FNTB (farnesyltransferase, CAAX box, subunit beta)

Gene

• Entrez ID: 2342
• Gene name: Farnesyltransferase, CAAX box, subunit beta
• Gene symbol: FNTB
• Synonyms (NCBI Gene): FPTB
• Chromosome: 14
• Chromosome location: 14q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004223	hsa-miR-346	Microarray	16822819
MIRT030444	hsa-miR-24-3p	Microarray	19748357
MIRT047154	hsa-miR-183-5p	CLASH	23622248
MIRT1000903	hsa-miR-1304	CLIP-seq
MIRT1000904	hsa-miR-1321	CLIP-seq
MIRT1000905	hsa-miR-185	CLIP-seq
MIRT1000906	hsa-miR-186	CLIP-seq
MIRT1000907	hsa-miR-1914	CLIP-seq
MIRT1000908	hsa-miR-214	CLIP-seq
MIRT1000909	hsa-miR-3064-5p	CLIP-seq
MIRT1000910	hsa-miR-3135b	CLIP-seq
MIRT1000911	hsa-miR-3162-5p	CLIP-seq
MIRT1000912	hsa-miR-3190	CLIP-seq
MIRT1000913	hsa-miR-361-3p	CLIP-seq
MIRT1000914	hsa-miR-3619-5p	CLIP-seq
MIRT1000915	hsa-miR-3652	CLIP-seq
MIRT1000916	hsa-miR-3911	CLIP-seq
MIRT1000917	hsa-miR-3934	CLIP-seq
MIRT1000918	hsa-miR-3978	CLIP-seq
MIRT1000919	hsa-miR-4257	CLIP-seq
MIRT1000920	hsa-miR-4291	CLIP-seq
MIRT1000921	hsa-miR-4306	CLIP-seq
MIRT1000922	hsa-miR-4312	CLIP-seq
MIRT1000923	hsa-miR-4430	CLIP-seq
MIRT1000924	hsa-miR-4481	CLIP-seq
MIRT1000925	hsa-miR-4487	CLIP-seq
MIRT1000926	hsa-miR-4505	CLIP-seq
MIRT1000927	hsa-miR-4519	CLIP-seq
MIRT1000928	hsa-miR-4529-5p	CLIP-seq
MIRT1000929	hsa-miR-4644	CLIP-seq
MIRT1000930	hsa-miR-4662a-3p	CLIP-seq
MIRT1000931	hsa-miR-4677-3p	CLIP-seq
MIRT1000932	hsa-miR-4739	CLIP-seq
MIRT1000933	hsa-miR-4745-5p	CLIP-seq
MIRT1000934	hsa-miR-4756-5p	CLIP-seq
MIRT1000935	hsa-miR-4782-5p	CLIP-seq
MIRT1000936	hsa-miR-5096	CLIP-seq
MIRT1000937	hsa-miR-514	CLIP-seq
MIRT1000938	hsa-miR-514b-3p	CLIP-seq
MIRT1000939	hsa-miR-552	CLIP-seq
MIRT1000940	hsa-miR-7	CLIP-seq
MIRT1000941	hsa-miR-760	CLIP-seq
MIRT1000942	hsa-miR-761	CLIP-seq
MIRT1000943	hsa-miR-922	CLIP-seq
MIRT1996542	hsa-miR-1226	CLIP-seq
MIRT1996543	hsa-miR-199a-5p	CLIP-seq
MIRT1996544	hsa-miR-199b-5p	CLIP-seq
MIRT1000912	hsa-miR-3190	CLIP-seq
MIRT1996545	hsa-miR-371-3p	CLIP-seq
MIRT1996546	hsa-miR-371b-3p	CLIP-seq
MIRT1996547	hsa-miR-3975	CLIP-seq
MIRT1996548	hsa-miR-432	CLIP-seq
MIRT1996549	hsa-miR-4797-5p	CLIP-seq
MIRT1996550	hsa-miR-515-3p	CLIP-seq
MIRT1996551	hsa-miR-515-5p	CLIP-seq
MIRT1996552	hsa-miR-519e	CLIP-seq
MIRT1996553	hsa-miR-548v	CLIP-seq
MIRT1996554	hsa-miR-766	CLIP-seq
MIRT2230583	hsa-miR-1208	CLIP-seq
MIRT2230584	hsa-miR-1288	CLIP-seq
MIRT1000904	hsa-miR-1321	CLIP-seq
MIRT2230585	hsa-miR-1587	CLIP-seq
MIRT2230586	hsa-miR-1827	CLIP-seq
MIRT2230587	hsa-miR-197	CLIP-seq
MIRT2230588	hsa-miR-2115	CLIP-seq
MIRT1000911	hsa-miR-3162-5p	CLIP-seq
MIRT2230589	hsa-miR-3545-3p	CLIP-seq
MIRT2230590	hsa-miR-3622b-5p	CLIP-seq
MIRT2230591	hsa-miR-3692	CLIP-seq
MIRT1000919	hsa-miR-4257	CLIP-seq
MIRT2230592	hsa-miR-4299	CLIP-seq
MIRT2230593	hsa-miR-4417	CLIP-seq
MIRT2230594	hsa-miR-4436b-5p	CLIP-seq
MIRT2230595	hsa-miR-4492	CLIP-seq
MIRT2230596	hsa-miR-4498	CLIP-seq
MIRT1000928	hsa-miR-4529-5p	CLIP-seq
MIRT2230597	hsa-miR-4656	CLIP-seq
MIRT2230598	hsa-miR-4675	CLIP-seq
MIRT2230599	hsa-miR-4691-5p	CLIP-seq
MIRT2230600	hsa-miR-4720-5p	CLIP-seq
MIRT1000932	hsa-miR-4739	CLIP-seq
MIRT2230601	hsa-miR-4741	CLIP-seq
MIRT1000934	hsa-miR-4756-5p	CLIP-seq
MIRT2230602	hsa-miR-4795-3p	CLIP-seq
MIRT2230603	hsa-miR-4799-3p	CLIP-seq
MIRT1000936	hsa-miR-5096	CLIP-seq
MIRT2230604	hsa-miR-516a-3p	CLIP-seq
MIRT2230605	hsa-miR-548q	CLIP-seq
MIRT2230606	hsa-miR-762	CLIP-seq
MIRT1996548	hsa-miR-432	CLIP-seq
MIRT2534613	hsa-miR-103a	CLIP-seq
MIRT2534614	hsa-miR-107	CLIP-seq
MIRT2534615	hsa-miR-1224-3p	CLIP-seq
MIRT1996542	hsa-miR-1226	CLIP-seq
MIRT2534616	hsa-miR-1228	CLIP-seq
MIRT2534617	hsa-miR-1252	CLIP-seq
MIRT2534618	hsa-miR-1264	CLIP-seq
MIRT2534619	hsa-miR-15a	CLIP-seq
MIRT2534620	hsa-miR-15b	CLIP-seq
MIRT2534621	hsa-miR-16	CLIP-seq
MIRT1000906	hsa-miR-186	CLIP-seq
MIRT1000907	hsa-miR-1914	CLIP-seq
MIRT2534622	hsa-miR-195	CLIP-seq
MIRT2230587	hsa-miR-197	CLIP-seq
MIRT1996543	hsa-miR-199a-5p	CLIP-seq
MIRT1996544	hsa-miR-199b-5p	CLIP-seq
MIRT2534623	hsa-miR-204	CLIP-seq
MIRT2534624	hsa-miR-211	CLIP-seq
MIRT2534625	hsa-miR-2117	CLIP-seq
MIRT2534626	hsa-miR-224	CLIP-seq
MIRT2534627	hsa-miR-2467-3p	CLIP-seq
MIRT1000912	hsa-miR-3190	CLIP-seq
MIRT2230589	hsa-miR-3545-3p	CLIP-seq
MIRT2534628	hsa-miR-3685	CLIP-seq
MIRT2230591	hsa-miR-3692	CLIP-seq
MIRT1996545	hsa-miR-371-3p	CLIP-seq
MIRT1996546	hsa-miR-371b-3p	CLIP-seq
MIRT2534629	hsa-miR-384	CLIP-seq
MIRT1000916	hsa-miR-3911	CLIP-seq
MIRT1000917	hsa-miR-3934	CLIP-seq
MIRT2534630	hsa-miR-3944-5p	CLIP-seq
MIRT1996547	hsa-miR-3975	CLIP-seq
MIRT1000918	hsa-miR-3978	CLIP-seq
MIRT2534631	hsa-miR-424	CLIP-seq
MIRT2534632	hsa-miR-4252	CLIP-seq
MIRT2534633	hsa-miR-4267	CLIP-seq
MIRT2534634	hsa-miR-4273	CLIP-seq
MIRT2534635	hsa-miR-4283	CLIP-seq
MIRT2534636	hsa-miR-4286	CLIP-seq
MIRT2534637	hsa-miR-4302	CLIP-seq
MIRT2534638	hsa-miR-431	CLIP-seq
MIRT2534639	hsa-miR-4428	CLIP-seq
MIRT2230594	hsa-miR-4436b-5p	CLIP-seq
MIRT2534640	hsa-miR-4437	CLIP-seq
MIRT2534641	hsa-miR-4446-5p	CLIP-seq
MIRT2534642	hsa-miR-4486	CLIP-seq
MIRT2534643	hsa-miR-4489	CLIP-seq
MIRT2534644	hsa-miR-4524	CLIP-seq
MIRT2230597	hsa-miR-4656	CLIP-seq
MIRT2534645	hsa-miR-4676-5p	CLIP-seq
MIRT2534646	hsa-miR-4683	CLIP-seq
MIRT2534647	hsa-miR-4691-3p	CLIP-seq
MIRT2534648	hsa-miR-4711-3p	CLIP-seq
MIRT2534649	hsa-miR-4715-3p	CLIP-seq
MIRT2534650	hsa-miR-4755-3p	CLIP-seq
MIRT2534651	hsa-miR-4755-5p	CLIP-seq
MIRT2534652	hsa-miR-4768-5p	CLIP-seq
MIRT1996549	hsa-miR-4797-5p	CLIP-seq
MIRT2534653	hsa-miR-497	CLIP-seq
MIRT2534654	hsa-miR-503	CLIP-seq
MIRT1996550	hsa-miR-515-3p	CLIP-seq
MIRT1996551	hsa-miR-515-5p	CLIP-seq
MIRT1996552	hsa-miR-519e	CLIP-seq
MIRT2534655	hsa-miR-520d-5p	CLIP-seq
MIRT2534656	hsa-miR-524-5p	CLIP-seq
MIRT2534657	hsa-miR-539	CLIP-seq
MIRT2534658	hsa-miR-548aa	CLIP-seq
MIRT1996553	hsa-miR-548v	CLIP-seq
MIRT1000939	hsa-miR-552	CLIP-seq
MIRT2534659	hsa-miR-575	CLIP-seq
MIRT2534660	hsa-miR-623	CLIP-seq
MIRT2534661	hsa-miR-646	CLIP-seq
MIRT2534662	hsa-miR-711	CLIP-seq
MIRT1996554	hsa-miR-766	CLIP-seq
MIRT2534663	hsa-miR-767-5p	CLIP-seq
MIRT2534664	hsa-miR-892a	CLIP-seq
MIRT1000943	hsa-miR-922	CLIP-seq
MIRT2534613	hsa-miR-103a	CLIP-seq
MIRT2534614	hsa-miR-107	CLIP-seq
MIRT2534615	hsa-miR-1224-3p	CLIP-seq
MIRT1996542	hsa-miR-1226	CLIP-seq
MIRT2534617	hsa-miR-1252	CLIP-seq
MIRT2534619	hsa-miR-15a	CLIP-seq
MIRT2534620	hsa-miR-15b	CLIP-seq
MIRT2534621	hsa-miR-16	CLIP-seq
MIRT1000906	hsa-miR-186	CLIP-seq
MIRT2681095	hsa-miR-1912	CLIP-seq
MIRT2534622	hsa-miR-195	CLIP-seq
MIRT2230587	hsa-miR-197	CLIP-seq
MIRT1996543	hsa-miR-199a-5p	CLIP-seq
MIRT1996544	hsa-miR-199b-5p	CLIP-seq
MIRT2534623	hsa-miR-204	CLIP-seq
MIRT2534624	hsa-miR-211	CLIP-seq
MIRT2534625	hsa-miR-2117	CLIP-seq
MIRT2534626	hsa-miR-224	CLIP-seq
MIRT2534627	hsa-miR-2467-3p	CLIP-seq
MIRT1000912	hsa-miR-3190	CLIP-seq
MIRT2230589	hsa-miR-3545-3p	CLIP-seq
MIRT2534628	hsa-miR-3685	CLIP-seq
MIRT2230591	hsa-miR-3692	CLIP-seq
MIRT1996545	hsa-miR-371-3p	CLIP-seq
MIRT1996546	hsa-miR-371b-3p	CLIP-seq
MIRT2534629	hsa-miR-384	CLIP-seq
MIRT1000916	hsa-miR-3911	CLIP-seq
MIRT1000917	hsa-miR-3934	CLIP-seq
MIRT2534630	hsa-miR-3944-5p	CLIP-seq
MIRT1996547	hsa-miR-3975	CLIP-seq
MIRT1000918	hsa-miR-3978	CLIP-seq
MIRT2534631	hsa-miR-424	CLIP-seq
MIRT2534632	hsa-miR-4252	CLIP-seq
MIRT2534633	hsa-miR-4267	CLIP-seq
MIRT2534634	hsa-miR-4273	CLIP-seq
MIRT2534636	hsa-miR-4286	CLIP-seq
MIRT2534637	hsa-miR-4302	CLIP-seq
MIRT2534639	hsa-miR-4428	CLIP-seq
MIRT2230594	hsa-miR-4436b-5p	CLIP-seq
MIRT2534640	hsa-miR-4437	CLIP-seq
MIRT2534641	hsa-miR-4446-5p	CLIP-seq
MIRT2534642	hsa-miR-4486	CLIP-seq
MIRT2534644	hsa-miR-4524	CLIP-seq
MIRT2534645	hsa-miR-4676-5p	CLIP-seq
MIRT2534646	hsa-miR-4683	CLIP-seq
MIRT2534647	hsa-miR-4691-3p	CLIP-seq
MIRT2534649	hsa-miR-4715-3p	CLIP-seq
MIRT2534650	hsa-miR-4755-3p	CLIP-seq
MIRT2534651	hsa-miR-4755-5p	CLIP-seq
MIRT2534652	hsa-miR-4768-5p	CLIP-seq
MIRT1996549	hsa-miR-4797-5p	CLIP-seq
MIRT2534653	hsa-miR-497	CLIP-seq
MIRT2534654	hsa-miR-503	CLIP-seq
MIRT1996550	hsa-miR-515-3p	CLIP-seq
MIRT1996551	hsa-miR-515-5p	CLIP-seq
MIRT1996552	hsa-miR-519e	CLIP-seq
MIRT2534655	hsa-miR-520d-5p	CLIP-seq
MIRT2534656	hsa-miR-524-5p	CLIP-seq
MIRT2534657	hsa-miR-539	CLIP-seq
MIRT2534658	hsa-miR-548aa	CLIP-seq
MIRT1996553	hsa-miR-548v	CLIP-seq
MIRT1000939	hsa-miR-552	CLIP-seq
MIRT2534659	hsa-miR-575	CLIP-seq
MIRT2534660	hsa-miR-623	CLIP-seq
MIRT2534661	hsa-miR-646	CLIP-seq
MIRT2534662	hsa-miR-711	CLIP-seq
MIRT1996554	hsa-miR-766	CLIP-seq
MIRT2534664	hsa-miR-892a	CLIP-seq
MIRT1000943	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004659	Function	Prenyltransferase activity	IEA
GO:0004660	Function	Protein farnesyltransferase activity	IBA
GO:0004660	Function	Protein farnesyltransferase activity	IDA	19228685
GO:0004660	Function	Protein farnesyltransferase activity	IDA	16893176
GO:0004660	Function	Protein farnesyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	11687658, 12036349, 12825937, 15170324, 15248757, 15451670, 24981860, 32296183, 32814053, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0005875	Component	Microtubule associated complex	IDA	19228685
GO:0005965	Component	Protein farnesyltransferase complex	IBA
GO:0005965	Component	Protein farnesyltransferase complex	IDA	16893176
GO:0005965	Component	Protein farnesyltransferase complex	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IDA	16893176
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008318	Function	Protein prenyltransferase activity	IEA
GO:0010698	Function	Acetyltransferase activator activity	IDA	19228685
GO:0016740	Function	Transferase activity	IEA
GO:0018343	Process	Protein farnesylation	IDA	16893176
GO:0019899	Function	Enzyme binding	IPI	19228685
GO:0042277	Function	Peptide binding	IEA
GO:0045787	Process	Positive regulation of cell cycle	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060632	Process	Regulation of microtubule-based movement	IDA	19228685

Other IDs

• MIM: 134636
• HGNC: 3785
• e!Ensembl: ENSG00000257365

Interactions View interactions

Pathways

KEGG:

Terpenoid backbone biosynthesis

Reactome:

Inactivation, recovery and regulation of the phototransduction cascade

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANXIETY DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations