Gene Gene information from NCBI Gene database.
Entrez ID 2526
Gene name Fucosyltransferase 4
Gene symbol FUT4
Synonyms (NCBI Gene)
CD15ELFTFCT3AFUC-TIVFUTIVLeXSSEA-1
Chromosome 11
Chromosome location 11q21
Summary The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
miRNA miRNA information provided by mirtarbase database.
359
miRTarBase ID miRNA Experiments Reference
MIRT006453 hsa-miR-199a-3p FlowImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot 22411914
MIRT722795 hsa-miR-5586-5p HITS-CLIP 19536157
MIRT722794 hsa-miR-383-3p HITS-CLIP 19536157
MIRT722793 hsa-miR-4530 HITS-CLIP 19536157
MIRT722792 hsa-miR-338-3p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
ELK1 Unknown 11006292
HSF1 Unknown 23959823
SP1 Unknown 23959823
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0005794 Component Golgi apparatus IEA
GO:0005794 Component Golgi apparatus TAS 11698403
GO:0005802 Component Trans-Golgi network IDA 23192350
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
104230 4015 ENSG00000196371
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P22083
Protein name Alpha-(1,3)-fucosyltransferase 4 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (ELAM-1 ligand fucosyltransferase) (Fucosyltransferase 4) (Fucosyltransferase IV) (Fuc-TIV) (FucT-IV) (Galactoside 3-L-fucosyltransferase)
Protein function [Isoform Short]: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17039 Glyco_tran_10_N 186 331 Fucosyltransferase, N-terminal Domain
PF00852 Glyco_transf_10 353 528 Glycosyltransferase family 10 (fucosyltransferase) C-term Family
Tissue specificity TISSUE SPECIFICITY: [Isoform Short]: Expressed at low levels in bone marrow-derived mesenchymal stem cells. {ECO:0000269|PubMed:29593094}.; TISSUE SPECIFICITY: Expressed in cord blood immature promyelocytes and in peripheral blood myeloid and lymphoid cel
Sequence
Sequence length 530
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mannose type O-glycan biosynthesis
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
  Lewis blood group biosynthesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
THROMBOSIS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 1375695
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 11520279, 11531016, 1477645, 30683310
★☆☆☆☆
Found in Text Mining only
Acute Myeloid Leukemia, M1 Myeloid Leukemia BEFREE 2646903
★☆☆☆☆
Found in Text Mining only
Acute myelomonocytic leukemia Myelomonocytic Leukemia BEFREE 25241285
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 21812014, 7815843
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 24195468
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 10747292, 10873613
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 28423676, 30357521
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Clear Cell Adenocarcinoma BEFREE 10608618
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 2885160
★☆☆☆☆
Found in Text Mining only