Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	252839
Gene name	Transmembrane protein 9
Gene symbol	TMEM9
Synonyms (NCBI Gene)	DERM4TMEM9A
Chromosome	1
Chromosome location	1q32.1

288

Show/Hide all (288)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050914	hsa-miR-17-5p	CLASH	23622248
MIRT046083	hsa-miR-125b-5p	CLASH	23622248
MIRT1439637	hsa-miR-1226	CLIP-seq
MIRT1439638	hsa-miR-136	CLIP-seq
MIRT1439639	hsa-miR-2277-3p	CLIP-seq
MIRT1439640	hsa-miR-329	CLIP-seq
MIRT1439641	hsa-miR-3591-3p	CLIP-seq
MIRT1439642	hsa-miR-3617	CLIP-seq
MIRT1439643	hsa-miR-362-3p	CLIP-seq
MIRT1439644	hsa-miR-3941	CLIP-seq
MIRT1439645	hsa-miR-4282	CLIP-seq
MIRT1439646	hsa-miR-466	CLIP-seq
MIRT1439647	hsa-miR-4672	CLIP-seq
MIRT1439648	hsa-miR-4768-5p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT1439652	hsa-miR-543	CLIP-seq
MIRT1439653	hsa-miR-603	CLIP-seq
MIRT1439654	hsa-miR-618	CLIP-seq
MIRT1439655	hsa-miR-641	CLIP-seq
MIRT2131635	hsa-miR-1254	CLIP-seq
MIRT2131636	hsa-miR-198	CLIP-seq
MIRT2131637	hsa-miR-2355-3p	CLIP-seq
MIRT2131638	hsa-miR-24	CLIP-seq
MIRT2131639	hsa-miR-3116	CLIP-seq
MIRT2131640	hsa-miR-320e	CLIP-seq
MIRT2131641	hsa-miR-3943	CLIP-seq
MIRT2131642	hsa-miR-4323	CLIP-seq
MIRT2131643	hsa-miR-4646-3p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT2131644	hsa-miR-671-5p	CLIP-seq
MIRT2131645	hsa-miR-885-3p	CLIP-seq
MIRT2352971	hsa-miR-1288	CLIP-seq
MIRT2352972	hsa-miR-135a	CLIP-seq
MIRT2352973	hsa-miR-135b	CLIP-seq
MIRT2352974	hsa-miR-3126-5p	CLIP-seq
MIRT2352975	hsa-miR-3175	CLIP-seq
MIRT2352976	hsa-miR-3199	CLIP-seq
MIRT2352977	hsa-miR-3667-5p	CLIP-seq
MIRT2352978	hsa-miR-4756-3p	CLIP-seq
MIRT2352979	hsa-miR-4779	CLIP-seq
MIRT2352980	hsa-miR-502-5p	CLIP-seq
MIRT2352981	hsa-miR-516a-3p	CLIP-seq
MIRT2352972	hsa-miR-135a	CLIP-seq
MIRT2352973	hsa-miR-135b	CLIP-seq
MIRT2352980	hsa-miR-502-5p	CLIP-seq
MIRT2352981	hsa-miR-516a-3p	CLIP-seq
MIRT2646487	hsa-miR-1200	CLIP-seq
MIRT1439637	hsa-miR-1226	CLIP-seq
MIRT2646488	hsa-miR-1237	CLIP-seq
MIRT2131635	hsa-miR-1254	CLIP-seq
MIRT2646489	hsa-miR-125a-3p	CLIP-seq
MIRT2646490	hsa-miR-1266	CLIP-seq
MIRT1439638	hsa-miR-136	CLIP-seq
MIRT2646491	hsa-miR-145	CLIP-seq
MIRT2646492	hsa-miR-148a	CLIP-seq
MIRT2646493	hsa-miR-148b	CLIP-seq
MIRT2646494	hsa-miR-149	CLIP-seq
MIRT2646495	hsa-miR-150	CLIP-seq
MIRT2646496	hsa-miR-152	CLIP-seq
MIRT2646497	hsa-miR-1825	CLIP-seq
MIRT2646498	hsa-miR-185	CLIP-seq
MIRT2131636	hsa-miR-198	CLIP-seq
MIRT2646499	hsa-miR-199a-5p	CLIP-seq
MIRT2646500	hsa-miR-199b-5p	CLIP-seq
MIRT2646501	hsa-miR-204	CLIP-seq
MIRT2646502	hsa-miR-211	CLIP-seq
MIRT2646503	hsa-miR-2115	CLIP-seq
MIRT1439639	hsa-miR-2277-3p	CLIP-seq
MIRT2131637	hsa-miR-2355-3p	CLIP-seq
MIRT2131638	hsa-miR-24	CLIP-seq
MIRT2646504	hsa-miR-3064-5p	CLIP-seq
MIRT2646505	hsa-miR-31	CLIP-seq
MIRT2131639	hsa-miR-3116	CLIP-seq
MIRT2646506	hsa-miR-3127-5p	CLIP-seq
MIRT2646507	hsa-miR-3130-5p	CLIP-seq
MIRT2646508	hsa-miR-3135b	CLIP-seq
MIRT2646509	hsa-miR-3144-5p	CLIP-seq
MIRT2646510	hsa-miR-3147	CLIP-seq
MIRT2646511	hsa-miR-3176	CLIP-seq
MIRT2646512	hsa-miR-3184	CLIP-seq
MIRT2646513	hsa-miR-3189-5p	CLIP-seq
MIRT2646514	hsa-miR-3197	CLIP-seq
MIRT2131640	hsa-miR-320e	CLIP-seq
MIRT1439640	hsa-miR-329	CLIP-seq
MIRT1439641	hsa-miR-3591-3p	CLIP-seq
MIRT1439642	hsa-miR-3617	CLIP-seq
MIRT2646515	hsa-miR-3620	CLIP-seq
MIRT1439643	hsa-miR-362-3p	CLIP-seq
MIRT2646516	hsa-miR-3652	CLIP-seq
MIRT2646517	hsa-miR-3665	CLIP-seq
MIRT2352977	hsa-miR-3667-5p	CLIP-seq
MIRT2646518	hsa-miR-3679-3p	CLIP-seq
MIRT2646519	hsa-miR-383	CLIP-seq
MIRT2646520	hsa-miR-3909	CLIP-seq
MIRT2646521	hsa-miR-3918	CLIP-seq
MIRT2646522	hsa-miR-3919	CLIP-seq
MIRT2646523	hsa-miR-3922-3p	CLIP-seq
MIRT2646524	hsa-miR-3938	CLIP-seq
MIRT1439644	hsa-miR-3941	CLIP-seq
MIRT2646525	hsa-miR-3942-3p	CLIP-seq
MIRT2131641	hsa-miR-3943	CLIP-seq
MIRT2646526	hsa-miR-423-5p	CLIP-seq
MIRT2646527	hsa-miR-4260	CLIP-seq
MIRT2646528	hsa-miR-4267	CLIP-seq
MIRT2646529	hsa-miR-4270	CLIP-seq
MIRT2646530	hsa-miR-4276	CLIP-seq
MIRT1439645	hsa-miR-4282	CLIP-seq
MIRT2646531	hsa-miR-4283	CLIP-seq
MIRT2646532	hsa-miR-4284	CLIP-seq
MIRT2646533	hsa-miR-4287	CLIP-seq
MIRT2646534	hsa-miR-4297	CLIP-seq
MIRT2646535	hsa-miR-4313	CLIP-seq
MIRT2131642	hsa-miR-4323	CLIP-seq
MIRT2646536	hsa-miR-4324	CLIP-seq
MIRT2646537	hsa-miR-4417	CLIP-seq
MIRT2646538	hsa-miR-4425	CLIP-seq
MIRT2646539	hsa-miR-4430	CLIP-seq
MIRT2646540	hsa-miR-4434	CLIP-seq
MIRT2646541	hsa-miR-4437	CLIP-seq
MIRT2646542	hsa-miR-4441	CLIP-seq
MIRT2646543	hsa-miR-4446-3p	CLIP-seq
MIRT2646544	hsa-miR-4482	CLIP-seq
MIRT2646545	hsa-miR-4489	CLIP-seq
MIRT2646546	hsa-miR-4492	CLIP-seq
MIRT2646547	hsa-miR-4498	CLIP-seq
MIRT2646548	hsa-miR-4505	CLIP-seq
MIRT2646549	hsa-miR-4516	CLIP-seq
MIRT2646550	hsa-miR-4518	CLIP-seq
MIRT2646551	hsa-miR-4633-3p	CLIP-seq
MIRT2131643	hsa-miR-4646-3p	CLIP-seq
MIRT2646552	hsa-miR-4649-3p	CLIP-seq
MIRT2646553	hsa-miR-4656	CLIP-seq
MIRT1439646	hsa-miR-466	CLIP-seq
MIRT1439647	hsa-miR-4672	CLIP-seq
MIRT2646554	hsa-miR-4674	CLIP-seq
MIRT2646555	hsa-miR-4675	CLIP-seq
MIRT2646556	hsa-miR-4685-3p	CLIP-seq
MIRT2646557	hsa-miR-4690-3p	CLIP-seq
MIRT2646558	hsa-miR-4694-5p	CLIP-seq
MIRT2646559	hsa-miR-4710	CLIP-seq
MIRT2646560	hsa-miR-4713-5p	CLIP-seq
MIRT2646561	hsa-miR-4731-5p	CLIP-seq
MIRT2646562	hsa-miR-4741	CLIP-seq
MIRT2646563	hsa-miR-4747-5p	CLIP-seq
MIRT2646564	hsa-miR-4755-5p	CLIP-seq
MIRT2352978	hsa-miR-4756-3p	CLIP-seq
MIRT2646565	hsa-miR-4758-3p	CLIP-seq
MIRT2646566	hsa-miR-4763-5p	CLIP-seq
MIRT1439648	hsa-miR-4768-5p	CLIP-seq
MIRT2646567	hsa-miR-4794	CLIP-seq
MIRT2646568	hsa-miR-483-3p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT2646569	hsa-miR-532-3p	CLIP-seq
MIRT1439652	hsa-miR-543	CLIP-seq
MIRT2646570	hsa-miR-544b	CLIP-seq
MIRT2646571	hsa-miR-562	CLIP-seq
MIRT2646572	hsa-miR-574-3p	CLIP-seq
MIRT2646573	hsa-miR-586	CLIP-seq
MIRT1439653	hsa-miR-603	CLIP-seq
MIRT1439654	hsa-miR-618	CLIP-seq
MIRT2646574	hsa-miR-623	CLIP-seq
MIRT1439655	hsa-miR-641	CLIP-seq
MIRT2646575	hsa-miR-657	CLIP-seq
MIRT2131644	hsa-miR-671-5p	CLIP-seq
MIRT2646576	hsa-miR-762	CLIP-seq
MIRT2131645	hsa-miR-885-3p	CLIP-seq
MIRT2646577	hsa-miR-922	CLIP-seq
MIRT2646487	hsa-miR-1200	CLIP-seq
MIRT1439637	hsa-miR-1226	CLIP-seq
MIRT2646488	hsa-miR-1237	CLIP-seq
MIRT2131635	hsa-miR-1254	CLIP-seq
MIRT2646489	hsa-miR-125a-3p	CLIP-seq
MIRT2646490	hsa-miR-1266	CLIP-seq
MIRT2352971	hsa-miR-1288	CLIP-seq
MIRT1439638	hsa-miR-136	CLIP-seq
MIRT2646491	hsa-miR-145	CLIP-seq
MIRT2646492	hsa-miR-148a	CLIP-seq
MIRT2646493	hsa-miR-148b	CLIP-seq
MIRT2646494	hsa-miR-149	CLIP-seq
MIRT2646495	hsa-miR-150	CLIP-seq
MIRT2646496	hsa-miR-152	CLIP-seq
MIRT2646497	hsa-miR-1825	CLIP-seq
MIRT2131636	hsa-miR-198	CLIP-seq
MIRT2646499	hsa-miR-199a-5p	CLIP-seq
MIRT2646500	hsa-miR-199b-5p	CLIP-seq
MIRT2646501	hsa-miR-204	CLIP-seq
MIRT2646502	hsa-miR-211	CLIP-seq
MIRT2646503	hsa-miR-2115	CLIP-seq
MIRT1439639	hsa-miR-2277-3p	CLIP-seq
MIRT2131637	hsa-miR-2355-3p	CLIP-seq
MIRT2131638	hsa-miR-24	CLIP-seq
MIRT2693569	hsa-miR-3064-3p	CLIP-seq
MIRT2646504	hsa-miR-3064-5p	CLIP-seq
MIRT2131639	hsa-miR-3116	CLIP-seq
MIRT2693570	hsa-miR-3119	CLIP-seq
MIRT2352974	hsa-miR-3126-5p	CLIP-seq
MIRT2646506	hsa-miR-3127-5p	CLIP-seq
MIRT2646507	hsa-miR-3130-5p	CLIP-seq
MIRT2646509	hsa-miR-3144-5p	CLIP-seq
MIRT2646510	hsa-miR-3147	CLIP-seq
MIRT2693571	hsa-miR-3150a-3p	CLIP-seq
MIRT2352975	hsa-miR-3175	CLIP-seq
MIRT2646511	hsa-miR-3176	CLIP-seq
MIRT2646512	hsa-miR-3184	CLIP-seq
MIRT2646513	hsa-miR-3189-5p	CLIP-seq
MIRT2352976	hsa-miR-3199	CLIP-seq
MIRT2131640	hsa-miR-320e	CLIP-seq
MIRT1439640	hsa-miR-329	CLIP-seq
MIRT1439641	hsa-miR-3591-3p	CLIP-seq
MIRT1439642	hsa-miR-3617	CLIP-seq
MIRT2646515	hsa-miR-3620	CLIP-seq
MIRT1439643	hsa-miR-362-3p	CLIP-seq
MIRT2646517	hsa-miR-3665	CLIP-seq
MIRT2352977	hsa-miR-3667-5p	CLIP-seq
MIRT2646518	hsa-miR-3679-3p	CLIP-seq
MIRT2646523	hsa-miR-3922-3p	CLIP-seq
MIRT2646524	hsa-miR-3938	CLIP-seq
MIRT1439644	hsa-miR-3941	CLIP-seq
MIRT2646525	hsa-miR-3942-3p	CLIP-seq
MIRT2131641	hsa-miR-3943	CLIP-seq
MIRT2646526	hsa-miR-423-5p	CLIP-seq
MIRT2646527	hsa-miR-4260	CLIP-seq
MIRT2646528	hsa-miR-4267	CLIP-seq
MIRT2646529	hsa-miR-4270	CLIP-seq
MIRT1439645	hsa-miR-4282	CLIP-seq
MIRT2646532	hsa-miR-4284	CLIP-seq
MIRT2646533	hsa-miR-4287	CLIP-seq
MIRT2646534	hsa-miR-4297	CLIP-seq
MIRT2646535	hsa-miR-4313	CLIP-seq
MIRT2131642	hsa-miR-4323	CLIP-seq
MIRT2646536	hsa-miR-4324	CLIP-seq
MIRT2646537	hsa-miR-4417	CLIP-seq
MIRT2646538	hsa-miR-4425	CLIP-seq
MIRT2646540	hsa-miR-4434	CLIP-seq
MIRT2646541	hsa-miR-4437	CLIP-seq
MIRT2693572	hsa-miR-4438	CLIP-seq
MIRT2646542	hsa-miR-4441	CLIP-seq
MIRT2693573	hsa-miR-4463	CLIP-seq
MIRT2646544	hsa-miR-4482	CLIP-seq
MIRT2646549	hsa-miR-4516	CLIP-seq
MIRT2646550	hsa-miR-4518	CLIP-seq
MIRT2131643	hsa-miR-4646-3p	CLIP-seq
MIRT2646552	hsa-miR-4649-3p	CLIP-seq
MIRT1439646	hsa-miR-466	CLIP-seq
MIRT2693574	hsa-miR-4667-5p	CLIP-seq
MIRT1439647	hsa-miR-4672	CLIP-seq
MIRT2646554	hsa-miR-4674	CLIP-seq
MIRT2646555	hsa-miR-4675	CLIP-seq
MIRT2646556	hsa-miR-4685-3p	CLIP-seq
MIRT2646557	hsa-miR-4690-3p	CLIP-seq
MIRT2646558	hsa-miR-4694-5p	CLIP-seq
MIRT2693575	hsa-miR-4700-5p	CLIP-seq
MIRT2646559	hsa-miR-4710	CLIP-seq
MIRT2646560	hsa-miR-4713-5p	CLIP-seq
MIRT2646562	hsa-miR-4741	CLIP-seq
MIRT2646563	hsa-miR-4747-5p	CLIP-seq
MIRT2646564	hsa-miR-4755-5p	CLIP-seq
MIRT2352978	hsa-miR-4756-3p	CLIP-seq
MIRT2646565	hsa-miR-4758-3p	CLIP-seq
MIRT2646566	hsa-miR-4763-5p	CLIP-seq
MIRT1439648	hsa-miR-4768-5p	CLIP-seq
MIRT2352979	hsa-miR-4779	CLIP-seq
MIRT2646567	hsa-miR-4794	CLIP-seq
MIRT2646568	hsa-miR-483-3p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT2646569	hsa-miR-532-3p	CLIP-seq
MIRT2646570	hsa-miR-544b	CLIP-seq
MIRT2646571	hsa-miR-562	CLIP-seq
MIRT2646572	hsa-miR-574-3p	CLIP-seq
MIRT2646573	hsa-miR-586	CLIP-seq
MIRT1439653	hsa-miR-603	CLIP-seq
MIRT1439654	hsa-miR-618	CLIP-seq
MIRT2646574	hsa-miR-623	CLIP-seq
MIRT1439655	hsa-miR-641	CLIP-seq
MIRT2646575	hsa-miR-657	CLIP-seq
MIRT2131644	hsa-miR-671-5p	CLIP-seq
MIRT2693576	hsa-miR-7	CLIP-seq
MIRT2131645	hsa-miR-885-3p	CLIP-seq
MIRT2646577	hsa-miR-922	CLIP-seq
MIRT2693577	hsa-miR-939	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30374053, 32296183, 33961781
GO:0005764	Component	Lysosome	IDA	12359240
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	30374053
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IDA	12359240
GO:0007042	Process	Lysosomal lumen acidification	IDA	30374053
GO:0015031	Process	Protein transport	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0032585	Component	Multivesicular body membrane	IDA	30374053
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0042176	Process	Regulation of protein catabolic process	IEA
GO:0042176	Process	Regulation of protein catabolic process	ISS
GO:0045171	Component	Intercellular bridge	IDA
GO:0048388	Process	Endosomal lumen acidification	IDA	30374053
GO:0070070	Process	Proton-transporting V-type ATPase complex assembly	IDA	30374053
GO:0072686	Component	Mitotic spindle	IDA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IDA	30374053
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA

MIM	HGNC	e!Ensembl
616877	18823	ENSG00000116857

Q9P0T7

Protein name

Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9)

Protein function

Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory prote

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05434	Tmemb_9	41 → 182	TMEM9	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate (PubMed:12359240). Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen (PubMed:12359240, PubMed:30374053). Low expression

Sequence

MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVE
PMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPD
AYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHK
MLS

Sequence length

183

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenomatous Polyposis Coli	Multiple polyposis syndrome	BEFREE	30374053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36596527	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31210410	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30374053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27220462		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	27220462		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	27220462		★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM9 (transmembrane protein 9)