Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23518
Gene name	R3H domain containing 1
Gene symbol	R3HDM1
Synonyms (NCBI Gene)	R3HDM
Chromosome	2
Chromosome location	2q21.3

102

Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044692	hsa-miR-320a	CLASH	23622248
MIRT1280505	hsa-miR-1206	CLIP-seq
MIRT1280506	hsa-miR-130a	CLIP-seq
MIRT1280507	hsa-miR-130b	CLIP-seq
MIRT1280508	hsa-miR-218	CLIP-seq
MIRT1280509	hsa-miR-23a	CLIP-seq
MIRT1280510	hsa-miR-23b	CLIP-seq
MIRT1280511	hsa-miR-23c	CLIP-seq
MIRT1280512	hsa-miR-301a	CLIP-seq
MIRT1280513	hsa-miR-301b	CLIP-seq
MIRT1280514	hsa-miR-302a	CLIP-seq
MIRT1280515	hsa-miR-302b	CLIP-seq
MIRT1280516	hsa-miR-302c	CLIP-seq
MIRT1280517	hsa-miR-302d	CLIP-seq
MIRT1280518	hsa-miR-302e	CLIP-seq
MIRT1280519	hsa-miR-3064-5p	CLIP-seq
MIRT1280520	hsa-miR-3127-5p	CLIP-seq
MIRT1280521	hsa-miR-324-5p	CLIP-seq
MIRT1280522	hsa-miR-3666	CLIP-seq
MIRT1280523	hsa-miR-372	CLIP-seq
MIRT1280524	hsa-miR-373	CLIP-seq
MIRT1280525	hsa-miR-374a	CLIP-seq
MIRT1280526	hsa-miR-374b	CLIP-seq
MIRT1280527	hsa-miR-4265	CLIP-seq
MIRT1280528	hsa-miR-4271	CLIP-seq
MIRT1280529	hsa-miR-4289	CLIP-seq
MIRT1280530	hsa-miR-4295	CLIP-seq
MIRT1280531	hsa-miR-4296	CLIP-seq
MIRT1280532	hsa-miR-4322	CLIP-seq
MIRT1280533	hsa-miR-4417	CLIP-seq
MIRT1280534	hsa-miR-4428	CLIP-seq
MIRT1280535	hsa-miR-4437	CLIP-seq
MIRT1280536	hsa-miR-454	CLIP-seq
MIRT1280537	hsa-miR-4674	CLIP-seq
MIRT1280538	hsa-miR-4725-3p	CLIP-seq
MIRT1280539	hsa-miR-4778-3p	CLIP-seq
MIRT1280540	hsa-miR-4802-3p	CLIP-seq
MIRT1280541	hsa-miR-500a	CLIP-seq
MIRT1280542	hsa-miR-519a	CLIP-seq
MIRT1280543	hsa-miR-519b-3p	CLIP-seq
MIRT1280544	hsa-miR-519c-3p	CLIP-seq
MIRT1280545	hsa-miR-520a-3p	CLIP-seq
MIRT1280546	hsa-miR-520b	CLIP-seq
MIRT1280547	hsa-miR-520c-3p	CLIP-seq
MIRT1280548	hsa-miR-520d-3p	CLIP-seq
MIRT1280549	hsa-miR-520e	CLIP-seq
MIRT1280550	hsa-miR-582-3p	CLIP-seq
MIRT1280551	hsa-miR-604	CLIP-seq
MIRT1280552	hsa-miR-647	CLIP-seq
MIRT1280553	hsa-miR-891b	CLIP-seq
MIRT2082865	hsa-miR-299-5p	CLIP-seq
MIRT2082866	hsa-miR-3127-3p	CLIP-seq
MIRT2082867	hsa-miR-3545-3p	CLIP-seq
MIRT2082868	hsa-miR-3658	CLIP-seq
MIRT2082869	hsa-miR-3941	CLIP-seq
MIRT2082870	hsa-miR-4327	CLIP-seq
MIRT2082871	hsa-miR-4635	CLIP-seq
MIRT2082872	hsa-miR-4652-3p	CLIP-seq
MIRT2082873	hsa-miR-466	CLIP-seq
MIRT2082874	hsa-miR-4672	CLIP-seq
MIRT2082875	hsa-miR-4711-5p	CLIP-seq
MIRT2082876	hsa-miR-4729	CLIP-seq
MIRT2082877	hsa-miR-4753-3p	CLIP-seq
MIRT2082878	hsa-miR-518a-5p	CLIP-seq
MIRT2082879	hsa-miR-527	CLIP-seq
MIRT2308192	hsa-miR-1245	CLIP-seq
MIRT2308193	hsa-miR-3065-3p	CLIP-seq
MIRT2082869	hsa-miR-3941	CLIP-seq
MIRT2308194	hsa-miR-409-3p	CLIP-seq
MIRT2082870	hsa-miR-4327	CLIP-seq
MIRT2082873	hsa-miR-466	CLIP-seq
MIRT2082874	hsa-miR-4672	CLIP-seq
MIRT2082875	hsa-miR-4711-5p	CLIP-seq
MIRT2082878	hsa-miR-518a-5p	CLIP-seq
MIRT2082879	hsa-miR-527	CLIP-seq
MIRT2308195	hsa-miR-586	CLIP-seq
MIRT2605432	hsa-miR-1256	CLIP-seq
MIRT2605433	hsa-miR-1258	CLIP-seq
MIRT2605434	hsa-miR-300	CLIP-seq
MIRT2605435	hsa-miR-3163	CLIP-seq
MIRT2605436	hsa-miR-3612	CLIP-seq
MIRT2605437	hsa-miR-381	CLIP-seq
MIRT2605438	hsa-miR-4266	CLIP-seq
MIRT2605439	hsa-miR-4695-5p	CLIP-seq
MIRT2605440	hsa-miR-4779	CLIP-seq
MIRT2605441	hsa-miR-4790-3p	CLIP-seq
MIRT2605442	hsa-miR-548n	CLIP-seq
MIRT2605443	hsa-miR-548t	CLIP-seq
MIRT2605444	hsa-miR-650	CLIP-seq
MIRT2605432	hsa-miR-1256	CLIP-seq
MIRT2605433	hsa-miR-1258	CLIP-seq
MIRT2605434	hsa-miR-300	CLIP-seq
MIRT2605435	hsa-miR-3163	CLIP-seq
MIRT2605436	hsa-miR-3612	CLIP-seq
MIRT2605437	hsa-miR-381	CLIP-seq
MIRT2605438	hsa-miR-4266	CLIP-seq
MIRT2605439	hsa-miR-4695-5p	CLIP-seq
MIRT2605440	hsa-miR-4779	CLIP-seq
MIRT2605441	hsa-miR-4790-3p	CLIP-seq
MIRT2605442	hsa-miR-548n	CLIP-seq
MIRT2605443	hsa-miR-548t	CLIP-seq
MIRT2605444	hsa-miR-650	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	32814053

MIM	HGNC	e!Ensembl
619474	9757	ENSG00000048991

Q15032

Protein name

R3H domain-containing protein 1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01424	R3H	169 → 227	R3H domain	Domain
PF12752	SUZ	249 → 302	SUZ domain	Domain

Sequence

MRMSDTVTVKDETATMKDLEAEVKDTTRVENLIKSENYGKILVEKNEHCIENNIDLQRPL
QSFGQTGKRSKSSSKLKLVRSLAVCEESPPPPAPEISQENQEKIQIQLTQSFEKEEKPSK
DEAEKEKASDKLPRKMLSRDSSQEYTDSTGIDLHEFLVNTLKNNPRDRMMLLKLEQEILD
FIGNNESPRKKFPPMTSYHRMLLHRVAAYFGLDHNVDQSGKSVIVNKTSNTRIPDQKFNE
HIKDDKGEDFQKRYILKRDNSSFDKDDNQMRIRLKDDRRSKSIEEREEEYQRARDRIFSQ
DSLCSQENYIIDKRLQDEDASSTQQRRQIFRVNKDASGRSTNSHQSSTENELKYSEPRPW
SSTDSDSSLRNLKPAVTKASSFSGISVLTRGDSSGSSKSIGRLSKTGSESSGSVGSSTGS
LSHIQQPLPGTALSQSSHGAPVVYPTVSTHSSLSFDGGLNGQVASPSTSFFLLPLEAAGI
PPGSILINPQTGQPFINPDGSPVVYNPPMTQQPVRSQVPGPPQPPLPAPPQQPAANHIFS
QDNLGSQFSHMSLARQPSADGSDPHAAMFQSTVVLQSPQQSGYIMTAAPPPHPPPPPPPP
PPPPPLPPGQPVPTAGYPASGHPVSQPVLQQQGYIQQPSPQMPACYCAPGHYHSSQPQYR
PVPSVHYNSHLNQPLPQPAQQTGYQVIPNQQQNYQGIVGVQQPQSQSLVSGQPNSIGNQI
QGVVIPYTSVPTYQVSLPQGSQGIPHQTYQQPVMFPNQSNQGSMPTTGMPVYYSVIPPGQ
QNNLSSSVGYLQHPGSEQVQFPRTTSPCSSQQLQGHQCTAGPPPPPGGGMVMMQLSVPNN
PQSCAHSPPQWKQNKYYCDHQRGQKCVEFSSVDNIVQHSPQLSSPIISPAQSPAPAQLST
LKTVRPSGPPLSIMPQFSRPFVPGQGDSRYPLLGQPLQYNPPAVLHGHIPNQQGQPGSRH
GNRGRRQAKKAASTDLGAGETVVGKVLEITELPDGITRMEAEKLFGELFKIGAKIRWLRD
PQSQPRRHPLCCGSGDNTANPERSKPSDLASTYTVLATFPSISAAQNALKKQINSVNKFK
LRTSKKHYDFHILERASSQ

Sequence length

1099

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Celiac Disease	Celiac disease	Pubtator	27650971	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Periodontitis	Periodontitis	Pubtator	35676670	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25117815	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia A	Hemophilia a	Pubtator	35182444	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrolithiasis	Nephrolithiasis	Pubtator	40664942	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	35676670	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	32065787	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

R3HDM1 (R3H domain containing 1)