Gene Gene information from NCBI Gene database.
Entrez ID 23780
Gene name Apolipoprotein L2
Gene symbol APOL2
Synonyms (NCBI Gene)
APOL-IIAPOL3
Chromosome 22
Chromosome location 22q12.3
Summary This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been
miRNA miRNA information provided by mirtarbase database.
385
miRTarBase ID miRNA Experiments Reference
MIRT017248 hsa-miR-335-5p Microarray 18185580
MIRT024143 hsa-miR-221-3p Sequencing 20371350
MIRT025355 hsa-miR-34a-5p Proteomics 21566225
MIRT671855 hsa-miR-4755-3p HITS-CLIP 23824327
MIRT671854 hsa-miR-4284 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding NAS 11374903
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005737 Component Cytoplasm IEA
GO:0005789 Component Endoplasmic reticulum membrane NAS 11374903
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607252 619 ENSG00000128335
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BQE5
Protein name Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II)
Protein function May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
PDB 7LF8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05461 ApoL 19 331 Apolipoprotein L Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea,
Sequence
Sequence length 337
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CANNABIS ABUSE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA CTD, ClinVar, Disgenet
CTD, ClinVar, Disgenet
CTD, ClinVar, Disgenet
CTD, ClinVar, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anxiety Anxiety disorder Pubtator 38051303 Associate
★☆☆☆☆
Found in Text Mining only
Delusions Delusions HPO_DG
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Major depressive disorder Pubtator 38051303 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes mellitus Pubtator 24385048 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Diabetes mellitus, type 2 Pubtator 24385048 Associate
★☆☆☆☆
Found in Text Mining only
Hallucinations Hallucinations HPO_DG
★☆☆☆☆
Found in Text Mining only
Irritable Bowel Syndrome Irritable Bowel Syndrome BEFREE 28191693
★☆☆☆☆
Found in Text Mining only
Irritable Bowel Syndrome Irritable bowel syndrome Pubtator 28191693 Associate
★☆☆☆☆
Found in Text Mining only
Kidney Diseases Kidney disease Pubtator 24385048 Associate
★☆☆☆☆
Found in Text Mining only
Kidney Failure Chronic Kidney failure Pubtator 24385048 Associate
★☆☆☆☆
Found in Text Mining only