Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23609
Gene name	Makorin ring finger protein 2
Gene symbol	MKRN2
Synonyms (NCBI Gene)	HSPC070RNF62
Chromosome	3
Chromosome location	3p25.2
Summary	This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense o

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Show/Hide all (215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020253	hsa-miR-130b-3p	Sequencing	20371350
MIRT032377	hsa-let-7b-5p	Proteomics	18668040
MIRT049766	hsa-miR-92a-3p	CLASH	23622248
MIRT042305	hsa-miR-484	CLASH	23622248
MIRT448166	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT448164	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT448163	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT448162	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT448166	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT448164	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT448163	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT448162	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT448166	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT448164	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT448163	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT448162	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT448166	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT448164	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT448163	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT448162	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT1150420	hsa-miR-137	CLIP-seq
MIRT1150421	hsa-miR-138	CLIP-seq
MIRT1150422	hsa-miR-147	CLIP-seq
MIRT1150423	hsa-miR-2053	CLIP-seq
MIRT1150424	hsa-miR-2116	CLIP-seq
MIRT1150425	hsa-miR-2276	CLIP-seq
MIRT1150426	hsa-miR-25	CLIP-seq
MIRT1150427	hsa-miR-3121-3p	CLIP-seq
MIRT1150428	hsa-miR-3121-5p	CLIP-seq
MIRT1150429	hsa-miR-3153	CLIP-seq
MIRT1150430	hsa-miR-3189-5p	CLIP-seq
MIRT1150431	hsa-miR-32	CLIP-seq
MIRT1150432	hsa-miR-3200-5p	CLIP-seq
MIRT1150433	hsa-miR-33a	CLIP-seq
MIRT1150434	hsa-miR-33b	CLIP-seq
MIRT1150435	hsa-miR-3620	CLIP-seq
MIRT1150436	hsa-miR-3622a-3p	CLIP-seq
MIRT1150437	hsa-miR-3622b-3p	CLIP-seq
MIRT1150438	hsa-miR-363	CLIP-seq
MIRT1150439	hsa-miR-365	CLIP-seq
MIRT1150440	hsa-miR-367	CLIP-seq
MIRT1150441	hsa-miR-375	CLIP-seq
MIRT1150442	hsa-miR-4267	CLIP-seq
MIRT1150443	hsa-miR-4278	CLIP-seq
MIRT1150444	hsa-miR-4289	CLIP-seq
MIRT1150445	hsa-miR-4422	CLIP-seq
MIRT1150446	hsa-miR-4432	CLIP-seq
MIRT1150447	hsa-miR-4446-3p	CLIP-seq
MIRT1150448	hsa-miR-4453	CLIP-seq
MIRT1150449	hsa-miR-4457	CLIP-seq
MIRT1150450	hsa-miR-4473	CLIP-seq
MIRT1150451	hsa-miR-4502	CLIP-seq
MIRT1150452	hsa-miR-4538	CLIP-seq
MIRT1150453	hsa-miR-4635	CLIP-seq
MIRT1150454	hsa-miR-4656	CLIP-seq
MIRT1150455	hsa-miR-4665-3p	CLIP-seq
MIRT1150456	hsa-miR-4668-5p	CLIP-seq
MIRT1150457	hsa-miR-4677-5p	CLIP-seq
MIRT1150458	hsa-miR-4688	CLIP-seq
MIRT1150459	hsa-miR-4728-3p	CLIP-seq
MIRT1150460	hsa-miR-4758-3p	CLIP-seq
MIRT1150461	hsa-miR-4775	CLIP-seq
MIRT1150462	hsa-miR-486-3p	CLIP-seq
MIRT1150463	hsa-miR-488	CLIP-seq
MIRT1150464	hsa-miR-512-3p	CLIP-seq
MIRT1150465	hsa-miR-513b	CLIP-seq
MIRT1150466	hsa-miR-520f	CLIP-seq
MIRT1150467	hsa-miR-526b	CLIP-seq
MIRT1150468	hsa-miR-561	CLIP-seq
MIRT1150469	hsa-miR-582-5p	CLIP-seq
MIRT1150470	hsa-miR-590-3p	CLIP-seq
MIRT1150471	hsa-miR-624	CLIP-seq
MIRT1150472	hsa-miR-9	CLIP-seq
MIRT1150473	hsa-miR-92a	CLIP-seq
MIRT1150474	hsa-miR-92b	CLIP-seq
MIRT1150429	hsa-miR-3153	CLIP-seq
MIRT2042850	hsa-miR-3158-3p	CLIP-seq
MIRT1150435	hsa-miR-3620	CLIP-seq
MIRT1150447	hsa-miR-4446-3p	CLIP-seq
MIRT2042851	hsa-miR-4534	CLIP-seq
MIRT1150455	hsa-miR-4665-3p	CLIP-seq
MIRT1150456	hsa-miR-4668-5p	CLIP-seq
MIRT2042852	hsa-miR-4704-5p	CLIP-seq
MIRT2042853	hsa-miR-4762-5p	CLIP-seq
MIRT1150468	hsa-miR-561	CLIP-seq
MIRT2042854	hsa-miR-604	CLIP-seq
MIRT2042855	hsa-miR-647	CLIP-seq
MIRT2042856	hsa-miR-888	CLIP-seq
MIRT2272472	hsa-miR-10a	CLIP-seq
MIRT2272473	hsa-miR-10b	CLIP-seq
MIRT2272474	hsa-miR-1236	CLIP-seq
MIRT2272475	hsa-miR-224	CLIP-seq
MIRT2272476	hsa-miR-2278	CLIP-seq
MIRT2272477	hsa-miR-2467-3p	CLIP-seq
MIRT2272478	hsa-miR-3064-5p	CLIP-seq
MIRT2272479	hsa-miR-31	CLIP-seq
MIRT2272480	hsa-miR-3188	CLIP-seq
MIRT2272481	hsa-miR-3652	CLIP-seq
MIRT2272482	hsa-miR-3691-3p	CLIP-seq
MIRT2272483	hsa-miR-4275	CLIP-seq
MIRT2272484	hsa-miR-4430	CLIP-seq
MIRT2272485	hsa-miR-4436a	CLIP-seq
MIRT2272486	hsa-miR-4468	CLIP-seq
MIRT2272487	hsa-miR-4505	CLIP-seq
MIRT2272488	hsa-miR-4659a-5p	CLIP-seq
MIRT2272489	hsa-miR-4659b-5p	CLIP-seq
MIRT2272490	hsa-miR-4666-3p	CLIP-seq
MIRT2042853	hsa-miR-4762-5p	CLIP-seq
MIRT2272491	hsa-miR-4776-3p	CLIP-seq
MIRT2042854	hsa-miR-604	CLIP-seq
MIRT2042855	hsa-miR-647	CLIP-seq
MIRT2272492	hsa-miR-659	CLIP-seq
MIRT2390935	hsa-miR-1262	CLIP-seq
MIRT2390936	hsa-miR-4701-3p	CLIP-seq
MIRT2454153	hsa-miR-3163	CLIP-seq
MIRT1150432	hsa-miR-3200-5p	CLIP-seq
MIRT2272483	hsa-miR-4275	CLIP-seq
MIRT2454154	hsa-miR-4281	CLIP-seq
MIRT1150451	hsa-miR-4502	CLIP-seq
MIRT2454155	hsa-miR-513a-3p	CLIP-seq
MIRT1150469	hsa-miR-582-5p	CLIP-seq
MIRT1150432	hsa-miR-3200-5p	CLIP-seq
MIRT2272483	hsa-miR-4275	CLIP-seq
MIRT2454154	hsa-miR-4281	CLIP-seq
MIRT1150451	hsa-miR-4502	CLIP-seq
MIRT1150469	hsa-miR-582-5p	CLIP-seq
MIRT2272472	hsa-miR-10a	CLIP-seq
MIRT2272473	hsa-miR-10b	CLIP-seq
MIRT2571367	hsa-miR-1183	CLIP-seq
MIRT2571368	hsa-miR-1253	CLIP-seq
MIRT2571369	hsa-miR-1278	CLIP-seq
MIRT2571370	hsa-miR-1284	CLIP-seq
MIRT2571371	hsa-miR-1302	CLIP-seq
MIRT2571372	hsa-miR-1909	CLIP-seq
MIRT2571373	hsa-miR-1912	CLIP-seq
MIRT2571374	hsa-miR-1976	CLIP-seq
MIRT2571375	hsa-miR-205	CLIP-seq
MIRT2272475	hsa-miR-224	CLIP-seq
MIRT2571376	hsa-miR-3122	CLIP-seq
MIRT2571377	hsa-miR-3130-5p	CLIP-seq
MIRT1150429	hsa-miR-3153	CLIP-seq
MIRT2571378	hsa-miR-3156-5p	CLIP-seq
MIRT2454153	hsa-miR-3163	CLIP-seq
MIRT2571379	hsa-miR-3185	CLIP-seq
MIRT1150432	hsa-miR-3200-5p	CLIP-seq
MIRT2571380	hsa-miR-335	CLIP-seq
MIRT1150435	hsa-miR-3620	CLIP-seq
MIRT2571381	hsa-miR-3672	CLIP-seq
MIRT2571382	hsa-miR-3688-5p	CLIP-seq
MIRT2272482	hsa-miR-3691-3p	CLIP-seq
MIRT2571383	hsa-miR-370	CLIP-seq
MIRT2571384	hsa-miR-3913-5p	CLIP-seq
MIRT2571385	hsa-miR-4268	CLIP-seq
MIRT2272483	hsa-miR-4275	CLIP-seq
MIRT2454154	hsa-miR-4281	CLIP-seq
MIRT2571386	hsa-miR-4298	CLIP-seq
MIRT2571387	hsa-miR-4434	CLIP-seq
MIRT2571388	hsa-miR-4436b-5p	CLIP-seq
MIRT2571389	hsa-miR-4448	CLIP-seq
MIRT2571390	hsa-miR-4475	CLIP-seq
MIRT2571391	hsa-miR-4482	CLIP-seq
MIRT1150451	hsa-miR-4502	CLIP-seq
MIRT2571392	hsa-miR-4516	CLIP-seq
MIRT2042851	hsa-miR-4534	CLIP-seq
MIRT1150455	hsa-miR-4665-3p	CLIP-seq
MIRT1150456	hsa-miR-4668-5p	CLIP-seq
MIRT2571393	hsa-miR-4712-5p	CLIP-seq
MIRT2042853	hsa-miR-4762-5p	CLIP-seq
MIRT1150468	hsa-miR-561	CLIP-seq
MIRT1150469	hsa-miR-582-5p	CLIP-seq
MIRT2042854	hsa-miR-604	CLIP-seq
MIRT2042855	hsa-miR-647	CLIP-seq
MIRT2571394	hsa-miR-770-5p	CLIP-seq
MIRT2042856	hsa-miR-888	CLIP-seq
MIRT2571367	hsa-miR-1183	CLIP-seq
MIRT2571368	hsa-miR-1253	CLIP-seq
MIRT2571369	hsa-miR-1278	CLIP-seq
MIRT2571370	hsa-miR-1284	CLIP-seq
MIRT2571372	hsa-miR-1909	CLIP-seq
MIRT2571373	hsa-miR-1912	CLIP-seq
MIRT2571374	hsa-miR-1976	CLIP-seq
MIRT2571375	hsa-miR-205	CLIP-seq
MIRT2272475	hsa-miR-224	CLIP-seq
MIRT2571377	hsa-miR-3130-5p	CLIP-seq
MIRT1150429	hsa-miR-3153	CLIP-seq
MIRT2571378	hsa-miR-3156-5p	CLIP-seq
MIRT2571379	hsa-miR-3185	CLIP-seq
MIRT1150432	hsa-miR-3200-5p	CLIP-seq
MIRT2571380	hsa-miR-335	CLIP-seq
MIRT1150435	hsa-miR-3620	CLIP-seq
MIRT2571381	hsa-miR-3672	CLIP-seq
MIRT2571382	hsa-miR-3688-5p	CLIP-seq
MIRT2272482	hsa-miR-3691-3p	CLIP-seq
MIRT2571383	hsa-miR-370	CLIP-seq
MIRT2571385	hsa-miR-4268	CLIP-seq
MIRT2272483	hsa-miR-4275	CLIP-seq
MIRT2454154	hsa-miR-4281	CLIP-seq
MIRT2571387	hsa-miR-4434	CLIP-seq
MIRT2571388	hsa-miR-4436b-5p	CLIP-seq
MIRT2571389	hsa-miR-4448	CLIP-seq
MIRT2571390	hsa-miR-4475	CLIP-seq
MIRT2571391	hsa-miR-4482	CLIP-seq
MIRT1150451	hsa-miR-4502	CLIP-seq
MIRT2571392	hsa-miR-4516	CLIP-seq
MIRT2042851	hsa-miR-4534	CLIP-seq
MIRT1150455	hsa-miR-4665-3p	CLIP-seq
MIRT1150456	hsa-miR-4668-5p	CLIP-seq
MIRT2571393	hsa-miR-4712-5p	CLIP-seq
MIRT2042853	hsa-miR-4762-5p	CLIP-seq
MIRT1150468	hsa-miR-561	CLIP-seq
MIRT1150469	hsa-miR-582-5p	CLIP-seq
MIRT2042854	hsa-miR-604	CLIP-seq
MIRT2042855	hsa-miR-647	CLIP-seq
MIRT2571394	hsa-miR-770-5p	CLIP-seq
MIRT2042856	hsa-miR-888	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0002862	Process	Negative regulation of inflammatory response to antigenic stimulus	IEA
GO:0002862	Process	Negative regulation of inflammatory response to antigenic stimulus	ISS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	17500595, 22046132, 25416956, 32296183, 32814053, 32838362, 36217029
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006351	Process	DNA-templated transcription	ISS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	ISS
GO:0007283	Process	Spermatogenesis	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	ISS
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	ISS

MIM	HGNC	e!Ensembl
608426	7113	ENSG00000075975

Q9H000

Protein name

E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)

Protein function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18044	zf-CCCH_4	6 → 27	CCCH-type zinc finger	Domain
PF00642	zf-CCCH	33 → 57	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
PF00642	zf-CCCH	167 → 191	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
PF00097	zf-C3HC4	238 → 291	Zinc finger, C3HC4 type (RING finger)	Domain
PF14608	zf-CCCH_2	326 → 348		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level) (PubMed:28008940). Widely expressed with expression in testis, ovary, small intestine, colon, periphera

Sequence

MSTKQITCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGTRCRYDHTRPSA
AAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAER
KTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSSYSNEQQLCPYAAAGECR
FGDACVYLHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSI
CMEVILEKASASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIP
SVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKP
RKQLSSQGTVRFFNSVRLWDFIENRESRHVPNNEDVDMTELGDLFMHLSGVESSEP

Sequence length

416

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEOPARD SYNDROME 2	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NOONAN SYNDROME 5	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinogenesis	Carcinogenesis	Pubtator	30103781	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36938725	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37218161	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	Pubtator	32728162	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	24675897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	24675897	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	22795057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	30103781	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	31814304		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	35196650	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

MKRN2 (makorin ring finger protein 2)