CNPY4 (canopy FGF signaling regulator 4)

Gene

• Entrez ID: 245812
• Gene name: Canopy FGF signaling regulator 4
• Gene symbol: CNPY4
• Synonyms (NCBI Gene): PRAT4B
• Chromosome: 7
• Chromosome location: 7q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005173	hsa-miR-30a-5p	pSILAC	18668040
MIRT005173	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT901330	hsa-miR-1289	CLIP-seq
MIRT901331	hsa-miR-3198	CLIP-seq
MIRT901332	hsa-miR-329	CLIP-seq
MIRT901333	hsa-miR-3620	CLIP-seq
MIRT901334	hsa-miR-362-3p	CLIP-seq
MIRT901335	hsa-miR-4294	CLIP-seq
MIRT901336	hsa-miR-4309	CLIP-seq
MIRT901337	hsa-miR-668	CLIP-seq
MIRT1967394	hsa-miR-4437	CLIP-seq
MIRT2386295	hsa-miR-199a-5p	CLIP-seq
MIRT2386296	hsa-miR-199b-5p	CLIP-seq
MIRT2505986	hsa-miR-1227	CLIP-seq
MIRT2505987	hsa-miR-1825	CLIP-seq
MIRT2386295	hsa-miR-199a-5p	CLIP-seq
MIRT2386296	hsa-miR-199b-5p	CLIP-seq
MIRT2505988	hsa-miR-2355-5p	CLIP-seq
MIRT2505989	hsa-miR-3925-3p	CLIP-seq
MIRT2505990	hsa-miR-4252	CLIP-seq
MIRT2505991	hsa-miR-628-5p	CLIP-seq
MIRT2505986	hsa-miR-1227	CLIP-seq
MIRT2678370	hsa-miR-1262	CLIP-seq
MIRT2678371	hsa-miR-1293	CLIP-seq
MIRT2505987	hsa-miR-1825	CLIP-seq
MIRT2386295	hsa-miR-199a-5p	CLIP-seq
MIRT2386296	hsa-miR-199b-5p	CLIP-seq
MIRT2505988	hsa-miR-2355-5p	CLIP-seq
MIRT2505989	hsa-miR-3925-3p	CLIP-seq
MIRT2505990	hsa-miR-4252	CLIP-seq
MIRT2678372	hsa-miR-4447	CLIP-seq
MIRT2678373	hsa-miR-4472	CLIP-seq
MIRT2678374	hsa-miR-4483	CLIP-seq
MIRT2678375	hsa-miR-450b-3p	CLIP-seq
MIRT2678376	hsa-miR-4651	CLIP-seq
MIRT2678377	hsa-miR-4654	CLIP-seq
MIRT2678378	hsa-miR-4701-3p	CLIP-seq
MIRT2678379	hsa-miR-4713-3p	CLIP-seq
MIRT2678380	hsa-miR-4769-5p	CLIP-seq
MIRT2678381	hsa-miR-608	CLIP-seq
MIRT2505991	hsa-miR-628-5p	CLIP-seq
MIRT2678382	hsa-miR-638	CLIP-seq
MIRT2678383	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IMP	16338228

Other IDs

• MIM: 610047
• HGNC: 28631
• e!Ensembl: ENSG00000166997

Protein

• UniProt ID: Q8N129
• Protein name: Protein canopy homolog 4
• Protein function: Plays a role in the regulation of the cell surface expression of TLR4.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11938	DUF3456	37 → 196	TLR4 regulator and MIR-interacting MSAP	Family

• Sequence:

  MGPVRLGILLFLFLAVHEAWAGMLKEEDDDTERLPSKCEVCKLLSTELQAELSRTGRSRE
  VLELGQVLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTM
  ATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVGDWYFHHQEQPLQ
  NFLCEGHVLPAAETACLQETWTGKEITDGEEKTEGEEEQEEEEEEEEEEGGDKMTKTGSH
  PKLDREDL

• Sequence length: 248

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations