Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	245806
Gene name	Vestigial like family member 2
Gene symbol	VGLL2
Synonyms (NCBI Gene)	VGL2VITO1
Chromosome	6
Chromosome location	6q22.1
Summary	This gene encodes a protein with a transcriptional enhancer factor 1 (TEF-1) interaction domain. The encoded protein may act as a co-factor of TEF-1 regulated gene expression during skeletal muscle development. Alternatively spliced transcript variants en

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miRTarBase ID	miRNA	Experiments	Reference
MIRT552960	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT552958	hsa-miR-1295b-5p	HITS-CLIP	23313552
MIRT552957	hsa-miR-1912	HITS-CLIP	23313552
MIRT552956	hsa-miR-3130-5p	HITS-CLIP	23313552
MIRT552955	hsa-miR-4482-5p	HITS-CLIP	23313552
MIRT552954	hsa-miR-369-3p	HITS-CLIP	23313552
MIRT552953	hsa-miR-5692b	HITS-CLIP	23313552
MIRT552952	hsa-miR-5692c	HITS-CLIP	23313552
MIRT552951	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT552950	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT552949	hsa-miR-586	HITS-CLIP	23313552
MIRT693776	hsa-miR-148a-3p	HITS-CLIP	23313552
MIRT693775	hsa-miR-148b-3p	HITS-CLIP	23313552
MIRT693774	hsa-miR-152-3p	HITS-CLIP	23313552
MIRT693773	hsa-miR-1825	HITS-CLIP	23313552
MIRT552948	hsa-miR-5689	HITS-CLIP	23313552
MIRT552945	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT552944	hsa-miR-5583-5p	HITS-CLIP	23313552
MIRT552960	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT552959	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT552958	hsa-miR-1295b-5p	PAR-CLIP	21572407
MIRT552957	hsa-miR-1912	PAR-CLIP	21572407
MIRT552956	hsa-miR-3130-5p	PAR-CLIP	21572407
MIRT552955	hsa-miR-4482-5p	PAR-CLIP	21572407
MIRT552954	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT552953	hsa-miR-5692b	PAR-CLIP	21572407
MIRT552952	hsa-miR-5692c	PAR-CLIP	21572407
MIRT552951	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT552950	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT552949	hsa-miR-586	PAR-CLIP	21572407
MIRT552948	hsa-miR-5689	PAR-CLIP	21572407
MIRT552947	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT552946	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT552945	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552944	hsa-miR-5583-5p	PAR-CLIP	21572407
MIRT552960	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT552958	hsa-miR-1295b-5p	HITS-CLIP	23313552
MIRT552957	hsa-miR-1912	HITS-CLIP	23313552
MIRT552956	hsa-miR-3130-5p	HITS-CLIP	23313552
MIRT552955	hsa-miR-4482-5p	HITS-CLIP	23313552
MIRT552954	hsa-miR-369-3p	HITS-CLIP	23313552
MIRT552953	hsa-miR-5692b	HITS-CLIP	23313552
MIRT552952	hsa-miR-5692c	HITS-CLIP	23313552
MIRT552951	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT552950	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT552949	hsa-miR-586	HITS-CLIP	23313552
MIRT693776	hsa-miR-148a-3p	HITS-CLIP	23313552
MIRT693775	hsa-miR-148b-3p	HITS-CLIP	23313552
MIRT693774	hsa-miR-152-3p	HITS-CLIP	23313552
MIRT693773	hsa-miR-1825	HITS-CLIP	23313552
MIRT552948	hsa-miR-5689	HITS-CLIP	23313552
MIRT552945	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT552944	hsa-miR-5583-5p	HITS-CLIP	23313552
MIRT552960	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT552959	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT552958	hsa-miR-1295b-5p	PAR-CLIP	21572407
MIRT552957	hsa-miR-1912	PAR-CLIP	21572407
MIRT552956	hsa-miR-3130-5p	PAR-CLIP	21572407
MIRT552955	hsa-miR-4482-5p	PAR-CLIP	21572407
MIRT552954	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT552953	hsa-miR-5692b	PAR-CLIP	21572407
MIRT552952	hsa-miR-5692c	PAR-CLIP	21572407
MIRT552951	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT552950	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT552949	hsa-miR-586	PAR-CLIP	21572407
MIRT552948	hsa-miR-5689	PAR-CLIP	21572407
MIRT552947	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT552946	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT552945	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552944	hsa-miR-5583-5p	PAR-CLIP	21572407
MIRT1484312	hsa-miR-106a	CLIP-seq
MIRT1484313	hsa-miR-106b	CLIP-seq
MIRT1484314	hsa-miR-17	CLIP-seq
MIRT1484315	hsa-miR-20a	CLIP-seq
MIRT1484316	hsa-miR-20b	CLIP-seq
MIRT1484317	hsa-miR-3127-3p	CLIP-seq
MIRT1484318	hsa-miR-3609	CLIP-seq
MIRT1484319	hsa-miR-4659a-3p	CLIP-seq
MIRT1484320	hsa-miR-4659b-3p	CLIP-seq
MIRT1484321	hsa-miR-4796-3p	CLIP-seq
MIRT1484322	hsa-miR-519d	CLIP-seq
MIRT1484323	hsa-miR-548ah	CLIP-seq
MIRT1484324	hsa-miR-93	CLIP-seq
MIRT2145786	hsa-miR-3185	CLIP-seq
MIRT2145787	hsa-miR-3612	CLIP-seq
MIRT2145788	hsa-miR-3915	CLIP-seq
MIRT2145789	hsa-miR-3928	CLIP-seq
MIRT2145790	hsa-miR-3929	CLIP-seq
MIRT2145791	hsa-miR-4419b	CLIP-seq
MIRT2145792	hsa-miR-4443	CLIP-seq
MIRT2145793	hsa-miR-4478	CLIP-seq
MIRT2145794	hsa-miR-4710	CLIP-seq
MIRT2145795	hsa-miR-485-5p	CLIP-seq
MIRT2145796	hsa-miR-516b	CLIP-seq
MIRT2145797	hsa-miR-650	CLIP-seq
MIRT2366207	hsa-miR-128	CLIP-seq
MIRT2366208	hsa-miR-2115	CLIP-seq
MIRT2366209	hsa-miR-27a	CLIP-seq
MIRT2366210	hsa-miR-27b	CLIP-seq
MIRT2145787	hsa-miR-3612	CLIP-seq
MIRT2145788	hsa-miR-3915	CLIP-seq
MIRT2145789	hsa-miR-3928	CLIP-seq
MIRT2145790	hsa-miR-3929	CLIP-seq
MIRT2145791	hsa-miR-4419b	CLIP-seq
MIRT2145792	hsa-miR-4443	CLIP-seq
MIRT2145793	hsa-miR-4478	CLIP-seq
MIRT2366211	hsa-miR-455-3p	CLIP-seq
MIRT2145794	hsa-miR-4710	CLIP-seq
MIRT2366212	hsa-miR-4716-5p	CLIP-seq
MIRT2145795	hsa-miR-485-5p	CLIP-seq
MIRT2366213	hsa-miR-513a-5p	CLIP-seq
MIRT2145796	hsa-miR-516b	CLIP-seq
MIRT2145797	hsa-miR-650	CLIP-seq
MIRT2396819	hsa-miR-3154	CLIP-seq
MIRT1484319	hsa-miR-4659a-3p	CLIP-seq
MIRT1484320	hsa-miR-4659b-3p	CLIP-seq
MIRT1484317	hsa-miR-3127-3p	CLIP-seq
MIRT1484319	hsa-miR-4659a-3p	CLIP-seq
MIRT1484320	hsa-miR-4659b-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007519	Process	Skeletal muscle tissue development	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

MIM	HGNC	e!Ensembl
609979	20232	ENSG00000170162

Q8N8G2

Protein name

Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1)

Protein function

May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07545	Vg_Tdu	79 → 109	Vestigial/Tondu family	Family

Tissue specificity

TISSUE SPECIFICITY: Skeletal muscle. {ECO:0000269|PubMed:12617818}.

Sequence

MSCLDVMYQVYGPPQPYFAAAYTPYHQKLAYYSKMQEAQECNASPSSSGSGSSSFSSQTP
ASIKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVDEHFSRALSQPSSYSPSCTSS
KAPRSSGPWRDCSFPMSQRSFPASFWNSAYQAPVPPPLGSPLATAHSELPFAAADPYSPA
ALHGHLHQGATEPWHHAHPHHAHPHHPYALGGALGAQAAPYPRPAAVHEVYAPHFDPRYG
PLLMPAASGRPARLATAPAPAPGSPPCELSGKGEPAGAAWAGPGGPFASPSGDVAQGLGL
SVDSARRYSLCGASLLS

Sequence length

317

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma	Carcinoma	Pubtator	26501226, 30181563, 32087612, 34067464, 35452896, 38607246	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	CTD_human_DG	22535842		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	31696361		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	Pubtator	38607246	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

VGLL2 (vestigial like family member 2)