Gene Gene information from NCBI Gene database.
Entrez ID 23367
Gene name La ribonucleoprotein 1, translational regulator
Gene symbol LARP1
Synonyms (NCBI Gene)
LARPLar1Lhp1
Chromosome 5
Chromosome location 5q33.2
miRNA miRNA information provided by mirtarbase database.
1691
miRTarBase ID miRNA Experiments Reference
MIRT022798 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT025490 hsa-miR-34a-5p Proteomics 21566225
MIRT031766 hsa-miR-16-5p Proteomics 18668040
MIRT052560 hsa-let-7a-5p CLASH 23622248
MIRT052312 hsa-let-7b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0000339 Function RNA cap binding IDA 24532714
GO:0000339 Function RNA cap binding IEA
GO:0000340 Function RNA 7-methylguanosine cap binding IDA 28379136
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612059 29531 ENSG00000155506
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6PKG0
Protein name La-related protein 1 (La ribonucleoprotein domain family member 1)
Protein function RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, Pub
PDB 4ZC4 , 5C0V , 5V4R , 5V7C , 5V87 , 6PW3 , 7SOO , 7SOP , 7SOQ , 7SOR , 7SOS , 7SOT , 7SOU , 7SOV , 7SOW , 8EY6 , 8EY7 , 8EY8 , 8G90 , 8G91 , 8XP2 , 8XP3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05383 La 407 463 La domain Domain
Sequence
MATQVEPLLPGGATLLQAEEHGGLVRKKPPPAPEGKGEPGPNDVRGGEPDGSARRPRPPC
AKPHKEGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAP
PPKVNPWTKNALPPVLTTVNGQSPPEHSAPAKVVRAAVPKQRKGSKVGDFGDAINWPTPG
EIAHKSVQPQSHKPQPTRKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQR
GGQKKKGNKHKWVPLQIDMKPEVPREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVA
PPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFD
YQFGYRKFDGVEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNL
ERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKD
SKVVEIVDEKVRRREEP
EKWPLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKT
LPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLPQQLPSQQLMSKDQD
EQEELDFLFDEEMEQMDGRKNTFTAWSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGGD
RTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQF
DTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNT
RTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSRE
HRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNE
RKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSY
GLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRR
LEDFRVDPPMGEEGNHKRHSVVAGGGGGEGRKRCPSQSSSRPAAMISQPPTPPTGQPVRE
DAKWTSQHSNTQTLGK
Sequence length 1096
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHOLECYSTITIS, ACUTE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIFFUSE GASTRIC ADENOCARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
5q-syndrome 5q-syndrome BEFREE 28673543
★☆☆☆☆
Found in Text Mining only
Anemia Macrocytic Macrocytic anemia Pubtator 28673543 Associate
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Autism Pubtator 39182167 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma Pubtator 39786317 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 24159927 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 29969631
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 26717985
★☆☆☆☆
Found in Text Mining only
Chromosome 5q Deletion Syndrome Chromosome 5q deletion syndrome Pubtator 28673543 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 27614686
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 27614686 Stimulate
★☆☆☆☆
Found in Text Mining only