Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23549
Gene name	Aspartyl aminopeptidase
Gene symbol	DNPEP
Synonyms (NCBI Gene)	ASPEPDAP
Chromosome	2
Chromosome location	2q35
Summary	The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several tra

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007029	hsa-miR-140-5p	Luciferase reporter assay	21576357
MIRT007029	hsa-miR-140-5p	Luciferase reporter assay	21576357
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT664623	hsa-miR-4794	HITS-CLIP	23824327
MIRT664624	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT664622	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT664621	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT664620	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664619	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT649179	hsa-miR-760	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT664618	hsa-miR-8057	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT649197	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649197	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649196	hsa-miR-3155a	HITS-CLIP	23824327
MIRT649195	hsa-miR-3155b	HITS-CLIP	23824327
MIRT649194	hsa-miR-484	HITS-CLIP	23824327
MIRT649193	hsa-miR-4301	HITS-CLIP	23824327
MIRT649192	hsa-miR-554	HITS-CLIP	23824327
MIRT649191	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649190	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT649189	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT649188	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT649179	hsa-miR-760	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT440788	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440788	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT664623	hsa-miR-4794	HITS-CLIP	23824327
MIRT664624	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT664622	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT664621	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT664620	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT664619	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT649179	hsa-miR-760	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT664618	hsa-miR-8057	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT649197	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649197	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649196	hsa-miR-3155a	HITS-CLIP	23824327
MIRT649195	hsa-miR-3155b	HITS-CLIP	23824327
MIRT649194	hsa-miR-484	HITS-CLIP	23824327
MIRT649193	hsa-miR-4301	HITS-CLIP	23824327
MIRT649192	hsa-miR-554	HITS-CLIP	23824327
MIRT649191	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649190	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT649189	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT649188	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT649187	hsa-miR-5693	HITS-CLIP	23824327
MIRT649186	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT649185	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT649184	hsa-miR-3135b	HITS-CLIP	23824327
MIRT649183	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT649182	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT649181	hsa-miR-4284	HITS-CLIP	23824327
MIRT649180	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT649179	hsa-miR-760	HITS-CLIP	23824327
MIRT649178	hsa-miR-3652	HITS-CLIP	23824327
MIRT649177	hsa-miR-4430	HITS-CLIP	23824327
MIRT649176	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT649175	hsa-miR-5698	HITS-CLIP	23824327
MIRT942667	hsa-miR-1253	CLIP-seq
MIRT942668	hsa-miR-1255a	CLIP-seq
MIRT942669	hsa-miR-1255b	CLIP-seq
MIRT942670	hsa-miR-1264	CLIP-seq
MIRT942671	hsa-miR-1272	CLIP-seq
MIRT942672	hsa-miR-1288	CLIP-seq
MIRT942673	hsa-miR-1297	CLIP-seq
MIRT942674	hsa-miR-1301	CLIP-seq
MIRT942675	hsa-miR-148a	CLIP-seq
MIRT942676	hsa-miR-148b	CLIP-seq
MIRT942677	hsa-miR-151-3p	CLIP-seq
MIRT942678	hsa-miR-152	CLIP-seq
MIRT942679	hsa-miR-1825	CLIP-seq
MIRT942680	hsa-miR-2278	CLIP-seq
MIRT942681	hsa-miR-26a	CLIP-seq
MIRT942682	hsa-miR-26b	CLIP-seq
MIRT942683	hsa-miR-298	CLIP-seq
MIRT942684	hsa-miR-3124-3p	CLIP-seq
MIRT942685	hsa-miR-3136-3p	CLIP-seq
MIRT942686	hsa-miR-3161	CLIP-seq
MIRT942687	hsa-miR-3179	CLIP-seq
MIRT942688	hsa-miR-3199	CLIP-seq
MIRT942689	hsa-miR-3681	CLIP-seq
MIRT942690	hsa-miR-3691-5p	CLIP-seq
MIRT942691	hsa-miR-3919	CLIP-seq
MIRT942692	hsa-miR-4251	CLIP-seq
MIRT942693	hsa-miR-4463	CLIP-seq
MIRT942694	hsa-miR-4465	CLIP-seq
MIRT942695	hsa-miR-4499	CLIP-seq
MIRT942696	hsa-miR-4517	CLIP-seq
MIRT942697	hsa-miR-4660	CLIP-seq
MIRT942698	hsa-miR-4663	CLIP-seq
MIRT942699	hsa-miR-4753-3p	CLIP-seq
MIRT942700	hsa-miR-4773	CLIP-seq
MIRT942701	hsa-miR-4795-5p	CLIP-seq
MIRT942702	hsa-miR-493	CLIP-seq
MIRT942703	hsa-miR-5047	CLIP-seq
MIRT942704	hsa-miR-513b	CLIP-seq
MIRT942705	hsa-miR-548ag	CLIP-seq
MIRT942706	hsa-miR-548ai	CLIP-seq
MIRT942707	hsa-miR-646	CLIP-seq
MIRT942708	hsa-miR-663b	CLIP-seq
MIRT942709	hsa-miR-938	CLIP-seq
MIRT942710	hsa-miR-942	CLIP-seq
MIRT1979130	hsa-miR-1185	CLIP-seq
MIRT1979131	hsa-miR-1207-3p	CLIP-seq
MIRT1979132	hsa-miR-1227	CLIP-seq
MIRT1979133	hsa-miR-1254	CLIP-seq
MIRT1979134	hsa-miR-125a-3p	CLIP-seq
MIRT942670	hsa-miR-1264	CLIP-seq
MIRT1979135	hsa-miR-1266	CLIP-seq
MIRT1979136	hsa-miR-146a	CLIP-seq
MIRT1979137	hsa-miR-146b-5p	CLIP-seq
MIRT1979138	hsa-miR-182	CLIP-seq
MIRT1979139	hsa-miR-197	CLIP-seq
MIRT1979140	hsa-miR-19a	CLIP-seq
MIRT1979141	hsa-miR-19b	CLIP-seq
MIRT1979142	hsa-miR-31	CLIP-seq
MIRT1979143	hsa-miR-3116	CLIP-seq
MIRT942684	hsa-miR-3124-3p	CLIP-seq
MIRT1979144	hsa-miR-3130-3p	CLIP-seq
MIRT1979145	hsa-miR-3605-5p	CLIP-seq
MIRT1979146	hsa-miR-3650	CLIP-seq
MIRT1979147	hsa-miR-3664-3p	CLIP-seq
MIRT1979148	hsa-miR-3679-5p	CLIP-seq
MIRT942691	hsa-miR-3919	CLIP-seq
MIRT1979149	hsa-miR-3934	CLIP-seq
MIRT942692	hsa-miR-4251	CLIP-seq
MIRT1979150	hsa-miR-4267	CLIP-seq
MIRT1979151	hsa-miR-4518	CLIP-seq
MIRT1979152	hsa-miR-4537	CLIP-seq
MIRT1979153	hsa-miR-4661-3p	CLIP-seq
MIRT1979154	hsa-miR-4708-3p	CLIP-seq
MIRT1979155	hsa-miR-4715-3p	CLIP-seq
MIRT1979156	hsa-miR-4716-5p	CLIP-seq
MIRT1979157	hsa-miR-4735-5p	CLIP-seq
MIRT1979158	hsa-miR-4757-5p	CLIP-seq
MIRT1979159	hsa-miR-4775	CLIP-seq
MIRT1979160	hsa-miR-4781-3p	CLIP-seq
MIRT1979161	hsa-miR-499a-5p	CLIP-seq
MIRT1979162	hsa-miR-5095	CLIP-seq
MIRT1979163	hsa-miR-5096	CLIP-seq
MIRT1979164	hsa-miR-518a-5p	CLIP-seq
MIRT1979165	hsa-miR-527	CLIP-seq
MIRT1979166	hsa-miR-552	CLIP-seq
MIRT1979167	hsa-miR-576-3p	CLIP-seq
MIRT1979168	hsa-miR-589	CLIP-seq
MIRT1979169	hsa-miR-590-3p	CLIP-seq
MIRT1979170	hsa-miR-629	CLIP-seq
MIRT1979171	hsa-miR-661	CLIP-seq
MIRT1979172	hsa-miR-764	CLIP-seq
MIRT1979173	hsa-miR-941	CLIP-seq
MIRT2214248	hsa-miR-122	CLIP-seq
MIRT2214249	hsa-miR-1245	CLIP-seq
MIRT2214250	hsa-miR-150	CLIP-seq
MIRT2214251	hsa-miR-1915	CLIP-seq
MIRT2214252	hsa-miR-4312	CLIP-seq
MIRT2214253	hsa-miR-4433	CLIP-seq
MIRT2214254	hsa-miR-4682	CLIP-seq
MIRT2214255	hsa-miR-4698	CLIP-seq
MIRT2214256	hsa-miR-4726-3p	CLIP-seq
MIRT1979158	hsa-miR-4757-5p	CLIP-seq
MIRT2214257	hsa-miR-4765	CLIP-seq
MIRT942702	hsa-miR-493	CLIP-seq
MIRT2214258	hsa-miR-515-5p	CLIP-seq
MIRT2214259	hsa-miR-548aa	CLIP-seq
MIRT2214260	hsa-miR-640	CLIP-seq
MIRT942708	hsa-miR-663b	CLIP-seq
MIRT2214261	hsa-miR-665	CLIP-seq
MIRT2387057	hsa-miR-4324	CLIP-seq
MIRT1979131	hsa-miR-1207-3p	CLIP-seq
MIRT1979132	hsa-miR-1227	CLIP-seq
MIRT1979133	hsa-miR-1254	CLIP-seq
MIRT1979134	hsa-miR-125a-3p	CLIP-seq
MIRT1979135	hsa-miR-1266	CLIP-seq
MIRT2518597	hsa-miR-129-5p	CLIP-seq
MIRT1979136	hsa-miR-146a	CLIP-seq
MIRT1979137	hsa-miR-146b-5p	CLIP-seq
MIRT1979138	hsa-miR-182	CLIP-seq
MIRT1979139	hsa-miR-197	CLIP-seq
MIRT1979140	hsa-miR-19a	CLIP-seq
MIRT1979141	hsa-miR-19b	CLIP-seq
MIRT1979142	hsa-miR-31	CLIP-seq
MIRT1979143	hsa-miR-3116	CLIP-seq
MIRT2518598	hsa-miR-3149	CLIP-seq
MIRT1979146	hsa-miR-3650	CLIP-seq
MIRT1979147	hsa-miR-3664-3p	CLIP-seq
MIRT942691	hsa-miR-3919	CLIP-seq
MIRT1979149	hsa-miR-3934	CLIP-seq
MIRT942692	hsa-miR-4251	CLIP-seq
MIRT1979150	hsa-miR-4267	CLIP-seq
MIRT2518599	hsa-miR-4436b-5p	CLIP-seq
MIRT1979151	hsa-miR-4518	CLIP-seq
MIRT1979154	hsa-miR-4708-3p	CLIP-seq
MIRT1979155	hsa-miR-4715-3p	CLIP-seq
MIRT1979156	hsa-miR-4716-5p	CLIP-seq
MIRT1979157	hsa-miR-4735-5p	CLIP-seq
MIRT1979159	hsa-miR-4775	CLIP-seq
MIRT1979160	hsa-miR-4781-3p	CLIP-seq
MIRT1979162	hsa-miR-5095	CLIP-seq
MIRT1979163	hsa-miR-5096	CLIP-seq
MIRT1979164	hsa-miR-518a-5p	CLIP-seq
MIRT1979165	hsa-miR-527	CLIP-seq
MIRT1979166	hsa-miR-552	CLIP-seq
MIRT1979168	hsa-miR-589	CLIP-seq
MIRT1979169	hsa-miR-590-3p	CLIP-seq
MIRT1979171	hsa-miR-661	CLIP-seq
MIRT1979172	hsa-miR-764	CLIP-seq
MIRT1979131	hsa-miR-1207-3p	CLIP-seq
MIRT1979132	hsa-miR-1227	CLIP-seq
MIRT1979133	hsa-miR-1254	CLIP-seq
MIRT1979134	hsa-miR-125a-3p	CLIP-seq
MIRT1979135	hsa-miR-1266	CLIP-seq
MIRT2518597	hsa-miR-129-5p	CLIP-seq
MIRT1979136	hsa-miR-146a	CLIP-seq
MIRT1979137	hsa-miR-146b-5p	CLIP-seq
MIRT1979138	hsa-miR-182	CLIP-seq
MIRT1979139	hsa-miR-197	CLIP-seq
MIRT1979140	hsa-miR-19a	CLIP-seq
MIRT1979141	hsa-miR-19b	CLIP-seq
MIRT1979142	hsa-miR-31	CLIP-seq
MIRT1979143	hsa-miR-3116	CLIP-seq
MIRT2518598	hsa-miR-3149	CLIP-seq
MIRT1979146	hsa-miR-3650	CLIP-seq
MIRT1979147	hsa-miR-3664-3p	CLIP-seq
MIRT1979149	hsa-miR-3934	CLIP-seq
MIRT942692	hsa-miR-4251	CLIP-seq
MIRT1979150	hsa-miR-4267	CLIP-seq
MIRT2518599	hsa-miR-4436b-5p	CLIP-seq
MIRT1979151	hsa-miR-4518	CLIP-seq
MIRT1979154	hsa-miR-4708-3p	CLIP-seq
MIRT1979155	hsa-miR-4715-3p	CLIP-seq
MIRT1979156	hsa-miR-4716-5p	CLIP-seq
MIRT1979157	hsa-miR-4735-5p	CLIP-seq
MIRT1979159	hsa-miR-4775	CLIP-seq
MIRT1979160	hsa-miR-4781-3p	CLIP-seq
MIRT1979162	hsa-miR-5095	CLIP-seq
MIRT1979163	hsa-miR-5096	CLIP-seq
MIRT1979164	hsa-miR-518a-5p	CLIP-seq
MIRT1979165	hsa-miR-527	CLIP-seq
MIRT1979166	hsa-miR-552	CLIP-seq
MIRT1979168	hsa-miR-589	CLIP-seq
MIRT1979169	hsa-miR-590-3p	CLIP-seq
MIRT1979171	hsa-miR-661	CLIP-seq
MIRT1979172	hsa-miR-764	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0004177	Function	Aminopeptidase activity	TAS	9632644
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 29892012, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9632644
GO:0005829	Component	Cytosol	IDA
GO:0006508	Process	Proteolysis	IEA
GO:0006518	Process	Peptide metabolic process	TAS	9632644
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0046872	Function	Metal ion binding	IEA
GO:0072562	Component	Blood microparticle	HDA	22516433

MIM	HGNC	e!Ensembl
611367	2981	ENSG00000123992

Q9ULA0

Protein name

Aspartyl aminopeptidase (EC 3.4.11.21)

Protein function

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

PDB

4DYO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02127	Peptidase_M18	24 → 462	Aminopeptidase I zinc metalloprotease (M18)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9632644}.

Sequence

MSGHSPTRGAMQVAMNGKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAGFSEL
KETEKWNIKPESKYFMTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRRSRRSQ
VGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVKCPTSGRLEQQLVHVERPILRIPHLAIH
LQRNINENFGPNTEMHLVPILATAIQEELEKGTPEPGPLNAVDERHHSVLMSLLCAHLGL
SPKDIVEMELCLADTQPAVLGGAYDEFIFAPRLDNLHSCFCALQALIDSCAGPGSLATEP
HVRMVTLYDNEEVGSESAQGAQSLLTELVLRRISASCQHPTAFEEAIPKSFMISADMAHA
VHPNYLDKHEENHRPLFHKGPVIKVNSKQRYASNAVSEALIREVANKVKVPLQDLMVRND
TPCGTTIGPILASRLGLRVLDLGSPQLAMHSIREMACTTGVLQTLTLFKGFFELFPSLSH
NLLVD

Sequence length

485

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (106)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	BEFREE	18587015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	18587015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	18587015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	18587015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	26722491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of pancreas	Pancreatic adenocarcinoma	BEFREE	16596173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Oligodendroglioma	Oligodendroglioma	BEFREE	24877104		★★★★★ ★☆☆☆☆ Found in Text Mining only
alpha-Thalassemia	alpha Thalassemia	BEFREE	27578458		★★★★★ ★☆☆☆☆ Found in Text Mining only
alpha^+^ Thalassemia	alpha Thalassemia	BEFREE	27578458		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	12030602		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	12030602		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	33213505	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	30370863		★★★★★ ★☆☆☆☆ Found in Text Mining only
ATRICHIA WITH PAPULAR LESIONS	Atrichia With Papular Lesions	BEFREE	18587015		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	11997670		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-CELL MALIGNANCY, LOW-GRADE	Lymphocytic Leukemia	BEFREE	16897188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	19958159, 27907054		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	12438260, 22798505, 25530065, 25684485, 31219614, 31228326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31228326	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	10361133		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22412903	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	10766168, 11306456, 11313698, 15471559, 16575786, 16596173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	19958159, 27907054		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	10995806, 11313698, 11956099, 12792765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	16985214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Central visual impairment	Central Visual Impairment	BEFREE	14617009		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	18425396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	18425396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Oligodendroglioma	Oligodendroglioma	BEFREE	24877104		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	17690039		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangitis, Sclerosing	Cholangitis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	16897188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ciliopathies	Ciliopathies	BEFREE	24882706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	12706863, 16575786, 23948443, 24270644		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	14504087		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Myasthenic Syndromes, Postsynaptic	Myasthenic Syndrome	BEFREE	27251582		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	26192919, 26974007, 28067908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	25229255		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eclampsia	Eclampsia	BEFREE	10508228		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial adenocarcinoma	Endometrial Adenocarcinoma	BEFREE	20878137, 22552543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	15048887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	15048887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	19224282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	19224282		★★★★★ ★☆☆☆☆ Found in Text Mining only
GATA2 Deficiency	Gata2 deficiency	Pubtator	12708480	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Giant Cell Arteritis	Giant Cell Arteritis	BEFREE	15809761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hashimoto Disease	Hashimoto Disease	BEFREE	11092525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	10361133		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	14617009		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASDB_DG	23128233		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	23128233, 26192919		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lambert-Eaton Myasthenic Syndrome	Lambert-Eaton Myasthenic Syndrome	BEFREE	27251582, 29191521, 31319693, 31419315		★★★★★ ★☆☆☆☆ Found in Text Mining only
LATERAL MENINGOCELE SYNDROME	Lateral Meningocele Syndrome	BEFREE	15492995		★★★★★ ★☆☆☆☆ Found in Text Mining only
leiomyosarcoma	Leiomyosarcoma	BEFREE	15492995		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	14504087, 18587015, 28391288		★★★★★ ★☆☆☆☆ Found in Text Mining only
LIMB-MAMMARY SYNDROME	Limb-Mammary Syndrome	BEFREE	15492995		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	12820391, 18351580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	33213505	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	10361133, 14617009		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	15003890, 16956827		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	12438260, 22798505, 25530065, 25684485, 31219614, 31228326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	19224282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	10995806, 11956099, 12473584, 12792765, 12912953		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	20210246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	12695555, 20150736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	12124340, 19958159, 27907054		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10361133, 11092525, 11313698, 11410512, 11839660, 11850841, 11997670, 12438260, 12448005, 12708480, 15003890, 15492995, 16596173, 19360750, 19878310 View all (5 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Squamous Cell Neoplasm	Neoplasm	BEFREE	16094112		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	18425396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	19917631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	2299192	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Monoclonal Gammopathy of Undetermined Significance	Monoclonal Gammapathies	BEFREE	17213358		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucosa-Associated Lymphoid Tissue Lymphoma	Mucosa-associated lymphoma	BEFREE	15003890		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	11410512, 11997670, 17213358, 17557868		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myasthenic Syndromes, Congenital	Myasthenic Syndrome	BEFREE	25159927, 25305004		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	14504087		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	11839660, 19221469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neck Neoplasms	Neck Neoplasms	BEFREE	11997670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10995806, 11094302, 11264190, 11313923, 11742505, 11839660, 11850841, 11997670, 12706879, 12820391, 14504087, 15448006, 15809761, 16157195, 16575786 View all (15 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephronophthisis	Nephronophthisis	BEFREE	24882706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	11020216		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuromuscular Diseases	Neuromuscular Diseases	BEFREE	31533480		★★★★★ ★☆☆☆☆ Found in Text Mining only
Niemann-Pick Disease, Type C	Niemann-Pick Disease	BEFREE	19221469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	10995806, 11313923, 12841866, 15634757, 19926549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	15448006		★★★★★ ★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	24877104		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	20210246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	23660957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	12950712		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxia Type 6 (disorder)	Spinocerebellar Ataxia	BEFREE	20181362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	12473584, 16094112, 26400283		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	18697202		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of mouth	Oral cavity carcinoma	BEFREE	26400283		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	17592394, 17785562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	12695555, 20150736		★★★★★ ★☆☆☆☆ Found in Text Mining only
T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	12708480		★★★★★ ★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	19958159		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	25684485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	CTD_human_DG	21297633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASDB_DG	21297633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	21297633, 26192919, 26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	21159370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vulvar Lichen Sclerosus	Vulvar Lichen Sclerosus	BEFREE	20885153, 22371043		★★★★★ ★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	24877104		★★★★★ ★☆☆☆☆ Found in Text Mining only

DNPEP (aspartyl aminopeptidase)