Gene Gene information from NCBI Gene database.
Entrez ID 23471
Gene name Translocation associated membrane protein 1
Gene symbol TRAM1
Synonyms (NCBI Gene)
PNAS8TRAMTRAMP
Chromosome 8
Chromosome location 8q13.3
Summary This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulati
miRNA miRNA information provided by mirtarbase database.
416
miRTarBase ID miRNA Experiments Reference
MIRT001493 hsa-miR-155-5p pSILAC 18668040
MIRT001493 hsa-miR-155-5p Proteomics;Other 18668040
MIRT028950 hsa-miR-26b-5p Sequencing 20371350
MIRT048770 hsa-miR-93-5p CLASH 23622248
MIRT452255 hsa-miR-141-3p PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18555783, 19121997, 32296183
GO:0005783 Component Endoplasmic reticulum IDA 18555783
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005783 Component Endoplasmic reticulum TAS 1315422
GO:0005789 Component Endoplasmic reticulum membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605190 20568 ENSG00000067167
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15629
Protein name Translocating chain-associated membrane protein 1 (Protein TRAM1)
Protein function Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:12475939, PubMed:1315422, PubMed:32013668, PubMed:8616892,
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08390 TRAM1 47 115 TRAM1-like protein Family
PF03798 TRAM_LAG1_CLN8 118 317 TLC domain Domain
Sequence
Sequence length 374
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Protein processing in endoplasmic reticulum  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
12
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 17638871, 19701244, 27634876, 30188869
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of prostate Prostate adenocarcinoma BEFREE 23842593, 27980106, 28095711
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 18688283
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 18688283
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 28676010
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 15169882
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 11279242 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 16452231, 28197388
★☆☆☆☆
Found in Text Mining only
Carcinoma, Neuroendocrine Carcinoma BEFREE 25298407
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 24885636
★☆☆☆☆
Found in Text Mining only