SHPK (sedoheptulokinase)

Gene

• Entrez ID: 23729
• Gene name: Sedoheptulokinase
• Gene symbol: SHPK
• Synonyms (NCBI Gene): CARKL, SHK
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs144071313	G>A,C	Affects	Coding sequence variant, missense variant, stop gained
rs748544120	C>A,G,T	Affects	Coding sequence variant, stop gained, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022509	hsa-miR-124-3p	Microarray	18668037
MIRT039817	hsa-miR-615-3p	CLASH	23622248
MIRT039817	hsa-miR-615-3p	CLASH	23622248
MIRT638050	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT638049	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT638048	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT638047	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT638046	hsa-miR-943	HITS-CLIP	23824327
MIRT638045	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT638044	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT638043	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT638042	hsa-miR-5096	HITS-CLIP	23824327
MIRT638050	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT638049	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT638048	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT638047	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT638046	hsa-miR-943	HITS-CLIP	23824327
MIRT638045	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT638044	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT638043	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT638042	hsa-miR-5096	HITS-CLIP	23824327
MIRT638041	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT638040	hsa-miR-3670	HITS-CLIP	23824327
MIRT638038	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT638039	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT638037	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT638036	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT638035	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT638034	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT638033	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT638050	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT638049	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT638048	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT638047	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT638046	hsa-miR-943	HITS-CLIP	23824327
MIRT638045	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT638044	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT638043	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT638042	hsa-miR-5096	HITS-CLIP	23824327
MIRT638050	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT638049	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT638048	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT638047	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT638046	hsa-miR-943	HITS-CLIP	23824327
MIRT638045	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT638044	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT638043	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT638042	hsa-miR-5096	HITS-CLIP	23824327
MIRT638041	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT638040	hsa-miR-3670	HITS-CLIP	23824327
MIRT638038	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT638039	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT638037	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT638036	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT638035	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT638034	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT638033	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT1347612	hsa-miR-103a	CLIP-seq
MIRT1347613	hsa-miR-107	CLIP-seq
MIRT1347614	hsa-miR-1200	CLIP-seq
MIRT1347615	hsa-miR-122	CLIP-seq
MIRT1347616	hsa-miR-1234	CLIP-seq
MIRT1347617	hsa-miR-1254	CLIP-seq
MIRT1347618	hsa-miR-130a	CLIP-seq
MIRT1347619	hsa-miR-130b	CLIP-seq
MIRT1347620	hsa-miR-134	CLIP-seq
MIRT1347621	hsa-miR-136	CLIP-seq
MIRT1347622	hsa-miR-183	CLIP-seq
MIRT1347623	hsa-miR-1908	CLIP-seq
MIRT1347624	hsa-miR-1911	CLIP-seq
MIRT1347625	hsa-miR-1976	CLIP-seq
MIRT1347626	hsa-miR-2110	CLIP-seq
MIRT1347627	hsa-miR-2467-5p	CLIP-seq
MIRT1347628	hsa-miR-301a	CLIP-seq
MIRT1347629	hsa-miR-301b	CLIP-seq
MIRT1347630	hsa-miR-3116	CLIP-seq
MIRT1347631	hsa-miR-3118	CLIP-seq
MIRT1347632	hsa-miR-3135b	CLIP-seq
MIRT1347633	hsa-miR-3136-3p	CLIP-seq
MIRT1347634	hsa-miR-3136-5p	CLIP-seq
MIRT1347635	hsa-miR-3177-3p	CLIP-seq
MIRT1347636	hsa-miR-3182	CLIP-seq
MIRT1347637	hsa-miR-3188	CLIP-seq
MIRT1347638	hsa-miR-3194-3p	CLIP-seq
MIRT1347639	hsa-miR-324-5p	CLIP-seq
MIRT1347640	hsa-miR-34b	CLIP-seq
MIRT1347641	hsa-miR-3652	CLIP-seq
MIRT1347642	hsa-miR-3666	CLIP-seq
MIRT1347643	hsa-miR-3690	CLIP-seq
MIRT1347644	hsa-miR-3929	CLIP-seq
MIRT1347645	hsa-miR-3944-5p	CLIP-seq
MIRT1347646	hsa-miR-3975	CLIP-seq
MIRT1347647	hsa-miR-4271	CLIP-seq
MIRT1347648	hsa-miR-4292	CLIP-seq
MIRT1347649	hsa-miR-4295	CLIP-seq
MIRT1347650	hsa-miR-4303	CLIP-seq
MIRT1347651	hsa-miR-4308	CLIP-seq
MIRT1347652	hsa-miR-431	CLIP-seq
MIRT1347653	hsa-miR-4324	CLIP-seq
MIRT1347654	hsa-miR-4419b	CLIP-seq
MIRT1347655	hsa-miR-4430	CLIP-seq
MIRT1347656	hsa-miR-4439	CLIP-seq
MIRT1347657	hsa-miR-4478	CLIP-seq
MIRT1347658	hsa-miR-4493	CLIP-seq
MIRT1347659	hsa-miR-4513	CLIP-seq
MIRT1347660	hsa-miR-451b	CLIP-seq
MIRT1347661	hsa-miR-454	CLIP-seq
MIRT1347662	hsa-miR-4634	CLIP-seq
MIRT1347663	hsa-miR-4649-3p	CLIP-seq
MIRT1347664	hsa-miR-4663	CLIP-seq
MIRT1347665	hsa-miR-4685-5p	CLIP-seq
MIRT1347666	hsa-miR-4694-3p	CLIP-seq
MIRT1347667	hsa-miR-4706	CLIP-seq
MIRT1347668	hsa-miR-4724-5p	CLIP-seq
MIRT1347669	hsa-miR-4725-3p	CLIP-seq
MIRT1347670	hsa-miR-4749-5p	CLIP-seq
MIRT1347671	hsa-miR-4764-5p	CLIP-seq
MIRT1347672	hsa-miR-485-5p	CLIP-seq
MIRT1347673	hsa-miR-491-5p	CLIP-seq
MIRT1347674	hsa-miR-544	CLIP-seq
MIRT1347675	hsa-miR-544b	CLIP-seq
MIRT1347676	hsa-miR-564	CLIP-seq
MIRT1347677	hsa-miR-652	CLIP-seq
MIRT1347678	hsa-miR-663	CLIP-seq
MIRT1347679	hsa-miR-665	CLIP-seq
MIRT1347680	hsa-miR-887	CLIP-seq
MIRT1347681	hsa-miR-924	CLIP-seq
MIRT1347682	hsa-miR-939	CLIP-seq
MIRT1347636	hsa-miR-3182	CLIP-seq
MIRT1347650	hsa-miR-4303	CLIP-seq
MIRT1347664	hsa-miR-4663	CLIP-seq
MIRT1347671	hsa-miR-4764-5p	CLIP-seq
MIRT1347674	hsa-miR-544	CLIP-seq
MIRT1347679	hsa-miR-665	CLIP-seq
MIRT1347636	hsa-miR-3182	CLIP-seq
MIRT1347612	hsa-miR-103a	CLIP-seq
MIRT1347613	hsa-miR-107	CLIP-seq
MIRT1347614	hsa-miR-1200	CLIP-seq
MIRT1347615	hsa-miR-122	CLIP-seq
MIRT2102924	hsa-miR-124	CLIP-seq
MIRT2102925	hsa-miR-1245b-3p	CLIP-seq
MIRT2102926	hsa-miR-1255a	CLIP-seq
MIRT2102927	hsa-miR-1255b	CLIP-seq
MIRT2102928	hsa-miR-1260	CLIP-seq
MIRT2102929	hsa-miR-1260b	CLIP-seq
MIRT1347618	hsa-miR-130a	CLIP-seq
MIRT1347619	hsa-miR-130b	CLIP-seq
MIRT2102930	hsa-miR-140-3p	CLIP-seq
MIRT2102931	hsa-miR-188-3p	CLIP-seq
MIRT1347624	hsa-miR-1911	CLIP-seq
MIRT1347625	hsa-miR-1976	CLIP-seq
MIRT1347627	hsa-miR-2467-5p	CLIP-seq
MIRT2102932	hsa-miR-25	CLIP-seq
MIRT1347628	hsa-miR-301a	CLIP-seq
MIRT1347629	hsa-miR-301b	CLIP-seq
MIRT2102933	hsa-miR-3074-5p	CLIP-seq
MIRT2102934	hsa-miR-3119	CLIP-seq
MIRT1347632	hsa-miR-3135b	CLIP-seq
MIRT2102935	hsa-miR-3153	CLIP-seq
MIRT2102936	hsa-miR-3156-3p	CLIP-seq
MIRT2102937	hsa-miR-3162-3p	CLIP-seq
MIRT1347636	hsa-miR-3182	CLIP-seq
MIRT1347637	hsa-miR-3188	CLIP-seq
MIRT1347638	hsa-miR-3194-3p	CLIP-seq
MIRT2102938	hsa-miR-32	CLIP-seq
MIRT1347640	hsa-miR-34b	CLIP-seq
MIRT2102939	hsa-miR-3529	CLIP-seq
MIRT2102940	hsa-miR-3591-3p	CLIP-seq
MIRT2102941	hsa-miR-363	CLIP-seq
MIRT2102942	hsa-miR-3650	CLIP-seq
MIRT1347641	hsa-miR-3652	CLIP-seq
MIRT1347642	hsa-miR-3666	CLIP-seq
MIRT2102943	hsa-miR-367	CLIP-seq
MIRT2102944	hsa-miR-3672	CLIP-seq
MIRT1347643	hsa-miR-3690	CLIP-seq
MIRT2102945	hsa-miR-370	CLIP-seq
MIRT2102946	hsa-miR-379	CLIP-seq
MIRT1347644	hsa-miR-3929	CLIP-seq
MIRT1347646	hsa-miR-3975	CLIP-seq
MIRT2102947	hsa-miR-4254	CLIP-seq
MIRT1347649	hsa-miR-4295	CLIP-seq
MIRT1347650	hsa-miR-4303	CLIP-seq
MIRT2102948	hsa-miR-4318	CLIP-seq
MIRT1347653	hsa-miR-4324	CLIP-seq
MIRT1347654	hsa-miR-4419b	CLIP-seq
MIRT1347655	hsa-miR-4430	CLIP-seq
MIRT2102949	hsa-miR-4451	CLIP-seq
MIRT2102950	hsa-miR-4457	CLIP-seq
MIRT2102951	hsa-miR-4477b	CLIP-seq
MIRT1347657	hsa-miR-4478	CLIP-seq
MIRT2102952	hsa-miR-4490	CLIP-seq
MIRT2102953	hsa-miR-4511	CLIP-seq
MIRT1347660	hsa-miR-451b	CLIP-seq
MIRT1347661	hsa-miR-454	CLIP-seq
MIRT1347662	hsa-miR-4634	CLIP-seq
MIRT1347663	hsa-miR-4649-3p	CLIP-seq
MIRT2102954	hsa-miR-4650-3p	CLIP-seq
MIRT1347664	hsa-miR-4663	CLIP-seq
MIRT2102955	hsa-miR-4667-3p	CLIP-seq
MIRT1347665	hsa-miR-4685-5p	CLIP-seq
MIRT2102956	hsa-miR-4693-5p	CLIP-seq
MIRT2102957	hsa-miR-4695-3p	CLIP-seq
MIRT2102958	hsa-miR-4708-3p	CLIP-seq
MIRT2102959	hsa-miR-4733-3p	CLIP-seq
MIRT2102960	hsa-miR-4753-3p	CLIP-seq
MIRT1347671	hsa-miR-4764-5p	CLIP-seq
MIRT2102961	hsa-miR-4773	CLIP-seq
MIRT2102962	hsa-miR-4774-5p	CLIP-seq
MIRT2102963	hsa-miR-4786-3p	CLIP-seq
MIRT1347672	hsa-miR-485-5p	CLIP-seq
MIRT2102964	hsa-miR-506	CLIP-seq
MIRT1347674	hsa-miR-544	CLIP-seq
MIRT1347675	hsa-miR-544b	CLIP-seq
MIRT2102965	hsa-miR-596	CLIP-seq
MIRT2102966	hsa-miR-603	CLIP-seq
MIRT2102967	hsa-miR-628-5p	CLIP-seq
MIRT2102968	hsa-miR-634	CLIP-seq
MIRT1347677	hsa-miR-652	CLIP-seq
MIRT1347679	hsa-miR-665	CLIP-seq
MIRT2102969	hsa-miR-671-5p	CLIP-seq
MIRT2102970	hsa-miR-767-3p	CLIP-seq
MIRT1347680	hsa-miR-887	CLIP-seq
MIRT2102971	hsa-miR-892a	CLIP-seq
MIRT2102972	hsa-miR-922	CLIP-seq
MIRT2102973	hsa-miR-92a	CLIP-seq
MIRT2102974	hsa-miR-92b	CLIP-seq
MIRT1347612	hsa-miR-103a	CLIP-seq
MIRT1347613	hsa-miR-107	CLIP-seq
MIRT1347614	hsa-miR-1200	CLIP-seq
MIRT1347615	hsa-miR-122	CLIP-seq
MIRT1347616	hsa-miR-1234	CLIP-seq
MIRT2102924	hsa-miR-124	CLIP-seq
MIRT1347617	hsa-miR-1254	CLIP-seq
MIRT2102928	hsa-miR-1260	CLIP-seq
MIRT2102929	hsa-miR-1260b	CLIP-seq
MIRT2327250	hsa-miR-1261	CLIP-seq
MIRT2327251	hsa-miR-1282	CLIP-seq
MIRT2327252	hsa-miR-1297	CLIP-seq
MIRT1347618	hsa-miR-130a	CLIP-seq
MIRT1347619	hsa-miR-130b	CLIP-seq
MIRT2102931	hsa-miR-188-3p	CLIP-seq
MIRT1347623	hsa-miR-1908	CLIP-seq
MIRT2327253	hsa-miR-1910	CLIP-seq
MIRT1347624	hsa-miR-1911	CLIP-seq
MIRT1347625	hsa-miR-1976	CLIP-seq
MIRT2327254	hsa-miR-2053	CLIP-seq
MIRT1347626	hsa-miR-2110	CLIP-seq
MIRT1347627	hsa-miR-2467-5p	CLIP-seq
MIRT2102932	hsa-miR-25	CLIP-seq
MIRT2327255	hsa-miR-26a	CLIP-seq
MIRT2327256	hsa-miR-26b	CLIP-seq
MIRT2327257	hsa-miR-27a	CLIP-seq
MIRT2327258	hsa-miR-27b	CLIP-seq
MIRT1347628	hsa-miR-301a	CLIP-seq
MIRT1347629	hsa-miR-301b	CLIP-seq
MIRT2102933	hsa-miR-3074-5p	CLIP-seq
MIRT1347630	hsa-miR-3116	CLIP-seq
MIRT2327259	hsa-miR-3126-3p	CLIP-seq
MIRT1347632	hsa-miR-3135b	CLIP-seq
MIRT2327260	hsa-miR-3138	CLIP-seq
MIRT2102936	hsa-miR-3156-3p	CLIP-seq
MIRT2102937	hsa-miR-3162-3p	CLIP-seq
MIRT1347636	hsa-miR-3182	CLIP-seq
MIRT1347637	hsa-miR-3188	CLIP-seq
MIRT1347638	hsa-miR-3194-3p	CLIP-seq
MIRT2102938	hsa-miR-32	CLIP-seq
MIRT1347639	hsa-miR-324-5p	CLIP-seq
MIRT2327261	hsa-miR-338-3p	CLIP-seq
MIRT2327262	hsa-miR-34c-3p	CLIP-seq
MIRT2327263	hsa-miR-3605-5p	CLIP-seq
MIRT2102941	hsa-miR-363	CLIP-seq
MIRT2102942	hsa-miR-3650	CLIP-seq
MIRT1347641	hsa-miR-3652	CLIP-seq
MIRT1347642	hsa-miR-3666	CLIP-seq
MIRT2102943	hsa-miR-367	CLIP-seq
MIRT1347643	hsa-miR-3690	CLIP-seq
MIRT1347644	hsa-miR-3929	CLIP-seq
MIRT2327264	hsa-miR-3936	CLIP-seq
MIRT1347646	hsa-miR-3975	CLIP-seq
MIRT1347647	hsa-miR-4271	CLIP-seq
MIRT2327265	hsa-miR-4274	CLIP-seq
MIRT2327266	hsa-miR-4282	CLIP-seq
MIRT1347649	hsa-miR-4295	CLIP-seq
MIRT1347650	hsa-miR-4303	CLIP-seq
MIRT2102948	hsa-miR-4318	CLIP-seq
MIRT1347653	hsa-miR-4324	CLIP-seq
MIRT1347654	hsa-miR-4419b	CLIP-seq
MIRT1347655	hsa-miR-4430	CLIP-seq
MIRT2327267	hsa-miR-4438	CLIP-seq
MIRT2327268	hsa-miR-4465	CLIP-seq
MIRT1347657	hsa-miR-4478	CLIP-seq
MIRT1347658	hsa-miR-4493	CLIP-seq
MIRT2327269	hsa-miR-450b-3p	CLIP-seq
MIRT2102953	hsa-miR-4511	CLIP-seq
MIRT1347660	hsa-miR-451b	CLIP-seq
MIRT1347661	hsa-miR-454	CLIP-seq
MIRT2327270	hsa-miR-455-3p	CLIP-seq
MIRT1347662	hsa-miR-4634	CLIP-seq
MIRT1347663	hsa-miR-4649-3p	CLIP-seq
MIRT2327271	hsa-miR-4652-5p	CLIP-seq
MIRT1347664	hsa-miR-4663	CLIP-seq
MIRT2102956	hsa-miR-4693-5p	CLIP-seq
MIRT2102957	hsa-miR-4695-3p	CLIP-seq
MIRT1347667	hsa-miR-4706	CLIP-seq
MIRT2327272	hsa-miR-4713-3p	CLIP-seq
MIRT2327273	hsa-miR-4713-5p	CLIP-seq
MIRT2327274	hsa-miR-4722-3p	CLIP-seq
MIRT1347669	hsa-miR-4725-3p	CLIP-seq
MIRT1347670	hsa-miR-4749-5p	CLIP-seq
MIRT1347671	hsa-miR-4764-5p	CLIP-seq
MIRT2327275	hsa-miR-4768-3p	CLIP-seq
MIRT2327276	hsa-miR-4772-3p	CLIP-seq
MIRT2327277	hsa-miR-4787-3p	CLIP-seq
MIRT2327278	hsa-miR-4800-5p	CLIP-seq
MIRT1347672	hsa-miR-485-5p	CLIP-seq
MIRT1347673	hsa-miR-491-5p	CLIP-seq
MIRT2102964	hsa-miR-506	CLIP-seq
MIRT2327279	hsa-miR-5095	CLIP-seq
MIRT2327280	hsa-miR-513a-5p	CLIP-seq
MIRT1347674	hsa-miR-544	CLIP-seq
MIRT1347675	hsa-miR-544b	CLIP-seq
MIRT2327281	hsa-miR-569	CLIP-seq
MIRT2327282	hsa-miR-579	CLIP-seq
MIRT2102965	hsa-miR-596	CLIP-seq
MIRT2102968	hsa-miR-634	CLIP-seq
MIRT2327283	hsa-miR-638	CLIP-seq
MIRT1347677	hsa-miR-652	CLIP-seq
MIRT1347678	hsa-miR-663	CLIP-seq
MIRT1347679	hsa-miR-665	CLIP-seq
MIRT2327284	hsa-miR-769-3p	CLIP-seq
MIRT2102971	hsa-miR-892a	CLIP-seq
MIRT2102972	hsa-miR-922	CLIP-seq
MIRT2102973	hsa-miR-92a	CLIP-seq
MIRT2102974	hsa-miR-92b	CLIP-seq
MIRT1347682	hsa-miR-939	CLIP-seq
MIRT1347616	hsa-miR-1234	CLIP-seq
MIRT1347617	hsa-miR-1254	CLIP-seq
MIRT2327250	hsa-miR-1261	CLIP-seq
MIRT1347623	hsa-miR-1908	CLIP-seq
MIRT1347626	hsa-miR-2110	CLIP-seq
MIRT1347630	hsa-miR-3116	CLIP-seq
MIRT1347636	hsa-miR-3182	CLIP-seq
MIRT1347638	hsa-miR-3194-3p	CLIP-seq
MIRT1347643	hsa-miR-3690	CLIP-seq
MIRT2327264	hsa-miR-3936	CLIP-seq
MIRT1347647	hsa-miR-4271	CLIP-seq
MIRT1347650	hsa-miR-4303	CLIP-seq
MIRT2102948	hsa-miR-4318	CLIP-seq
MIRT2327271	hsa-miR-4652-5p	CLIP-seq
MIRT1347664	hsa-miR-4663	CLIP-seq
MIRT2102956	hsa-miR-4693-5p	CLIP-seq
MIRT1347666	hsa-miR-4694-3p	CLIP-seq
MIRT1347667	hsa-miR-4706	CLIP-seq
MIRT1347669	hsa-miR-4725-3p	CLIP-seq
MIRT1347670	hsa-miR-4749-5p	CLIP-seq
MIRT1347671	hsa-miR-4764-5p	CLIP-seq
MIRT1347673	hsa-miR-491-5p	CLIP-seq
MIRT1347674	hsa-miR-544	CLIP-seq
MIRT1347678	hsa-miR-663	CLIP-seq
MIRT1347679	hsa-miR-665	CLIP-seq
MIRT2102971	hsa-miR-892a	CLIP-seq
MIRT1347682	hsa-miR-939	CLIP-seq
MIRT1347615	hsa-miR-122	CLIP-seq
MIRT1347618	hsa-miR-130a	CLIP-seq
MIRT1347619	hsa-miR-130b	CLIP-seq
MIRT1347628	hsa-miR-301a	CLIP-seq
MIRT1347629	hsa-miR-301b	CLIP-seq
MIRT1347632	hsa-miR-3135b	CLIP-seq
MIRT2102937	hsa-miR-3162-3p	CLIP-seq
MIRT1347641	hsa-miR-3652	CLIP-seq
MIRT1347642	hsa-miR-3666	CLIP-seq
MIRT1347649	hsa-miR-4295	CLIP-seq
MIRT1347655	hsa-miR-4430	CLIP-seq
MIRT1347661	hsa-miR-454	CLIP-seq
MIRT1347662	hsa-miR-4634	CLIP-seq
MIRT2102957	hsa-miR-4695-3p	CLIP-seq
MIRT2459332	hsa-miR-4740-3p	CLIP-seq
MIRT2327276	hsa-miR-4772-3p	CLIP-seq
MIRT1347677	hsa-miR-652	CLIP-seq
MIRT2459333	hsa-miR-888	CLIP-seq
MIRT1347614	hsa-miR-1200	CLIP-seq
MIRT1347615	hsa-miR-122	CLIP-seq
MIRT2327250	hsa-miR-1261	CLIP-seq
MIRT2327252	hsa-miR-1297	CLIP-seq
MIRT2622568	hsa-miR-1299	CLIP-seq
MIRT1347618	hsa-miR-130a	CLIP-seq
MIRT1347619	hsa-miR-130b	CLIP-seq
MIRT2327255	hsa-miR-26a	CLIP-seq
MIRT2327256	hsa-miR-26b	CLIP-seq
MIRT1347628	hsa-miR-301a	CLIP-seq
MIRT1347629	hsa-miR-301b	CLIP-seq
MIRT2102933	hsa-miR-3074-5p	CLIP-seq
MIRT1347632	hsa-miR-3135b	CLIP-seq
MIRT2622569	hsa-miR-3149	CLIP-seq
MIRT1347641	hsa-miR-3652	CLIP-seq
MIRT1347642	hsa-miR-3666	CLIP-seq
MIRT2327264	hsa-miR-3936	CLIP-seq
MIRT1347649	hsa-miR-4295	CLIP-seq
MIRT1347653	hsa-miR-4324	CLIP-seq
MIRT1347655	hsa-miR-4430	CLIP-seq
MIRT2327268	hsa-miR-4465	CLIP-seq
MIRT2622570	hsa-miR-4522	CLIP-seq
MIRT1347661	hsa-miR-454	CLIP-seq
MIRT1347662	hsa-miR-4634	CLIP-seq
MIRT2327271	hsa-miR-4652-5p	CLIP-seq
MIRT2102957	hsa-miR-4695-3p	CLIP-seq
MIRT2327274	hsa-miR-4722-3p	CLIP-seq
MIRT2459332	hsa-miR-4740-3p	CLIP-seq
MIRT2327276	hsa-miR-4772-3p	CLIP-seq
MIRT1347675	hsa-miR-544b	CLIP-seq
MIRT1347677	hsa-miR-652	CLIP-seq
MIRT2622571	hsa-miR-7	CLIP-seq
MIRT2622572	hsa-miR-875-3p	CLIP-seq
MIRT1347614	hsa-miR-1200	CLIP-seq
MIRT1347615	hsa-miR-122	CLIP-seq
MIRT2690726	hsa-miR-1245	CLIP-seq
MIRT2327252	hsa-miR-1297	CLIP-seq
MIRT2622568	hsa-miR-1299	CLIP-seq
MIRT1347618	hsa-miR-130a	CLIP-seq
MIRT1347619	hsa-miR-130b	CLIP-seq
MIRT2327255	hsa-miR-26a	CLIP-seq
MIRT2327256	hsa-miR-26b	CLIP-seq
MIRT1347628	hsa-miR-301a	CLIP-seq
MIRT1347629	hsa-miR-301b	CLIP-seq
MIRT2102933	hsa-miR-3074-5p	CLIP-seq
MIRT1347632	hsa-miR-3135b	CLIP-seq
MIRT2622569	hsa-miR-3149	CLIP-seq
MIRT2690727	hsa-miR-3187-3p	CLIP-seq
MIRT1347641	hsa-miR-3652	CLIP-seq
MIRT1347642	hsa-miR-3666	CLIP-seq
MIRT2690728	hsa-miR-383	CLIP-seq
MIRT2690729	hsa-miR-4269	CLIP-seq
MIRT1347649	hsa-miR-4295	CLIP-seq
MIRT1347653	hsa-miR-4324	CLIP-seq
MIRT1347655	hsa-miR-4430	CLIP-seq
MIRT2690730	hsa-miR-4435	CLIP-seq
MIRT2327267	hsa-miR-4438	CLIP-seq
MIRT2327268	hsa-miR-4465	CLIP-seq
MIRT2690731	hsa-miR-4514	CLIP-seq
MIRT2622570	hsa-miR-4522	CLIP-seq
MIRT1347661	hsa-miR-454	CLIP-seq
MIRT1347662	hsa-miR-4634	CLIP-seq
MIRT2690732	hsa-miR-4692	CLIP-seq
MIRT2102957	hsa-miR-4695-3p	CLIP-seq
MIRT2690733	hsa-miR-4701-5p	CLIP-seq
MIRT2327274	hsa-miR-4722-3p	CLIP-seq
MIRT2459332	hsa-miR-4740-3p	CLIP-seq
MIRT2690734	hsa-miR-4742-5p	CLIP-seq
MIRT2690735	hsa-miR-4765	CLIP-seq
MIRT2327276	hsa-miR-4772-3p	CLIP-seq
MIRT2690736	hsa-miR-4772-5p	CLIP-seq
MIRT2327279	hsa-miR-5095	CLIP-seq
MIRT1347675	hsa-miR-544b	CLIP-seq
MIRT2690737	hsa-miR-548s	CLIP-seq
MIRT2690738	hsa-miR-588	CLIP-seq
MIRT1347677	hsa-miR-652	CLIP-seq
MIRT2622571	hsa-miR-7	CLIP-seq
MIRT2690739	hsa-miR-759	CLIP-seq
MIRT2622572	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IDA	19413330
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0005975	Process	Carbohydrate metabolic process	TAS	10673275
GO:0006098	Process	Pentose-phosphate shunt	IEA
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0009052	Process	Pentose-phosphate shunt, non-oxidative branch	IBA
GO:0009052	Process	Pentose-phosphate shunt, non-oxidative branch	IEA
GO:0009052	Process	Pentose-phosphate shunt, non-oxidative branch	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016310	Process	Phosphorylation	IDA	19413330
GO:0016740	Function	Transferase activity	IEA
GO:0035963	Process	Cellular response to interleukin-13	IEA
GO:0035963	Process	Cellular response to interleukin-13	ISS
GO:0043030	Process	Regulation of macrophage activation	IBA
GO:0043030	Process	Regulation of macrophage activation	IEA
GO:0043030	Process	Regulation of macrophage activation	ISS
GO:0050277	Function	Sedoheptulokinase activity	IBA
GO:0050277	Function	Sedoheptulokinase activity	IDA	19413330
GO:0050277	Function	Sedoheptulokinase activity	IEA
GO:0050277	Function	Sedoheptulokinase activity	TAS
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	22682222
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071353	Process	Cellular response to interleukin-4	IEA
GO:0071353	Process	Cellular response to interleukin-4	ISS

Other IDs

• MIM: 605060
• HGNC: 1492
• e!Ensembl: ENSG00000197417

Protein

• UniProt ID: Q9UHJ6
• Protein name: Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein)
• Protein function: Acts as a modulator of macrophage activation through control of glucose metabolism.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00370	FGGY_N	6 → 265	FGGY family of carbohydrate kinases, N-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain. {ECO:0000269|PubMed:10673275}.
• Sequence:

  MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQ
  DVSRILQALHECLAALPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRA
  VSHLVTWQDGRCSSEFLASLPQPKSHLSVATGFGCATIFWLLKYRPEFLKSYDAAGTIHD
  YVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVHLLPDIAEPGSVAGRT
  SHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDP
  TAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQ
  QRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQ
  DWGVERVMGSGSALSRNDVLKQEVQRAFPLPMSFGQDVDAAVGAALVMLRRHLNQKES

• Sequence length: 478

Pathways

KEGG:

Pentose phosphate pathway
Metabolic pathways

Reactome:

Pentose phosphate pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEFICIENCY OF SEDOHEPTULOKINASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Isolated sedoheptulokinase deficiency	Benign; Likely benign; Uncertain significance; Affects	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SHPK-related disorder	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthrogryposis	Arthrogryposis multiplex congenita	HPO_DG			★☆☆☆☆ Found in Text Mining only
Asphyxia Neonatorum	Postnatal asphyxia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cholestatic liver disease	Cholestatic liver disease	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cystinosis	Cystinosis	Pubtator	11505338	Associate	★☆☆☆☆ Found in Text Mining only
Deficiency of sedoheptulokinase	Deficiency Of Sedoheptulokinase	ORPHANET_DG	25647543		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Deficiency of sedoheptulokinase	Deficiency Of Sedoheptulokinase	GENOMICS_ENGLAND_DG	27604308		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Deficiency of sedoheptulokinase	Deficiency Of Sedoheptulokinase	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	17984097	Associate	★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35682658	Stimulate	★☆☆☆☆ Found in Text Mining only
Isolated sedoheptulokinase deficiency	Isolated Sedoheptulokinase Deficiency	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Macrocephaly	Macrocephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Microcytic hypochromic anemia (disorder)	Anemia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	17984097	Inhibit	★☆☆☆☆ Found in Text Mining only
Portal Hypertension	Portal Hypertension	HPO_DG			★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Renal Insufficiency	HPO_DG			★☆☆☆☆ Found in Text Mining only
Subcortical cerebral atrophy	Subcortical cerebral atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only