Gene Gene information from NCBI Gene database.
Entrez ID 253430
Gene name Inositol polyphosphate multikinase
Gene symbol IPMK
Synonyms (NCBI Gene)
-
Chromosome 10
Chromosome location 10q21.1
Summary This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,
miRNA miRNA information provided by mirtarbase database.
596
miRTarBase ID miRNA Experiments Reference
MIRT017660 hsa-miR-335-5p Microarray 18185580
MIRT042775 hsa-miR-339-5p CLASH 23622248
MIRT544115 hsa-miR-519a-3p PAR-CLIP 21572407
MIRT544114 hsa-miR-519b-3p PAR-CLIP 21572407
MIRT544113 hsa-miR-519c-3p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000823 Function Inositol-1,4,5-trisphosphate 6-kinase activity ISS
GO:0000824 Function Inositol-1,4,5,6-tetrakisphosphate 3-kinase activity IEA
GO:0000824 Function Inositol-1,4,5,6-tetrakisphosphate 3-kinase activity ISS
GO:0000824 Function Inositol-1,4,5,6-tetrakisphosphate 3-kinase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609851 20739 ENSG00000151151
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NFU5
Protein name Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)
Protein function Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphos
PDB 5W2G , 5W2H , 5W2I , 6E7F , 6M88 , 6M89 , 6M8A , 6M8B , 6M8C , 6M8D , 6M8E , 8V6W , 8V6X , 8V6Y , 8V6Z , 8V70 , 8V71 , 8V72 , 8V73 , 8V74 , 8V75 , 8V76 , 8V77 , 8V78 , 8V79
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03770 IPK 127 411 Inositol polyphosphate kinase Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon. {ECO:0000269|PubMed:12223481}.
Sequence
Sequence length 416
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of IPs in the nucleus
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease, Late Onset Alzheimer disease BEFREE 27088644
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune disease Pubtator 34143178 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 35864548 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 25865046 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoid Tumor Carcinoid tumor Pubtator 25865046 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 28588697
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 39333335 Associate
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease BEFREE 27088644
★☆☆☆☆
Found in Text Mining only
Gaucher Disease Gaucher disease Pubtator 34143178 Associate
★☆☆☆☆
Found in Text Mining only
Graves Disease Graves disease Pubtator 34143178 Associate
★☆☆☆☆
Found in Text Mining only