Gene Gene information from NCBI Gene database.
Entrez ID 23673
Gene name Syntaxin 12
Gene symbol STX12
Synonyms (NCBI Gene)
STX13STX14
Chromosome 1
Chromosome location 1p35.3
miRNA miRNA information provided by mirtarbase database.
519
miRTarBase ID miRNA Experiments Reference
MIRT029247 hsa-miR-26b-5p Microarray 19088304
MIRT050667 hsa-miR-18a-5p CLASH 23622248
MIRT044373 hsa-miR-106b-5p CLASH 23622248
MIRT698742 hsa-miR-613 HITS-CLIP 23313552
MIRT698741 hsa-miR-206 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA
GO:0000045 Process Autophagosome assembly IMP 24095276
GO:0000139 Component Golgi membrane IEA
GO:0000149 Function SNARE binding IBA
GO:0000407 Component Phagophore assembly site IMP 24095276
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606892 11430 ENSG00000117758
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86Y82
Protein name Syntaxin-12
Protein function SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex forma
PDB 2DNX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14523 Syntaxin_2 29 132 Syntaxin-like protein Domain
PF05739 SNARE 214 266 SNARE domain Family
Sequence
MSYGPLDMYRNPGPSGPQLRDFSSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQ
ENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQRLQKERLMNDFSAALNNFQAV
QRRVSEKEKESI
ARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLEL
IKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERATEQLQRA
AYYQKKSRKKMCILVLVLSVIILILG
LIIWLVYKTK
Sequence length 276
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Phagosome  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Cholecystolithiasis Cholecystolithiasis GWASDB_DG 17632509
★☆☆☆☆
Found in Text Mining only
Cholelithiasis Cholelithiasis GWASDB_DG 17632509
★☆☆☆☆
Found in Text Mining only
Fibrosis of pancreas Fibrosis Of Pancreas BEFREE 28202235
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Pancreatitis, Chronic Pancreatitis BEFREE 28202235
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia Pubtator 22441714 Associate
★☆☆☆☆
Found in Text Mining only