SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)

Gene

• Entrez ID: 23380
• Gene name: SLIT-ROBO Rho GTPase activating protein 2
• Gene symbol: SRGAP2
• Synonyms (NCBI Gene): ARHGAP34, FNBP2, SRGAP2A, SRGAP3
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting fro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024967	hsa-miR-214-3p	Reporter assay	21276775
MIRT025878	hsa-miR-7-5p	Sequencing	20371350
MIRT027717	hsa-miR-98-5p	Microarray	19088304
MIRT045795	hsa-miR-191-5p	CLASH	23622248
MIRT045756	hsa-miR-125a-5p	CLASH	23622248
MIRT045164	hsa-miR-186-5p	CLASH	23622248
MIRT438268	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT438268	hsa-miR-29a-3p	Luciferase reporter assay	24085298
MIRT707870	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT707869	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT707868	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT707867	hsa-miR-8485	HITS-CLIP	21572407
MIRT707866	hsa-miR-603	HITS-CLIP	21572407
MIRT707865	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707864	hsa-miR-1228-3p	HITS-CLIP	21572407
MIRT707862	hsa-miR-3941	HITS-CLIP	21572407
MIRT707863	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707861	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT639907	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT639906	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT639905	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT639904	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT639903	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT639902	hsa-miR-323b-5p	HITS-CLIP	23824327
MIRT639901	hsa-miR-410-5p	HITS-CLIP	23824327
MIRT639900	hsa-miR-494-5p	HITS-CLIP	23824327
MIRT639899	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT520962	hsa-miR-3662	PAR-CLIP	23446348
MIRT520961	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT520960	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT520959	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT520958	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT496724	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496723	hsa-miR-4662a-5p	PAR-CLIP	22291592
MIRT496722	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496721	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT496720	hsa-miR-218-1-3p	PAR-CLIP	22291592
MIRT445238	hsa-miR-4661-3p	PAR-CLIP	22100165
MIRT445236	hsa-miR-6755-5p	PAR-CLIP	22100165
MIRT445237	hsa-miR-1298-3p	PAR-CLIP	22100165
MIRT445235	hsa-miR-204-3p	PAR-CLIP	22100165
MIRT445234	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT445233	hsa-miR-3192-5p	PAR-CLIP	22100165
MIRT445232	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445231	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT445230	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT445229	hsa-miR-4314	PAR-CLIP	22100165
MIRT445228	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445227	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT445226	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT445225	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT445238	hsa-miR-4661-3p	PAR-CLIP	22100165
MIRT445236	hsa-miR-6755-5p	PAR-CLIP	22100165
MIRT445237	hsa-miR-1298-3p	PAR-CLIP	22100165
MIRT445235	hsa-miR-204-3p	PAR-CLIP	22100165
MIRT445234	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT445233	hsa-miR-3192-5p	PAR-CLIP	22100165
MIRT445232	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445231	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT445230	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT445229	hsa-miR-4314	PAR-CLIP	22100165
MIRT445228	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445227	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT445226	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT445225	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT520962	hsa-miR-3662	HITS-CLIP	27418678
MIRT520960	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT520960	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT520958	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT520958	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT520959	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT520959	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT733324	hsa-miR-145-5p	Immunofluorescence, Immunoprecipitaion (IP), In situ hybridization, Luciferase reporter assay, Western blotting	33859759
MIRT707870	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT707869	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT707868	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT707867	hsa-miR-8485	HITS-CLIP	21572407
MIRT707866	hsa-miR-603	HITS-CLIP	21572407
MIRT707865	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707864	hsa-miR-1228-3p	HITS-CLIP	21572407
MIRT707862	hsa-miR-3941	HITS-CLIP	21572407
MIRT707863	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707861	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT639907	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT639906	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT639905	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT639904	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT639903	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT639902	hsa-miR-323b-5p	HITS-CLIP	23824327
MIRT639901	hsa-miR-410-5p	HITS-CLIP	23824327
MIRT639900	hsa-miR-494-5p	HITS-CLIP	23824327
MIRT639899	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT520962	hsa-miR-3662	PAR-CLIP	23446348
MIRT520961	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT520960	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT520959	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT520958	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT496724	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496723	hsa-miR-4662a-5p	PAR-CLIP	22291592
MIRT496722	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496721	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT496720	hsa-miR-218-1-3p	PAR-CLIP	22291592
MIRT445238	hsa-miR-4661-3p	PAR-CLIP	22100165
MIRT445236	hsa-miR-6755-5p	PAR-CLIP	22100165
MIRT445237	hsa-miR-1298-3p	PAR-CLIP	22100165
MIRT445235	hsa-miR-204-3p	PAR-CLIP	22100165
MIRT445234	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT445233	hsa-miR-3192-5p	PAR-CLIP	22100165
MIRT445232	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445231	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT445230	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT445229	hsa-miR-4314	PAR-CLIP	22100165
MIRT445228	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445227	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT445226	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT445225	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT445238	hsa-miR-4661-3p	PAR-CLIP	22100165
MIRT445236	hsa-miR-6755-5p	PAR-CLIP	22100165
MIRT445237	hsa-miR-1298-3p	PAR-CLIP	22100165
MIRT445235	hsa-miR-204-3p	PAR-CLIP	22100165
MIRT445234	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT445233	hsa-miR-3192-5p	PAR-CLIP	22100165
MIRT445232	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445231	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT445230	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT445229	hsa-miR-4314	PAR-CLIP	22100165
MIRT445228	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445227	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT445226	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT445225	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT755964	hsa-miR-29b-3p	Luciferase reporter assay, Western blotting, qRT-PCR, in vitro cullelar assays, ELISA	36277474
MIRT1388800	hsa-miR-106a	CLIP-seq
MIRT1388801	hsa-miR-106b	CLIP-seq
MIRT1388802	hsa-miR-1305	CLIP-seq
MIRT1388803	hsa-miR-130a	CLIP-seq
MIRT1388804	hsa-miR-130b	CLIP-seq
MIRT1388805	hsa-miR-145	CLIP-seq
MIRT1388806	hsa-miR-17	CLIP-seq
MIRT1388807	hsa-miR-19a	CLIP-seq
MIRT1388808	hsa-miR-19b	CLIP-seq
MIRT1388809	hsa-miR-20a	CLIP-seq
MIRT1388810	hsa-miR-20b	CLIP-seq
MIRT1388811	hsa-miR-2467-5p	CLIP-seq
MIRT1388812	hsa-miR-298	CLIP-seq
MIRT1388813	hsa-miR-301a	CLIP-seq
MIRT1388814	hsa-miR-301b	CLIP-seq
MIRT1388815	hsa-miR-3127-5p	CLIP-seq
MIRT1388816	hsa-miR-3188	CLIP-seq
MIRT1388817	hsa-miR-3646	CLIP-seq
MIRT1388818	hsa-miR-3666	CLIP-seq
MIRT1388819	hsa-miR-3667-3p	CLIP-seq
MIRT1388820	hsa-miR-3928	CLIP-seq
MIRT1388821	hsa-miR-3973	CLIP-seq
MIRT1388822	hsa-miR-3975	CLIP-seq
MIRT1388823	hsa-miR-4264	CLIP-seq
MIRT1388824	hsa-miR-4279	CLIP-seq
MIRT1388825	hsa-miR-4295	CLIP-seq
MIRT1388826	hsa-miR-4300	CLIP-seq
MIRT1388827	hsa-miR-4302	CLIP-seq
MIRT1388828	hsa-miR-4316	CLIP-seq
MIRT1388829	hsa-miR-4436b-3p	CLIP-seq
MIRT1388830	hsa-miR-4455	CLIP-seq
MIRT1388831	hsa-miR-4468	CLIP-seq
MIRT1388832	hsa-miR-4505	CLIP-seq
MIRT1388833	hsa-miR-454	CLIP-seq
MIRT1388834	hsa-miR-4633-3p	CLIP-seq
MIRT1388835	hsa-miR-4643	CLIP-seq
MIRT1388836	hsa-miR-4684-3p	CLIP-seq
MIRT1388837	hsa-miR-4710	CLIP-seq
MIRT1388838	hsa-miR-4717-5p	CLIP-seq
MIRT1388839	hsa-miR-4797-3p	CLIP-seq
MIRT1388840	hsa-miR-485-5p	CLIP-seq
MIRT1388841	hsa-miR-519a	CLIP-seq
MIRT1388842	hsa-miR-519b-3p	CLIP-seq
MIRT1388843	hsa-miR-519c-3p	CLIP-seq
MIRT1388844	hsa-miR-519d	CLIP-seq
MIRT1388845	hsa-miR-520g	CLIP-seq
MIRT1388846	hsa-miR-520h	CLIP-seq
MIRT1388847	hsa-miR-607	CLIP-seq
MIRT1388848	hsa-miR-609	CLIP-seq
MIRT1388849	hsa-miR-642b	CLIP-seq
MIRT1388850	hsa-miR-920	CLIP-seq
MIRT1388851	hsa-miR-93	CLIP-seq
MIRT1388852	hsa-miR-939	CLIP-seq
MIRT1388853	hsa-miR-1225-5p	CLIP-seq
MIRT1388854	hsa-miR-185	CLIP-seq
MIRT1388855	hsa-miR-2052	CLIP-seq
MIRT1388856	hsa-miR-31	CLIP-seq
MIRT1388857	hsa-miR-3135b	CLIP-seq
MIRT1388858	hsa-miR-3150b-3p	CLIP-seq
MIRT1388859	hsa-miR-335	CLIP-seq
MIRT1388860	hsa-miR-3591-3p	CLIP-seq
MIRT1388861	hsa-miR-383	CLIP-seq
MIRT1388862	hsa-miR-4306	CLIP-seq
MIRT1388863	hsa-miR-4328	CLIP-seq
MIRT1388864	hsa-miR-4419a	CLIP-seq
MIRT1388865	hsa-miR-4510	CLIP-seq
MIRT1388866	hsa-miR-4644	CLIP-seq
MIRT1388867	hsa-miR-4772-5p	CLIP-seq
MIRT1388868	hsa-miR-4784	CLIP-seq
MIRT1388869	hsa-miR-4802-5p	CLIP-seq
MIRT1388870	hsa-miR-488	CLIP-seq
MIRT1388871	hsa-miR-595	CLIP-seq
MIRT1388872	hsa-miR-765	CLIP-seq
MIRT1388830	hsa-miR-4455	CLIP-seq
MIRT1388836	hsa-miR-4684-3p	CLIP-seq
MIRT1388848	hsa-miR-609	CLIP-seq
MIRT1388802	hsa-miR-1305	CLIP-seq
MIRT2116559	hsa-miR-133a	CLIP-seq
MIRT2116560	hsa-miR-133b	CLIP-seq
MIRT2116561	hsa-miR-198	CLIP-seq
MIRT2116562	hsa-miR-320a	CLIP-seq
MIRT2116563	hsa-miR-320b	CLIP-seq
MIRT2116564	hsa-miR-320c	CLIP-seq
MIRT2116565	hsa-miR-320d	CLIP-seq
MIRT2116566	hsa-miR-320e	CLIP-seq
MIRT2116567	hsa-miR-325	CLIP-seq
MIRT1388821	hsa-miR-3973	CLIP-seq
MIRT1388822	hsa-miR-3975	CLIP-seq
MIRT2116568	hsa-miR-411	CLIP-seq
MIRT1388823	hsa-miR-4264	CLIP-seq
MIRT2116569	hsa-miR-4283	CLIP-seq
MIRT2116570	hsa-miR-4292	CLIP-seq
MIRT1388827	hsa-miR-4302	CLIP-seq
MIRT2116571	hsa-miR-4422	CLIP-seq
MIRT2116572	hsa-miR-4429	CLIP-seq
MIRT2116573	hsa-miR-4489	CLIP-seq
MIRT2116574	hsa-miR-4734	CLIP-seq
MIRT2116575	hsa-miR-4786-3p	CLIP-seq
MIRT1388839	hsa-miR-4797-3p	CLIP-seq
MIRT2116576	hsa-miR-520a-5p	CLIP-seq
MIRT1388845	hsa-miR-520g	CLIP-seq
MIRT1388846	hsa-miR-520h	CLIP-seq
MIRT2116577	hsa-miR-525-5p	CLIP-seq
MIRT1388847	hsa-miR-607	CLIP-seq
MIRT2116578	hsa-miR-9	CLIP-seq
MIRT2338914	hsa-miR-1231	CLIP-seq
MIRT2338915	hsa-miR-3064-5p	CLIP-seq
MIRT2338916	hsa-miR-3189-3p	CLIP-seq
MIRT2338917	hsa-miR-3663-5p	CLIP-seq
MIRT2338918	hsa-miR-3691-5p	CLIP-seq
MIRT2338919	hsa-miR-4687-3p	CLIP-seq
MIRT2338920	hsa-miR-4711-3p	CLIP-seq
MIRT2338921	hsa-miR-4752	CLIP-seq
MIRT2338922	hsa-miR-4764-5p	CLIP-seq
MIRT2338923	hsa-miR-7	CLIP-seq
MIRT2395168	hsa-miR-1293	CLIP-seq
MIRT2395169	hsa-miR-3064-3p	CLIP-seq
MIRT2395170	hsa-miR-3138	CLIP-seq
MIRT2395171	hsa-miR-4483	CLIP-seq
MIRT2395172	hsa-miR-4520a-3p	CLIP-seq
MIRT2632454	hsa-miR-1193	CLIP-seq
MIRT2632455	hsa-miR-1206	CLIP-seq
MIRT2632456	hsa-miR-1208	CLIP-seq
MIRT2632457	hsa-miR-1225-3p	CLIP-seq
MIRT2632458	hsa-miR-1233	CLIP-seq
MIRT2632459	hsa-miR-127-5p	CLIP-seq
MIRT2632460	hsa-miR-128	CLIP-seq
MIRT2632461	hsa-miR-1283	CLIP-seq
MIRT2632462	hsa-miR-1288	CLIP-seq
MIRT2632463	hsa-miR-1322	CLIP-seq
MIRT2632464	hsa-miR-138	CLIP-seq
MIRT1388805	hsa-miR-145	CLIP-seq
MIRT2632465	hsa-miR-149	CLIP-seq
MIRT2632466	hsa-miR-199a-5p	CLIP-seq
MIRT2632467	hsa-miR-199b-5p	CLIP-seq
MIRT2632468	hsa-miR-27a	CLIP-seq
MIRT2632469	hsa-miR-27b	CLIP-seq
MIRT2632470	hsa-miR-296-3p	CLIP-seq
MIRT2338915	hsa-miR-3064-5p	CLIP-seq
MIRT2632471	hsa-miR-3146	CLIP-seq
MIRT2632472	hsa-miR-3169	CLIP-seq
MIRT2632473	hsa-miR-3180-5p	CLIP-seq
MIRT2632474	hsa-miR-3184	CLIP-seq
MIRT2632475	hsa-miR-3194-3p	CLIP-seq
MIRT2632476	hsa-miR-326	CLIP-seq
MIRT2632477	hsa-miR-330-5p	CLIP-seq
MIRT2632478	hsa-miR-3661	CLIP-seq
MIRT2338917	hsa-miR-3663-5p	CLIP-seq
MIRT2632479	hsa-miR-3664-3p	CLIP-seq
MIRT2632480	hsa-miR-3670	CLIP-seq
MIRT2632481	hsa-miR-3672	CLIP-seq
MIRT2632482	hsa-miR-377	CLIP-seq
MIRT2632483	hsa-miR-3909	CLIP-seq
MIRT2632484	hsa-miR-3915	CLIP-seq
MIRT1388820	hsa-miR-3928	CLIP-seq
MIRT2632485	hsa-miR-423-5p	CLIP-seq
MIRT2632486	hsa-miR-4263	CLIP-seq
MIRT2632487	hsa-miR-4277	CLIP-seq
MIRT2632488	hsa-miR-4278	CLIP-seq
MIRT2632489	hsa-miR-4287	CLIP-seq
MIRT2632490	hsa-miR-4311	CLIP-seq
MIRT2632491	hsa-miR-433	CLIP-seq
MIRT2632492	hsa-miR-4421	CLIP-seq
MIRT2632493	hsa-miR-4436a	CLIP-seq
MIRT2632494	hsa-miR-4438	CLIP-seq
MIRT2632495	hsa-miR-4469	CLIP-seq
MIRT2632496	hsa-miR-4476	CLIP-seq
MIRT2632497	hsa-miR-4511	CLIP-seq
MIRT2632498	hsa-miR-4641	CLIP-seq
MIRT2632499	hsa-miR-4651	CLIP-seq
MIRT2632500	hsa-miR-4659a-5p	CLIP-seq
MIRT2632501	hsa-miR-4659b-5p	CLIP-seq
MIRT2632502	hsa-miR-4685-3p	CLIP-seq
MIRT2632503	hsa-miR-4716-3p	CLIP-seq
MIRT2632504	hsa-miR-4725-5p	CLIP-seq
MIRT2632505	hsa-miR-4733-3p	CLIP-seq
MIRT2632506	hsa-miR-4747-3p	CLIP-seq
MIRT2632507	hsa-miR-4786-5p	CLIP-seq
MIRT2632508	hsa-miR-4794	CLIP-seq
MIRT2632509	hsa-miR-4799-5p	CLIP-seq
MIRT1388870	hsa-miR-488	CLIP-seq
MIRT2632510	hsa-miR-504	CLIP-seq
MIRT2632511	hsa-miR-5095	CLIP-seq
MIRT2632512	hsa-miR-513a-5p	CLIP-seq
MIRT2632513	hsa-miR-539	CLIP-seq
MIRT2632514	hsa-miR-548b-3p	CLIP-seq
MIRT2632515	hsa-miR-570	CLIP-seq
MIRT2632516	hsa-miR-576-5p	CLIP-seq
MIRT2632517	hsa-miR-593	CLIP-seq
MIRT2632518	hsa-miR-608	CLIP-seq
MIRT2632519	hsa-miR-631	CLIP-seq
MIRT2632520	hsa-miR-649	CLIP-seq
MIRT2632521	hsa-miR-665	CLIP-seq
MIRT2632522	hsa-miR-759	CLIP-seq
MIRT2632523	hsa-miR-769-5p	CLIP-seq
MIRT2632454	hsa-miR-1193	CLIP-seq
MIRT2632455	hsa-miR-1206	CLIP-seq
MIRT2632456	hsa-miR-1208	CLIP-seq
MIRT2632457	hsa-miR-1225-3p	CLIP-seq
MIRT2632458	hsa-miR-1233	CLIP-seq
MIRT2632459	hsa-miR-127-5p	CLIP-seq
MIRT2632461	hsa-miR-1283	CLIP-seq
MIRT2632462	hsa-miR-1288	CLIP-seq
MIRT2632463	hsa-miR-1322	CLIP-seq
MIRT2632464	hsa-miR-138	CLIP-seq
MIRT1388805	hsa-miR-145	CLIP-seq
MIRT2632466	hsa-miR-199a-5p	CLIP-seq
MIRT2632467	hsa-miR-199b-5p	CLIP-seq
MIRT2632470	hsa-miR-296-3p	CLIP-seq
MIRT2632471	hsa-miR-3146	CLIP-seq
MIRT2632472	hsa-miR-3169	CLIP-seq
MIRT2632473	hsa-miR-3180-5p	CLIP-seq
MIRT2632474	hsa-miR-3184	CLIP-seq
MIRT2338917	hsa-miR-3663-5p	CLIP-seq
MIRT2632479	hsa-miR-3664-3p	CLIP-seq
MIRT2632481	hsa-miR-3672	CLIP-seq
MIRT2632482	hsa-miR-377	CLIP-seq
MIRT2632483	hsa-miR-3909	CLIP-seq
MIRT2632484	hsa-miR-3915	CLIP-seq
MIRT1388820	hsa-miR-3928	CLIP-seq
MIRT2632485	hsa-miR-423-5p	CLIP-seq
MIRT2632486	hsa-miR-4263	CLIP-seq
MIRT2632487	hsa-miR-4277	CLIP-seq
MIRT2632488	hsa-miR-4278	CLIP-seq
MIRT2632489	hsa-miR-4287	CLIP-seq
MIRT2691956	hsa-miR-4308	CLIP-seq
MIRT2632491	hsa-miR-433	CLIP-seq
MIRT2632493	hsa-miR-4436a	CLIP-seq
MIRT2632494	hsa-miR-4438	CLIP-seq
MIRT2632495	hsa-miR-4469	CLIP-seq
MIRT2632496	hsa-miR-4476	CLIP-seq
MIRT2691957	hsa-miR-4640-5p	CLIP-seq
MIRT2632498	hsa-miR-4641	CLIP-seq
MIRT2632499	hsa-miR-4651	CLIP-seq
MIRT2632500	hsa-miR-4659a-5p	CLIP-seq
MIRT2632501	hsa-miR-4659b-5p	CLIP-seq
MIRT2632502	hsa-miR-4685-3p	CLIP-seq
MIRT2632503	hsa-miR-4716-3p	CLIP-seq
MIRT2632504	hsa-miR-4725-5p	CLIP-seq
MIRT2691958	hsa-miR-4726-5p	CLIP-seq
MIRT2632505	hsa-miR-4733-3p	CLIP-seq
MIRT2632507	hsa-miR-4786-5p	CLIP-seq
MIRT2632508	hsa-miR-4794	CLIP-seq
MIRT2632509	hsa-miR-4799-5p	CLIP-seq
MIRT2632510	hsa-miR-504	CLIP-seq
MIRT2632511	hsa-miR-5095	CLIP-seq
MIRT2632516	hsa-miR-576-5p	CLIP-seq
MIRT2632518	hsa-miR-608	CLIP-seq
MIRT2632521	hsa-miR-665	CLIP-seq
MIRT2632522	hsa-miR-759	CLIP-seq
MIRT2632523	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003363	Process	Lamellipodium assembly involved in ameboidal cell migration	IMP	20810653
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	21148482, 27373832
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	IMP	20810653
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	15161933, 16318909, 17500595, 19807924, 20810653, 21148482, 22559944, 26365803, 28514442, 33961781, 35271311, 36931259
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	21148482
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007399	Process	Nervous system development	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0016020	Component	Membrane	IEA
GO:0021816	Process	Extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	IEA
GO:0021816	Process	Extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	ISS
GO:0030027	Component	Lamellipodium	IDA	20810653
GO:0030027	Component	Lamellipodium	IEA
GO:0030334	Process	Regulation of cell migration	IEA
GO:0030336	Process	Negative regulation of cell migration	IBA
GO:0031267	Function	Small GTPase binding	IDA	20810653, 21148482
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IMP	20810653
GO:0042802	Function	Identical protein binding	IPI	20810653, 26365803
GO:0042803	Function	Protein homodimerization activity	IDA	20810653
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043197	Component	Dendritic spine	IBA
GO:0043197	Component	Dendritic spine	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	21148482, 27373832
GO:0043547	Process	Positive regulation of GTPase activity	IMP	20810653
GO:0044327	Component	Dendritic spine head	IDA	22559944
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045335	Component	Phagocytic vesicle	ISS
GO:0046847	Process	Filopodium assembly	IDA	22559944
GO:0046847	Process	Filopodium assembly	IEA
GO:0048812	Process	Neuron projection morphogenesis	IEA
GO:0048812	Process	Neuron projection morphogenesis	ISS
GO:0051014	Process	Actin filament severing	IDA	21148482
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051963	Process	Regulation of synapse assembly	IBA
GO:0051963	Process	Regulation of synapse assembly	IEA
GO:0060996	Process	Dendritic spine development	IDA	22559944
GO:0060996	Process	Dendritic spine development	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1904861	Process	Excitatory synapse assembly	IDA	27373832
GO:1904861	Process	Excitatory synapse assembly	IEA
GO:1904862	Process	Inhibitory synapse assembly	IDA	27373832
GO:1904862	Process	Inhibitory synapse assembly	IEA
GO:2001223	Process	Negative regulation of neuron migration	IDA	22559944

Other IDs

• MIM: 606524
• HGNC: 19751
• e!Ensembl: ENSG00000266028

Protein

• UniProt ID: O75044
• Protein name: SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)
• Protein function: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibi
• PDB: 2DL8, 4RTT, 4RUG, 5I6J, 5I6R, 5I7D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00611	FCH	31 → 115	Fes/CIP4, and EFC/F-BAR homology domain	Family
  PF00620	RhoGAP	505 → 657	RhoGAP domain	Domain
  PF00018	SH3_1	734 → 779	SH3 domain	Domain

• Sequence:

  MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE
  MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY
  LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK
  LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT
  ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL
  NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ
  PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME
  SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE
  SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN
  AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH
  IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC
  QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE
  HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ
  YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR
  PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS
  LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL
  ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC
  AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV

• Sequence length: 1071

Pathways

KEGG:

Axon guidance

Reactome:

Rho GTPase cycle
RHO GTPases Activate Formins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
NON-SPECIFIC EARLY-ONSET EPILEPTIC ENCEPHALOPATHY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SRGAP2-associated Neurodevelopmental Disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	Pubtator	35205259	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	21738711, 23108406		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21738711	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35913371	Associate	★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	LHGDN	12736724		★☆☆☆☆ Found in Text Mining only
Chromosome 3, monosomy 3p	Monosomy 3p	GENOMICS_ENGLAND_DG	26350204		★☆☆☆☆ Found in Text Mining only
Chromosome 3, monosomy 3p25	Monosomy 3p25	CTD_human_DG	21082655		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	23040932	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	19760623		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	37952894	Inhibit	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	29242313		★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	Pubtator	28912560	Associate	★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Hydatidiform Mole	BEFREE	22559943		★☆☆☆☆ Found in Text Mining only
HYDATIDIFORM MOLE, RECURRENT, 1	Hydatidiform Mole	BEFREE	22559943		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	GWASDB_DG	22384028		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	12195014, 17215396, 19760623, 21082655, 21325512, 22965684, 23127797, 23505444, 29568072		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intellectual Disability	Mental retardation	LHGDN	12195014		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intellectual Disability	Mental retardation	CTD_human_DG	21082655		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intellectual Disability	Intellectual developmental disorder	Pubtator	23040932	Associate	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Malignant neoplasm of breast	Breast Cancer	BEFREE	21738711, 23108406		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26458489		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	LHGDN	12736724		★☆☆☆☆ Found in Text Mining only
Mental deficiency	Mental retardation	CTD_human_DG	21082655		★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	12195014, 17215396, 19760623, 21082655, 21325512, 23505444, 29568072		★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	BEFREE	22965684		★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23108406, 29242313		★☆☆☆☆ Found in Text Mining only
Neoplasms, Germ Cell and Embryonal	Neoplasm	LHGDN	12736724		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	23505444		★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	CTD_human_DG	28191889		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	27966608		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	36277474	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	20035503		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	20035503	Associate	★☆☆☆☆ Found in Text Mining only
Pilomyxoid astrocytoma	Pilomyxoid Astrocytoma	ORPHANET_DG	19363522, 22159586		★☆☆☆☆ Found in Text Mining only
Pilomyxoid astrocytoma	Pilomyxoid Astrocytoma	Orphanet			★☆☆☆☆ Found in Text Mining only
Profound Mental Retardation	Mental retardation	CTD_human_DG	21082655		★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	LHGDN	12736724		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	PSYGENET_DG	22820399		★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	BEFREE	12195014		★☆☆☆☆ Found in Text Mining only
X-linked infantile spasms	Spasms X-Linked	BEFREE	22106086		★☆☆☆☆ Found in Text Mining only