Gene Gene information from NCBI Gene database.
Entrez ID 23390
Gene name ZDHHC palmitoyltransferase 17
Gene symbol ZDHHC17
Synonyms (NCBI Gene)
DHHC-17DHHC17HIP14HIP3HSPC294HYPH
Chromosome 12
Chromosome location 12q21.2
miRNA miRNA information provided by mirtarbase database.
327
miRTarBase ID miRNA Experiments Reference
MIRT019308 hsa-miR-148b-3p Microarray 17612493
MIRT023433 hsa-miR-30b-5p Sequencing 20371350
MIRT019308 hsa-miR-148b-3p CLASH 23622248
MIRT609806 hsa-miR-8485 HITS-CLIP 23824327
MIRT609805 hsa-miR-329-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 18794299
GO:0000139 Component Golgi membrane IEA
GO:0005102 Function Signaling receptor binding IEA
GO:0005515 Function Protein binding IPI 15603740, 23275563, 24705354, 25416956, 29997244, 32296183, 32814053, 33961781
GO:0005794 Component Golgi apparatus IDA 16647879
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607799 18412 ENSG00000186908
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IUH5
Protein name Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP
Protein function Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15489887, PubMed:15603740, PubMed:24705354, PubMed:27911442, PubMed:28757145). Has no string
PDB 3EU9 , 5W7I , 5W7J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 61 154 Ankyrin repeats (3 copies) Repeat
PF12796 Ank_2 161 255 Ankyrin repeats (3 copies) Repeat
PF01529 DHHC 434 570 DHHC palmitoyltransferase Family
Tissue specificity TISSUE SPECIFICITY: Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. {ECO:0000269|PubMed:12393793}.
Sequence
MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWD
IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLG
GDLNSTPLHWATRQGHLSMVVQLMKYGADPSLID
GEGCSCIHLAAQFGHTSIVAYLIAKG
QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTV
ISLLLEAGANVDAQN
IKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKE
FRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPL
GIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQK
KKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHR
YFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVF
HFMWVAVLLMCQMYQISCLGITTNERMNAR
RYKHFKVTTTSIESPFNHGCVRNIIDFFEF
RCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
Sequence length 632
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus BEFREE 21705657
★☆☆☆☆
Found in Text Mining only
Huntington Disease Huntington Disease BEFREE 12393793, 16847693, 22155432, 22649491, 24705354, 25849918, 27911442
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 16891450
★☆☆☆☆
Found in Text Mining only
Tourette Syndrome Tourette syndrome Pubtator 33837273 Associate
★☆☆☆☆
Found in Text Mining only