Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23423
Gene name	Transmembrane p24 trafficking protein 3
Gene symbol	TMED3
Synonyms (NCBI Gene)	C15orf22P24Bp24g4p24gamma4p26
Chromosome	15
Chromosome location	15q25.1

180

Show/Hide all (180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005140	hsa-miR-30a-5p	pSILAC	18668040
MIRT005140	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT530825	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT530823	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT530822	hsa-miR-188-3p	PAR-CLIP	22012620
MIRT530821	hsa-miR-1260a	PAR-CLIP	22012620
MIRT530820	hsa-miR-1260b	PAR-CLIP	22012620
MIRT530819	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT530817	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT530825	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT530823	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT530822	hsa-miR-188-3p	PAR-CLIP	22012620
MIRT530821	hsa-miR-1260a	PAR-CLIP	22012620
MIRT530820	hsa-miR-1260b	PAR-CLIP	22012620
MIRT530819	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT530817	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT1428998	hsa-miR-1207-3p	CLIP-seq
MIRT1428999	hsa-miR-1260	CLIP-seq
MIRT1429000	hsa-miR-2278	CLIP-seq
MIRT1429001	hsa-miR-3184	CLIP-seq
MIRT1429002	hsa-miR-3663-5p	CLIP-seq
MIRT1429003	hsa-miR-3920	CLIP-seq
MIRT1429004	hsa-miR-3921	CLIP-seq
MIRT1429005	hsa-miR-3945	CLIP-seq
MIRT1429006	hsa-miR-423-5p	CLIP-seq
MIRT1429007	hsa-miR-4251	CLIP-seq
MIRT1429008	hsa-miR-4253	CLIP-seq
MIRT1429009	hsa-miR-4328	CLIP-seq
MIRT1429010	hsa-miR-4329	CLIP-seq
MIRT1429011	hsa-miR-4653-5p	CLIP-seq
MIRT1429012	hsa-miR-4663	CLIP-seq
MIRT1429013	hsa-miR-4696	CLIP-seq
MIRT1429014	hsa-miR-4762-3p	CLIP-seq
MIRT1429015	hsa-miR-4786-5p	CLIP-seq
MIRT1429016	hsa-miR-486-3p	CLIP-seq
MIRT1429017	hsa-miR-593	CLIP-seq
MIRT1429018	hsa-miR-661	CLIP-seq
MIRT1429019	hsa-miR-766	CLIP-seq
MIRT1429020	hsa-miR-769-5p	CLIP-seq
MIRT2128489	hsa-miR-1178	CLIP-seq
MIRT1428998	hsa-miR-1207-3p	CLIP-seq
MIRT2128490	hsa-miR-1208	CLIP-seq
MIRT2128491	hsa-miR-1238	CLIP-seq
MIRT1428999	hsa-miR-1260	CLIP-seq
MIRT2128492	hsa-miR-1915	CLIP-seq
MIRT2128493	hsa-miR-224	CLIP-seq
MIRT2128494	hsa-miR-2276	CLIP-seq
MIRT2128495	hsa-miR-2861	CLIP-seq
MIRT2128496	hsa-miR-3117-5p	CLIP-seq
MIRT2128497	hsa-miR-3918	CLIP-seq
MIRT2128498	hsa-miR-3919	CLIP-seq
MIRT2128499	hsa-miR-3925-5p	CLIP-seq
MIRT1429009	hsa-miR-4328	CLIP-seq
MIRT2128500	hsa-miR-4468	CLIP-seq
MIRT2128501	hsa-miR-4512	CLIP-seq
MIRT1429012	hsa-miR-4663	CLIP-seq
MIRT2128502	hsa-miR-4685-5p	CLIP-seq
MIRT1429013	hsa-miR-4696	CLIP-seq
MIRT2128503	hsa-miR-4772-3p	CLIP-seq
MIRT1429015	hsa-miR-4786-5p	CLIP-seq
MIRT2128504	hsa-miR-4792	CLIP-seq
MIRT2128505	hsa-miR-4797-5p	CLIP-seq
MIRT2128506	hsa-miR-518a-5p	CLIP-seq
MIRT2128507	hsa-miR-527	CLIP-seq
MIRT2128508	hsa-miR-589	CLIP-seq
MIRT1429020	hsa-miR-769-5p	CLIP-seq
MIRT2128489	hsa-miR-1178	CLIP-seq
MIRT2128490	hsa-miR-1208	CLIP-seq
MIRT2128491	hsa-miR-1238	CLIP-seq
MIRT2128492	hsa-miR-1915	CLIP-seq
MIRT2128493	hsa-miR-224	CLIP-seq
MIRT2128494	hsa-miR-2276	CLIP-seq
MIRT2128495	hsa-miR-2861	CLIP-seq
MIRT2128496	hsa-miR-3117-5p	CLIP-seq
MIRT2128497	hsa-miR-3918	CLIP-seq
MIRT1429009	hsa-miR-4328	CLIP-seq
MIRT2128500	hsa-miR-4468	CLIP-seq
MIRT2128501	hsa-miR-4512	CLIP-seq
MIRT2128502	hsa-miR-4685-5p	CLIP-seq
MIRT2128503	hsa-miR-4772-3p	CLIP-seq
MIRT2128504	hsa-miR-4792	CLIP-seq
MIRT2128505	hsa-miR-4797-5p	CLIP-seq
MIRT2128506	hsa-miR-518a-5p	CLIP-seq
MIRT2128507	hsa-miR-527	CLIP-seq
MIRT1429019	hsa-miR-766	CLIP-seq
MIRT2128489	hsa-miR-1178	CLIP-seq
MIRT2128490	hsa-miR-1208	CLIP-seq
MIRT2395905	hsa-miR-3074-5p	CLIP-seq
MIRT2128496	hsa-miR-3117-5p	CLIP-seq
MIRT2395906	hsa-miR-3198	CLIP-seq
MIRT2395907	hsa-miR-4309	CLIP-seq
MIRT2395908	hsa-miR-432	CLIP-seq
MIRT2128500	hsa-miR-4468	CLIP-seq
MIRT2395909	hsa-miR-4653-3p	CLIP-seq
MIRT2395910	hsa-miR-4722-3p	CLIP-seq
MIRT2128504	hsa-miR-4792	CLIP-seq
MIRT2128489	hsa-miR-1178	CLIP-seq
MIRT1428998	hsa-miR-1207-3p	CLIP-seq
MIRT2128490	hsa-miR-1208	CLIP-seq
MIRT2643621	hsa-miR-1225-3p	CLIP-seq
MIRT2128491	hsa-miR-1238	CLIP-seq
MIRT2643622	hsa-miR-136	CLIP-seq
MIRT2643623	hsa-miR-140-3p	CLIP-seq
MIRT2643624	hsa-miR-15a	CLIP-seq
MIRT2643625	hsa-miR-15b	CLIP-seq
MIRT2643626	hsa-miR-16	CLIP-seq
MIRT2128492	hsa-miR-1915	CLIP-seq
MIRT2643627	hsa-miR-195	CLIP-seq
MIRT2128493	hsa-miR-224	CLIP-seq
MIRT2128494	hsa-miR-2276	CLIP-seq
MIRT2128495	hsa-miR-2861	CLIP-seq
MIRT2128496	hsa-miR-3117-5p	CLIP-seq
MIRT2128497	hsa-miR-3918	CLIP-seq
MIRT2128498	hsa-miR-3919	CLIP-seq
MIRT2128499	hsa-miR-3925-5p	CLIP-seq
MIRT1429005	hsa-miR-3945	CLIP-seq
MIRT2643628	hsa-miR-424	CLIP-seq
MIRT1429008	hsa-miR-4253	CLIP-seq
MIRT2128500	hsa-miR-4468	CLIP-seq
MIRT2128501	hsa-miR-4512	CLIP-seq
MIRT2643629	hsa-miR-4659a-3p	CLIP-seq
MIRT2643630	hsa-miR-4659b-3p	CLIP-seq
MIRT1429012	hsa-miR-4663	CLIP-seq
MIRT2128502	hsa-miR-4685-5p	CLIP-seq
MIRT1429013	hsa-miR-4696	CLIP-seq
MIRT2128503	hsa-miR-4772-3p	CLIP-seq
MIRT1429015	hsa-miR-4786-5p	CLIP-seq
MIRT2128504	hsa-miR-4792	CLIP-seq
MIRT2128505	hsa-miR-4797-5p	CLIP-seq
MIRT2643631	hsa-miR-488	CLIP-seq
MIRT2643632	hsa-miR-497	CLIP-seq
MIRT2643633	hsa-miR-515-5p	CLIP-seq
MIRT2128506	hsa-miR-518a-5p	CLIP-seq
MIRT2128507	hsa-miR-527	CLIP-seq
MIRT2643634	hsa-miR-548an	CLIP-seq
MIRT2128508	hsa-miR-589	CLIP-seq
MIRT1429020	hsa-miR-769-5p	CLIP-seq
MIRT2643635	hsa-miR-942	CLIP-seq
MIRT2128489	hsa-miR-1178	CLIP-seq
MIRT1428998	hsa-miR-1207-3p	CLIP-seq
MIRT2128490	hsa-miR-1208	CLIP-seq
MIRT2643621	hsa-miR-1225-3p	CLIP-seq
MIRT2128491	hsa-miR-1238	CLIP-seq
MIRT1428999	hsa-miR-1260	CLIP-seq
MIRT2643622	hsa-miR-136	CLIP-seq
MIRT2643623	hsa-miR-140-3p	CLIP-seq
MIRT2128492	hsa-miR-1915	CLIP-seq
MIRT2128493	hsa-miR-224	CLIP-seq
MIRT2128494	hsa-miR-2276	CLIP-seq
MIRT2128495	hsa-miR-2861	CLIP-seq
MIRT2128496	hsa-miR-3117-5p	CLIP-seq
MIRT2693275	hsa-miR-3130-5p	CLIP-seq
MIRT2128497	hsa-miR-3918	CLIP-seq
MIRT2128498	hsa-miR-3919	CLIP-seq
MIRT2128499	hsa-miR-3925-5p	CLIP-seq
MIRT1429005	hsa-miR-3945	CLIP-seq
MIRT1429008	hsa-miR-4253	CLIP-seq
MIRT1429009	hsa-miR-4328	CLIP-seq
MIRT2128500	hsa-miR-4468	CLIP-seq
MIRT2693276	hsa-miR-4482	CLIP-seq
MIRT2693277	hsa-miR-4496	CLIP-seq
MIRT2128501	hsa-miR-4512	CLIP-seq
MIRT2643629	hsa-miR-4659a-3p	CLIP-seq
MIRT2643630	hsa-miR-4659b-3p	CLIP-seq
MIRT1429012	hsa-miR-4663	CLIP-seq
MIRT2693278	hsa-miR-4672	CLIP-seq
MIRT2128502	hsa-miR-4685-5p	CLIP-seq
MIRT1429013	hsa-miR-4696	CLIP-seq
MIRT2128503	hsa-miR-4772-3p	CLIP-seq
MIRT1429015	hsa-miR-4786-5p	CLIP-seq
MIRT2128504	hsa-miR-4792	CLIP-seq
MIRT2128505	hsa-miR-4797-5p	CLIP-seq
MIRT2643631	hsa-miR-488	CLIP-seq
MIRT2643633	hsa-miR-515-5p	CLIP-seq
MIRT2128506	hsa-miR-518a-5p	CLIP-seq
MIRT2128507	hsa-miR-527	CLIP-seq
MIRT2643634	hsa-miR-548an	CLIP-seq
MIRT2128508	hsa-miR-589	CLIP-seq
MIRT1429020	hsa-miR-769-5p	CLIP-seq
MIRT2643635	hsa-miR-942	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	12237308
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IBA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IDA	12237308
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	12237308
GO:0005794	Component	Golgi apparatus	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0007030	Process	Golgi organization	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0030126	Component	COPI vesicle coat	IBA
GO:0030126	Component	COPI vesicle coat	IEA
GO:0030126	Component	COPI vesicle coat	ISS
GO:0030133	Component	Transport vesicle	TAS
GO:0030134	Component	COPII-coated ER to Golgi transport vesicle	IBA
GO:0030663	Component	COPI-coated vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	IEA
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	TAS

MIM	HGNC	e!Ensembl
620437	28889	ENSG00000166557

Q9Y3Q3

Protein name

Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26)

Protein function

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01105	EMP24_GP25L	28 → 206	emp24/gp25L/p24 family/GOLD	Domain

Sequence

MGSTVPRSASVLLLLLLLRRAEQPCGAELTFELPDNAKQCFHEEVEQGVKFSLDYQVITG
GHYDVDCYVEDPQGNTIYRETKKQYDSFTYRAEVKGVYQFCFSNEFSTFSHKTVYFDFQV
GDEPPILPDMGNRVTALTQMESACVTIHEALKTVIDSQTHYRLREAQDRARAEDLNSRVS
YWSVGETIALFVVSFSQVLLLKSFFTEKRPISRAVHS

Sequence length

217

Interactions

View interactions

	Reactome
			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cholangiocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TMED3-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (17)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anemia	Anemia	BEFREE	29982961		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30976199		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	27901021, 31057605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31253868	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	31057605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	37059363	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35951089	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27901021, 31057605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	9326355	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30976199		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22761906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	27901021, 31057605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	36769103	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nijmegen Breakage Syndrome	Nijmegen Breakage Syndrome	BEFREE	25485873, 31836699		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22761906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	22761906, 37925432	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	BEFREE	29480079		★★★★★ ★☆☆☆☆ Found in Text Mining only

TMED3 (transmembrane p24 trafficking protein 3)