Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	248
Gene name	Alkaline phosphatase, intestinal
Gene symbol	ALPI
Synonyms (NCBI Gene)	IAP
Chromosome	2
Chromosome location	2q37.1
Summary	There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a comp

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019330	hsa-miR-148b-3p	Microarray	17612493
MIRT029513	hsa-miR-26b-5p	Microarray	19088304
MIRT695519	hsa-miR-3200-5p	HITS-CLIP	23313552
MIRT695518	hsa-miR-4682	HITS-CLIP	23313552
MIRT695517	hsa-miR-6128	HITS-CLIP	23313552
MIRT695516	hsa-miR-637	HITS-CLIP	23313552
MIRT695515	hsa-miR-4481	HITS-CLIP	23313552
MIRT695514	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT695513	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT695512	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT695511	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT695510	hsa-miR-206	HITS-CLIP	23313552
MIRT695509	hsa-miR-613	HITS-CLIP	23313552
MIRT695508	hsa-miR-7974	HITS-CLIP	23313552
MIRT695507	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695506	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT695505	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT695504	hsa-miR-6795-5p	HITS-CLIP	23313552
MIRT695503	hsa-miR-6887-5p	HITS-CLIP	23313552
MIRT695502	hsa-miR-328-5p	HITS-CLIP	23313552
MIRT695501	hsa-miR-6885-5p	HITS-CLIP	23313552
MIRT695500	hsa-miR-134-5p	HITS-CLIP	23313552
MIRT695499	hsa-miR-3118	HITS-CLIP	23313552
MIRT695498	hsa-miR-3164	HITS-CLIP	23313552
MIRT695497	hsa-miR-6820-3p	HITS-CLIP	23313552
MIRT695496	hsa-miR-1238-5p	HITS-CLIP	23313552
MIRT695495	hsa-miR-4758-5p	HITS-CLIP	23313552
MIRT695494	hsa-miR-7109-5p	HITS-CLIP	23313552
MIRT695519	hsa-miR-3200-5p	HITS-CLIP	23313552
MIRT695518	hsa-miR-4682	HITS-CLIP	23313552
MIRT695517	hsa-miR-6128	HITS-CLIP	23313552
MIRT695516	hsa-miR-637	HITS-CLIP	23313552
MIRT695515	hsa-miR-4481	HITS-CLIP	23313552
MIRT695514	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT695513	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT695512	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT695511	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT695510	hsa-miR-206	HITS-CLIP	23313552
MIRT695509	hsa-miR-613	HITS-CLIP	23313552
MIRT695508	hsa-miR-7974	HITS-CLIP	23313552
MIRT695507	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695506	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT695505	hsa-miR-486-3p	HITS-CLIP	23313552
MIRT695504	hsa-miR-6795-5p	HITS-CLIP	23313552
MIRT695503	hsa-miR-6887-5p	HITS-CLIP	23313552
MIRT695502	hsa-miR-328-5p	HITS-CLIP	23313552
MIRT695501	hsa-miR-6885-5p	HITS-CLIP	23313552
MIRT695500	hsa-miR-134-5p	HITS-CLIP	23313552
MIRT695499	hsa-miR-3118	HITS-CLIP	23313552
MIRT695498	hsa-miR-3164	HITS-CLIP	23313552
MIRT695497	hsa-miR-6820-3p	HITS-CLIP	23313552
MIRT695496	hsa-miR-1238-5p	HITS-CLIP	23313552
MIRT695495	hsa-miR-4758-5p	HITS-CLIP	23313552
MIRT695494	hsa-miR-7109-5p	HITS-CLIP	23313552
MIRT778940	hsa-miR-1231	CLIP-seq
MIRT778941	hsa-miR-204	CLIP-seq
MIRT778942	hsa-miR-211	CLIP-seq
MIRT778943	hsa-miR-24	CLIP-seq
MIRT778944	hsa-miR-2467-3p	CLIP-seq
MIRT778945	hsa-miR-3169	CLIP-seq
MIRT778946	hsa-miR-3175	CLIP-seq
MIRT778947	hsa-miR-331-3p	CLIP-seq
MIRT778948	hsa-miR-342-5p	CLIP-seq
MIRT778949	hsa-miR-3664-3p	CLIP-seq
MIRT778950	hsa-miR-4288	CLIP-seq
MIRT778951	hsa-miR-4292	CLIP-seq
MIRT778952	hsa-miR-4467	CLIP-seq
MIRT778953	hsa-miR-4646-5p	CLIP-seq
MIRT778954	hsa-miR-4651	CLIP-seq
MIRT778955	hsa-miR-4664-5p	CLIP-seq
MIRT778956	hsa-miR-4667-5p	CLIP-seq
MIRT778957	hsa-miR-4700-5p	CLIP-seq
MIRT778958	hsa-miR-4712-5p	CLIP-seq
MIRT778959	hsa-miR-4795-5p	CLIP-seq
MIRT778960	hsa-miR-592	CLIP-seq
MIRT778961	hsa-miR-597	CLIP-seq
MIRT778962	hsa-miR-608	CLIP-seq
MIRT778963	hsa-miR-632	CLIP-seq
MIRT778964	hsa-miR-639	CLIP-seq
MIRT778965	hsa-miR-770-5p	CLIP-seq
MIRT778966	hsa-miR-892a	CLIP-seq
MIRT778967	hsa-miR-922	CLIP-seq
MIRT2170697	hsa-miR-125a-3p	CLIP-seq
MIRT2170698	hsa-miR-133a	CLIP-seq
MIRT2170699	hsa-miR-133b	CLIP-seq
MIRT2170700	hsa-miR-3934	CLIP-seq
MIRT2170701	hsa-miR-4281	CLIP-seq
MIRT2170702	hsa-miR-764	CLIP-seq
MIRT2170698	hsa-miR-133a	CLIP-seq
MIRT2170699	hsa-miR-133b	CLIP-seq
MIRT778943	hsa-miR-24	CLIP-seq
MIRT2384094	hsa-miR-326	CLIP-seq
MIRT2384095	hsa-miR-330-5p	CLIP-seq
MIRT778952	hsa-miR-4467	CLIP-seq
MIRT778959	hsa-miR-4795-5p	CLIP-seq
MIRT2384096	hsa-miR-593	CLIP-seq
MIRT778964	hsa-miR-639	CLIP-seq
MIRT2170702	hsa-miR-764	CLIP-seq

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Transcription factor	Regulation	Reference
KLF4	Activation	12919939

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	ISS
GO:0002020	Function	Protease binding	IPI	18307834
GO:0004035	Function	Alkaline phosphatase activity	IBA
GO:0004035	Function	Alkaline phosphatase activity	IEA
GO:0004035	Function	Alkaline phosphatase activity	ISS
GO:0004035	Function	Alkaline phosphatase activity	NAS	2841341
GO:0005515	Function	Protein binding	IPI	25416956, 31515488
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0008270	Function	Zinc ion binding	ISS
GO:0016020	Component	Membrane	IEA
GO:0016311	Process	Dephosphorylation	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0098552	Component	Side of membrane	IEA

MIM	HGNC	e!Ensembl
171740	437	ENSG00000163295

P09923

Protein name

Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)

Protein function

Alkaline phosphatase that can hydrolyze various phosphate compounds.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00245	Alk_phosphatase	52 → 487	Alkaline phosphatase	Domain

Sequence

MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLG
DGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLC
GVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYA
HTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADA
SQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRD
PTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERA
GQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVF
NSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHV
MAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP

Sequence length

528

Interactions

View interactions

	KEGG		Reactome
	Thiamine metabolism Folate biosynthesis Metabolic pathways Biosynthesis of cofactors		Synthesis of PA Post-translational modification: synthesis of GPI-anchored proteins Digestion

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALPI-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Inflammatory bowel disease	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ALPI (alkaline phosphatase, intestinal)