WBP2 (WW domain binding protein 2)

Gene

• Entrez ID: 23558
• Gene name: WW domain binding protein 2
• Gene symbol: WBP2
• Synonyms (NCBI Gene): DFNB107, GRAMD6, WBP-2
• Chromosome: 17
• Chromosome location: 17q25.1
• Summary: The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs202022024	C>T	Pathogenic	Intron variant, coding sequence variant, missense variant
rs1555604549	G>A	Pathogenic	Coding sequence variant, missense variant
rs1555604710	T>G	Pathogenic	Intron variant, coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018302	hsa-miR-335-5p	Microarray	18185580
MIRT031220	hsa-miR-19b-3p	Sequencing	20371350
MIRT044096	hsa-miR-361-5p	CLASH	23622248
MIRT043192	hsa-miR-324-5p	CLASH	23622248
MIRT038101	hsa-miR-423-5p	CLASH	23622248
MIRT037894	hsa-miR-455-3p	CLASH	23622248
MIRT037483	hsa-miR-744-5p	CLASH	23622248
MIRT520195	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT520192	hsa-miR-3146	PAR-CLIP	20371350
MIRT520191	hsa-miR-6834-3p	PAR-CLIP	20371350
MIRT520189	hsa-miR-4490	PAR-CLIP	20371350
MIRT520180	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT520179	hsa-miR-4772-5p	PAR-CLIP	20371350
MIRT520178	hsa-miR-18b-3p	PAR-CLIP	20371350
MIRT520177	hsa-miR-8086	PAR-CLIP	20371350
MIRT520173	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT520172	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT520171	hsa-miR-1343-3p	PAR-CLIP	20371350
MIRT520170	hsa-miR-6783-3p	PAR-CLIP	20371350
MIRT520169	hsa-miR-449c-3p	PAR-CLIP	20371350
MIRT520167	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT520195	hsa-miR-513b-3p	PAR-CLIP	23446348
MIRT520194	hsa-miR-619-3p	PAR-CLIP	23446348
MIRT520193	hsa-miR-6760-5p	PAR-CLIP	23446348
MIRT520192	hsa-miR-3146	PAR-CLIP	23446348
MIRT520191	hsa-miR-6834-3p	PAR-CLIP	23446348
MIRT520190	hsa-miR-4254	PAR-CLIP	23446348
MIRT520189	hsa-miR-4490	PAR-CLIP	23446348
MIRT520188	hsa-miR-3661	PAR-CLIP	23446348
MIRT520187	hsa-miR-631	PAR-CLIP	23446348
MIRT520186	hsa-miR-4419a	PAR-CLIP	23446348
MIRT520185	hsa-miR-4510	PAR-CLIP	23446348
MIRT520184	hsa-miR-6127	PAR-CLIP	23446348
MIRT520183	hsa-miR-6129	PAR-CLIP	23446348
MIRT520182	hsa-miR-6130	PAR-CLIP	23446348
MIRT520181	hsa-miR-6133	PAR-CLIP	23446348
MIRT520180	hsa-miR-383-5p	PAR-CLIP	23446348
MIRT520179	hsa-miR-4772-5p	PAR-CLIP	23446348
MIRT520178	hsa-miR-18b-3p	PAR-CLIP	23446348
MIRT520177	hsa-miR-8086	PAR-CLIP	23446348
MIRT520176	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT520175	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT520174	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT520173	hsa-miR-4433a-5p	PAR-CLIP	23446348
MIRT520172	hsa-miR-188-3p	PAR-CLIP	23446348
MIRT520171	hsa-miR-1343-3p	PAR-CLIP	23446348
MIRT520170	hsa-miR-6783-3p	PAR-CLIP	23446348
MIRT520169	hsa-miR-449c-3p	PAR-CLIP	23446348
MIRT520168	hsa-miR-6515-5p	PAR-CLIP	23446348
MIRT520167	hsa-miR-4433b-5p	PAR-CLIP	23446348
MIRT464025	hsa-miR-1-3p	PAR-CLIP	23592263
MIRT464024	hsa-miR-206	PAR-CLIP	23592263
MIRT464023	hsa-miR-613	PAR-CLIP	23592263
MIRT078862	hsa-miR-8066	PAR-CLIP	23592263
MIRT464022	hsa-miR-634	PAR-CLIP	23592263
MIRT464020	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT464021	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT464019	hsa-miR-922	PAR-CLIP	23592263
MIRT464018	hsa-miR-4530	PAR-CLIP	23592263
MIRT464017	hsa-miR-4468	PAR-CLIP	23592263
MIRT464016	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT464015	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT726112	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT031220	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT520195	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT520192	hsa-miR-3146	PAR-CLIP	20371350
MIRT520191	hsa-miR-6834-3p	PAR-CLIP	20371350
MIRT520189	hsa-miR-4490	PAR-CLIP	20371350
MIRT520180	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT520179	hsa-miR-4772-5p	PAR-CLIP	20371350
MIRT520178	hsa-miR-18b-3p	PAR-CLIP	20371350
MIRT520177	hsa-miR-8086	PAR-CLIP	20371350
MIRT520173	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT520172	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT520171	hsa-miR-1343-3p	PAR-CLIP	20371350
MIRT520170	hsa-miR-6783-3p	PAR-CLIP	20371350
MIRT520169	hsa-miR-449c-3p	PAR-CLIP	20371350
MIRT520167	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT520195	hsa-miR-513b-3p	PAR-CLIP	23446348
MIRT520194	hsa-miR-619-3p	PAR-CLIP	23446348
MIRT520193	hsa-miR-6760-5p	PAR-CLIP	23446348
MIRT520192	hsa-miR-3146	PAR-CLIP	23446348
MIRT520191	hsa-miR-6834-3p	PAR-CLIP	23446348
MIRT520190	hsa-miR-4254	PAR-CLIP	23446348
MIRT520189	hsa-miR-4490	PAR-CLIP	23446348
MIRT520188	hsa-miR-3661	PAR-CLIP	23446348
MIRT520187	hsa-miR-631	PAR-CLIP	23446348
MIRT520186	hsa-miR-4419a	PAR-CLIP	23446348
MIRT520185	hsa-miR-4510	PAR-CLIP	23446348
MIRT520184	hsa-miR-6127	PAR-CLIP	23446348
MIRT520183	hsa-miR-6129	PAR-CLIP	23446348
MIRT520182	hsa-miR-6130	PAR-CLIP	23446348
MIRT520181	hsa-miR-6133	PAR-CLIP	23446348
MIRT520180	hsa-miR-383-5p	PAR-CLIP	23446348
MIRT520179	hsa-miR-4772-5p	PAR-CLIP	23446348
MIRT520178	hsa-miR-18b-3p	PAR-CLIP	23446348
MIRT520177	hsa-miR-8086	PAR-CLIP	23446348
MIRT520176	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT520175	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT520174	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT520173	hsa-miR-4433a-5p	PAR-CLIP	23446348
MIRT520172	hsa-miR-188-3p	PAR-CLIP	23446348
MIRT520171	hsa-miR-1343-3p	PAR-CLIP	23446348
MIRT520170	hsa-miR-6783-3p	PAR-CLIP	23446348
MIRT520169	hsa-miR-449c-3p	PAR-CLIP	23446348
MIRT520168	hsa-miR-6515-5p	PAR-CLIP	23446348
MIRT520167	hsa-miR-4433b-5p	PAR-CLIP	23446348
MIRT464025	hsa-miR-1-3p	PAR-CLIP	23592263
MIRT464024	hsa-miR-206	PAR-CLIP	23592263
MIRT464023	hsa-miR-613	PAR-CLIP	23592263
MIRT078862	hsa-miR-8066	PAR-CLIP	23592263
MIRT464022	hsa-miR-634	PAR-CLIP	23592263
MIRT464020	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT464021	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT464019	hsa-miR-922	PAR-CLIP	23592263
MIRT464018	hsa-miR-4530	PAR-CLIP	23592263
MIRT464017	hsa-miR-4468	PAR-CLIP	23592263
MIRT464016	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT464015	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT1489138	hsa-miR-1	CLIP-seq
MIRT1489139	hsa-miR-1182	CLIP-seq
MIRT1489140	hsa-miR-1207-5p	CLIP-seq
MIRT1489141	hsa-miR-1243	CLIP-seq
MIRT1489142	hsa-miR-1252	CLIP-seq
MIRT1489143	hsa-miR-1257	CLIP-seq
MIRT1489144	hsa-miR-1285	CLIP-seq
MIRT1489145	hsa-miR-1290	CLIP-seq
MIRT1489146	hsa-miR-129-5p	CLIP-seq
MIRT1489147	hsa-miR-1321	CLIP-seq
MIRT1489148	hsa-miR-143	CLIP-seq
MIRT1489149	hsa-miR-145	CLIP-seq
MIRT1489150	hsa-miR-1538	CLIP-seq
MIRT1489151	hsa-miR-1827	CLIP-seq
MIRT1489152	hsa-miR-19a	CLIP-seq
MIRT1489153	hsa-miR-19b	CLIP-seq
MIRT1489154	hsa-miR-23a	CLIP-seq
MIRT1489155	hsa-miR-23b	CLIP-seq
MIRT1489156	hsa-miR-23c	CLIP-seq
MIRT1489157	hsa-miR-24	CLIP-seq
MIRT1489158	hsa-miR-3064-5p	CLIP-seq
MIRT1489159	hsa-miR-3121-3p	CLIP-seq
MIRT1489160	hsa-miR-3126-5p	CLIP-seq
MIRT1489161	hsa-miR-3128	CLIP-seq
MIRT1489162	hsa-miR-3138	CLIP-seq
MIRT1489163	hsa-miR-3167	CLIP-seq
MIRT1489164	hsa-miR-3185	CLIP-seq
MIRT1489165	hsa-miR-3187-5p	CLIP-seq
MIRT1489166	hsa-miR-326	CLIP-seq
MIRT1489167	hsa-miR-330-5p	CLIP-seq
MIRT1489168	hsa-miR-3612	CLIP-seq
MIRT1489169	hsa-miR-3616-5p	CLIP-seq
MIRT1489170	hsa-miR-3647-5p	CLIP-seq
MIRT1489171	hsa-miR-3652	CLIP-seq
MIRT1489172	hsa-miR-3663-5p	CLIP-seq
MIRT1489173	hsa-miR-3671	CLIP-seq
MIRT1489174	hsa-miR-3688-5p	CLIP-seq
MIRT1489175	hsa-miR-3689a-3p	CLIP-seq
MIRT1489176	hsa-miR-3689c	CLIP-seq
MIRT1489177	hsa-miR-3918	CLIP-seq
MIRT1489178	hsa-miR-3936	CLIP-seq
MIRT1489179	hsa-miR-4265	CLIP-seq
MIRT1489180	hsa-miR-4270	CLIP-seq
MIRT1489181	hsa-miR-4271	CLIP-seq
MIRT1489182	hsa-miR-4284	CLIP-seq
MIRT1489183	hsa-miR-4291	CLIP-seq
MIRT1489184	hsa-miR-4296	CLIP-seq
MIRT1489185	hsa-miR-4318	CLIP-seq
MIRT1489186	hsa-miR-4322	CLIP-seq
MIRT1489187	hsa-miR-4417	CLIP-seq
MIRT1489188	hsa-miR-4430	CLIP-seq
MIRT1489189	hsa-miR-4437	CLIP-seq
MIRT1489190	hsa-miR-4441	CLIP-seq
MIRT1489191	hsa-miR-4505	CLIP-seq
MIRT1489192	hsa-miR-4520a-3p	CLIP-seq
MIRT1489193	hsa-miR-4527	CLIP-seq
MIRT1489194	hsa-miR-4674	CLIP-seq
MIRT1489195	hsa-miR-4685-5p	CLIP-seq
MIRT1489196	hsa-miR-4688	CLIP-seq
MIRT1489197	hsa-miR-4690-5p	CLIP-seq
MIRT1489198	hsa-miR-4691-3p	CLIP-seq
MIRT1489199	hsa-miR-4710	CLIP-seq
MIRT1489200	hsa-miR-4720-3p	CLIP-seq
MIRT1489201	hsa-miR-4720-5p	CLIP-seq
MIRT1489202	hsa-miR-4725-3p	CLIP-seq
MIRT1489203	hsa-miR-4728-5p	CLIP-seq
MIRT1489204	hsa-miR-4731-5p	CLIP-seq
MIRT1489205	hsa-miR-4736	CLIP-seq
MIRT1489206	hsa-miR-4739	CLIP-seq
MIRT1489207	hsa-miR-4745-3p	CLIP-seq
MIRT1489208	hsa-miR-4753-3p	CLIP-seq
MIRT1489209	hsa-miR-4756-5p	CLIP-seq
MIRT1489210	hsa-miR-4758-3p	CLIP-seq
MIRT1489211	hsa-miR-4763-3p	CLIP-seq
MIRT1489212	hsa-miR-4770	CLIP-seq
MIRT1489213	hsa-miR-4795-5p	CLIP-seq
MIRT1489214	hsa-miR-4799-3p	CLIP-seq
MIRT1489215	hsa-miR-545	CLIP-seq
MIRT1489216	hsa-miR-573	CLIP-seq
MIRT1489217	hsa-miR-579	CLIP-seq
MIRT1489218	hsa-miR-582-3p	CLIP-seq
MIRT1489219	hsa-miR-586	CLIP-seq
MIRT1489220	hsa-miR-612	CLIP-seq
MIRT1489221	hsa-miR-629	CLIP-seq
MIRT1489222	hsa-miR-637	CLIP-seq
MIRT1489223	hsa-miR-650	CLIP-seq
MIRT1489224	hsa-miR-656	CLIP-seq
MIRT1489225	hsa-miR-7	CLIP-seq
MIRT1489226	hsa-miR-873	CLIP-seq
MIRT1489227	hsa-miR-876-5p	CLIP-seq
MIRT1489228	hsa-miR-889	CLIP-seq
MIRT1489229	hsa-miR-940	CLIP-seq
MIRT1489154	hsa-miR-23a	CLIP-seq
MIRT1489155	hsa-miR-23b	CLIP-seq
MIRT1489156	hsa-miR-23c	CLIP-seq
MIRT1489224	hsa-miR-656	CLIP-seq
MIRT1489228	hsa-miR-889	CLIP-seq
MIRT1489140	hsa-miR-1207-5p	CLIP-seq
MIRT2147387	hsa-miR-1237	CLIP-seq
MIRT1489141	hsa-miR-1243	CLIP-seq
MIRT2147388	hsa-miR-1248	CLIP-seq
MIRT1489142	hsa-miR-1252	CLIP-seq
MIRT2147389	hsa-miR-1269	CLIP-seq
MIRT2147390	hsa-miR-1269b	CLIP-seq
MIRT2147391	hsa-miR-1288	CLIP-seq
MIRT1489145	hsa-miR-1290	CLIP-seq
MIRT1489146	hsa-miR-129-5p	CLIP-seq
MIRT2147392	hsa-miR-1343	CLIP-seq
MIRT1489149	hsa-miR-145	CLIP-seq
MIRT2147393	hsa-miR-1973	CLIP-seq
MIRT2147394	hsa-miR-224	CLIP-seq
MIRT1489154	hsa-miR-23a	CLIP-seq
MIRT1489155	hsa-miR-23b	CLIP-seq
MIRT1489156	hsa-miR-23c	CLIP-seq
MIRT1489157	hsa-miR-24	CLIP-seq
MIRT2147395	hsa-miR-2467-5p	CLIP-seq
MIRT1489158	hsa-miR-3064-5p	CLIP-seq
MIRT1489159	hsa-miR-3121-3p	CLIP-seq
MIRT1489160	hsa-miR-3126-5p	CLIP-seq
MIRT2147396	hsa-miR-3153	CLIP-seq
MIRT2147397	hsa-miR-3154	CLIP-seq
MIRT1489163	hsa-miR-3167	CLIP-seq
MIRT2147398	hsa-miR-3188	CLIP-seq
MIRT2147399	hsa-miR-3605-3p	CLIP-seq
MIRT1489169	hsa-miR-3616-5p	CLIP-seq
MIRT1489170	hsa-miR-3647-5p	CLIP-seq
MIRT1489171	hsa-miR-3652	CLIP-seq
MIRT1489172	hsa-miR-3663-5p	CLIP-seq
MIRT1489173	hsa-miR-3671	CLIP-seq
MIRT1489174	hsa-miR-3688-5p	CLIP-seq
MIRT2147400	hsa-miR-377	CLIP-seq
MIRT2147401	hsa-miR-378	CLIP-seq
MIRT2147402	hsa-miR-378b	CLIP-seq
MIRT2147403	hsa-miR-378c	CLIP-seq
MIRT2147404	hsa-miR-378d	CLIP-seq
MIRT2147405	hsa-miR-378e	CLIP-seq
MIRT2147406	hsa-miR-378f	CLIP-seq
MIRT2147407	hsa-miR-378h	CLIP-seq
MIRT2147408	hsa-miR-378i	CLIP-seq
MIRT2147409	hsa-miR-3929	CLIP-seq
MIRT2147410	hsa-miR-3975	CLIP-seq
MIRT2147411	hsa-miR-422a	CLIP-seq
MIRT2147412	hsa-miR-4274	CLIP-seq
MIRT1489182	hsa-miR-4284	CLIP-seq
MIRT1489183	hsa-miR-4291	CLIP-seq
MIRT2147413	hsa-miR-4300	CLIP-seq
MIRT2147414	hsa-miR-4419b	CLIP-seq
MIRT1489188	hsa-miR-4430	CLIP-seq
MIRT2147415	hsa-miR-4448	CLIP-seq
MIRT2147416	hsa-miR-4478	CLIP-seq
MIRT2147417	hsa-miR-4487	CLIP-seq
MIRT2147418	hsa-miR-4494	CLIP-seq
MIRT2147419	hsa-miR-4499	CLIP-seq
MIRT1489191	hsa-miR-4505	CLIP-seq
MIRT2147420	hsa-miR-4515	CLIP-seq
MIRT2147421	hsa-miR-4519	CLIP-seq
MIRT1489193	hsa-miR-4527	CLIP-seq
MIRT1489199	hsa-miR-4710	CLIP-seq
MIRT2147422	hsa-miR-4740-5p	CLIP-seq
MIRT2147423	hsa-miR-4746-3p	CLIP-seq
MIRT1489208	hsa-miR-4753-3p	CLIP-seq
MIRT1489211	hsa-miR-4763-3p	CLIP-seq
MIRT2147424	hsa-miR-4777-5p	CLIP-seq
MIRT1489213	hsa-miR-4795-5p	CLIP-seq
MIRT2147425	hsa-miR-485-5p	CLIP-seq
MIRT2147426	hsa-miR-494	CLIP-seq
MIRT2147427	hsa-miR-518d-5p	CLIP-seq
MIRT2147428	hsa-miR-519b-5p	CLIP-seq
MIRT2147429	hsa-miR-519c-5p	CLIP-seq
MIRT2147430	hsa-miR-520c-5p	CLIP-seq
MIRT2147431	hsa-miR-526a	CLIP-seq
MIRT1489215	hsa-miR-545	CLIP-seq
MIRT1489216	hsa-miR-573	CLIP-seq
MIRT1489226	hsa-miR-873	CLIP-seq
MIRT1489227	hsa-miR-876-5p	CLIP-seq
MIRT2147432	hsa-miR-920	CLIP-seq
MIRT1489140	hsa-miR-1207-5p	CLIP-seq
MIRT2147387	hsa-miR-1237	CLIP-seq
MIRT2147388	hsa-miR-1248	CLIP-seq
MIRT1489152	hsa-miR-19a	CLIP-seq
MIRT1489153	hsa-miR-19b	CLIP-seq
MIRT2367792	hsa-miR-2114	CLIP-seq
MIRT2147394	hsa-miR-224	CLIP-seq
MIRT1489154	hsa-miR-23a	CLIP-seq
MIRT1489155	hsa-miR-23b	CLIP-seq
MIRT1489156	hsa-miR-23c	CLIP-seq
MIRT1489157	hsa-miR-24	CLIP-seq
MIRT1489158	hsa-miR-3064-5p	CLIP-seq
MIRT2147397	hsa-miR-3154	CLIP-seq
MIRT2367793	hsa-miR-3175	CLIP-seq
MIRT1489169	hsa-miR-3616-5p	CLIP-seq
MIRT1489170	hsa-miR-3647-5p	CLIP-seq
MIRT1489171	hsa-miR-3652	CLIP-seq
MIRT1489172	hsa-miR-3663-5p	CLIP-seq
MIRT1489174	hsa-miR-3688-5p	CLIP-seq
MIRT2147400	hsa-miR-377	CLIP-seq
MIRT2367794	hsa-miR-4279	CLIP-seq
MIRT1489182	hsa-miR-4284	CLIP-seq
MIRT1489183	hsa-miR-4291	CLIP-seq
MIRT2367795	hsa-miR-4323	CLIP-seq
MIRT1489188	hsa-miR-4430	CLIP-seq
MIRT2367796	hsa-miR-4434	CLIP-seq
MIRT2147415	hsa-miR-4448	CLIP-seq
MIRT1489191	hsa-miR-4505	CLIP-seq
MIRT2367797	hsa-miR-4516	CLIP-seq
MIRT1489193	hsa-miR-4527	CLIP-seq
MIRT1489195	hsa-miR-4685-5p	CLIP-seq
MIRT2367798	hsa-miR-4693-3p	CLIP-seq
MIRT1489205	hsa-miR-4736	CLIP-seq
MIRT1489211	hsa-miR-4763-3p	CLIP-seq
MIRT2147424	hsa-miR-4777-5p	CLIP-seq
MIRT1489213	hsa-miR-4795-5p	CLIP-seq
MIRT2147426	hsa-miR-494	CLIP-seq
MIRT2147427	hsa-miR-518d-5p	CLIP-seq
MIRT2147428	hsa-miR-519b-5p	CLIP-seq
MIRT2147429	hsa-miR-519c-5p	CLIP-seq
MIRT2147430	hsa-miR-520c-5p	CLIP-seq
MIRT2147431	hsa-miR-526a	CLIP-seq
MIRT1489215	hsa-miR-545	CLIP-seq
MIRT1489216	hsa-miR-573	CLIP-seq
MIRT1489217	hsa-miR-579	CLIP-seq
MIRT1489221	hsa-miR-629	CLIP-seq
MIRT1489225	hsa-miR-7	CLIP-seq
MIRT1489226	hsa-miR-873	CLIP-seq
MIRT2147389	hsa-miR-1269	CLIP-seq
MIRT2147390	hsa-miR-1269b	CLIP-seq
MIRT2147391	hsa-miR-1288	CLIP-seq
MIRT1489157	hsa-miR-24	CLIP-seq
MIRT2147395	hsa-miR-2467-5p	CLIP-seq
MIRT1489158	hsa-miR-3064-5p	CLIP-seq
MIRT1489160	hsa-miR-3126-5p	CLIP-seq
MIRT2147398	hsa-miR-3188	CLIP-seq
MIRT1489169	hsa-miR-3616-5p	CLIP-seq
MIRT1489170	hsa-miR-3647-5p	CLIP-seq
MIRT1489171	hsa-miR-3652	CLIP-seq
MIRT2396907	hsa-miR-3659	CLIP-seq
MIRT1489172	hsa-miR-3663-5p	CLIP-seq
MIRT2147401	hsa-miR-378	CLIP-seq
MIRT2147402	hsa-miR-378b	CLIP-seq
MIRT2147403	hsa-miR-378c	CLIP-seq
MIRT2147404	hsa-miR-378d	CLIP-seq
MIRT2147405	hsa-miR-378e	CLIP-seq
MIRT2147406	hsa-miR-378f	CLIP-seq
MIRT2147407	hsa-miR-378h	CLIP-seq
MIRT2147408	hsa-miR-378i	CLIP-seq
MIRT2147409	hsa-miR-3929	CLIP-seq
MIRT2147410	hsa-miR-3975	CLIP-seq
MIRT2147411	hsa-miR-422a	CLIP-seq
MIRT2396908	hsa-miR-4280	CLIP-seq
MIRT1489182	hsa-miR-4284	CLIP-seq
MIRT2147413	hsa-miR-4300	CLIP-seq
MIRT2147414	hsa-miR-4419b	CLIP-seq
MIRT1489188	hsa-miR-4430	CLIP-seq
MIRT2147416	hsa-miR-4478	CLIP-seq
MIRT2147417	hsa-miR-4487	CLIP-seq
MIRT2147418	hsa-miR-4494	CLIP-seq
MIRT2147419	hsa-miR-4499	CLIP-seq
MIRT1489191	hsa-miR-4505	CLIP-seq
MIRT2147420	hsa-miR-4515	CLIP-seq
MIRT1489193	hsa-miR-4527	CLIP-seq
MIRT2396909	hsa-miR-4658	CLIP-seq
MIRT2147422	hsa-miR-4740-5p	CLIP-seq
MIRT2147423	hsa-miR-4746-3p	CLIP-seq
MIRT1489213	hsa-miR-4795-5p	CLIP-seq
MIRT2147425	hsa-miR-485-5p	CLIP-seq
MIRT1489216	hsa-miR-573	CLIP-seq
MIRT2396910	hsa-miR-574-5p	CLIP-seq
MIRT2147432	hsa-miR-920	CLIP-seq
MIRT2147393	hsa-miR-1973	CLIP-seq
MIRT2147399	hsa-miR-3605-3p	CLIP-seq
MIRT1489142	hsa-miR-1252	CLIP-seq
MIRT2147393	hsa-miR-1973	CLIP-seq
MIRT2147399	hsa-miR-3605-3p	CLIP-seq
MIRT1489138	hsa-miR-1	CLIP-seq
MIRT1489139	hsa-miR-1182	CLIP-seq
MIRT2661320	hsa-miR-1207-3p	CLIP-seq
MIRT1489140	hsa-miR-1207-5p	CLIP-seq
MIRT2661321	hsa-miR-1225-3p	CLIP-seq
MIRT2661322	hsa-miR-1226	CLIP-seq
MIRT2147387	hsa-miR-1237	CLIP-seq
MIRT2147388	hsa-miR-1248	CLIP-seq
MIRT1489142	hsa-miR-1252	CLIP-seq
MIRT1489144	hsa-miR-1285	CLIP-seq
MIRT2661323	hsa-miR-1301	CLIP-seq
MIRT1489147	hsa-miR-1321	CLIP-seq
MIRT1489149	hsa-miR-145	CLIP-seq
MIRT1489150	hsa-miR-1538	CLIP-seq
MIRT2661324	hsa-miR-1908	CLIP-seq
MIRT2147393	hsa-miR-1973	CLIP-seq
MIRT2147394	hsa-miR-224	CLIP-seq
MIRT2661325	hsa-miR-298	CLIP-seq
MIRT1489158	hsa-miR-3064-5p	CLIP-seq
MIRT1489160	hsa-miR-3126-5p	CLIP-seq
MIRT1489161	hsa-miR-3128	CLIP-seq
MIRT2147397	hsa-miR-3154	CLIP-seq
MIRT2661326	hsa-miR-3158-3p	CLIP-seq
MIRT2661327	hsa-miR-3178	CLIP-seq
MIRT1489165	hsa-miR-3187-5p	CLIP-seq
MIRT2661328	hsa-miR-320e	CLIP-seq
MIRT1489166	hsa-miR-326	CLIP-seq
MIRT1489167	hsa-miR-330-5p	CLIP-seq
MIRT2661329	hsa-miR-3591-3p	CLIP-seq
MIRT2147399	hsa-miR-3605-3p	CLIP-seq
MIRT2661330	hsa-miR-3622b-5p	CLIP-seq
MIRT2661331	hsa-miR-3673	CLIP-seq
MIRT1489174	hsa-miR-3688-5p	CLIP-seq
MIRT2661332	hsa-miR-3714	CLIP-seq
MIRT2147400	hsa-miR-377	CLIP-seq
MIRT1489177	hsa-miR-3918	CLIP-seq
MIRT2661333	hsa-miR-4251	CLIP-seq
MIRT1489179	hsa-miR-4265	CLIP-seq
MIRT1489184	hsa-miR-4296	CLIP-seq
MIRT2661334	hsa-miR-4303	CLIP-seq
MIRT2661335	hsa-miR-4308	CLIP-seq
MIRT1489185	hsa-miR-4318	CLIP-seq
MIRT1489186	hsa-miR-4322	CLIP-seq
MIRT2367795	hsa-miR-4323	CLIP-seq
MIRT2661336	hsa-miR-4329	CLIP-seq
MIRT1489187	hsa-miR-4417	CLIP-seq
MIRT1489189	hsa-miR-4437	CLIP-seq
MIRT2147415	hsa-miR-4448	CLIP-seq
MIRT2661337	hsa-miR-4481	CLIP-seq
MIRT2661338	hsa-miR-4486	CLIP-seq
MIRT2661339	hsa-miR-4492	CLIP-seq
MIRT2661340	hsa-miR-4498	CLIP-seq
MIRT1489194	hsa-miR-4674	CLIP-seq
MIRT1489199	hsa-miR-4710	CLIP-seq
MIRT1489201	hsa-miR-4720-5p	CLIP-seq
MIRT2661341	hsa-miR-4725-5p	CLIP-seq
MIRT1489205	hsa-miR-4736	CLIP-seq
MIRT1489206	hsa-miR-4739	CLIP-seq
MIRT2661342	hsa-miR-4740-3p	CLIP-seq
MIRT1489207	hsa-miR-4745-3p	CLIP-seq
MIRT2661343	hsa-miR-4745-5p	CLIP-seq
MIRT1489209	hsa-miR-4756-5p	CLIP-seq
MIRT2661344	hsa-miR-4758-5p	CLIP-seq
MIRT1489211	hsa-miR-4763-3p	CLIP-seq
MIRT2661345	hsa-miR-4767	CLIP-seq
MIRT2147424	hsa-miR-4777-5p	CLIP-seq
MIRT2661346	hsa-miR-4786-5p	CLIP-seq
MIRT1489214	hsa-miR-4799-3p	CLIP-seq
MIRT2147426	hsa-miR-494	CLIP-seq
MIRT2661347	hsa-miR-504	CLIP-seq
MIRT2147427	hsa-miR-518d-5p	CLIP-seq
MIRT2147428	hsa-miR-519b-5p	CLIP-seq
MIRT2147429	hsa-miR-519c-5p	CLIP-seq
MIRT2147430	hsa-miR-520c-5p	CLIP-seq
MIRT2147431	hsa-miR-526a	CLIP-seq
MIRT1489215	hsa-miR-545	CLIP-seq
MIRT2661348	hsa-miR-548an	CLIP-seq
MIRT2661349	hsa-miR-548p	CLIP-seq
MIRT1489219	hsa-miR-586	CLIP-seq
MIRT1489220	hsa-miR-612	CLIP-seq
MIRT2661350	hsa-miR-663	CLIP-seq
MIRT2661351	hsa-miR-671-5p	CLIP-seq
MIRT1489225	hsa-miR-7	CLIP-seq
MIRT2661352	hsa-miR-711	CLIP-seq
MIRT2661353	hsa-miR-762	CLIP-seq
MIRT2661354	hsa-miR-769-5p	CLIP-seq
MIRT1489226	hsa-miR-873	CLIP-seq
MIRT1489138	hsa-miR-1	CLIP-seq
MIRT1489139	hsa-miR-1182	CLIP-seq
MIRT2661320	hsa-miR-1207-3p	CLIP-seq
MIRT1489140	hsa-miR-1207-5p	CLIP-seq
MIRT2661321	hsa-miR-1225-3p	CLIP-seq
MIRT2147387	hsa-miR-1237	CLIP-seq
MIRT2147388	hsa-miR-1248	CLIP-seq
MIRT1489142	hsa-miR-1252	CLIP-seq
MIRT1489144	hsa-miR-1285	CLIP-seq
MIRT2661323	hsa-miR-1301	CLIP-seq
MIRT1489147	hsa-miR-1321	CLIP-seq
MIRT1489149	hsa-miR-145	CLIP-seq
MIRT1489150	hsa-miR-1538	CLIP-seq
MIRT2661324	hsa-miR-1908	CLIP-seq
MIRT2147393	hsa-miR-1973	CLIP-seq
MIRT1489158	hsa-miR-3064-5p	CLIP-seq
MIRT1489160	hsa-miR-3126-5p	CLIP-seq
MIRT1489161	hsa-miR-3128	CLIP-seq
MIRT2661327	hsa-miR-3178	CLIP-seq
MIRT1489165	hsa-miR-3187-5p	CLIP-seq
MIRT2661328	hsa-miR-320e	CLIP-seq
MIRT1489166	hsa-miR-326	CLIP-seq
MIRT1489167	hsa-miR-330-5p	CLIP-seq
MIRT2147399	hsa-miR-3605-3p	CLIP-seq
MIRT2661330	hsa-miR-3622b-5p	CLIP-seq
MIRT2661331	hsa-miR-3673	CLIP-seq
MIRT1489177	hsa-miR-3918	CLIP-seq
MIRT2661333	hsa-miR-4251	CLIP-seq
MIRT1489179	hsa-miR-4265	CLIP-seq
MIRT1489184	hsa-miR-4296	CLIP-seq
MIRT2661334	hsa-miR-4303	CLIP-seq
MIRT1489185	hsa-miR-4318	CLIP-seq
MIRT1489186	hsa-miR-4322	CLIP-seq
MIRT2367795	hsa-miR-4323	CLIP-seq
MIRT2661336	hsa-miR-4329	CLIP-seq
MIRT1489187	hsa-miR-4417	CLIP-seq
MIRT1489189	hsa-miR-4437	CLIP-seq
MIRT2147415	hsa-miR-4448	CLIP-seq
MIRT2661337	hsa-miR-4481	CLIP-seq
MIRT2661338	hsa-miR-4486	CLIP-seq
MIRT2661339	hsa-miR-4492	CLIP-seq
MIRT2661340	hsa-miR-4498	CLIP-seq
MIRT1489194	hsa-miR-4674	CLIP-seq
MIRT1489199	hsa-miR-4710	CLIP-seq
MIRT1489201	hsa-miR-4720-5p	CLIP-seq
MIRT2661341	hsa-miR-4725-5p	CLIP-seq
MIRT1489205	hsa-miR-4736	CLIP-seq
MIRT1489206	hsa-miR-4739	CLIP-seq
MIRT2661342	hsa-miR-4740-3p	CLIP-seq
MIRT1489207	hsa-miR-4745-3p	CLIP-seq
MIRT2661343	hsa-miR-4745-5p	CLIP-seq
MIRT1489209	hsa-miR-4756-5p	CLIP-seq
MIRT2661344	hsa-miR-4758-5p	CLIP-seq
MIRT1489211	hsa-miR-4763-3p	CLIP-seq
MIRT2661345	hsa-miR-4767	CLIP-seq
MIRT2661346	hsa-miR-4786-5p	CLIP-seq
MIRT1489214	hsa-miR-4799-3p	CLIP-seq
MIRT2147426	hsa-miR-494	CLIP-seq
MIRT2661347	hsa-miR-504	CLIP-seq
MIRT1489219	hsa-miR-586	CLIP-seq
MIRT1489220	hsa-miR-612	CLIP-seq
MIRT2661350	hsa-miR-663	CLIP-seq
MIRT1489225	hsa-miR-7	CLIP-seq
MIRT2661352	hsa-miR-711	CLIP-seq
MIRT2661353	hsa-miR-762	CLIP-seq
MIRT2661354	hsa-miR-769-5p	CLIP-seq
MIRT1489226	hsa-miR-873	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	23233354
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	23233354
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	21642474
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IMP	23233354
GO:0005515	Function	Protein binding	IPI	16772533, 20972459, 24255178, 24366813, 25036637, 25283809, 25416956, 25751139, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	21642474
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21642474
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0030331	Function	Nuclear estrogen receptor binding	IPI	21642474
GO:0031490	Function	Chromatin DNA binding	IBA
GO:0031490	Function	Chromatin DNA binding	IMP	23233354
GO:0032570	Process	Response to progesterone	IDA	16772533
GO:0033148	Process	Positive regulation of intracellular estrogen receptor signaling pathway	IDA	16772533
GO:0043627	Process	Response to estrogen	IDA	16772533
GO:0045815	Process	Transcription initiation-coupled chromatin remodeling	IMP	23233354
GO:0045893	Process	Positive regulation of DNA-templated transcription	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	23233354
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	16772533
GO:0071169	Process	Establishment of protein localization to chromatin	IMP	23233354
GO:0071391	Process	Cellular response to estrogen stimulus	IMP	23233354

Other IDs

• MIM: 606962
• HGNC: 12738
• e!Ensembl: ENSG00000132471

Protein

• UniProt ID: Q969T9
• Protein name: WW domain-binding protein 2 (WBP-2)
• Protein function: Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Synergizes with YAP1 to enhance
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02893	GRAM	11 → 132	GRAM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVIFL
  SKGKDAMQSFMMPFYLMKDCEIKQPVFGANYIKGTVKAEAGGGWEGSASYKLTFTAGGAI
  EFGQRMLQVASQASRGEVPSGAYGYSYMPSGAYVYPPPVANGMYPCPPGYPYPPPPPEFY
  PGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPDVPSTPAAEAKAAEAAASAYYNPGNPHNV
  YMPTSQPPPPPYYPPEDKKTQ

• Sequence length: 261

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Hearing loss, autosomal recessive 107	Likely pathogenic	rs770968991	RCV001580612	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 107	—	Disgenet, HPO Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS, AUTOSOMAL RECESSIVE	—	ClinGen, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WBP2-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Autosomal recessive non-syndromic sensorineural deafness type DFNB	Non-Syndromic Sensorineural Deafness	Orphanet			★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21642474, 28391353, 28724435, 29497031, 29937544, 30183375, 30442712, 30593516		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	17855441, 30442712, 34197030	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	32820148	Inhibit	★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	Deafness	CLINGEN_DG	26881968		★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE 107	Deafness	UNIPROT_DG	26881968		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 107	Deafness	GENOMICS_ENGLAND_DG	26881968		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 107	Deafness	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	BEFREE	29497031		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29497031		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29497031		★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	34197030	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31706018		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21642474, 28391353, 28724435, 29497031, 29937544, 30183375, 30442712, 30593516		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25417742, 30183375		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	30593516		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21642474, 30092563, 31706018		★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	28391353, 30092563		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30092563, 30442712		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	30442712, 34197030	Associate	★☆☆☆☆ Found in Text Mining only