FPGS (folylpolyglutamate synthase)

Gene

• Entrez ID: 2356
• Gene name: Folylpolyglutamate synthase
• Gene symbol: FPGS
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q34.11
• Summary: This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023124	hsa-miR-124-3p	Microarray	18668037
MIRT046816	hsa-miR-222-3p	CLASH	23622248
MIRT045414	hsa-miR-149-5p	CLASH	23622248
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT706741	hsa-miR-4438	HITS-CLIP	21572407
MIRT706740	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT706738	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT706739	hsa-miR-3199	HITS-CLIP	21572407
MIRT706737	hsa-miR-8052	HITS-CLIP	21572407
MIRT706736	hsa-miR-365a-5p	HITS-CLIP	21572407
MIRT706735	hsa-miR-365b-5p	HITS-CLIP	21572407
MIRT706734	hsa-miR-5095	HITS-CLIP	21572407
MIRT706733	hsa-miR-7151-3p	HITS-CLIP	21572407
MIRT706739	hsa-miR-3199	PAR-CLIP	27292025
MIRT706736	hsa-miR-365a-5p	PAR-CLIP	27292025
MIRT706735	hsa-miR-365b-5p	PAR-CLIP	27292025
MIRT706741	hsa-miR-4438	PAR-CLIP	27292025
MIRT706740	hsa-miR-4740-3p	PAR-CLIP	27292025
MIRT706734	hsa-miR-5095	PAR-CLIP	27292025
MIRT706738	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT706733	hsa-miR-7151-3p	PAR-CLIP	27292025
MIRT706737	hsa-miR-8052	PAR-CLIP	27292025
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT706741	hsa-miR-4438	HITS-CLIP	21572407
MIRT706740	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT706738	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT706739	hsa-miR-3199	HITS-CLIP	21572407
MIRT706737	hsa-miR-8052	HITS-CLIP	21572407
MIRT706736	hsa-miR-365a-5p	HITS-CLIP	21572407
MIRT706735	hsa-miR-365b-5p	HITS-CLIP	21572407
MIRT706734	hsa-miR-5095	HITS-CLIP	21572407
MIRT706733	hsa-miR-7151-3p	HITS-CLIP	21572407
MIRT1003869	hsa-miR-1206	CLIP-seq
MIRT1003870	hsa-miR-124	CLIP-seq
MIRT1003871	hsa-miR-1254	CLIP-seq
MIRT1003872	hsa-miR-3116	CLIP-seq
MIRT1003873	hsa-miR-3150a-3p	CLIP-seq
MIRT1003874	hsa-miR-3175	CLIP-seq
MIRT1003875	hsa-miR-3665	CLIP-seq
MIRT1003876	hsa-miR-380	CLIP-seq
MIRT1003877	hsa-miR-3934	CLIP-seq
MIRT1003878	hsa-miR-4495	CLIP-seq
MIRT1003879	hsa-miR-4514	CLIP-seq
MIRT1003880	hsa-miR-4692	CLIP-seq
MIRT1003881	hsa-miR-4720-5p	CLIP-seq
MIRT1003882	hsa-miR-4736	CLIP-seq
MIRT1003883	hsa-miR-4799-3p	CLIP-seq
MIRT1003884	hsa-miR-506	CLIP-seq
MIRT1003885	hsa-miR-548an	CLIP-seq
MIRT1003886	hsa-miR-661	CLIP-seq
MIRT1003887	hsa-miR-939	CLIP-seq
MIRT1003888	hsa-miR-940	CLIP-seq
MIRT1003889	hsa-miR-1226	CLIP-seq
MIRT1003890	hsa-miR-125a-5p	CLIP-seq
MIRT1003891	hsa-miR-125b	CLIP-seq
MIRT1003892	hsa-miR-128	CLIP-seq
MIRT1003893	hsa-miR-148a	CLIP-seq
MIRT1003894	hsa-miR-148b	CLIP-seq
MIRT1003895	hsa-miR-152	CLIP-seq
MIRT1003875	hsa-miR-3665	CLIP-seq
MIRT1003896	hsa-miR-4319	CLIP-seq
MIRT1003897	hsa-miR-4732-3p	CLIP-seq
MIRT1003898	hsa-miR-657	CLIP-seq
MIRT1003899	hsa-miR-670	CLIP-seq
MIRT1997568	hsa-miR-2861	CLIP-seq
MIRT1997569	hsa-miR-31	CLIP-seq
MIRT1997570	hsa-miR-3667-5p	CLIP-seq
MIRT1003879	hsa-miR-4514	CLIP-seq
MIRT1003880	hsa-miR-4692	CLIP-seq
MIRT1997571	hsa-miR-4696	CLIP-seq
MIRT1997572	hsa-miR-4717-3p	CLIP-seq
MIRT1997573	hsa-miR-4749-3p	CLIP-seq
MIRT2231234	hsa-miR-4755-3p	CLIP-seq
MIRT1003879	hsa-miR-4514	CLIP-seq
MIRT1003880	hsa-miR-4692	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT2535161	hsa-miR-1225-3p	CLIP-seq
MIRT2535162	hsa-miR-3157-5p	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2535163	hsa-miR-4532	CLIP-seq
MIRT2535164	hsa-miR-4691-3p	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT1997573	hsa-miR-4749-3p	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT1003887	hsa-miR-939	CLIP-seq
MIRT2535161	hsa-miR-1225-3p	CLIP-seq
MIRT1003870	hsa-miR-124	CLIP-seq
MIRT2681161	hsa-miR-185	CLIP-seq
MIRT2681162	hsa-miR-3125	CLIP-seq
MIRT2535162	hsa-miR-3157-5p	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2681163	hsa-miR-3916	CLIP-seq
MIRT2681164	hsa-miR-4306	CLIP-seq
MIRT2681165	hsa-miR-4428	CLIP-seq
MIRT2681166	hsa-miR-4476	CLIP-seq
MIRT2535163	hsa-miR-4532	CLIP-seq
MIRT2681167	hsa-miR-4533	CLIP-seq
MIRT2681168	hsa-miR-4644	CLIP-seq
MIRT2535164	hsa-miR-4691-3p	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT1997573	hsa-miR-4749-3p	CLIP-seq
MIRT2681169	hsa-miR-4786-5p	CLIP-seq
MIRT1003884	hsa-miR-506	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT1003887	hsa-miR-939	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	20072153

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004326	Function	Tetrahydrofolylpolyglutamate synthase activity	IBA
GO:0004326	Function	Tetrahydrofolylpolyglutamate synthase activity	IDA	3619447, 8408020, 25164808
GO:0004326	Function	Tetrahydrofolylpolyglutamate synthase activity	IEA
GO:0004326	Function	Tetrahydrofolylpolyglutamate synthase activity	TAS	7721888
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	1409616
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	25164808
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	7721888
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	8408020
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	25164808
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	7721888
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	7721888
GO:0006536	Process	Glutamate metabolic process	IDA	3619447
GO:0006730	Process	One-carbon metabolic process	IEA
GO:0006760	Process	Folic acid-containing compound metabolic process	IDA	3619447
GO:0008283	Process	Cell population proliferation	IMP	25164808
GO:0009396	Process	Folic acid-containing compound biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0016881	Function	Acid-amino acid ligase activity	IEA
GO:0046655	Process	Folic acid metabolic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0046901	Process	Tetrahydrofolylpolyglutamate biosynthetic process	IBA
GO:0046901	Process	Tetrahydrofolylpolyglutamate biosynthetic process	IDA	3619447, 8408020, 25164808
GO:0046901	Process	Tetrahydrofolylpolyglutamate biosynthetic process	IEA

Other IDs

• MIM: 136510
• HGNC: 3824
• e!Ensembl: ENSG00000136877

Protein

• UniProt ID: Q05932
• Protein name: Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)
• Protein function: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that
• Sequence:

  MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
  YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
  YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
  LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
  WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
  HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
  PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
  PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
  QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
  PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ

• Sequence length: 587

Pathways

KEGG:

Folate biosynthesis
Metabolic pathways
Biosynthesis of cofactors
Antifolate resistance
Folate transport and metabolism

Reactome:

Metabolism of folate and pterines

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARTHRITIS, RHEUMATOID	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	31452789		★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	15630450, 20072153, 24908438, 9224825		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	27987582		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	15630450, 20072153, 24908438, 9224825		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	27752107, 32940699	Associate	★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	15630450	Inhibit	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26895662	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Large Cell	Large cell carcinoma	Pubtator	27064343	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	15630450, 20072153, 24908438, 26107232, 9224825		★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	CTD_human_DG	25013492		★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	37452621	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	14676127		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	14676127, 16512993, 18418463, 19636555, 20037791, 26676887		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	CTD_human_DG	15814641		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	14676127		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	15542523, 18418463, 26676887	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal Neoplasms	CTD_human_DG	15814641		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diffuse Mixed-Cell Lymphoma	Diffuse Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Folate Malabsorption Hereditary	Hereditary folate malabsorption	Pubtator	15047700	Associate	★☆☆☆☆ Found in Text Mining only
Folic Acid Deficiency	Folic Acid Deficiency	BEFREE	21093159		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	10413425		★☆☆☆☆ Found in Text Mining only
Hematologic Diseases	Hematologic disease	Pubtator	32481505	Associate	★☆☆☆☆ Found in Text Mining only
Hemorrhage	Hemorrhage	Pubtator	36952646	Associate	★☆☆☆☆ Found in Text Mining only
High Grade Lymphoma (neoplasm)	High Grade Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	37452621	Associate	★☆☆☆☆ Found in Text Mining only
L2 Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	CTD_human_DG	25013492		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	10507318, 12494465, 25229333		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	16707018, 19131550, 25229333	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	25229333	Associate	★☆☆☆☆ Found in Text Mining only
Low Grade Lymphoma (neoplasm)	Low Grade Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Lymphoma, Diffuse	Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Lymphoma, Intermediate-Grade	Intermediate Grade Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Lymphoma, Mixed-Cell	Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Lymphoma, Small Noncleaved-Cell	Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Lymphoma, Undifferentiated	Lymphoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27620954		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	14676127		★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	23449276	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10964921, 14676127, 18039426, 18676755, 27064343, 8605241		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	23949282, 30851225		★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	16707018		★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	CTD_human_DG	25013492		★☆☆☆☆ Found in Text Mining only
Reticulosarcoma	Reticulosarcoma	CTD_human_DG	17119116		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	17286537, 26652611, 27752107, 31611592		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	CTD_human_DG	23897011		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	27064343	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31754833	Associate	★☆☆☆☆ Found in Text Mining only