Gene Gene information from NCBI Gene database.
Entrez ID 2537
Gene name Interferon alpha inducible protein 6
Gene symbol IFI6
Synonyms (NCBI Gene)
6-16FAM14CG1P3IFI-6-16IFI616
Chromosome 1
Chromosome location 1p35.3
Summary This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mam
miRNA miRNA information provided by mirtarbase database.
242
miRTarBase ID miRNA Experiments Reference
MIRT019676 hsa-miR-375 Microarray 20215506
MIRT054332 hsa-miR-1225-3p MicroarrayqRT-PCR 23593351
MIRT1060280 hsa-miR-1285 CLIP-seq
MIRT1060281 hsa-miR-1299 CLIP-seq
MIRT1060282 hsa-miR-1469 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 15685448
GO:0005739 Component Mitochondrion IDA 15685448, 25757571
GO:0005739 Component Mitochondrion IEA
GO:0005741 Component Mitochondrial outer membrane TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147572 4054 ENSG00000126709
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09912
Protein name Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16)
Protein function Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06140 Ifi-6-16 41 119 Interferon-induced 6-16 family Family
Sequence
Sequence length 130
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Interferon alpha/beta signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DEPRESSIVE DISORDER, MAJOR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adult type dermatomyositis Dermatomyositis BEFREE 30383435
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 15685448 Associate
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 23148572 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 15647832, 29899394
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 12841681, 29899394, 34055036, 35075167, 36766731 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 35301803 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 24098334 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36596524 Associate
★☆☆☆☆
Found in Text Mining only
Dermatitis Allergic Contact Allergic contact dermatitis Pubtator 35028126 Associate
★☆☆☆☆
Found in Text Mining only
Dermatomyositis Dermatomyositis BEFREE 30383435
★☆☆☆☆
Found in Text Mining only