Gene Gene information from NCBI Gene database.
Entrez ID 23401
Gene name FRAT regulator of Wnt signaling pathway 2
Gene symbol FRAT2
Synonyms (NCBI Gene)
FRAT-2
Chromosome 10
Chromosome location 10q24.1
Summary The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul
miRNA miRNA information provided by mirtarbase database.
292
miRTarBase ID miRNA Experiments Reference
MIRT030658 hsa-miR-22-3p Sequencing 20371350
MIRT049687 hsa-miR-92a-3p CLASH 23622248
MIRT046089 hsa-miR-125b-5p CLASH 23622248
MIRT044758 hsa-miR-320a CLASH 23622248
MIRT039961 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus ISS
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm ISS
GO:0005829 Component Cytosol TAS
GO:0016055 Process Wnt signaling pathway IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605006 16048 ENSG00000181274
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75474
Protein name GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2)
Protein function Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05350 GSK-3_bind 1 214 Glycogen synthase kinase-3 binding Family
Sequence
Sequence length 233
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Wnt signaling pathway
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Pathways in cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHOLELITHIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GALLSTONES GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 38092781 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis Juvenile Juvenile arthritis Pubtator 35967305 Associate
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 23074275
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus Systemic Systemic lupus erythematosus Pubtator 39290707 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of stomach Stomach Neoplasms BEFREE 11445844
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 11445844
★☆☆☆☆
Found in Text Mining only
Moyamoya Disease Moyamoya disease Pubtator 39290707 Associate
★☆☆☆☆
Found in Text Mining only
Stomach Carcinoma Stomach Carcinoma BEFREE 11445844
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach neoplasms Pubtator 36153370 Associate
★☆☆☆☆
Found in Text Mining only