ANGPTL5 (angiopoietin like 5)

Gene

• Entrez ID: 253935
• Gene name: Angiopoietin like 5
• Gene symbol: ANGPTL5
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT781554	hsa-miR-3614-5p	CLIP-seq
MIRT781555	hsa-miR-4642	CLIP-seq
MIRT781556	hsa-miR-4703-3p	CLIP-seq
MIRT781557	hsa-miR-494	CLIP-seq
MIRT781558	hsa-miR-513a-3p	CLIP-seq
MIRT1930685	hsa-miR-382	CLIP-seq
MIRT1930686	hsa-miR-4476	CLIP-seq
MIRT781558	hsa-miR-513a-3p	CLIP-seq
MIRT1930687	hsa-miR-590-3p	CLIP-seq
MIRT1930688	hsa-miR-651	CLIP-seq
MIRT1930689	hsa-miR-7	CLIP-seq
MIRT2171284	hsa-miR-3616-5p	CLIP-seq
MIRT2171285	hsa-miR-3647-5p	CLIP-seq
MIRT2171286	hsa-miR-4670-3p	CLIP-seq
MIRT2171287	hsa-miR-573	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22660330, 24899623
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0031012	Component	Extracellular matrix	IBA

Other IDs

• MIM: 607666
• HGNC: 19705
• e!Ensembl: ENSG00000187151

Protein

• UniProt ID: Q86XS5
• Protein name: Angiopoietin-related protein 5 (Angiopoietin-like protein 5)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00147	Fibrinogen_C	146 → 382	Fibrinogen beta and gamma chains, C-terminal globular domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Mainly expressed in adult heart. {ECO:0000269|PubMed:12624729}.
• Sequence:

  MMSPSQASLLFLNVCIFICGEAVQGNCVHHSTDSSVVNIVEDGSNAKDESKSNDTVCKED
  CEESCDVKTKITREEKHFMCRNLQNSIVSYTRSTKKLLRNMMDEQQASLDYLSNQVNELM
  NRVLLLTTEVFRKQLDPFPHRPVQSHGLDCTDIKDTIGSVTKTPSGLYIIHPEGSSYPFE
  VMCDMDYRGGGRTVIQKRIDGIIDFQRLWCDYLDGFGDLLGEFWLGLKKIFYIVNQKNTS
  FMLYVALESEDDTLAYASYDNFWLEDETRFFKMHLGRYSGNAGDAFRGLKKEDNQNAMPF
  STSDVDNDGCRPACLVNGQSVKSCSHLHNKTGWWFNECGLANLNGIHHFSGKLLATGIQW
  GTWTKNNSPVKIKSVSMKIRRMYNPYFK

• Sequence length: 388

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
JUVENILE IDIOPATHIC ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	34685578	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	31396158		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	31396158		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31396158		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	36588538	Associate	★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	GWASCAT_DG	24709693		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	25482926		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	31396158		★☆☆☆☆ Found in Text Mining only