ORC6 (origin recognition complex subunit 6)

Gene

• Entrez ID: 23594
• Gene name: Origin recognition complex subunit 6
• Gene symbol: ORC6
• Synonyms (NCBI Gene): ORC6L
• Chromosome: 16
• Chromosome location: 16q11.2
• Summary: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs200089121	T>A,C	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant
rs387906969	A>C	Pathogenic	Non coding transcript variant, coding sequence variant, genic downstream transcript variant, missense variant
rs572314014	G>A	Pathogenic	Intron variant
rs786205258	TT>-	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs879255692	AGAA>-	Pathogenic	Downstream transcript variant, genic downstream transcript variant, coding sequence variant, frameshift variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016286	hsa-miR-193b-3p	Microarray	20304954
MIRT049645	hsa-miR-92a-3p	CLASH	23622248
MIRT041879	hsa-miR-484	CLASH	23622248
MIRT689529	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689528	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT689527	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689526	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689525	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT689524	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT689523	hsa-miR-6134	HITS-CLIP	23313552
MIRT689522	hsa-miR-3926	HITS-CLIP	23313552
MIRT689521	hsa-miR-3672	HITS-CLIP	23313552
MIRT689520	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT689519	hsa-miR-548s	HITS-CLIP	23313552
MIRT642516	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642515	hsa-miR-662	HITS-CLIP	23824327
MIRT549668	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642514	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642513	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT549666	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642512	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642511	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT642510	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT642509	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT642508	hsa-miR-4284	HITS-CLIP	23824327
MIRT642507	hsa-miR-1297	HITS-CLIP	23824327
MIRT642506	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT642505	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT642504	hsa-miR-4465	HITS-CLIP	23824327
MIRT642503	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT642502	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	20371350
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	20371350
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	20371350
MIRT570785	hsa-miR-3135b	PAR-CLIP	20371350
MIRT549664	hsa-miR-504-3p	PAR-CLIP	20371350
MIRT549663	hsa-miR-122-5p	PAR-CLIP	20371350
MIRT570784	hsa-miR-3652	PAR-CLIP	20371350
MIRT570783	hsa-miR-4430	PAR-CLIP	20371350
MIRT549668	hsa-miR-6741-3p	PAR-CLIP	21572407
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	21572407
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	21572407
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	21572407
MIRT549664	hsa-miR-504-3p	PAR-CLIP	21572407
MIRT549663	hsa-miR-122-5p	PAR-CLIP	21572407
MIRT689529	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT689529	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689528	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT689527	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689526	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689525	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT689524	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT689523	hsa-miR-6134	HITS-CLIP	23313552
MIRT689522	hsa-miR-3926	HITS-CLIP	23313552
MIRT689521	hsa-miR-3672	HITS-CLIP	23313552
MIRT689520	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT689519	hsa-miR-548s	HITS-CLIP	23313552
MIRT642516	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642515	hsa-miR-662	HITS-CLIP	23824327
MIRT549668	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642514	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642513	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT549666	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642512	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642511	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT642510	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT642509	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT642508	hsa-miR-4284	HITS-CLIP	23824327
MIRT642507	hsa-miR-1297	HITS-CLIP	23824327
MIRT642506	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT642505	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT642504	hsa-miR-4465	HITS-CLIP	23824327
MIRT642503	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT642502	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	20371350
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	20371350
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	20371350
MIRT570785	hsa-miR-3135b	PAR-CLIP	20371350
MIRT549664	hsa-miR-504-3p	PAR-CLIP	20371350
MIRT549663	hsa-miR-122-5p	PAR-CLIP	20371350
MIRT570784	hsa-miR-3652	PAR-CLIP	20371350
MIRT570783	hsa-miR-4430	PAR-CLIP	20371350
MIRT549668	hsa-miR-6741-3p	PAR-CLIP	21572407
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	21572407
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	21572407
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	21572407
MIRT549664	hsa-miR-504-3p	PAR-CLIP	21572407
MIRT549663	hsa-miR-122-5p	PAR-CLIP	21572407
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1205655	hsa-miR-1264	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT1205658	hsa-miR-28-5p	CLIP-seq
MIRT1205659	hsa-miR-3139	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205661	hsa-miR-3150b-3p	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1205664	hsa-miR-3929	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205666	hsa-miR-4419b	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT1205669	hsa-miR-4478	CLIP-seq
MIRT1205670	hsa-miR-4487	CLIP-seq
MIRT1205671	hsa-miR-4689	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205673	hsa-miR-4712-3p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205678	hsa-miR-4784	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205680	hsa-miR-501-3p	CLIP-seq
MIRT1205681	hsa-miR-502-3p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1205686	hsa-miR-708	CLIP-seq
MIRT1205687	hsa-miR-720	CLIP-seq
MIRT1205688	hsa-miR-767-5p	CLIP-seq
MIRT1922294	hsa-miR-1224-3p	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1922300	hsa-miR-640	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT2059245	hsa-miR-106a	CLIP-seq
MIRT2059246	hsa-miR-106b	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2059248	hsa-miR-150	CLIP-seq
MIRT2059249	hsa-miR-155	CLIP-seq
MIRT2059250	hsa-miR-17	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2059251	hsa-miR-20a	CLIP-seq
MIRT2059252	hsa-miR-20b	CLIP-seq
MIRT2059253	hsa-miR-302a	CLIP-seq
MIRT2059254	hsa-miR-302b	CLIP-seq
MIRT2059255	hsa-miR-302c	CLIP-seq
MIRT2059256	hsa-miR-302d	CLIP-seq
MIRT2059257	hsa-miR-302e	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT2059258	hsa-miR-372	CLIP-seq
MIRT2059259	hsa-miR-373	CLIP-seq
MIRT1205664	hsa-miR-3929	CLIP-seq
MIRT2059260	hsa-miR-4269	CLIP-seq
MIRT2059261	hsa-miR-4318	CLIP-seq
MIRT1205666	hsa-miR-4419b	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT2059262	hsa-miR-4474-3p	CLIP-seq
MIRT1205669	hsa-miR-4478	CLIP-seq
MIRT2059263	hsa-miR-4484	CLIP-seq
MIRT2059264	hsa-miR-4505	CLIP-seq
MIRT2059265	hsa-miR-4514	CLIP-seq
MIRT2059266	hsa-miR-4692	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT2059267	hsa-miR-4731-5p	CLIP-seq
MIRT2059268	hsa-miR-4742-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT2059269	hsa-miR-4757-5p	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT2059271	hsa-miR-512-3p	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT2059272	hsa-miR-519d	CLIP-seq
MIRT2059273	hsa-miR-520a-3p	CLIP-seq
MIRT2059274	hsa-miR-520b	CLIP-seq
MIRT2059275	hsa-miR-520c-3p	CLIP-seq
MIRT2059276	hsa-miR-520d-3p	CLIP-seq
MIRT2059277	hsa-miR-520e	CLIP-seq
MIRT2059278	hsa-miR-520g	CLIP-seq
MIRT2059279	hsa-miR-520h	CLIP-seq
MIRT2059280	hsa-miR-548an	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT2059281	hsa-miR-601	CLIP-seq
MIRT1205687	hsa-miR-720	CLIP-seq
MIRT2059282	hsa-miR-93	CLIP-seq
MIRT2287346	hsa-miR-1	CLIP-seq
MIRT2287347	hsa-miR-1178	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205655	hsa-miR-1264	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059249	hsa-miR-155	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2287348	hsa-miR-206	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT2287349	hsa-miR-3194-5p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT2287350	hsa-miR-3673	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT2059261	hsa-miR-4318	CLIP-seq
MIRT2287351	hsa-miR-4328	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT2059262	hsa-miR-4474-3p	CLIP-seq
MIRT2059264	hsa-miR-4505	CLIP-seq
MIRT2287352	hsa-miR-4690-3p	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT2059281	hsa-miR-601	CLIP-seq
MIRT2287353	hsa-miR-613	CLIP-seq
MIRT1205687	hsa-miR-720	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT2059245	hsa-miR-106a	CLIP-seq
MIRT2059246	hsa-miR-106b	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1922294	hsa-miR-1224-3p	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2585570	hsa-miR-132	CLIP-seq
MIRT2059248	hsa-miR-150	CLIP-seq
MIRT2059250	hsa-miR-17	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2059251	hsa-miR-20a	CLIP-seq
MIRT2059252	hsa-miR-20b	CLIP-seq
MIRT2585571	hsa-miR-212	CLIP-seq
MIRT2585572	hsa-miR-26a	CLIP-seq
MIRT2585573	hsa-miR-26b	CLIP-seq
MIRT2059253	hsa-miR-302a	CLIP-seq
MIRT2059254	hsa-miR-302b	CLIP-seq
MIRT2059255	hsa-miR-302c	CLIP-seq
MIRT2059256	hsa-miR-302d	CLIP-seq
MIRT2059257	hsa-miR-302e	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT2287349	hsa-miR-3194-5p	CLIP-seq
MIRT2059258	hsa-miR-372	CLIP-seq
MIRT2059259	hsa-miR-373	CLIP-seq
MIRT1205664	hsa-miR-3929	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205666	hsa-miR-4419b	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT1205669	hsa-miR-4478	CLIP-seq
MIRT2059263	hsa-miR-4484	CLIP-seq
MIRT2585574	hsa-miR-4640-5p	CLIP-seq
MIRT2585575	hsa-miR-4661-3p	CLIP-seq
MIRT2287352	hsa-miR-4690-3p	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT2585576	hsa-miR-4709-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT2585577	hsa-miR-4726-5p	CLIP-seq
MIRT2059267	hsa-miR-4731-5p	CLIP-seq
MIRT2585578	hsa-miR-4733-3p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT2059269	hsa-miR-4757-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205680	hsa-miR-501-3p	CLIP-seq
MIRT1205681	hsa-miR-502-3p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT2059271	hsa-miR-512-3p	CLIP-seq
MIRT2059272	hsa-miR-519d	CLIP-seq
MIRT2059273	hsa-miR-520a-3p	CLIP-seq
MIRT2059274	hsa-miR-520b	CLIP-seq
MIRT2059275	hsa-miR-520c-3p	CLIP-seq
MIRT2059276	hsa-miR-520d-3p	CLIP-seq
MIRT2059277	hsa-miR-520e	CLIP-seq
MIRT2059278	hsa-miR-520g	CLIP-seq
MIRT2059279	hsa-miR-520h	CLIP-seq
MIRT2059280	hsa-miR-548an	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1922300	hsa-miR-640	CLIP-seq
MIRT2585579	hsa-miR-651	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT1205688	hsa-miR-767-5p	CLIP-seq
MIRT2059282	hsa-miR-93	CLIP-seq
MIRT2059245	hsa-miR-106a	CLIP-seq
MIRT2059246	hsa-miR-106b	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1922294	hsa-miR-1224-3p	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2059248	hsa-miR-150	CLIP-seq
MIRT2059250	hsa-miR-17	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2059251	hsa-miR-20a	CLIP-seq
MIRT2059252	hsa-miR-20b	CLIP-seq
MIRT2059253	hsa-miR-302a	CLIP-seq
MIRT2059254	hsa-miR-302b	CLIP-seq
MIRT2059255	hsa-miR-302c	CLIP-seq
MIRT2059256	hsa-miR-302d	CLIP-seq
MIRT2059257	hsa-miR-302e	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT2059258	hsa-miR-372	CLIP-seq
MIRT2059259	hsa-miR-373	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT2059267	hsa-miR-4731-5p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT2059269	hsa-miR-4757-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205680	hsa-miR-501-3p	CLIP-seq
MIRT1205681	hsa-miR-502-3p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT2059271	hsa-miR-512-3p	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT2059272	hsa-miR-519d	CLIP-seq
MIRT2059273	hsa-miR-520a-3p	CLIP-seq
MIRT2059274	hsa-miR-520b	CLIP-seq
MIRT2059275	hsa-miR-520c-3p	CLIP-seq
MIRT2059276	hsa-miR-520d-3p	CLIP-seq
MIRT2059277	hsa-miR-520e	CLIP-seq
MIRT2059278	hsa-miR-520g	CLIP-seq
MIRT2059279	hsa-miR-520h	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1922300	hsa-miR-640	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT1205688	hsa-miR-767-5p	CLIP-seq
MIRT2059282	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000808	Component	Origin recognition complex	IDA	17716973
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15232106, 17716973, 18234858, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	32808929
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005664	Component	Nuclear origin of replication recognition complex	IBA
GO:0005664	Component	Nuclear origin of replication recognition complex	IEA
GO:0005664	Component	Nuclear origin of replication recognition complex	IPI	16549788
GO:0005829	Component	Cytosol	TAS
GO:0006260	Process	DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006270	Process	DNA replication initiation	IBA
GO:0006270	Process	DNA replication initiation	IDA	16549788
GO:0016020	Component	Membrane	HDA	19946888

Other IDs

• MIM: 607213
• HGNC: 17151
• e!Ensembl: ENSG00000091651

Protein

• UniProt ID: Q9Y5N6
• Protein name: Origin recognition complex subunit 6
• Protein function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-re
• PDB: 3M03, 6KVG, 8S0B, 8S0D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05460	ORC6	6 → 96	Origin recognition complex subunit 6 (ORC6)	Family

• Sequence:

  MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMK
  CPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKS
  YESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLE
  KIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKIL
  ENAASAQKATAE

• Sequence length: 252

Pathways

KEGG:

Cell cycle

Reactome:

Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Meier-Gorlin syndrome 3	Pathogenic; Likely pathogenic	rs2143010039, rs1279789023, rs879255692, rs35441257, rs786205258, rs387906969, rs777153067, rs2548892306	RCV001527366 RCV001527365 RCV000239709 RCV005433474 RCV000023632 RCV000023633 RCV000499481 RCV001255839	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DESBUQUOIS SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR-PATELLA-SHORT STATURE SYNDROME	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Meier-Gorlin syndrome	Likely benign; Uncertain significance	ClinVar CTD, Disgenet CTD, Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Melanoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ORC6-related disorder	Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Papillary renal cell carcinoma type 1	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	35886011, 38104894	Associate	★☆☆☆☆ Found in Text Mining only
Bronchomalacia	Bronchomalacia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36205357	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37901236, 40255404	Associate	★☆☆☆☆ Found in Text Mining only
Chronic myeloproliferative disorder	Myeloproliferative disorder	GENOMICS_ENGLAND_DG	21358632		★☆☆☆☆ Found in Text Mining only
Clinodactyly of the 5th finger	Camptodactyly of fingers	HPO_DG			★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	19112505		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	LHGDN	19112505		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	19112505, 37096556	Stimulate	★☆☆☆☆ Found in Text Mining only
Congenital absence of breast	Breast aplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital absence of external ear	Anotia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital absence of mandible	Mandibular aplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital clubfoot	Congenital Clubfoot	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of breast	Breast hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of penis	Congenital Hypoplasia Of Penis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital small ears	Microtia	GENOMICS_ENGLAND_DG	7710253		★☆☆☆☆ Found in Text Mining only
Congenital small ears	Microtia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Craniosynostosis	Craniosynostosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	BEFREE	29036220		★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ear Diseases	Ear disease	Pubtator	23516378	Associate	★☆☆☆☆ Found in Text Mining only
EAR, PATELLA, SHORT STATURE SYNDROME	Ear Diseases	ORPHANET_DG	21358632, 23516378		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	Ear Diseases	CTD_human_DG	21358632		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	Ear Diseases	BEFREE	24137536, 25691413, 26139588, 29036220		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ear-patella-short stature syndrome	Ear-Patella-Short Stature Syndrome	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epispadias	Epispadias	HPO_DG			★☆☆☆☆ Found in Text Mining only
Gastroesophageal reflux disease	Gastroesophageal Reflux Disease	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37901236	Stimulate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	21358632	Associate	★☆☆☆☆ Found in Text Mining only
Hypertrophy of clitoris	Hypertrophy Of Clitoris	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypoplasia of the maxilla	Hypoplasia of the maxilla	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Jeune syndrome	Jeune syndrome	Pubtator	36012502	Associate	★☆☆☆☆ Found in Text Mining only
Laryngomalacia	Laryngomalacia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19112505		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	19112505		★☆☆☆☆ Found in Text Mining only
MEIER-GORLIN SYNDROME 3	Meier-Gorlin Syndrome	UNIPROT_DG	21358632		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
MEIER-GORLIN SYNDROME 3	Meier-Gorlin Syndrome	GENOMICS_ENGLAND_DG	21358632, 26381604, 7710253		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
MEIER-GORLIN SYNDROME 3	Meier-Gorlin Syndrome	CLINVAR_DG	22333897		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Microcephaly	Microcephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Micrognathism	Micrognathism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Microstomia	Microstomia	HPO_DG			★☆☆☆☆ Found in Text Mining only
MUNGAN SYNDROME	MUNGAN SYNDROME	BEFREE	26139588		★☆☆☆☆ Found in Text Mining only
Penis agenesis	Penis Agenesis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Posteriorly rotated ear	Posteriorly Rotated Ear	HPO_DG			★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36978046	Associate	★☆☆☆☆ Found in Text Mining only
Respiratory Failure	Respiratory Failure	HPO_DG			★☆☆☆☆ Found in Text Mining only
Seckel syndrome	Seckel Syndrome	GENOMICS_ENGLAND_DG	21358632		★☆☆☆☆ Found in Text Mining only
Specific learning disability	Specific Learning Disorder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Submucous cleft of hard palate	Submucosal cleft palate	HPO_DG			★☆☆☆☆ Found in Text Mining only
Tracheomalacia	Tracheomalacia	HPO_DG			★☆☆☆☆ Found in Text Mining only