Gene Gene information from NCBI Gene database.
Entrez ID 253832
Gene name ZDHHC palmitoyltransferase 20
Gene symbol ZDHHC20
Synonyms (NCBI Gene)
4933421L13RikDHHC-20DHHC20
Chromosome 13
Chromosome location 13q12.11
miRNA miRNA information provided by mirtarbase database.
1149
miRTarBase ID miRNA Experiments Reference
MIRT018634 hsa-miR-335-5p Microarray 18185580
MIRT680169 hsa-miR-383-3p HITS-CLIP 23824327
MIRT680168 hsa-miR-7162-3p HITS-CLIP 23824327
MIRT680167 hsa-miR-7854-3p HITS-CLIP 23824327
MIRT680166 hsa-miR-6134 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane IMP 29326245
GO:0000139 Component Golgi membrane TAS
GO:0005515 Function Protein binding IPI 32814053
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617972 20749 ENSG00000180776
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5W0Z9
Protein name Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20)
Protein function Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates
PDB 6BML , 6BMM , 6BMN , 7KHM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01529 DHHC 121 247 DHHC palmitoyltransferase Family
Sequence
MAPWTLWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGNEENGKTVVYLVAFHL
FFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTS
ASKTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLL
YCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFISVLSLFSYHCWLVGKNRT
TIESFRA
PTFSYGPDGNGFSLGCSKNWRQVFGDEKKYWLLPIFSSLGDGCSFPTRLVGMD
PEQASVTNQNEYARSSGSNQPFPIKPLSESKNRLLDSESQWLENGAEEGIVKSGTNNHVT
VAIEN
Sequence length 365
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anterior segment mesenchymal dysgenesis Anterior segment mesenchymal dysgenesis Pubtator 37239394 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 38056161 Associate
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 20334580, 27153536
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 20334580
★☆☆☆☆
Found in Text Mining only