MIRT2629836	hsa-miR-491-5p	CLIP-seq
MIRT2629837	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 28514442, 32296183, 33961781, 37158588, 39073202
GO:0005768	Component	Endosome	IBA
GO:0005769	Component	Early endosome	IDA	37158588
GO:0005770	Component	Late endosome	IDA	39073202
GO:0005802	Component	Trans-Golgi network	IDA	37158588
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IDA	37158588
GO:0015031	Process	Protein transport	IEA
GO:0016197	Process	Endosomal transport	IDA	37158588
GO:0016241	Process	Regulation of macroautophagy	NAS	26172538
GO:0030904	Component	Retromer complex	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0032510	Process	Endosome to lysosome transport via multivesicular body sorting pathway	IMP	39073202
GO:0034452	Function	Dynactin binding	IEA
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IEA
GO:0055037	Component	Recycling endosome	IDA	37158588
GO:0097422	Component	Tubular endosome	IEA
GO:1990138	Process	Neuron projection extension	ISS

Other IDs

• MIM: 621073
• HGNC: 26423
• e!Ensembl: ENSG00000172803

Protein

• UniProt ID: Q86XE0
• Protein name: Sorting nexin-32 (Sorting nexin-6B)
• Protein function: May be involved in several stages of intracellular trafficking.
• PDB: 6E8R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00787	PX	50 → 164	PX domain	Domain
  PF09325	Vps5	182 → 342	Vps5 C terminal like	Domain
  PF09325	Vps5	324 → 392	Vps5 C terminal like	Domain

• Sequence:

  METYAEVGKEGKPSCASVDLQGDSSLQVEISDAVSERDKVKFTVQTKSCLPHFAQTEFSV
  VRQHEEFIWLHDAYVENEEYAGLIIPPAPPRPDFEASREKLQKLGEGDSSVTREEFAKMK
  QELEAEYLAIFKKTVAMHEVFLQRLAAHPTLRRDHNFFVFLEYGQDLSVRGKNRKELLGG
  FLRNIVKSADEALITGMSGLKEVDDFFEHERTFLLEYHTRIRDACLRADRVMRAHKCLAD
  DYIPISAALSSLGTQEVNQLRTSFLKLAELFERLRKLEGRVASDEDLKLSDMLRYYMRDS
  QAAKDLLYRRLRALADYENANKALDKARTRNREVRPAESHQQLCCQRFERLSDSAKQELM
  DFKSRRVSSFRKNLIELAELELKHAKASTLILRNTLVALKGEP

• Sequence length: 403

Pathways

KEGG:

Endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BASAL CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	32413284	Stimulate	★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	34937778	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	29915430		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29316957	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	29915430		★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	29915430		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	29915430		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	29915430		★☆☆☆☆ Found in Text Mining only