Gene Gene information from NCBI Gene database.
Entrez ID 23635
Gene name Single stranded DNA binding protein 2
Gene symbol SSBP2
Synonyms (NCBI Gene)
HSPC116SOSS-B2
Chromosome 5
Chromosome location 5q14.1
Summary This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene ma
miRNA miRNA information provided by mirtarbase database.
390
miRTarBase ID miRNA Experiments Reference
MIRT679312 hsa-miR-8062 HITS-CLIP 23824327
MIRT679311 hsa-miR-6513-3p HITS-CLIP 23824327
MIRT679310 hsa-miR-4258 HITS-CLIP 23824327
MIRT679309 hsa-miR-7108-3p HITS-CLIP 23824327
MIRT679308 hsa-miR-4485-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003697 Function Single-stranded DNA binding IEA
GO:0003697 Function Single-stranded DNA binding NAS 12079286
GO:0005515 Function Protein binding IPI 16189514, 33961781
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607389 15831 ENSG00000145687
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P81877
Protein name Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)
PDB 6IWV , 6TYD , 8HIB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04503 SSDP 83 125 Family
PF04503 SSDP 124 338 Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12079286}.
Sequence
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGF
LHSWWCVFWDLYCAAPERRETCEHSSEAKAFHDYSAAAAPSPVLGNIPPGDGMPVGPVPP
GFF
QPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTP
PRGMVPLGPQNYGGAMRPPLNALGGPGMPGMNMGPGGGRPWPNPTNANSIPYSSASPGNY
VGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGSDGPMGGLGGM
ESHHMNGSLGSGDMDSISKNSPNNMSLSNQPGTPRDDG
EMGGNFLNPFQSESYSPSMTMS
V
Sequence length 361
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
17
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 18618714
★☆☆☆☆
Found in Text Mining only
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 18559593
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder CTD_human_DG 31043756
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar Disorder GWASCAT_DG 31043756
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 25824743 Associate
★☆☆☆☆
Found in Text Mining only
Cakut Congenital anomalies of the kidney and urinary tract Pubtator 40774958 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 30541499 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 31882468 Inhibit
★☆☆☆☆
Found in Text Mining only
Cholecystitis Cholecystitis BEFREE 25066711
★☆☆☆☆
Found in Text Mining only
Cholecystitis Cholecystitis Pubtator 25066711 Associate
★☆☆☆☆
Found in Text Mining only