Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23403
Gene name	F-box protein 46
Gene symbol	FBXO46
Synonyms (NCBI Gene)	20D7-FC4FBXO34LFbx46
Chromosome	19
Chromosome location	19q13.32
Summary	Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr

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Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT725517	hsa-miR-27b-3p	HITS-CLIP	19536157
MIRT725516	hsa-miR-27a-3p	HITS-CLIP	19536157
MIRT725515	hsa-miR-3158-3p	HITS-CLIP	19536157
MIRT725514	hsa-miR-3675-5p	HITS-CLIP	19536157
MIRT725513	hsa-miR-6890-5p	HITS-CLIP	19536157
MIRT725512	hsa-miR-3115	HITS-CLIP	19536157
MIRT725511	hsa-miR-513a-5p	HITS-CLIP	19536157
MIRT725517	hsa-miR-27b-3p	HITS-CLIP	19536157
MIRT725516	hsa-miR-27a-3p	HITS-CLIP	19536157
MIRT725515	hsa-miR-3158-3p	HITS-CLIP	19536157
MIRT725514	hsa-miR-3675-5p	HITS-CLIP	19536157
MIRT725513	hsa-miR-6890-5p	HITS-CLIP	19536157
MIRT725512	hsa-miR-3115	HITS-CLIP	19536157
MIRT725511	hsa-miR-513a-5p	HITS-CLIP	19536157
MIRT992795	hsa-miR-1236	CLIP-seq
MIRT992796	hsa-miR-1321	CLIP-seq
MIRT992797	hsa-miR-185	CLIP-seq
MIRT992798	hsa-miR-1913	CLIP-seq
MIRT992799	hsa-miR-2115	CLIP-seq
MIRT992800	hsa-miR-3144-5p	CLIP-seq
MIRT992801	hsa-miR-3150b-3p	CLIP-seq
MIRT992802	hsa-miR-3173-3p	CLIP-seq
MIRT992803	hsa-miR-3180-5p	CLIP-seq
MIRT992804	hsa-miR-324-3p	CLIP-seq
MIRT992805	hsa-miR-342-5p	CLIP-seq
MIRT992806	hsa-miR-3652	CLIP-seq
MIRT992807	hsa-miR-3688-3p	CLIP-seq
MIRT992808	hsa-miR-3978	CLIP-seq
MIRT992809	hsa-miR-4260	CLIP-seq
MIRT992810	hsa-miR-4270	CLIP-seq
MIRT992811	hsa-miR-4283	CLIP-seq
MIRT992812	hsa-miR-4306	CLIP-seq
MIRT992813	hsa-miR-4313	CLIP-seq
MIRT992814	hsa-miR-4428	CLIP-seq
MIRT992815	hsa-miR-4430	CLIP-seq
MIRT992816	hsa-miR-4441	CLIP-seq
MIRT992817	hsa-miR-4453	CLIP-seq
MIRT992818	hsa-miR-4463	CLIP-seq
MIRT992819	hsa-miR-4474-3p	CLIP-seq
MIRT992820	hsa-miR-4477b	CLIP-seq
MIRT992821	hsa-miR-4489	CLIP-seq
MIRT992822	hsa-miR-4505	CLIP-seq
MIRT992823	hsa-miR-4538	CLIP-seq
MIRT992824	hsa-miR-4640-5p	CLIP-seq
MIRT992825	hsa-miR-4644	CLIP-seq
MIRT992826	hsa-miR-4651	CLIP-seq
MIRT992827	hsa-miR-4656	CLIP-seq
MIRT992828	hsa-miR-4664-5p	CLIP-seq
MIRT992829	hsa-miR-4689	CLIP-seq
MIRT992830	hsa-miR-4710	CLIP-seq
MIRT992831	hsa-miR-4726-5p	CLIP-seq
MIRT992832	hsa-miR-4728-5p	CLIP-seq
MIRT992833	hsa-miR-4731-5p	CLIP-seq
MIRT992834	hsa-miR-4739	CLIP-seq
MIRT992835	hsa-miR-4756-5p	CLIP-seq
MIRT992836	hsa-miR-4784	CLIP-seq
MIRT992837	hsa-miR-4790-3p	CLIP-seq
MIRT992838	hsa-miR-520a-5p	CLIP-seq
MIRT992839	hsa-miR-525-5p	CLIP-seq
MIRT992840	hsa-miR-570	CLIP-seq
MIRT992841	hsa-miR-608	CLIP-seq
MIRT1994432	hsa-miR-1207-5p	CLIP-seq
MIRT1994433	hsa-miR-1258	CLIP-seq
MIRT1994434	hsa-miR-186	CLIP-seq
MIRT1994435	hsa-miR-27a	CLIP-seq
MIRT1994436	hsa-miR-27b	CLIP-seq
MIRT1994437	hsa-miR-3170	CLIP-seq
MIRT1994438	hsa-miR-3189-3p	CLIP-seq
MIRT992805	hsa-miR-342-5p	CLIP-seq
MIRT1994439	hsa-miR-3688-5p	CLIP-seq
MIRT1994440	hsa-miR-370	CLIP-seq
MIRT1994441	hsa-miR-384	CLIP-seq
MIRT1994442	hsa-miR-4266	CLIP-seq
MIRT1994443	hsa-miR-4440	CLIP-seq
MIRT1994444	hsa-miR-4649-5p	CLIP-seq
MIRT992826	hsa-miR-4651	CLIP-seq
MIRT992828	hsa-miR-4664-5p	CLIP-seq
MIRT1994445	hsa-miR-4736	CLIP-seq
MIRT1994446	hsa-miR-4738-5p	CLIP-seq
MIRT1994447	hsa-miR-4763-3p	CLIP-seq
MIRT992841	hsa-miR-608	CLIP-seq
MIRT1994448	hsa-miR-635	CLIP-seq
MIRT1994449	hsa-miR-644	CLIP-seq
MIRT1994450	hsa-miR-657	CLIP-seq
MIRT1994451	hsa-miR-766	CLIP-seq
MIRT1994432	hsa-miR-1207-5p	CLIP-seq
MIRT2228428	hsa-miR-1245b-3p	CLIP-seq
MIRT1994433	hsa-miR-1258	CLIP-seq
MIRT2228429	hsa-miR-1343	CLIP-seq
MIRT2228430	hsa-miR-144	CLIP-seq
MIRT1994434	hsa-miR-186	CLIP-seq
MIRT2228431	hsa-miR-21	CLIP-seq
MIRT992799	hsa-miR-2115	CLIP-seq
MIRT2228432	hsa-miR-2392	CLIP-seq
MIRT2228433	hsa-miR-2467-3p	CLIP-seq
MIRT1994435	hsa-miR-27a	CLIP-seq
MIRT1994436	hsa-miR-27b	CLIP-seq
MIRT2228434	hsa-miR-3064-3p	CLIP-seq
MIRT2228435	hsa-miR-3074-5p	CLIP-seq
MIRT2228436	hsa-miR-3124-3p	CLIP-seq
MIRT2228437	hsa-miR-3126-5p	CLIP-seq
MIRT992800	hsa-miR-3144-5p	CLIP-seq
MIRT1994437	hsa-miR-3170	CLIP-seq
MIRT992802	hsa-miR-3173-3p	CLIP-seq
MIRT992803	hsa-miR-3180-5p	CLIP-seq
MIRT992805	hsa-miR-342-5p	CLIP-seq
MIRT2228438	hsa-miR-34a	CLIP-seq
MIRT2228439	hsa-miR-34c-5p	CLIP-seq
MIRT2228440	hsa-miR-3605-5p	CLIP-seq
MIRT2228441	hsa-miR-3679-3p	CLIP-seq
MIRT1994439	hsa-miR-3688-5p	CLIP-seq
MIRT992808	hsa-miR-3978	CLIP-seq
MIRT2228442	hsa-miR-421	CLIP-seq
MIRT1994442	hsa-miR-4266	CLIP-seq
MIRT2228443	hsa-miR-4286	CLIP-seq
MIRT2228444	hsa-miR-4419a	CLIP-seq
MIRT992814	hsa-miR-4428	CLIP-seq
MIRT1994443	hsa-miR-4440	CLIP-seq
MIRT992817	hsa-miR-4453	CLIP-seq
MIRT992820	hsa-miR-4477b	CLIP-seq
MIRT2228445	hsa-miR-449a	CLIP-seq
MIRT2228446	hsa-miR-449b	CLIP-seq
MIRT2228447	hsa-miR-4510	CLIP-seq
MIRT992823	hsa-miR-4538	CLIP-seq
MIRT992824	hsa-miR-4640-5p	CLIP-seq
MIRT992826	hsa-miR-4651	CLIP-seq
MIRT992828	hsa-miR-4664-5p	CLIP-seq
MIRT2228448	hsa-miR-4698	CLIP-seq
MIRT2228449	hsa-miR-4709-5p	CLIP-seq
MIRT992830	hsa-miR-4710	CLIP-seq
MIRT2228450	hsa-miR-4721	CLIP-seq
MIRT992831	hsa-miR-4726-5p	CLIP-seq
MIRT1994445	hsa-miR-4736	CLIP-seq
MIRT1994446	hsa-miR-4738-5p	CLIP-seq
MIRT1994447	hsa-miR-4763-3p	CLIP-seq
MIRT992838	hsa-miR-520a-5p	CLIP-seq
MIRT992839	hsa-miR-525-5p	CLIP-seq
MIRT2228451	hsa-miR-548c-3p	CLIP-seq
MIRT992840	hsa-miR-570	CLIP-seq
MIRT2228452	hsa-miR-590-5p	CLIP-seq
MIRT992841	hsa-miR-608	CLIP-seq
MIRT2228453	hsa-miR-633	CLIP-seq
MIRT1994449	hsa-miR-644	CLIP-seq
MIRT1994450	hsa-miR-657	CLIP-seq
MIRT2228454	hsa-miR-765	CLIP-seq
MIRT1994451	hsa-miR-766	CLIP-seq
MIRT1994432	hsa-miR-1207-5p	CLIP-seq
MIRT1994445	hsa-miR-4736	CLIP-seq
MIRT1994447	hsa-miR-4763-3p	CLIP-seq
MIRT1994432	hsa-miR-1207-5p	CLIP-seq
MIRT1994433	hsa-miR-1258	CLIP-seq
MIRT1994434	hsa-miR-186	CLIP-seq
MIRT2532265	hsa-miR-2277-3p	CLIP-seq
MIRT2532266	hsa-miR-3153	CLIP-seq
MIRT1994437	hsa-miR-3170	CLIP-seq
MIRT1994438	hsa-miR-3189-3p	CLIP-seq
MIRT992805	hsa-miR-342-5p	CLIP-seq
MIRT1994439	hsa-miR-3688-5p	CLIP-seq
MIRT1994441	hsa-miR-384	CLIP-seq
MIRT2532267	hsa-miR-3943	CLIP-seq
MIRT1994442	hsa-miR-4266	CLIP-seq
MIRT1994443	hsa-miR-4440	CLIP-seq
MIRT1994444	hsa-miR-4649-5p	CLIP-seq
MIRT992826	hsa-miR-4651	CLIP-seq
MIRT992828	hsa-miR-4664-5p	CLIP-seq
MIRT2532268	hsa-miR-4668-5p	CLIP-seq
MIRT992830	hsa-miR-4710	CLIP-seq
MIRT1994445	hsa-miR-4736	CLIP-seq
MIRT1994446	hsa-miR-4738-5p	CLIP-seq
MIRT1994447	hsa-miR-4763-3p	CLIP-seq
MIRT992841	hsa-miR-608	CLIP-seq
MIRT1994448	hsa-miR-635	CLIP-seq
MIRT1994449	hsa-miR-644	CLIP-seq
MIRT1994450	hsa-miR-657	CLIP-seq
MIRT1994451	hsa-miR-766	CLIP-seq
MIRT1994432	hsa-miR-1207-5p	CLIP-seq
MIRT1994433	hsa-miR-1258	CLIP-seq
MIRT2532265	hsa-miR-2277-3p	CLIP-seq
MIRT2532266	hsa-miR-3153	CLIP-seq
MIRT1994438	hsa-miR-3189-3p	CLIP-seq
MIRT1994439	hsa-miR-3688-5p	CLIP-seq
MIRT1994441	hsa-miR-384	CLIP-seq
MIRT2532267	hsa-miR-3943	CLIP-seq
MIRT1994442	hsa-miR-4266	CLIP-seq
MIRT1994443	hsa-miR-4440	CLIP-seq
MIRT1994444	hsa-miR-4649-5p	CLIP-seq
MIRT2532268	hsa-miR-4668-5p	CLIP-seq
MIRT1994445	hsa-miR-4736	CLIP-seq
MIRT1994447	hsa-miR-4763-3p	CLIP-seq
MIRT1994448	hsa-miR-635	CLIP-seq
MIRT1994449	hsa-miR-644	CLIP-seq
MIRT1994450	hsa-miR-657	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19159283, 27705803, 33961781
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	30171069
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	30171069
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	30171069

MIM	HGNC	e!Ensembl
609117	25069	ENSG00000177051

Q6PJ61

Protein name

F-box only protein 46 (F-box only protein 34-like)

Protein function

Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degrada

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12937	F-box-like	473 → 510	F-box-like	Domain

Sequence

MDRGSLLPFQLWCPRPFGTYSQNQPRPPSAALKPSACPEPGGGAEPDHGPAHSENTPPAL
ATEVPASQPAPLLSAAAAGDEGRVLLDTWYVIKPGNTKEKVAFFVAHQCGGGSRASSMKV
KGHWGSDSSKAKRRRRCLDPTKAPPDPGGREGPPAAEEGPASAGEDVDLLSVAEMVALVE
QRAALALQSYPRPTTPAPVVFVSAEQGGPAKGVGSERRSGGGDCSRVAEAVAHFEAQRDS
PPTKGLRKEERPGPGPGEVRIAFRISNGREPRAPDSGLPSGGGGRPGCAYPGSPGPGARA
KDKITCDLYQLISPSRDALPSNVEFLLARADEASEGDSPAPARPEDTPPAPPPPPARDCG
ASGFHVDVVVTGVVDECIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQNRGPDGPP
EPPPADSPATAPGPDDAEGTADTSLCRLYRHVSHDFLEIRFKIQRLLEPRQYMLLLPEHV
LVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRWSRDPLYRDDPCKQCRKRYEKG
DVSLCRWHPKPYHHDLPYGRSYWMCCRRADRETPGCRLGLHDNNWVLPCNGPGGGRAGRE
EGR

Sequence length

603

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLSTONES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITRAL VALVE PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31387239	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

FBXO46 (F-box protein 46)