Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2528
Gene name	Fucosyltransferase 6
Gene symbol	FUT6
Synonyms (NCBI Gene)	FCT3AFT1AFuc-TVIFucT-VI
Chromosome	19
Chromosome location	19p13.3
Summary	The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same p

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Show/Hide all (173)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047444	hsa-miR-10b-5p	CLASH	23622248
MIRT642970	hsa-miR-4475	HITS-CLIP	23824327
MIRT642969	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT642968	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT642967	hsa-miR-5681a	HITS-CLIP	23824327
MIRT642970	hsa-miR-4475	HITS-CLIP	23824327
MIRT642969	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT642968	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT642967	hsa-miR-5681a	HITS-CLIP	23824327
MIRT642966	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT642965	hsa-miR-3672	HITS-CLIP	23824327
MIRT642964	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT642963	hsa-miR-578	HITS-CLIP	23824327
MIRT642970	hsa-miR-4475	HITS-CLIP	23824327
MIRT642969	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT642968	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT642967	hsa-miR-5681a	HITS-CLIP	23824327
MIRT642970	hsa-miR-4475	HITS-CLIP	23824327
MIRT642969	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT642968	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT642967	hsa-miR-5681a	HITS-CLIP	23824327
MIRT642966	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT642965	hsa-miR-3672	HITS-CLIP	23824327
MIRT642964	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT642963	hsa-miR-578	HITS-CLIP	23824327
MIRT1006746	hsa-miR-1193	CLIP-seq
MIRT1006747	hsa-miR-122	CLIP-seq
MIRT1006748	hsa-miR-1279	CLIP-seq
MIRT1006749	hsa-miR-1307	CLIP-seq
MIRT1006750	hsa-miR-1915	CLIP-seq
MIRT1006751	hsa-miR-197	CLIP-seq
MIRT1006752	hsa-miR-1976	CLIP-seq
MIRT1006753	hsa-miR-217	CLIP-seq
MIRT1006754	hsa-miR-2392	CLIP-seq
MIRT1006755	hsa-miR-3135b	CLIP-seq
MIRT1006756	hsa-miR-3187-3p	CLIP-seq
MIRT1006757	hsa-miR-3652	CLIP-seq
MIRT1006758	hsa-miR-3918	CLIP-seq
MIRT1006759	hsa-miR-411	CLIP-seq
MIRT1006760	hsa-miR-4418	CLIP-seq
MIRT1006761	hsa-miR-4430	CLIP-seq
MIRT1006762	hsa-miR-4431	CLIP-seq
MIRT1006763	hsa-miR-4435	CLIP-seq
MIRT1006764	hsa-miR-4454	CLIP-seq
MIRT1006765	hsa-miR-4638-5p	CLIP-seq
MIRT1006766	hsa-miR-4685-5p	CLIP-seq
MIRT1006767	hsa-miR-4701-5p	CLIP-seq
MIRT1006768	hsa-miR-4726-3p	CLIP-seq
MIRT1006769	hsa-miR-4755-3p	CLIP-seq
MIRT1006770	hsa-miR-4763-5p	CLIP-seq
MIRT1006771	hsa-miR-4772-3p	CLIP-seq
MIRT1006772	hsa-miR-4797-5p	CLIP-seq
MIRT1006773	hsa-miR-483-5p	CLIP-seq
MIRT1006774	hsa-miR-509-3-5p	CLIP-seq
MIRT1006775	hsa-miR-509-5p	CLIP-seq
MIRT1006776	hsa-miR-5096	CLIP-seq
MIRT1006777	hsa-miR-548s	CLIP-seq
MIRT1006778	hsa-miR-588	CLIP-seq
MIRT1006779	hsa-miR-720	CLIP-seq
MIRT1006746	hsa-miR-1193	CLIP-seq
MIRT1006747	hsa-miR-122	CLIP-seq
MIRT1006748	hsa-miR-1279	CLIP-seq
MIRT1006751	hsa-miR-197	CLIP-seq
MIRT1006752	hsa-miR-1976	CLIP-seq
MIRT1006754	hsa-miR-2392	CLIP-seq
MIRT1006755	hsa-miR-3135b	CLIP-seq
MIRT1998283	hsa-miR-326	CLIP-seq
MIRT1998284	hsa-miR-330-5p	CLIP-seq
MIRT1006757	hsa-miR-3652	CLIP-seq
MIRT1006759	hsa-miR-411	CLIP-seq
MIRT1006761	hsa-miR-4430	CLIP-seq
MIRT1006764	hsa-miR-4454	CLIP-seq
MIRT1998285	hsa-miR-4634	CLIP-seq
MIRT1006769	hsa-miR-4755-3p	CLIP-seq
MIRT1006770	hsa-miR-4763-5p	CLIP-seq
MIRT1006773	hsa-miR-483-5p	CLIP-seq
MIRT1998286	hsa-miR-5095	CLIP-seq
MIRT1006776	hsa-miR-5096	CLIP-seq
MIRT2231956	hsa-miR-106a	CLIP-seq
MIRT2231957	hsa-miR-106b	CLIP-seq
MIRT1006747	hsa-miR-122	CLIP-seq
MIRT2231958	hsa-miR-1234	CLIP-seq
MIRT1006748	hsa-miR-1279	CLIP-seq
MIRT1006749	hsa-miR-1307	CLIP-seq
MIRT2231959	hsa-miR-150	CLIP-seq
MIRT2231960	hsa-miR-17	CLIP-seq
MIRT1006751	hsa-miR-197	CLIP-seq
MIRT1006752	hsa-miR-1976	CLIP-seq
MIRT2231961	hsa-miR-20a	CLIP-seq
MIRT2231962	hsa-miR-20b	CLIP-seq
MIRT1006753	hsa-miR-217	CLIP-seq
MIRT2231963	hsa-miR-302a	CLIP-seq
MIRT2231964	hsa-miR-302b	CLIP-seq
MIRT2231965	hsa-miR-302c	CLIP-seq
MIRT2231966	hsa-miR-302d	CLIP-seq
MIRT2231967	hsa-miR-302e	CLIP-seq
MIRT1006755	hsa-miR-3135b	CLIP-seq
MIRT1998283	hsa-miR-326	CLIP-seq
MIRT1998284	hsa-miR-330-5p	CLIP-seq
MIRT1006757	hsa-miR-3652	CLIP-seq
MIRT2231968	hsa-miR-372	CLIP-seq
MIRT2231969	hsa-miR-373	CLIP-seq
MIRT1006759	hsa-miR-411	CLIP-seq
MIRT1006760	hsa-miR-4418	CLIP-seq
MIRT1006761	hsa-miR-4430	CLIP-seq
MIRT1006764	hsa-miR-4454	CLIP-seq
MIRT1998285	hsa-miR-4634	CLIP-seq
MIRT1006765	hsa-miR-4638-5p	CLIP-seq
MIRT2231970	hsa-miR-4731-5p	CLIP-seq
MIRT1006769	hsa-miR-4755-3p	CLIP-seq
MIRT1006770	hsa-miR-4763-5p	CLIP-seq
MIRT1006772	hsa-miR-4797-5p	CLIP-seq
MIRT1006773	hsa-miR-483-5p	CLIP-seq
MIRT1006774	hsa-miR-509-3-5p	CLIP-seq
MIRT1998286	hsa-miR-5095	CLIP-seq
MIRT1006775	hsa-miR-509-5p	CLIP-seq
MIRT1006776	hsa-miR-5096	CLIP-seq
MIRT2231971	hsa-miR-512-3p	CLIP-seq
MIRT2231972	hsa-miR-519d	CLIP-seq
MIRT2231973	hsa-miR-520a-3p	CLIP-seq
MIRT2231974	hsa-miR-520b	CLIP-seq
MIRT2231975	hsa-miR-520c-3p	CLIP-seq
MIRT2231976	hsa-miR-520d-3p	CLIP-seq
MIRT2231977	hsa-miR-520e	CLIP-seq
MIRT2231978	hsa-miR-520g	CLIP-seq
MIRT2231979	hsa-miR-520h	CLIP-seq
MIRT2231980	hsa-miR-562	CLIP-seq
MIRT1006779	hsa-miR-720	CLIP-seq
MIRT2231981	hsa-miR-93	CLIP-seq
MIRT1006749	hsa-miR-1307	CLIP-seq
MIRT1998285	hsa-miR-4634	CLIP-seq
MIRT1006765	hsa-miR-4638-5p	CLIP-seq
MIRT1006747	hsa-miR-122	CLIP-seq
MIRT2449943	hsa-miR-1226	CLIP-seq
MIRT1006755	hsa-miR-3135b	CLIP-seq
MIRT1006757	hsa-miR-3652	CLIP-seq
MIRT1006761	hsa-miR-4430	CLIP-seq
MIRT2449944	hsa-miR-4690-3p	CLIP-seq
MIRT1006769	hsa-miR-4755-3p	CLIP-seq
MIRT2449945	hsa-miR-4758-3p	CLIP-seq
MIRT1006772	hsa-miR-4797-5p	CLIP-seq
MIRT1006779	hsa-miR-720	CLIP-seq
MIRT1006747	hsa-miR-122	CLIP-seq
MIRT1006755	hsa-miR-3135b	CLIP-seq
MIRT1006757	hsa-miR-3652	CLIP-seq
MIRT1006761	hsa-miR-4430	CLIP-seq
MIRT1006769	hsa-miR-4755-3p	CLIP-seq
MIRT1006772	hsa-miR-4797-5p	CLIP-seq
MIRT1006779	hsa-miR-720	CLIP-seq
MIRT1006747	hsa-miR-122	CLIP-seq
MIRT1006755	hsa-miR-3135b	CLIP-seq
MIRT1998283	hsa-miR-326	CLIP-seq
MIRT1998284	hsa-miR-330-5p	CLIP-seq
MIRT1006757	hsa-miR-3652	CLIP-seq
MIRT1006761	hsa-miR-4430	CLIP-seq
MIRT1006762	hsa-miR-4431	CLIP-seq
MIRT1998285	hsa-miR-4634	CLIP-seq
MIRT1006769	hsa-miR-4755-3p	CLIP-seq
MIRT1006772	hsa-miR-4797-5p	CLIP-seq
MIRT2535884	hsa-miR-498	CLIP-seq
MIRT1006779	hsa-miR-720	CLIP-seq
MIRT1006747	hsa-miR-122	CLIP-seq
MIRT1006755	hsa-miR-3135b	CLIP-seq
MIRT1998283	hsa-miR-326	CLIP-seq
MIRT1998284	hsa-miR-330-5p	CLIP-seq
MIRT1006757	hsa-miR-3652	CLIP-seq
MIRT1006761	hsa-miR-4430	CLIP-seq
MIRT1006762	hsa-miR-4431	CLIP-seq
MIRT1998285	hsa-miR-4634	CLIP-seq
MIRT1006769	hsa-miR-4755-3p	CLIP-seq
MIRT1006772	hsa-miR-4797-5p	CLIP-seq
MIRT2535884	hsa-miR-498	CLIP-seq
MIRT1006779	hsa-miR-720	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005576	Component	Extracellular region	IDA	9451035
GO:0005576	Component	Extracellular region	IEA
GO:0005794	Component	Golgi apparatus	IDA	9451035
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	TAS	11698403
GO:0006486	Process	Protein glycosylation	IEA
GO:0006486	Process	Protein glycosylation	TAS	11698403
GO:0006487	Process	Protein N-linked glycosylation	IDA	29593094
GO:0006493	Process	Protein O-linked glycosylation	IDA	29593094
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0006672	Process	Ceramide metabolic process	IDA	17604274
GO:0006688	Process	Glycosphingolipid biosynthetic process	IDA	29593094
GO:0007309	Process	Oocyte axis specification	IBA
GO:0008417	Function	Fucosyltransferase activity	IDA	17604274
GO:0008417	Function	Fucosyltransferase activity	IEA
GO:0008417	Function	Fucosyltransferase activity	TAS	8175676
GO:0009312	Process	Oligosaccharide biosynthetic process	IEA
GO:0009312	Process	Oligosaccharide biosynthetic process	TAS
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0017083	Function	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA	9363434, 17604274, 29593094
GO:0017083	Function	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0034709	Component	Methylosome	IBA
GO:0036071	Process	N-glycan fucosylation	IDA	9363434
GO:0042355	Process	L-fucose catabolic process	NAS	11698403
GO:0046920	Function	Alpha-(1->3)-fucosyltransferase activity	TAS	11698403
GO:0070062	Component	Extracellular exosome	HDA	19199708

MIM	HGNC	e!Ensembl
136836	4017	ENSG00000156413

P51993

Protein name

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (EC 2.4.1.152) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase)

Protein function

[Isoform 1]: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines ch

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17039	Glyco_tran_10_N	59 → 169	Fucosyltransferase, N-terminal	Domain
PF00852	Glyco_transf_10	188 → 358	Glycosyltransferase family 10 (fucosyltransferase) C-term	Family

Tissue specificity

TISSUE SPECIFICITY: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

Sequence

MDPLGPAKPQWSWRCCLTTLLFQLLMAVCFFSYLRVSQDDPTVYPNGSRFPDSTGTPAHS
IPLILLWTWPFNKPIALPRCSEMVPGTADCNITADRKVYPQADAVIVHHREVMYNPSAQL
PRSPRRQGQRWIWFSMESPSHCWQLKAMDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAH
PPLNLSAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRY
KFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKD
LARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQTRGIAAWFT

Sequence length

359

Interactions

View interactions

	KEGG		Reactome
	Glycosphingolipid biosynthesis - lacto and neolacto series Metabolic pathways		Lewis blood group biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATROPHIC MACULAR DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEFICIENCY ANEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Fucosyltransferase 6 deficiency	Conflicting classifications of pathogenicity; Uncertain significance; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FUT6-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLSTONES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC PULMONARY FIBROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITAMIN B DEFICIENCY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vitamin B12 deficiency	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WET MACULAR DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (32)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of colon	Adenocarcinoma Of Colon	BEFREE	30589515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Age related macular degeneration	Age-related macular degeneration	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	27519168		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	27519168	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	9690558		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24232099	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	31860772	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35955933	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	12670495, 20965272		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	30589515	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	24253505, 28771224, 30742932, 9690558		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24253505, 28771224, 33167483	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	27374856	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	27374856		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	39375968	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Exudative age-related macular degeneration	Exudative Macular Degeneration	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
exudative macular degeneration	Exudative macular degeneration	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver Alcoholic	Fatty liver, alcoholic	Pubtator	31941930	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Geographic Atrophy	Geographic Atrophy	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31209266		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	10536043, 17054948, 18274891, 22155250, 24232099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	10536043		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27519168		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24178760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	24947433		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24253505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	20965272		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24253505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	24178760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19889975	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary malignant neoplasm of colon and/or rectum	Colorectal Neoplasms	BEFREE	24253505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	24947433		★★★★★ ★☆☆☆☆ Found in Text Mining only

FUT6 (fucosyltransferase 6)