Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23378
Gene name	Ribosomal RNA processing 8
Gene symbol	RRP8
Synonyms (NCBI Gene)	KIAA0409NML
Chromosome	11
Chromosome location	11p15.4

126

Show/Hide all (126)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005242	hsa-let-7b-5p	pSILAC	18668040
MIRT005242	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT719754	hsa-miR-6771-3p	HITS-CLIP	19536157
MIRT719753	hsa-miR-4999-3p	HITS-CLIP	19536157
MIRT719752	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT719751	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT719750	hsa-miR-4786-5p	HITS-CLIP	19536157
MIRT719749	hsa-miR-3926	HITS-CLIP	19536157
MIRT719748	hsa-miR-548s	HITS-CLIP	19536157
MIRT532112	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT532111	hsa-miR-5583-3p	PAR-CLIP	22012620
MIRT532110	hsa-miR-8076	PAR-CLIP	22012620
MIRT532109	hsa-miR-1246	PAR-CLIP	22012620
MIRT532108	hsa-miR-3973	PAR-CLIP	22012620
MIRT532107	hsa-miR-520g-3p	PAR-CLIP	22012620
MIRT532106	hsa-miR-520h	PAR-CLIP	22012620
MIRT532105	hsa-miR-323b-3p	PAR-CLIP	22012620
MIRT532104	hsa-miR-4764-5p	PAR-CLIP	22012620
MIRT532103	hsa-miR-578	PAR-CLIP	22012620
MIRT447855	hsa-miR-100-3p	PAR-CLIP	22291592
MIRT447854	hsa-miR-3928-3p	PAR-CLIP	22291592
MIRT447853	hsa-miR-3915	PAR-CLIP	22291592
MIRT447852	hsa-miR-1224-5p	PAR-CLIP	22291592
MIRT447851	hsa-miR-4689	PAR-CLIP	22291592
MIRT447850	hsa-miR-6858-5p	PAR-CLIP	22291592
MIRT447849	hsa-miR-3978	PAR-CLIP	22291592
MIRT447855	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447854	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447853	hsa-miR-3915	PAR-CLIP	22100165
MIRT447852	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447851	hsa-miR-4689	PAR-CLIP	22100165
MIRT447850	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT447849	hsa-miR-3978	PAR-CLIP	22100165
MIRT447855	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447854	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447853	hsa-miR-3915	PAR-CLIP	22100165
MIRT447852	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447851	hsa-miR-4689	PAR-CLIP	22100165
MIRT447850	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT447849	hsa-miR-3978	PAR-CLIP	22100165
MIRT532109	hsa-miR-1246	PAR-CLIP	27292025
MIRT532109	hsa-miR-1246	PAR-CLIP	27292025
MIRT532109	hsa-miR-1246	PAR-CLIP	27292025
MIRT532105	hsa-miR-323b-3p	PAR-CLIP	27292025
MIRT532105	hsa-miR-323b-3p	PAR-CLIP	27292025
MIRT532105	hsa-miR-323b-3p	PAR-CLIP	27292025
MIRT532108	hsa-miR-3973	PAR-CLIP	27292025
MIRT532108	hsa-miR-3973	PAR-CLIP	27292025
MIRT532108	hsa-miR-3973	PAR-CLIP	27292025
MIRT532104	hsa-miR-4764-5p	PAR-CLIP	27292025
MIRT532104	hsa-miR-4764-5p	PAR-CLIP	27292025
MIRT532107	hsa-miR-520g-3p	PAR-CLIP	27292025
MIRT532107	hsa-miR-520g-3p	PAR-CLIP	27292025
MIRT532107	hsa-miR-520g-3p	PAR-CLIP	27292025
MIRT532106	hsa-miR-520h	PAR-CLIP	27292025
MIRT532106	hsa-miR-520h	PAR-CLIP	27292025
MIRT532106	hsa-miR-520h	PAR-CLIP	27292025
MIRT532111	hsa-miR-5583-3p	PAR-CLIP	27292025
MIRT532111	hsa-miR-5583-3p	PAR-CLIP	27292025
MIRT532111	hsa-miR-5583-3p	PAR-CLIP	27292025
MIRT532103	hsa-miR-578	PAR-CLIP	27292025
MIRT532103	hsa-miR-578	PAR-CLIP	27292025
MIRT532103	hsa-miR-578	PAR-CLIP	27292025
MIRT532112	hsa-miR-6507-3p	PAR-CLIP	27292025
MIRT532112	hsa-miR-6507-3p	PAR-CLIP	27292025
MIRT532112	hsa-miR-6507-3p	PAR-CLIP	27292025
MIRT532110	hsa-miR-8076	PAR-CLIP	27292025
MIRT532110	hsa-miR-8076	PAR-CLIP	27292025
MIRT532110	hsa-miR-8076	PAR-CLIP	27292025
MIRT719754	hsa-miR-6771-3p	HITS-CLIP	19536157
MIRT719753	hsa-miR-4999-3p	HITS-CLIP	19536157
MIRT719752	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT719751	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT719750	hsa-miR-4786-5p	HITS-CLIP	19536157
MIRT719749	hsa-miR-3926	HITS-CLIP	19536157
MIRT719748	hsa-miR-548s	HITS-CLIP	19536157
MIRT532112	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT532111	hsa-miR-5583-3p	PAR-CLIP	22012620
MIRT532110	hsa-miR-8076	PAR-CLIP	22012620
MIRT532109	hsa-miR-1246	PAR-CLIP	22012620
MIRT532108	hsa-miR-3973	PAR-CLIP	22012620
MIRT532107	hsa-miR-520g-3p	PAR-CLIP	22012620
MIRT532106	hsa-miR-520h	PAR-CLIP	22012620
MIRT532105	hsa-miR-323b-3p	PAR-CLIP	22012620
MIRT532104	hsa-miR-4764-5p	PAR-CLIP	22012620
MIRT532103	hsa-miR-578	PAR-CLIP	22012620
MIRT447855	hsa-miR-100-3p	PAR-CLIP	22291592
MIRT447854	hsa-miR-3928-3p	PAR-CLIP	22291592
MIRT447853	hsa-miR-3915	PAR-CLIP	22291592
MIRT447852	hsa-miR-1224-5p	PAR-CLIP	22291592
MIRT447851	hsa-miR-4689	PAR-CLIP	22291592
MIRT447850	hsa-miR-6858-5p	PAR-CLIP	22291592
MIRT447849	hsa-miR-3978	PAR-CLIP	22291592
MIRT447855	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447854	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447853	hsa-miR-3915	PAR-CLIP	22100165
MIRT447852	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447851	hsa-miR-4689	PAR-CLIP	22100165
MIRT447850	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT447849	hsa-miR-3978	PAR-CLIP	22100165
MIRT447855	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447854	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447853	hsa-miR-3915	PAR-CLIP	22100165
MIRT447852	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447851	hsa-miR-4689	PAR-CLIP	22100165
MIRT447850	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT447849	hsa-miR-3978	PAR-CLIP	22100165
MIRT1320765	hsa-miR-1266	CLIP-seq
MIRT1320766	hsa-miR-3914	CLIP-seq
MIRT1320767	hsa-miR-4518	CLIP-seq
MIRT1320768	hsa-miR-4733-3p	CLIP-seq
MIRT1320769	hsa-miR-873	CLIP-seq
MIRT2319579	hsa-miR-199a-3p	CLIP-seq
MIRT2319580	hsa-miR-199b-3p	CLIP-seq
MIRT2319581	hsa-miR-2278	CLIP-seq
MIRT2319582	hsa-miR-3129-5p	CLIP-seq
MIRT2319583	hsa-miR-3164	CLIP-seq
MIRT2319584	hsa-miR-3943	CLIP-seq
MIRT2319585	hsa-miR-4257	CLIP-seq
MIRT2319586	hsa-miR-4303	CLIP-seq
MIRT2319587	hsa-miR-4323	CLIP-seq
MIRT2319588	hsa-miR-4732-5p	CLIP-seq
MIRT2319589	hsa-miR-936	CLIP-seq
MIRT2393923	hsa-miR-2355-3p	CLIP-seq
MIRT2393924	hsa-miR-4646-3p	CLIP-seq
MIRT2393925	hsa-miR-676	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000183	Process	RDNA heterochromatin formation	IBA
GO:0000183	Process	RDNA heterochromatin formation	IDA	18485871
GO:0000183	Process	RDNA heterochromatin formation	IMP	18485871
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	18485871, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005677	Component	Chromatin silencing complex	IBA
GO:0005677	Component	Chromatin silencing complex	IDA	18485871
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	18485871
GO:0005730	Component	Nucleolus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0033553	Component	RDNA heterochromatin	IBA
GO:0033553	Component	RDNA heterochromatin	IDA	18485871
GO:0042149	Process	Cellular response to glucose starvation	IBA
GO:0042149	Process	Cellular response to glucose starvation	IMP	18485871, 21471221
GO:0045786	Process	Negative regulation of cell cycle	IMP	18485871
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	18485871
GO:0046015	Process	Regulation of transcription by glucose	IBA
GO:0046015	Process	Regulation of transcription by glucose	IMP	18485871, 21471221
GO:0061773	Component	ENoSc complex	IPI	18485871
GO:0062072	Function	Histone H3K9me2/3 reader activity	TAS	18485871
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IMP	21471221
GO:0097009	Process	Energy homeostasis	IMP	18485871
GO:1903450	Process	Regulation of G1 to G0 transition	IMP	21471221

MIM	HGNC	e!Ensembl
615818	29030	ENSG00000132275

O43159

Protein name

Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)

Protein function

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to

PDB

2ZFU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05148	Methyltransf_8	237 → 456	Hypothetical methyltransferase	Family

Sequence

MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLC
ISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQA
LVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPP
HTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRA
RMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIA
RDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVA
VFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLT
NSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR

Sequence length

456

Interactions

View interactions

	Reactome
			SIRT1 negatively regulates rRNA expression

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Autism spectrum disorder	association	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35833147	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	25807976		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	26505814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	30093689		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic syndrome	Pubtator	30093689	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30093689	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RRP8 (ribosomal RNA processing 8)