FRK (fyn related Src family tyrosine kinase)

Gene

• Entrez ID: 2444
• Gene name: Fyn related Src family tyrosine kinase
• Gene symbol: FRK
• Synonyms (NCBI Gene): GTK, PTK5, RAK
• Chromosome: 6
• Chromosome location: 6q22.1
• Summary: The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018568	hsa-miR-335-5p	Microarray	18185580
MIRT715686	hsa-miR-6819-3p	HITS-CLIP	19536157
MIRT715685	hsa-miR-6877-3p	HITS-CLIP	19536157
MIRT715684	hsa-miR-5571-3p	HITS-CLIP	19536157
MIRT715682	hsa-miR-7975	HITS-CLIP	19536157
MIRT715683	hsa-miR-4520-3p	HITS-CLIP	19536157
MIRT715681	hsa-miR-384	HITS-CLIP	19536157
MIRT715680	hsa-miR-4520-2-3p	HITS-CLIP	19536157
MIRT715678	hsa-miR-4529-3p	HITS-CLIP	19536157
MIRT715679	hsa-miR-7850-5p	HITS-CLIP	19536157
MIRT658070	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT658069	hsa-miR-1248	HITS-CLIP	23824327
MIRT508174	hsa-miR-3133	PAR-CLIP	20371350
MIRT508173	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT508172	hsa-miR-1243	PAR-CLIP	20371350
MIRT508171	hsa-miR-4499	PAR-CLIP	20371350
MIRT508170	hsa-miR-4463	PAR-CLIP	20371350
MIRT508169	hsa-miR-3688-5p	PAR-CLIP	20371350
MIRT508168	hsa-miR-891a-3p	PAR-CLIP	20371350
MIRT508167	hsa-miR-151a-3p	PAR-CLIP	20371350
MIRT525104	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT525103	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT525102	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT525101	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT525100	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT525099	hsa-miR-4694-3p	PAR-CLIP	22012620
MIRT525098	hsa-miR-224-3p	PAR-CLIP	22012620
MIRT525097	hsa-miR-522-3p	PAR-CLIP	22012620
MIRT525096	hsa-miR-541-5p	PAR-CLIP	22012620
MIRT525095	hsa-miR-4661-5p	PAR-CLIP	22012620
MIRT525094	hsa-miR-3654	PAR-CLIP	22012620
MIRT525093	hsa-miR-3938	PAR-CLIP	22012620
MIRT525092	hsa-miR-454-5p	PAR-CLIP	22012620
MIRT525091	hsa-miR-4738-3p	PAR-CLIP	22012620
MIRT525090	hsa-miR-711	PAR-CLIP	22012620
MIRT525089	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT525088	hsa-miR-3153	PAR-CLIP	22012620
MIRT525087	hsa-miR-6733-5p	PAR-CLIP	22012620
MIRT525086	hsa-miR-6739-5p	PAR-CLIP	22012620
MIRT525085	hsa-miR-4271	PAR-CLIP	22012620
MIRT525084	hsa-miR-4725-3p	PAR-CLIP	22012620
MIRT525083	hsa-miR-6780b-5p	PAR-CLIP	22012620
MIRT525082	hsa-miR-4694-5p	PAR-CLIP	22012620
MIRT525081	hsa-miR-4425	PAR-CLIP	22012620
MIRT525080	hsa-miR-3147	PAR-CLIP	22012620
MIRT525079	hsa-miR-6883-3p	PAR-CLIP	22012620
MIRT525078	hsa-miR-2110	PAR-CLIP	22012620
MIRT525077	hsa-miR-450a-1-3p	PAR-CLIP	22012620
MIRT525076	hsa-miR-8076	PAR-CLIP	22012620
MIRT525075	hsa-miR-3688-3p	PAR-CLIP	22012620
MIRT525074	hsa-miR-103b	PAR-CLIP	22012620
MIRT525073	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT525072	hsa-miR-4476	PAR-CLIP	22012620
MIRT525071	hsa-miR-6876-5p	PAR-CLIP	22012620
MIRT525070	hsa-miR-16-2-3p	PAR-CLIP	22012620
MIRT525069	hsa-miR-195-3p	PAR-CLIP	22012620
MIRT525068	hsa-miR-490-5p	PAR-CLIP	22012620
MIRT525067	hsa-miR-6847-3p	PAR-CLIP	22012620
MIRT525066	hsa-miR-5191	PAR-CLIP	22012620
MIRT525065	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT525064	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT525063	hsa-miR-8063	PAR-CLIP	22012620
MIRT525062	hsa-miR-4698	PAR-CLIP	22012620
MIRT525061	hsa-miR-4742-5p	PAR-CLIP	22012620
MIRT525060	hsa-miR-4269	PAR-CLIP	22012620
MIRT525059	hsa-miR-6715b-5p	PAR-CLIP	22012620
MIRT525058	hsa-miR-4514	PAR-CLIP	22012620
MIRT525057	hsa-miR-4692	PAR-CLIP	22012620
MIRT525056	hsa-miR-4685-5p	PAR-CLIP	22012620
MIRT525055	hsa-miR-6837-5p	PAR-CLIP	22012620
MIRT525054	hsa-miR-3190-5p	PAR-CLIP	22012620
MIRT525053	hsa-miR-3176	PAR-CLIP	22012620
MIRT525052	hsa-miR-3922-3p	PAR-CLIP	22012620
MIRT525051	hsa-miR-31-5p	PAR-CLIP	22012620
MIRT525050	hsa-miR-503-3p	PAR-CLIP	22012620
MIRT525049	hsa-miR-3671	PAR-CLIP	22012620
MIRT525048	hsa-miR-488-3p	PAR-CLIP	22012620
MIRT525047	hsa-miR-4435	PAR-CLIP	22012620
MIRT525046	hsa-miR-607	PAR-CLIP	22012620
MIRT525045	hsa-miR-4728-3p	PAR-CLIP	22012620
MIRT525044	hsa-miR-105-5p	PAR-CLIP	22012620
MIRT525043	hsa-miR-7853-5p	PAR-CLIP	22012620
MIRT525042	hsa-miR-6761-5p	PAR-CLIP	22012620
MIRT525041	hsa-miR-4663	PAR-CLIP	22012620
MIRT525040	hsa-miR-7160-5p	PAR-CLIP	22012620
MIRT525039	hsa-miR-8077	PAR-CLIP	22012620
MIRT525038	hsa-miR-3646	PAR-CLIP	22012620
MIRT525037	hsa-miR-3974	PAR-CLIP	22012620
MIRT525036	hsa-miR-4436b-3p	PAR-CLIP	22012620
MIRT525035	hsa-miR-4632-5p	PAR-CLIP	22012620
MIRT525034	hsa-miR-6735-5p	PAR-CLIP	22012620
MIRT525033	hsa-miR-6879-5p	PAR-CLIP	22012620
MIRT525032	hsa-miR-7843-5p	PAR-CLIP	22012620
MIRT525031	hsa-miR-6730-5p	PAR-CLIP	22012620
MIRT525030	hsa-miR-203a-3p	PAR-CLIP	22012620
MIRT525029	hsa-miR-6892-5p	PAR-CLIP	22012620
MIRT508174	hsa-miR-3133	PAR-CLIP	23446348
MIRT508173	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT508171	hsa-miR-4499	PAR-CLIP	23446348
MIRT508170	hsa-miR-4463	PAR-CLIP	23446348
MIRT508169	hsa-miR-3688-5p	PAR-CLIP	23446348
MIRT508168	hsa-miR-891a-3p	PAR-CLIP	23446348
MIRT508167	hsa-miR-151a-3p	PAR-CLIP	23446348
MIRT508174	hsa-miR-3133	PAR-CLIP	23446348
MIRT508173	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT508172	hsa-miR-1243	PAR-CLIP	23446348
MIRT508171	hsa-miR-4499	PAR-CLIP	23446348
MIRT508170	hsa-miR-4463	PAR-CLIP	23446348
MIRT508169	hsa-miR-3688-5p	PAR-CLIP	23446348
MIRT508168	hsa-miR-891a-3p	PAR-CLIP	23446348
MIRT508167	hsa-miR-151a-3p	PAR-CLIP	23446348
MIRT508166	hsa-miR-1261	PAR-CLIP	23446348
MIRT498512	hsa-miR-4282	PAR-CLIP	24398324
MIRT498511	hsa-miR-6871-5p	PAR-CLIP	24398324
MIRT498509	hsa-miR-4714-3p	PAR-CLIP	24398324
MIRT498510	hsa-miR-6878-5p	PAR-CLIP	24398324
MIRT498508	hsa-miR-6731-5p	PAR-CLIP	24398324
MIRT498507	hsa-miR-8085	PAR-CLIP	24398324
MIRT498506	hsa-miR-30c-1-3p	PAR-CLIP	24398324
MIRT498505	hsa-miR-30c-2-3p	PAR-CLIP	24398324
MIRT498504	hsa-miR-6788-5p	PAR-CLIP	24398324
MIRT498503	hsa-miR-450b-5p	PAR-CLIP	24398324
MIRT498502	hsa-miR-507	PAR-CLIP	24398324
MIRT498501	hsa-miR-557	PAR-CLIP	24398324
MIRT498500	hsa-miR-3680-3p	PAR-CLIP	24398324
MIRT498499	hsa-miR-129-5p	PAR-CLIP	24398324
MIRT498498	hsa-miR-6835-3p	PAR-CLIP	24398324
MIRT498497	hsa-miR-4422	PAR-CLIP	24398324
MIRT476723	hsa-miR-6873-5p	PAR-CLIP	24398324
MIRT476722	hsa-miR-29a-3p	PAR-CLIP	24398324
MIRT476721	hsa-miR-29b-3p	PAR-CLIP	24398324
MIRT476720	hsa-miR-29c-3p	PAR-CLIP	24398324
MIRT498496	hsa-miR-6871-3p	PAR-CLIP	24398324
MIRT476719	hsa-miR-4519	PAR-CLIP	24398324
MIRT476718	hsa-miR-5584-5p	PAR-CLIP	24398324
MIRT498495	hsa-miR-4302	PAR-CLIP	24398324
MIRT476717	hsa-miR-6499-3p	PAR-CLIP	24398324
MIRT476715	hsa-miR-6832-5p	PAR-CLIP	24398324
MIRT476716	hsa-miR-4732-5p	PAR-CLIP	24398324
MIRT476714	hsa-miR-9-3p	PAR-CLIP	24398324
MIRT476713	hsa-miR-5682	PAR-CLIP	24398324
MIRT476712	hsa-miR-6867-5p	PAR-CLIP	24398324
MIRT476723	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT476722	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT476721	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT476720	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT476719	hsa-miR-4519	PAR-CLIP	23592263
MIRT476718	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT476717	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT476715	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT476716	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT476714	hsa-miR-9-3p	PAR-CLIP	23592263
MIRT476713	hsa-miR-5682	PAR-CLIP	23592263
MIRT476712	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT715686	hsa-miR-6819-3p	HITS-CLIP	19536157
MIRT715685	hsa-miR-6877-3p	HITS-CLIP	19536157
MIRT715684	hsa-miR-5571-3p	HITS-CLIP	19536157
MIRT715682	hsa-miR-7975	HITS-CLIP	19536157
MIRT715683	hsa-miR-4520-3p	HITS-CLIP	19536157
MIRT715681	hsa-miR-384	HITS-CLIP	19536157
MIRT715680	hsa-miR-4520-2-3p	HITS-CLIP	19536157
MIRT715678	hsa-miR-4529-3p	HITS-CLIP	19536157
MIRT715679	hsa-miR-7850-5p	HITS-CLIP	19536157
MIRT658070	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT658069	hsa-miR-1248	HITS-CLIP	23824327
MIRT508174	hsa-miR-3133	PAR-CLIP	20371350
MIRT508173	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT508172	hsa-miR-1243	PAR-CLIP	20371350
MIRT508171	hsa-miR-4499	PAR-CLIP	20371350
MIRT508170	hsa-miR-4463	PAR-CLIP	20371350
MIRT508169	hsa-miR-3688-5p	PAR-CLIP	20371350
MIRT508168	hsa-miR-891a-3p	PAR-CLIP	20371350
MIRT508167	hsa-miR-151a-3p	PAR-CLIP	20371350
MIRT525104	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT525103	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT525102	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT525101	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT525100	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT525099	hsa-miR-4694-3p	PAR-CLIP	22012620
MIRT525098	hsa-miR-224-3p	PAR-CLIP	22012620
MIRT525097	hsa-miR-522-3p	PAR-CLIP	22012620
MIRT525096	hsa-miR-541-5p	PAR-CLIP	22012620
MIRT525095	hsa-miR-4661-5p	PAR-CLIP	22012620
MIRT525094	hsa-miR-3654	PAR-CLIP	22012620
MIRT525093	hsa-miR-3938	PAR-CLIP	22012620
MIRT525092	hsa-miR-454-5p	PAR-CLIP	22012620
MIRT525091	hsa-miR-4738-3p	PAR-CLIP	22012620
MIRT525090	hsa-miR-711	PAR-CLIP	22012620
MIRT525089	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT525088	hsa-miR-3153	PAR-CLIP	22012620
MIRT525087	hsa-miR-6733-5p	PAR-CLIP	22012620
MIRT525086	hsa-miR-6739-5p	PAR-CLIP	22012620
MIRT525085	hsa-miR-4271	PAR-CLIP	22012620
MIRT525084	hsa-miR-4725-3p	PAR-CLIP	22012620
MIRT525083	hsa-miR-6780b-5p	PAR-CLIP	22012620
MIRT525082	hsa-miR-4694-5p	PAR-CLIP	22012620
MIRT525081	hsa-miR-4425	PAR-CLIP	22012620
MIRT525080	hsa-miR-3147	PAR-CLIP	22012620
MIRT525079	hsa-miR-6883-3p	PAR-CLIP	22012620
MIRT525078	hsa-miR-2110	PAR-CLIP	22012620
MIRT525077	hsa-miR-450a-1-3p	PAR-CLIP	22012620
MIRT525076	hsa-miR-8076	PAR-CLIP	22012620
MIRT525075	hsa-miR-3688-3p	PAR-CLIP	22012620
MIRT525074	hsa-miR-103b	PAR-CLIP	22012620
MIRT525073	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT525072	hsa-miR-4476	PAR-CLIP	22012620
MIRT525071	hsa-miR-6876-5p	PAR-CLIP	22012620
MIRT525070	hsa-miR-16-2-3p	PAR-CLIP	22012620
MIRT525069	hsa-miR-195-3p	PAR-CLIP	22012620
MIRT525068	hsa-miR-490-5p	PAR-CLIP	22012620
MIRT525067	hsa-miR-6847-3p	PAR-CLIP	22012620
MIRT525066	hsa-miR-5191	PAR-CLIP	22012620
MIRT525065	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT525064	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT525063	hsa-miR-8063	PAR-CLIP	22012620
MIRT525062	hsa-miR-4698	PAR-CLIP	22012620
MIRT525061	hsa-miR-4742-5p	PAR-CLIP	22012620
MIRT525060	hsa-miR-4269	PAR-CLIP	22012620
MIRT525059	hsa-miR-6715b-5p	PAR-CLIP	22012620
MIRT525058	hsa-miR-4514	PAR-CLIP	22012620
MIRT525057	hsa-miR-4692	PAR-CLIP	22012620
MIRT525056	hsa-miR-4685-5p	PAR-CLIP	22012620
MIRT525055	hsa-miR-6837-5p	PAR-CLIP	22012620
MIRT525054	hsa-miR-3190-5p	PAR-CLIP	22012620
MIRT525053	hsa-miR-3176	PAR-CLIP	22012620
MIRT525052	hsa-miR-3922-3p	PAR-CLIP	22012620
MIRT525051	hsa-miR-31-5p	PAR-CLIP	22012620
MIRT525050	hsa-miR-503-3p	PAR-CLIP	22012620
MIRT525049	hsa-miR-3671	PAR-CLIP	22012620
MIRT525048	hsa-miR-488-3p	PAR-CLIP	22012620
MIRT525047	hsa-miR-4435	PAR-CLIP	22012620
MIRT525046	hsa-miR-607	PAR-CLIP	22012620
MIRT525045	hsa-miR-4728-3p	PAR-CLIP	22012620
MIRT525044	hsa-miR-105-5p	PAR-CLIP	22012620
MIRT525043	hsa-miR-7853-5p	PAR-CLIP	22012620
MIRT525042	hsa-miR-6761-5p	PAR-CLIP	22012620
MIRT525041	hsa-miR-4663	PAR-CLIP	22012620
MIRT525040	hsa-miR-7160-5p	PAR-CLIP	22012620
MIRT525039	hsa-miR-8077	PAR-CLIP	22012620
MIRT525038	hsa-miR-3646	PAR-CLIP	22012620
MIRT525037	hsa-miR-3974	PAR-CLIP	22012620
MIRT525036	hsa-miR-4436b-3p	PAR-CLIP	22012620
MIRT525035	hsa-miR-4632-5p	PAR-CLIP	22012620
MIRT525034	hsa-miR-6735-5p	PAR-CLIP	22012620
MIRT525033	hsa-miR-6879-5p	PAR-CLIP	22012620
MIRT525032	hsa-miR-7843-5p	PAR-CLIP	22012620
MIRT525031	hsa-miR-6730-5p	PAR-CLIP	22012620
MIRT525030	hsa-miR-203a-3p	PAR-CLIP	22012620
MIRT525029	hsa-miR-6892-5p	PAR-CLIP	22012620
MIRT508174	hsa-miR-3133	PAR-CLIP	23446348
MIRT508173	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT508171	hsa-miR-4499	PAR-CLIP	23446348
MIRT508170	hsa-miR-4463	PAR-CLIP	23446348
MIRT508169	hsa-miR-3688-5p	PAR-CLIP	23446348
MIRT508168	hsa-miR-891a-3p	PAR-CLIP	23446348
MIRT508167	hsa-miR-151a-3p	PAR-CLIP	23446348
MIRT508174	hsa-miR-3133	PAR-CLIP	23446348
MIRT508173	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT508172	hsa-miR-1243	PAR-CLIP	23446348
MIRT508171	hsa-miR-4499	PAR-CLIP	23446348
MIRT508170	hsa-miR-4463	PAR-CLIP	23446348
MIRT508169	hsa-miR-3688-5p	PAR-CLIP	23446348
MIRT508168	hsa-miR-891a-3p	PAR-CLIP	23446348
MIRT508167	hsa-miR-151a-3p	PAR-CLIP	23446348
MIRT508166	hsa-miR-1261	PAR-CLIP	23446348
MIRT498512	hsa-miR-4282	PAR-CLIP	24398324
MIRT498511	hsa-miR-6871-5p	PAR-CLIP	24398324
MIRT498509	hsa-miR-4714-3p	PAR-CLIP	24398324
MIRT498510	hsa-miR-6878-5p	PAR-CLIP	24398324
MIRT498508	hsa-miR-6731-5p	PAR-CLIP	24398324
MIRT498507	hsa-miR-8085	PAR-CLIP	24398324
MIRT498506	hsa-miR-30c-1-3p	PAR-CLIP	24398324
MIRT498505	hsa-miR-30c-2-3p	PAR-CLIP	24398324
MIRT498504	hsa-miR-6788-5p	PAR-CLIP	24398324
MIRT498503	hsa-miR-450b-5p	PAR-CLIP	24398324
MIRT498502	hsa-miR-507	PAR-CLIP	24398324
MIRT498501	hsa-miR-557	PAR-CLIP	24398324
MIRT498500	hsa-miR-3680-3p	PAR-CLIP	24398324
MIRT498499	hsa-miR-129-5p	PAR-CLIP	24398324
MIRT498498	hsa-miR-6835-3p	PAR-CLIP	24398324
MIRT498497	hsa-miR-4422	PAR-CLIP	24398324
MIRT476723	hsa-miR-6873-5p	PAR-CLIP	24398324
MIRT476722	hsa-miR-29a-3p	PAR-CLIP	24398324
MIRT476721	hsa-miR-29b-3p	PAR-CLIP	24398324
MIRT476720	hsa-miR-29c-3p	PAR-CLIP	24398324
MIRT498496	hsa-miR-6871-3p	PAR-CLIP	24398324
MIRT476719	hsa-miR-4519	PAR-CLIP	24398324
MIRT476718	hsa-miR-5584-5p	PAR-CLIP	24398324
MIRT498495	hsa-miR-4302	PAR-CLIP	24398324
MIRT476717	hsa-miR-6499-3p	PAR-CLIP	24398324
MIRT476715	hsa-miR-6832-5p	PAR-CLIP	24398324
MIRT476716	hsa-miR-4732-5p	PAR-CLIP	24398324
MIRT476714	hsa-miR-9-3p	PAR-CLIP	24398324
MIRT476713	hsa-miR-5682	PAR-CLIP	24398324
MIRT476712	hsa-miR-6867-5p	PAR-CLIP	24398324
MIRT476723	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT476722	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT476721	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT476720	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT476719	hsa-miR-4519	PAR-CLIP	23592263
MIRT476718	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT476717	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT476715	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT476716	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT476714	hsa-miR-9-3p	PAR-CLIP	23592263
MIRT476713	hsa-miR-5682	PAR-CLIP	23592263
MIRT476712	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT1004437	hsa-miR-103a	CLIP-seq
MIRT1004438	hsa-miR-107	CLIP-seq
MIRT1004439	hsa-miR-219-5p	CLIP-seq
MIRT1004440	hsa-miR-330-3p	CLIP-seq
MIRT1004441	hsa-miR-370	CLIP-seq
MIRT1004442	hsa-miR-3944-5p	CLIP-seq
MIRT1004443	hsa-miR-4445	CLIP-seq
MIRT1004444	hsa-miR-4724-5p	CLIP-seq
MIRT1004445	hsa-miR-4782-3p	CLIP-seq
MIRT1004446	hsa-miR-4789-3p	CLIP-seq
MIRT1004447	hsa-miR-508-3p	CLIP-seq
MIRT1004448	hsa-miR-514	CLIP-seq
MIRT1004449	hsa-miR-514b-3p	CLIP-seq
MIRT1004450	hsa-miR-545	CLIP-seq
MIRT1004451	hsa-miR-548g	CLIP-seq
MIRT1004452	hsa-miR-642b	CLIP-seq
MIRT1997738	hsa-miR-1237	CLIP-seq
MIRT1997739	hsa-miR-221	CLIP-seq
MIRT1997740	hsa-miR-222	CLIP-seq
MIRT1997741	hsa-miR-2276	CLIP-seq
MIRT1997742	hsa-miR-30a	CLIP-seq
MIRT1997743	hsa-miR-30b	CLIP-seq
MIRT1997744	hsa-miR-30c	CLIP-seq
MIRT1997745	hsa-miR-30d	CLIP-seq
MIRT1997746	hsa-miR-30e	CLIP-seq
MIRT1997747	hsa-miR-3115	CLIP-seq
MIRT1997748	hsa-miR-3662	CLIP-seq
MIRT1997749	hsa-miR-3682-5p	CLIP-seq
MIRT1004442	hsa-miR-3944-5p	CLIP-seq
MIRT1997750	hsa-miR-421	CLIP-seq
MIRT1997751	hsa-miR-4264	CLIP-seq
MIRT1997752	hsa-miR-4330	CLIP-seq
MIRT1997753	hsa-miR-4477a	CLIP-seq
MIRT1997754	hsa-miR-4494	CLIP-seq
MIRT1997755	hsa-miR-4709-5p	CLIP-seq
MIRT1997756	hsa-miR-4772-3p	CLIP-seq
MIRT1997757	hsa-miR-4797-3p	CLIP-seq
MIRT1997758	hsa-miR-499a-5p	CLIP-seq
MIRT1997759	hsa-miR-510	CLIP-seq
MIRT1997760	hsa-miR-512-5p	CLIP-seq
MIRT1997761	hsa-miR-513c	CLIP-seq
MIRT1997762	hsa-miR-514b-5p	CLIP-seq
MIRT1997763	hsa-miR-544	CLIP-seq
MIRT1004450	hsa-miR-545	CLIP-seq
MIRT1997764	hsa-miR-548u	CLIP-seq
MIRT1997765	hsa-miR-548v	CLIP-seq
MIRT2231418	hsa-miR-132	CLIP-seq
MIRT2231419	hsa-miR-212	CLIP-seq
MIRT1997742	hsa-miR-30a	CLIP-seq
MIRT1997743	hsa-miR-30b	CLIP-seq
MIRT1997744	hsa-miR-30c	CLIP-seq
MIRT1997745	hsa-miR-30d	CLIP-seq
MIRT1997746	hsa-miR-30e	CLIP-seq
MIRT1997748	hsa-miR-3662	CLIP-seq
MIRT2231420	hsa-miR-3915	CLIP-seq
MIRT2231421	hsa-miR-3928	CLIP-seq
MIRT1997755	hsa-miR-4709-5p	CLIP-seq
MIRT1997759	hsa-miR-510	CLIP-seq
MIRT1997760	hsa-miR-512-5p	CLIP-seq
MIRT1997764	hsa-miR-548u	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	12837246
GO:0000166	Function	Nucleotide binding	IEA
GO:0002221	Process	Pattern recognition receptor signaling pathway	IDA	23910378
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	IDA	29441066
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	EXP	19345329
GO:0004713	Function	Protein tyrosine kinase activity	IDA	35723276
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	TAS	7510261
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	7664264, 19345329, 21516116, 25416956, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7696183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	7696183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0035580	Component	Specific granule lumen	TAS
GO:0039537	Process	Symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway	IDA	34811497
GO:0045824	Process	Negative regulation of innate immune response	IDA	34811497
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 606573
• HGNC: 3955
• e!Ensembl: ENSG00000111816

Protein

• UniProt ID: P42685
• Protein name: Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
• Protein function: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by r
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00018	SH3_1	48 → 102	SH3 domain	Domain
  PF00017	SH2	116 → 193	SH2 domain	Domain
  PF07714	PK_Tyr_Ser-Thr	234 → 487	Protein tyrosine and serine/threonine kinase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. {ECO:0000269|PubMed:7696183}.
• Sequence:

  MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED
  LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA
  IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR
  RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL
  GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED
  PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV
  LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG
  ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF
  ETLRWKLEDYFETDSSYSDANNFIR

• Sequence length: 505

Pathways

Reactome:

Neutrophil degranulation
Regulation of PTEN stability and activity

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Craniofacial microsomia 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMIFACIAL MICROSOMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Age related macular degeneration	Age-related macular degeneration	BEFREE	21665990		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	26519433	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis, Gouty	Gouty arthritis	GWASDB_DG	23263486		★☆☆☆☆ Found in Text Mining only
Asthenozoospermia	Asthenozoospermia	BEFREE	31808565		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28077797, 29348886, 9029174		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20057140, 9729531	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28077797, 31681835	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31251822		★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	33213062	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	31883420	Associate	★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	27665472		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	27665472		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34888857	Associate	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	31043790		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	20057140	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35723276	Inhibit	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	24969324, 28077797, 30993511, 31395336		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	28077797, 35723276	Associate	★☆☆☆☆ Found in Text Mining only
Gout	Gout	GWASDB_DG	23263486		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular Adenoma	Hepatocellular adenoma	BEFREE	24735922		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	15611931		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	23267173		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28077797, 29348886, 9029174		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	31043790		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31251822		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24448834, 9500213		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27665472, 31251822, 31395336, 9029174		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	27665472		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	12569567		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28077797, 29348886, 30993511, 31395336, 31681835		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31251822		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	33435956	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	33213062	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	24448834, 9500213		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25472581	Associate	★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	31043790		★☆☆☆☆ Found in Text Mining only