CARHSP1 (calcium regulated heat stable protein 1)

Gene

• Entrez ID: 23589
• Gene name: Calcium regulated heat stable protein 1
• Gene symbol: CARHSP1
• Synonyms (NCBI Gene): CRHSP-24, CRHSP24, CSDC1
• Chromosome: 16
• Chromosome location: 16p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001645	hsa-let-7b-5p	pSILAC	18668040
MIRT020567	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT001645	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT052503	hsa-let-7a-5p	CLASH	23622248
MIRT052503	hsa-let-7a-5p	CLASH	23622248
MIRT047684	hsa-miR-10a-5p	CLASH	23622248
MIRT045955	hsa-miR-125b-5p	CLASH	23622248
MIRT052882	hsa-miR-3909	CLASH	23622248
MIRT721513	hsa-miR-4255	HITS-CLIP	19536157
MIRT721514	hsa-miR-6513-3p	HITS-CLIP	19536157
MIRT721512	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT721511	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT721510	hsa-miR-3183	HITS-CLIP	19536157
MIRT721509	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT721508	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT721507	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT721506	hsa-miR-2115-5p	HITS-CLIP	19536157
MIRT721505	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT721504	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT721503	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT721502	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT721501	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT721500	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT659836	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT659835	hsa-miR-3176	HITS-CLIP	23824327
MIRT659834	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT659833	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT659832	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT659831	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT659830	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT659829	hsa-miR-548s	HITS-CLIP	23824327
MIRT659828	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT659827	hsa-miR-588	HITS-CLIP	23824327
MIRT659826	hsa-miR-4435	HITS-CLIP	23824327
MIRT659825	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT631333	hsa-miR-548av-5p	HITS-CLIP	23824327
MIRT631332	hsa-miR-548k	HITS-CLIP	23824327
MIRT631331	hsa-miR-8054	HITS-CLIP	23824327
MIRT631330	hsa-miR-1278	HITS-CLIP	23824327
MIRT631329	hsa-miR-3973	HITS-CLIP	23824327
MIRT631328	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT631327	hsa-miR-520h	HITS-CLIP	23824327
MIRT631326	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631325	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT631324	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT631323	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT631322	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT631321	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT631320	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT631319	hsa-miR-4312	HITS-CLIP	23824327
MIRT631318	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT631317	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT631316	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT721513	hsa-miR-4255	HITS-CLIP	19536157
MIRT721514	hsa-miR-6513-3p	HITS-CLIP	19536157
MIRT721512	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT721511	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT721510	hsa-miR-3183	HITS-CLIP	19536157
MIRT721509	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT721508	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT721507	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT721506	hsa-miR-2115-5p	HITS-CLIP	19536157
MIRT721505	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT721504	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT721503	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT721502	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT721501	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT721500	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT659836	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT659835	hsa-miR-3176	HITS-CLIP	23824327
MIRT659834	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT659833	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT659832	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT659831	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT659830	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT659829	hsa-miR-548s	HITS-CLIP	23824327
MIRT659828	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT659827	hsa-miR-588	HITS-CLIP	23824327
MIRT659826	hsa-miR-4435	HITS-CLIP	23824327
MIRT659825	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT631333	hsa-miR-548av-5p	HITS-CLIP	23824327
MIRT631332	hsa-miR-548k	HITS-CLIP	23824327
MIRT631331	hsa-miR-8054	HITS-CLIP	23824327
MIRT631330	hsa-miR-1278	HITS-CLIP	23824327
MIRT631329	hsa-miR-3973	HITS-CLIP	23824327
MIRT631328	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT631327	hsa-miR-520h	HITS-CLIP	23824327
MIRT631326	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631325	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT631324	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT631323	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT631322	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT631321	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT631320	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT631319	hsa-miR-4312	HITS-CLIP	23824327
MIRT631318	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT631317	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT631316	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT862900	hsa-miR-1202	CLIP-seq
MIRT862901	hsa-miR-1272	CLIP-seq
MIRT862902	hsa-miR-1273f	CLIP-seq
MIRT862903	hsa-miR-1292	CLIP-seq
MIRT862904	hsa-miR-2054	CLIP-seq
MIRT862905	hsa-miR-24	CLIP-seq
MIRT862906	hsa-miR-2467-3p	CLIP-seq
MIRT862907	hsa-miR-2964a-3p	CLIP-seq
MIRT862908	hsa-miR-3197	CLIP-seq
MIRT862909	hsa-miR-3200-5p	CLIP-seq
MIRT862910	hsa-miR-342-3p	CLIP-seq
MIRT862911	hsa-miR-3616-3p	CLIP-seq
MIRT862912	hsa-miR-3663-5p	CLIP-seq
MIRT862913	hsa-miR-3664-3p	CLIP-seq
MIRT862914	hsa-miR-3972	CLIP-seq
MIRT862915	hsa-miR-4254	CLIP-seq
MIRT862916	hsa-miR-4257	CLIP-seq
MIRT862917	hsa-miR-4267	CLIP-seq
MIRT862918	hsa-miR-4284	CLIP-seq
MIRT862919	hsa-miR-4308	CLIP-seq
MIRT862920	hsa-miR-4433	CLIP-seq
MIRT862921	hsa-miR-4436b-3p	CLIP-seq
MIRT862922	hsa-miR-4459	CLIP-seq
MIRT862923	hsa-miR-4471	CLIP-seq
MIRT862924	hsa-miR-4499	CLIP-seq
MIRT862925	hsa-miR-4649-3p	CLIP-seq
MIRT862926	hsa-miR-4684-5p	CLIP-seq
MIRT862927	hsa-miR-4768-3p	CLIP-seq
MIRT862928	hsa-miR-490-3p	CLIP-seq
MIRT862929	hsa-miR-510	CLIP-seq
MIRT862930	hsa-miR-512-5p	CLIP-seq
MIRT862931	hsa-miR-541	CLIP-seq
MIRT862932	hsa-miR-603	CLIP-seq
MIRT862933	hsa-miR-654-5p	CLIP-seq
MIRT862934	hsa-miR-665	CLIP-seq
MIRT862935	hsa-miR-766	CLIP-seq
MIRT862906	hsa-miR-2467-3p	CLIP-seq
MIRT1546165	hsa-miR-320e	CLIP-seq
MIRT862916	hsa-miR-4257	CLIP-seq
MIRT1955913	hsa-miR-1245b-3p	CLIP-seq
MIRT862903	hsa-miR-1292	CLIP-seq
MIRT1955914	hsa-miR-2355-5p	CLIP-seq
MIRT862906	hsa-miR-2467-3p	CLIP-seq
MIRT1955915	hsa-miR-298	CLIP-seq
MIRT1955916	hsa-miR-3181	CLIP-seq
MIRT862908	hsa-miR-3197	CLIP-seq
MIRT1955917	hsa-miR-3679-3p	CLIP-seq
MIRT1955918	hsa-miR-3714	CLIP-seq
MIRT1955919	hsa-miR-4252	CLIP-seq
MIRT862917	hsa-miR-4267	CLIP-seq
MIRT1955920	hsa-miR-4286	CLIP-seq
MIRT862923	hsa-miR-4471	CLIP-seq
MIRT1955921	hsa-miR-4530	CLIP-seq
MIRT862927	hsa-miR-4768-3p	CLIP-seq
MIRT1955922	hsa-miR-4793-3p	CLIP-seq
MIRT1955923	hsa-miR-498	CLIP-seq
MIRT1955924	hsa-miR-508-5p	CLIP-seq
MIRT862931	hsa-miR-541	CLIP-seq
MIRT862932	hsa-miR-603	CLIP-seq
MIRT862933	hsa-miR-654-5p	CLIP-seq
MIRT1955925	hsa-miR-922	CLIP-seq
MIRT862903	hsa-miR-1292	CLIP-seq
MIRT2193544	hsa-miR-1915	CLIP-seq
MIRT1955914	hsa-miR-2355-5p	CLIP-seq
MIRT1955917	hsa-miR-3679-3p	CLIP-seq
MIRT1955920	hsa-miR-4286	CLIP-seq
MIRT862923	hsa-miR-4471	CLIP-seq
MIRT1955923	hsa-miR-498	CLIP-seq
MIRT862931	hsa-miR-541	CLIP-seq
MIRT862932	hsa-miR-603	CLIP-seq
MIRT862933	hsa-miR-654-5p	CLIP-seq
MIRT862935	hsa-miR-766	CLIP-seq
MIRT1955921	hsa-miR-4530	CLIP-seq
MIRT1955925	hsa-miR-922	CLIP-seq
MIRT862903	hsa-miR-1292	CLIP-seq
MIRT862906	hsa-miR-2467-3p	CLIP-seq
MIRT862923	hsa-miR-4471	CLIP-seq
MIRT862931	hsa-miR-541	CLIP-seq
MIRT862933	hsa-miR-654-5p	CLIP-seq
MIRT2436046	hsa-miR-4668-3p	CLIP-seq
MIRT2436047	hsa-miR-548c-3p	CLIP-seq
MIRT2436048	hsa-miR-605	CLIP-seq
MIRT2436046	hsa-miR-4668-3p	CLIP-seq
MIRT2436047	hsa-miR-548c-3p	CLIP-seq
MIRT2436048	hsa-miR-605	CLIP-seq
MIRT2496677	hsa-miR-548an	CLIP-seq
MIRT2496678	hsa-miR-1185	CLIP-seq
MIRT2496679	hsa-miR-1265	CLIP-seq
MIRT2496680	hsa-miR-185	CLIP-seq
MIRT2193544	hsa-miR-1915	CLIP-seq
MIRT2496681	hsa-miR-193a-5p	CLIP-seq
MIRT862904	hsa-miR-2054	CLIP-seq
MIRT862906	hsa-miR-2467-3p	CLIP-seq
MIRT1955915	hsa-miR-298	CLIP-seq
MIRT2496682	hsa-miR-3188	CLIP-seq
MIRT2496683	hsa-miR-3190	CLIP-seq
MIRT2496684	hsa-miR-34a	CLIP-seq
MIRT2496685	hsa-miR-34c-5p	CLIP-seq
MIRT2496686	hsa-miR-3605-5p	CLIP-seq
MIRT2496687	hsa-miR-3615	CLIP-seq
MIRT862912	hsa-miR-3663-5p	CLIP-seq
MIRT2496688	hsa-miR-3679-5p	CLIP-seq
MIRT1955918	hsa-miR-3714	CLIP-seq
MIRT2496689	hsa-miR-4260	CLIP-seq
MIRT2496690	hsa-miR-4306	CLIP-seq
MIRT2496691	hsa-miR-4320	CLIP-seq
MIRT2496692	hsa-miR-4480	CLIP-seq
MIRT2496693	hsa-miR-449a	CLIP-seq
MIRT2496694	hsa-miR-449b	CLIP-seq
MIRT1955921	hsa-miR-4530	CLIP-seq
MIRT2496695	hsa-miR-4644	CLIP-seq
MIRT862926	hsa-miR-4684-5p	CLIP-seq
MIRT2496696	hsa-miR-4687-3p	CLIP-seq
MIRT2496697	hsa-miR-4687-5p	CLIP-seq
MIRT2496698	hsa-miR-4710	CLIP-seq
MIRT2496699	hsa-miR-4726-3p	CLIP-seq
MIRT2496700	hsa-miR-4727-5p	CLIP-seq
MIRT862927	hsa-miR-4768-3p	CLIP-seq
MIRT2496701	hsa-miR-4769-3p	CLIP-seq
MIRT2496702	hsa-miR-4779	CLIP-seq
MIRT2496703	hsa-miR-4786-3p	CLIP-seq
MIRT2496704	hsa-miR-486-3p	CLIP-seq
MIRT862928	hsa-miR-490-3p	CLIP-seq
MIRT2496705	hsa-miR-513a-5p	CLIP-seq
MIRT2436047	hsa-miR-548c-3p	CLIP-seq
MIRT2496706	hsa-miR-647	CLIP-seq
MIRT1955925	hsa-miR-922	CLIP-seq
MIRT2496678	hsa-miR-1185	CLIP-seq
MIRT2677364	hsa-miR-1224-3p	CLIP-seq
MIRT2677365	hsa-miR-1260	CLIP-seq
MIRT2677366	hsa-miR-1260b	CLIP-seq
MIRT2496679	hsa-miR-1265	CLIP-seq
MIRT862902	hsa-miR-1273f	CLIP-seq
MIRT2677367	hsa-miR-1280	CLIP-seq
MIRT2677368	hsa-miR-150	CLIP-seq
MIRT2193544	hsa-miR-1915	CLIP-seq
MIRT862904	hsa-miR-2054	CLIP-seq
MIRT862906	hsa-miR-2467-3p	CLIP-seq
MIRT1955915	hsa-miR-298	CLIP-seq
MIRT2496686	hsa-miR-3605-5p	CLIP-seq
MIRT2677369	hsa-miR-3620	CLIP-seq
MIRT862912	hsa-miR-3663-5p	CLIP-seq
MIRT2677370	hsa-miR-3672	CLIP-seq
MIRT2496688	hsa-miR-3679-5p	CLIP-seq
MIRT1955918	hsa-miR-3714	CLIP-seq
MIRT2677371	hsa-miR-4261	CLIP-seq
MIRT2677372	hsa-miR-4264	CLIP-seq
MIRT2677373	hsa-miR-4496	CLIP-seq
MIRT1955921	hsa-miR-4530	CLIP-seq
MIRT2677374	hsa-miR-4651	CLIP-seq
MIRT862926	hsa-miR-4684-5p	CLIP-seq
MIRT2496698	hsa-miR-4710	CLIP-seq
MIRT2677375	hsa-miR-4713-5p	CLIP-seq
MIRT2677376	hsa-miR-4722-3p	CLIP-seq
MIRT2677377	hsa-miR-4731-5p	CLIP-seq
MIRT862927	hsa-miR-4768-3p	CLIP-seq
MIRT2496702	hsa-miR-4779	CLIP-seq
MIRT862928	hsa-miR-490-3p	CLIP-seq
MIRT2677378	hsa-miR-512-3p	CLIP-seq
MIRT2677379	hsa-miR-532-3p	CLIP-seq
MIRT2436047	hsa-miR-548c-3p	CLIP-seq
MIRT2677380	hsa-miR-608	CLIP-seq
MIRT2677381	hsa-miR-622	CLIP-seq
MIRT2677382	hsa-miR-624	CLIP-seq
MIRT1955925	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000177	Component	Cytoplasmic exosome (RNase complex)	IEA
GO:0000177	Component	Cytoplasmic exosome (RNase complex)	ISS
GO:0000932	Component	P-body	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IBA
GO:0003730	Function	MRNA 3'-UTR binding	IDA	21078874
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0019902	Function	Phosphatase binding	NAS	12801884
GO:0035556	Process	Intracellular signal transduction	TAS	9712905
GO:0043186	Component	P granule	IEA
GO:0043186	Component	P granule	ISS
GO:0043488	Process	Regulation of mRNA stability	IBA
GO:0043488	Process	Regulation of mRNA stability	IEA
GO:0043488	Process	Regulation of mRNA stability	ISS

Other IDs

• MIM: 616885
• HGNC: 17150
• e!Ensembl: ENSG00000153048

Protein

• UniProt ID: Q9Y2V2
• Protein name: Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24)
• Protein function: Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).
• PDB: 3AQQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00313	CSD	63 → 129		Domain

• Sequence:

  MSSEPPPPPQPPTHQASVGLLDTPRSRERSPSPLRGNVVPSPLPTRRTRTFSATVRASQG
  PVYKGVCKCFCRSKGHGFITPADGGPDIFLHISDVEGEYVPVEGDEVTYKMCSIPPKNEK
  LQAVEVVITHLAPGTKHETWSGHVISS

• Sequence length: 147

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BRAIN ANEURYSM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	34937778	Associate	★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	26899994		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	26899994		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	26899994	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	34290231	Stimulate	★☆☆☆☆ Found in Text Mining only
Infertility Male	Male infertility	Pubtator	34604380	Associate	★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial Aneurysm	GWASCAT_DG	29531279		★☆☆☆☆ Found in Text Mining only
Lewy Body Disease	Lewy body disease	Pubtator	34937778	Associate	★☆☆☆☆ Found in Text Mining only