Gene Gene information from NCBI Gene database.
Entrez ID 252983
Gene name Syntaxin binding protein 4
Gene symbol STXBP4
Synonyms (NCBI Gene)
Synip
Chromosome 17
Chromosome location 17q22
miRNA miRNA information provided by mirtarbase database.
462
miRTarBase ID miRNA Experiments Reference
MIRT026794 hsa-miR-192-5p Microarray 19074876
MIRT043123 hsa-miR-324-5p CLASH 23622248
MIRT534023 hsa-miR-556-5p PAR-CLIP 22012620
MIRT534022 hsa-miR-3670 PAR-CLIP 22012620
MIRT534021 hsa-miR-4448 PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19451233
GO:0005737 Component Cytoplasm IEA
GO:0006605 Process Protein targeting IEA
GO:0006950 Process Response to stress IEA
GO:0006974 Process DNA damage response IDA 19451233
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610415 19694 ENSG00000166263
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZWJ1
Protein name Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)
Protein function Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between ST
PDB 2YSG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00595 PDZ 21 99 PDZ domain Domain
PF00397 WW 498 527 WW domain Domain
Sequence
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYK
DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLES
AWEIAFIRQKSDNIQPENLSC
TSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALR
QQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL
KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMAR
KTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLAL
ESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN
EEDCSRELPNQKS
Sequence length 553
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Blood Coagulation Disorders Blood coagulation disorder Pubtator 25042561 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma GWASCAT_DG 19330027, 23535729, 25751625, 29059683
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma BEFREE 22863968, 23893088, 27600471, 28422318, 31539133
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma CTD_human_DG 29915430
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 19330027, 20699374, 21118973, 21194473, 21596841, 21791674, 21949660, 22532573, 23635555, 23893088, 26472073, 27600471, 32115800, 35772352 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 35772352 Stimulate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Male Male breast neoplasms Pubtator 21949660 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 32993587 Associate
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 31782549
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 40593136 Associate
★☆☆☆☆
Found in Text Mining only