Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23660
Gene name	Zinc finger with KRAB and SCAN domains 5
Gene symbol	ZKSCAN5
Synonyms (NCBI Gene)	ZFP-95ZFP95ZNF914ZSCAN37
Chromosome	7
Chromosome location	7q22.1
Summary	This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative sp

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021052	hsa-miR-155-5p	Proteomics;Other	20584899
MIRT223217	hsa-miR-382-5p	PAR-CLIP	22100165
MIRT223220	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT223224	hsa-miR-4635	PAR-CLIP	22100165
MIRT445128	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT223221	hsa-miR-3148	PAR-CLIP	22100165
MIRT445127	hsa-miR-6124	PAR-CLIP	22100165
MIRT223222	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT223219	hsa-miR-573	PAR-CLIP	22100165
MIRT223223	hsa-miR-1273e	PAR-CLIP	22100165
MIRT223217	hsa-miR-382-5p	PAR-CLIP	22100165
MIRT223220	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT223224	hsa-miR-4635	PAR-CLIP	22100165
MIRT445128	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT223221	hsa-miR-3148	PAR-CLIP	22100165
MIRT445127	hsa-miR-6124	PAR-CLIP	22100165
MIRT223222	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT223219	hsa-miR-573	PAR-CLIP	22100165
MIRT223223	hsa-miR-1273e	PAR-CLIP	22100165
MIRT021052	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT021052	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT223217	hsa-miR-382-5p	PAR-CLIP	22100165
MIRT223220	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT223224	hsa-miR-4635	PAR-CLIP	22100165
MIRT445128	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT223221	hsa-miR-3148	PAR-CLIP	22100165
MIRT445127	hsa-miR-6124	PAR-CLIP	22100165
MIRT223222	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT223219	hsa-miR-573	PAR-CLIP	22100165
MIRT223223	hsa-miR-1273e	PAR-CLIP	22100165
MIRT223217	hsa-miR-382-5p	PAR-CLIP	22100165
MIRT223220	hsa-miR-875-3p	PAR-CLIP	22100165
MIRT223224	hsa-miR-4635	PAR-CLIP	22100165
MIRT445128	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT223221	hsa-miR-3148	PAR-CLIP	22100165
MIRT445127	hsa-miR-6124	PAR-CLIP	22100165
MIRT223222	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT223219	hsa-miR-573	PAR-CLIP	22100165
MIRT223223	hsa-miR-1273e	PAR-CLIP	22100165
MIRT1514030	hsa-miR-1207-3p	CLIP-seq
MIRT1514031	hsa-miR-1304	CLIP-seq
MIRT1514032	hsa-miR-1321	CLIP-seq
MIRT1514033	hsa-miR-2278	CLIP-seq
MIRT1514034	hsa-miR-3126-5p	CLIP-seq
MIRT1514035	hsa-miR-4419a	CLIP-seq
MIRT1514036	hsa-miR-4421	CLIP-seq
MIRT1514037	hsa-miR-4450	CLIP-seq
MIRT1514038	hsa-miR-4510	CLIP-seq
MIRT1514039	hsa-miR-4667-5p	CLIP-seq
MIRT1514040	hsa-miR-4700-5p	CLIP-seq
MIRT1514041	hsa-miR-4728-5p	CLIP-seq
MIRT1514042	hsa-miR-4731-5p	CLIP-seq
MIRT1514043	hsa-miR-4739	CLIP-seq
MIRT1514044	hsa-miR-4756-5p	CLIP-seq
MIRT1514045	hsa-miR-494	CLIP-seq
MIRT1514046	hsa-miR-646	CLIP-seq
MIRT1514047	hsa-miR-767-3p	CLIP-seq
MIRT1514048	hsa-miR-942	CLIP-seq
MIRT1514049	hsa-miR-125a-5p	CLIP-seq
MIRT1514050	hsa-miR-125b	CLIP-seq
MIRT1514031	hsa-miR-1304	CLIP-seq
MIRT1514032	hsa-miR-1321	CLIP-seq
MIRT1514051	hsa-miR-155	CLIP-seq
MIRT1514052	hsa-miR-1976	CLIP-seq
MIRT1514053	hsa-miR-219-2-3p	CLIP-seq
MIRT1514054	hsa-miR-2964a-3p	CLIP-seq
MIRT1514034	hsa-miR-3126-5p	CLIP-seq
MIRT1514055	hsa-miR-3140-5p	CLIP-seq
MIRT1514056	hsa-miR-3714	CLIP-seq
MIRT1514057	hsa-miR-3973	CLIP-seq
MIRT1514058	hsa-miR-4279	CLIP-seq
MIRT1514059	hsa-miR-4318	CLIP-seq
MIRT1514060	hsa-miR-4319	CLIP-seq
MIRT1514035	hsa-miR-4419a	CLIP-seq
MIRT1514061	hsa-miR-4427	CLIP-seq
MIRT1514038	hsa-miR-4510	CLIP-seq
MIRT1514062	hsa-miR-4521	CLIP-seq
MIRT1514063	hsa-miR-4639-5p	CLIP-seq
MIRT1514064	hsa-miR-4680-3p	CLIP-seq
MIRT1514065	hsa-miR-4693-5p	CLIP-seq
MIRT1514066	hsa-miR-4712-5p	CLIP-seq
MIRT1514041	hsa-miR-4728-5p	CLIP-seq
MIRT1514067	hsa-miR-4732-3p	CLIP-seq
MIRT1514043	hsa-miR-4739	CLIP-seq
MIRT1514044	hsa-miR-4756-5p	CLIP-seq
MIRT1514068	hsa-miR-4796-3p	CLIP-seq
MIRT1514045	hsa-miR-494	CLIP-seq
MIRT1514069	hsa-miR-520g	CLIP-seq
MIRT1514070	hsa-miR-520h	CLIP-seq
MIRT1514071	hsa-miR-569	CLIP-seq
MIRT1514072	hsa-miR-582-5p	CLIP-seq
MIRT1514073	hsa-miR-670	CLIP-seq
MIRT1514074	hsa-miR-770-5p	CLIP-seq
MIRT1514075	hsa-miR-892a	CLIP-seq
MIRT1514076	hsa-miR-933	CLIP-seq
MIRT1514055	hsa-miR-3140-5p	CLIP-seq
MIRT2155058	hsa-miR-4699-5p	CLIP-seq
MIRT2155059	hsa-miR-4777-5p	CLIP-seq
MIRT2463996	hsa-miR-24	CLIP-seq
MIRT2463997	hsa-miR-3155	CLIP-seq
MIRT2463998	hsa-miR-3155b	CLIP-seq
MIRT2463999	hsa-miR-4287	CLIP-seq
MIRT2464000	hsa-miR-4438	CLIP-seq
MIRT2464001	hsa-miR-4469	CLIP-seq
MIRT2464002	hsa-miR-4639-3p	CLIP-seq
MIRT2464003	hsa-miR-4685-3p	CLIP-seq
MIRT2464004	hsa-miR-484	CLIP-seq
MIRT2464005	hsa-miR-548p	CLIP-seq
MIRT2463996	hsa-miR-24	CLIP-seq
MIRT2463997	hsa-miR-3155	CLIP-seq
MIRT2463998	hsa-miR-3155b	CLIP-seq
MIRT2463999	hsa-miR-4287	CLIP-seq
MIRT2464000	hsa-miR-4438	CLIP-seq
MIRT2464001	hsa-miR-4469	CLIP-seq
MIRT2464002	hsa-miR-4639-3p	CLIP-seq
MIRT2464003	hsa-miR-4685-3p	CLIP-seq
MIRT2464004	hsa-miR-484	CLIP-seq
MIRT2464005	hsa-miR-548p	CLIP-seq
MIRT1514055	hsa-miR-3140-5p	CLIP-seq
MIRT1514056	hsa-miR-3714	CLIP-seq
MIRT1514067	hsa-miR-4732-3p	CLIP-seq
MIRT2667444	hsa-miR-1237	CLIP-seq
MIRT2667445	hsa-miR-124	CLIP-seq
MIRT2667446	hsa-miR-1248	CLIP-seq
MIRT1514049	hsa-miR-125a-5p	CLIP-seq
MIRT1514050	hsa-miR-125b	CLIP-seq
MIRT2667447	hsa-miR-133a	CLIP-seq
MIRT2667448	hsa-miR-133b	CLIP-seq
MIRT2667449	hsa-miR-139-5p	CLIP-seq
MIRT2667450	hsa-miR-1912	CLIP-seq
MIRT2667451	hsa-miR-197	CLIP-seq
MIRT1514052	hsa-miR-1976	CLIP-seq
MIRT2667452	hsa-miR-199a-3p	CLIP-seq
MIRT2667453	hsa-miR-199b-3p	CLIP-seq
MIRT1514053	hsa-miR-219-2-3p	CLIP-seq
MIRT2667454	hsa-miR-27a	CLIP-seq
MIRT2667455	hsa-miR-27b	CLIP-seq
MIRT1514054	hsa-miR-2964a-3p	CLIP-seq
MIRT2667456	hsa-miR-3065-3p	CLIP-seq
MIRT2667457	hsa-miR-3074-3p	CLIP-seq
MIRT2667458	hsa-miR-3129-5p	CLIP-seq
MIRT1514055	hsa-miR-3140-5p	CLIP-seq
MIRT2667459	hsa-miR-3165	CLIP-seq
MIRT2667460	hsa-miR-3649	CLIP-seq
MIRT2667461	hsa-miR-3659	CLIP-seq
MIRT2667462	hsa-miR-3686	CLIP-seq
MIRT1514056	hsa-miR-3714	CLIP-seq
MIRT2667463	hsa-miR-3910	CLIP-seq
MIRT2667464	hsa-miR-3913-3p	CLIP-seq
MIRT2667465	hsa-miR-3919	CLIP-seq
MIRT2667466	hsa-miR-3927	CLIP-seq
MIRT1514058	hsa-miR-4279	CLIP-seq
MIRT2667467	hsa-miR-4314	CLIP-seq
MIRT1514059	hsa-miR-4318	CLIP-seq
MIRT1514060	hsa-miR-4319	CLIP-seq
MIRT1514061	hsa-miR-4427	CLIP-seq
MIRT2667468	hsa-miR-4451	CLIP-seq
MIRT1514062	hsa-miR-4521	CLIP-seq
MIRT2667469	hsa-miR-4539	CLIP-seq
MIRT1514063	hsa-miR-4639-5p	CLIP-seq
MIRT1514039	hsa-miR-4667-5p	CLIP-seq
MIRT1514064	hsa-miR-4680-3p	CLIP-seq
MIRT1514065	hsa-miR-4693-5p	CLIP-seq
MIRT2667470	hsa-miR-4700-3p	CLIP-seq
MIRT1514040	hsa-miR-4700-5p	CLIP-seq
MIRT1514066	hsa-miR-4712-5p	CLIP-seq
MIRT2667471	hsa-miR-4724-5p	CLIP-seq
MIRT1514042	hsa-miR-4731-5p	CLIP-seq
MIRT1514067	hsa-miR-4732-3p	CLIP-seq
MIRT2667472	hsa-miR-4738-3p	CLIP-seq
MIRT2667473	hsa-miR-4742-3p	CLIP-seq
MIRT2667474	hsa-miR-4768-3p	CLIP-seq
MIRT2667475	hsa-miR-4778-5p	CLIP-seq
MIRT2667476	hsa-miR-4789-3p	CLIP-seq
MIRT2667477	hsa-miR-4795-5p	CLIP-seq
MIRT2667478	hsa-miR-486-3p	CLIP-seq
MIRT2667479	hsa-miR-489	CLIP-seq
MIRT2667480	hsa-miR-506	CLIP-seq
MIRT2667481	hsa-miR-513a-5p	CLIP-seq
MIRT1514072	hsa-miR-582-5p	CLIP-seq
MIRT2667482	hsa-miR-606	CLIP-seq
MIRT2667483	hsa-miR-624	CLIP-seq
MIRT2667484	hsa-miR-637	CLIP-seq
MIRT1514073	hsa-miR-670	CLIP-seq
MIRT1514074	hsa-miR-770-5p	CLIP-seq
MIRT1514075	hsa-miR-892a	CLIP-seq
MIRT2667485	hsa-miR-922	CLIP-seq
MIRT1514076	hsa-miR-933	CLIP-seq
MIRT2667486	hsa-miR-936	CLIP-seq
MIRT1514055	hsa-miR-3140-5p	CLIP-seq
MIRT1514056	hsa-miR-3714	CLIP-seq
MIRT1514067	hsa-miR-4732-3p	CLIP-seq
MIRT2667444	hsa-miR-1237	CLIP-seq
MIRT2667446	hsa-miR-1248	CLIP-seq
MIRT2667449	hsa-miR-139-5p	CLIP-seq
MIRT2667450	hsa-miR-1912	CLIP-seq
MIRT2667451	hsa-miR-197	CLIP-seq
MIRT1514052	hsa-miR-1976	CLIP-seq
MIRT2667452	hsa-miR-199a-3p	CLIP-seq
MIRT2667453	hsa-miR-199b-3p	CLIP-seq
MIRT1514053	hsa-miR-219-2-3p	CLIP-seq
MIRT2463996	hsa-miR-24	CLIP-seq
MIRT2667454	hsa-miR-27a	CLIP-seq
MIRT2667455	hsa-miR-27b	CLIP-seq
MIRT1514054	hsa-miR-2964a-3p	CLIP-seq
MIRT2667456	hsa-miR-3065-3p	CLIP-seq
MIRT2667457	hsa-miR-3074-3p	CLIP-seq
MIRT2667458	hsa-miR-3129-5p	CLIP-seq
MIRT1514055	hsa-miR-3140-5p	CLIP-seq
MIRT2463997	hsa-miR-3155	CLIP-seq
MIRT2463998	hsa-miR-3155b	CLIP-seq
MIRT2667460	hsa-miR-3649	CLIP-seq
MIRT2667461	hsa-miR-3659	CLIP-seq
MIRT2667462	hsa-miR-3686	CLIP-seq
MIRT2667464	hsa-miR-3913-3p	CLIP-seq
MIRT2667466	hsa-miR-3927	CLIP-seq
MIRT1514058	hsa-miR-4279	CLIP-seq
MIRT2463999	hsa-miR-4287	CLIP-seq
MIRT2667467	hsa-miR-4314	CLIP-seq
MIRT2464000	hsa-miR-4438	CLIP-seq
MIRT2667468	hsa-miR-4451	CLIP-seq
MIRT2464001	hsa-miR-4469	CLIP-seq
MIRT2667469	hsa-miR-4539	CLIP-seq
MIRT2464002	hsa-miR-4639-3p	CLIP-seq
MIRT1514039	hsa-miR-4667-5p	CLIP-seq
MIRT1514064	hsa-miR-4680-3p	CLIP-seq
MIRT2464003	hsa-miR-4685-3p	CLIP-seq
MIRT2667470	hsa-miR-4700-3p	CLIP-seq
MIRT1514040	hsa-miR-4700-5p	CLIP-seq
MIRT1514066	hsa-miR-4712-5p	CLIP-seq
MIRT2667471	hsa-miR-4724-5p	CLIP-seq
MIRT1514042	hsa-miR-4731-5p	CLIP-seq
MIRT1514067	hsa-miR-4732-3p	CLIP-seq
MIRT2667472	hsa-miR-4738-3p	CLIP-seq
MIRT2667473	hsa-miR-4742-3p	CLIP-seq
MIRT2667474	hsa-miR-4768-3p	CLIP-seq
MIRT2667475	hsa-miR-4778-5p	CLIP-seq
MIRT2667476	hsa-miR-4789-3p	CLIP-seq
MIRT2464004	hsa-miR-484	CLIP-seq
MIRT2667478	hsa-miR-486-3p	CLIP-seq
MIRT2667479	hsa-miR-489	CLIP-seq
MIRT2667481	hsa-miR-513a-5p	CLIP-seq
MIRT2464005	hsa-miR-548p	CLIP-seq
MIRT1514072	hsa-miR-582-5p	CLIP-seq
MIRT2667482	hsa-miR-606	CLIP-seq
MIRT2667483	hsa-miR-624	CLIP-seq
MIRT2667484	hsa-miR-637	CLIP-seq
MIRT1514074	hsa-miR-770-5p	CLIP-seq
MIRT2667486	hsa-miR-936	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	10585779
GO:0005515	Function	Protein binding	IPI	23455924, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	10585779
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	10585779
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	NAS	10585779
GO:0010558	Process	Negative regulation of macromolecule biosynthetic process	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
611272	12867	ENSG00000196652

Q9Y2L8

Protein name

Zinc finger protein with KRAB and SCAN domains 5 (Zinc finger protein 95 homolog) (Zfp-95)

Protein function

May be involved in transcriptional regulation.

PDB

2EM5 , 2EMM , 2EMZ , 2EN3 , 2EOM , 2EON , 2EOO , 2YSO , 2YTG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02023	SCAN	46 → 135	SCAN domain	Domain
PF01352	KRAB	220 → 258	KRAB box	Family
PF00096	zf-C2H2	346 → 368	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	374 → 396	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	402 → 424	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	430 → 452	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	549 → 571	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	577 → 599	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	605 → 627	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	633 → 655	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	717 → 739	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	773 → 795	Zinc finger, C2H2 type	Domain

Sequence

MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFYQRFRHFQYHE
ASGPREALSQLRVLCCEWLRPELHTKEQILELLVLEQFLTILPEEFQPWVREHHPESGEE
AVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQKPRL
LEENALPVLQVPSLPLKDSQELTASLLSTGSQKLVKIEEVADVAVSFILEEWGHLDQSQK
SLYRDDRKENYGSITSMGYESRDNMELIVKQISDDSESHWVAPEHTERSVPQDPDFAEVS
DLKGMVQRWQVNPTVGKSRQNPSQKRDLDAITDISPKQSTHGERGHRCSDCGKFFLQASN
FIQHRRIHTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEKPYKCQVCGKAFRVSSHLVQH
HSVHSGERPYGCNECGKNFGRHSHLIEHLKRHFREKSQRCSDKRSKNTKLSVKKKISEYS
EADMELSGKTQRNVSQVQDFGEGCEFQGKLDRKQGIPMKEILGQPSSKRMNYSEVPYVHK
KSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHT
GEKPYTCPLCGKAFRVRSHLVQHQSVHSGERPFKCNECGKGFGRRSHLAGHLRLHSREKS
HQCRECGEIFFQYVSLIEHQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCD
ICGKAFGYSSDLIQHYRTHTAEKPYQCDICRENVGQCSHTKQHQKIYSSTKSHQCHECGR
GFTLKSHLNQHQRIHTGEKPFQCKECGMNFSWSCSLFKHLRSHERTDPINTLSVEGSLL

Sequence length

839

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	28712091	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	GWASCAT_DG	30093612		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	33345608	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Peritoneal Neoplasms	Peritoneal neoplasm	Pubtator	34476575	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZKSCAN5 (zinc finger with KRAB and SCAN domains 5)