ARHGEF12 (Rho guanine nucleotide exchange factor 12)

Gene

• Entrez ID: 23365
• Gene name: Rho guanine nucleotide exchange factor 12
• Gene symbol: ARHGEF12
• Synonyms (NCBI Gene): LARG, PRO2792
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This pr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030993	hsa-miR-21-5p	Microarray	18591254
MIRT047997	hsa-miR-30c-5p	CLASH	23622248
MIRT036542	hsa-miR-1225-3p	CLASH	23622248
MIRT705580	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT705579	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT705578	hsa-miR-660-5p	HITS-CLIP	23313552
MIRT705577	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT705576	hsa-miR-7-5p	HITS-CLIP	23313552
MIRT705575	hsa-miR-6077	HITS-CLIP	23313552
MIRT705580	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT705579	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT705578	hsa-miR-660-5p	HITS-CLIP	23313552
MIRT705577	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT705576	hsa-miR-7-5p	HITS-CLIP	23313552
MIRT705575	hsa-miR-6077	HITS-CLIP	23313552
MIRT795356	hsa-miR-1183	CLIP-seq
MIRT795357	hsa-miR-1185	CLIP-seq
MIRT795358	hsa-miR-1224-3p	CLIP-seq
MIRT795359	hsa-miR-1224-5p	CLIP-seq
MIRT795360	hsa-miR-124	CLIP-seq
MIRT795361	hsa-miR-1243	CLIP-seq
MIRT795362	hsa-miR-1260	CLIP-seq
MIRT795363	hsa-miR-1260b	CLIP-seq
MIRT795364	hsa-miR-1261	CLIP-seq
MIRT795365	hsa-miR-1271	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT795367	hsa-miR-1280	CLIP-seq
MIRT795368	hsa-miR-1284	CLIP-seq
MIRT795369	hsa-miR-1297	CLIP-seq
MIRT795370	hsa-miR-1301	CLIP-seq
MIRT795371	hsa-miR-1305	CLIP-seq
MIRT795372	hsa-miR-130a	CLIP-seq
MIRT795373	hsa-miR-130b	CLIP-seq
MIRT795374	hsa-miR-15a	CLIP-seq
MIRT795375	hsa-miR-15b	CLIP-seq
MIRT795376	hsa-miR-16	CLIP-seq
MIRT795377	hsa-miR-182	CLIP-seq
MIRT795378	hsa-miR-195	CLIP-seq
MIRT795379	hsa-miR-200b	CLIP-seq
MIRT795380	hsa-miR-200c	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT795382	hsa-miR-22	CLIP-seq
MIRT795383	hsa-miR-26a	CLIP-seq
MIRT795384	hsa-miR-26b	CLIP-seq
MIRT795385	hsa-miR-301a	CLIP-seq
MIRT795386	hsa-miR-301b	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT795388	hsa-miR-3124-3p	CLIP-seq
MIRT795389	hsa-miR-337-3p	CLIP-seq
MIRT795390	hsa-miR-3605-5p	CLIP-seq
MIRT795391	hsa-miR-3606	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT795393	hsa-miR-3613-3p	CLIP-seq
MIRT795394	hsa-miR-361-5p	CLIP-seq
MIRT795395	hsa-miR-3654	CLIP-seq
MIRT795396	hsa-miR-3660	CLIP-seq
MIRT795397	hsa-miR-3662	CLIP-seq
MIRT795398	hsa-miR-3666	CLIP-seq
MIRT795399	hsa-miR-3673	CLIP-seq
MIRT795400	hsa-miR-3679-5p	CLIP-seq
MIRT795401	hsa-miR-3714	CLIP-seq
MIRT795402	hsa-miR-3910	CLIP-seq
MIRT795403	hsa-miR-3915	CLIP-seq
MIRT795404	hsa-miR-3919	CLIP-seq
MIRT795405	hsa-miR-3928	CLIP-seq
MIRT795406	hsa-miR-3941	CLIP-seq
MIRT795407	hsa-miR-3944-5p	CLIP-seq
MIRT795408	hsa-miR-424	CLIP-seq
MIRT795409	hsa-miR-4259	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT795411	hsa-miR-4274	CLIP-seq
MIRT795412	hsa-miR-429	CLIP-seq
MIRT795413	hsa-miR-4295	CLIP-seq
MIRT795414	hsa-miR-4420	CLIP-seq
MIRT795415	hsa-miR-4453	CLIP-seq
MIRT795416	hsa-miR-4465	CLIP-seq
MIRT795417	hsa-miR-4470	CLIP-seq
MIRT795418	hsa-miR-4473	CLIP-seq
MIRT795419	hsa-miR-4519	CLIP-seq
MIRT795420	hsa-miR-4520a-3p	CLIP-seq
MIRT795421	hsa-miR-4524	CLIP-seq
MIRT795422	hsa-miR-4526	CLIP-seq
MIRT795423	hsa-miR-4538	CLIP-seq
MIRT795424	hsa-miR-454	CLIP-seq
MIRT795425	hsa-miR-4638-3p	CLIP-seq
MIRT795426	hsa-miR-4645-3p	CLIP-seq
MIRT795427	hsa-miR-466	CLIP-seq
MIRT795428	hsa-miR-4660	CLIP-seq
MIRT795429	hsa-miR-4671-3p	CLIP-seq
MIRT795430	hsa-miR-4672	CLIP-seq
MIRT795431	hsa-miR-4677-3p	CLIP-seq
MIRT795432	hsa-miR-4686	CLIP-seq
MIRT795433	hsa-miR-4689	CLIP-seq
MIRT795434	hsa-miR-4704-3p	CLIP-seq
MIRT795435	hsa-miR-4715-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795437	hsa-miR-4731-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT795439	hsa-miR-4756-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT795441	hsa-miR-4763-5p	CLIP-seq
MIRT795442	hsa-miR-4766-3p	CLIP-seq
MIRT795443	hsa-miR-4781-3p	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT795445	hsa-miR-4801	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT795447	hsa-miR-497	CLIP-seq
MIRT795448	hsa-miR-498	CLIP-seq
MIRT795449	hsa-miR-503	CLIP-seq
MIRT795450	hsa-miR-5047	CLIP-seq
MIRT795451	hsa-miR-506	CLIP-seq
MIRT795452	hsa-miR-515-3p	CLIP-seq
MIRT795453	hsa-miR-519e	CLIP-seq
MIRT795454	hsa-miR-520d-5p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT795456	hsa-miR-524-5p	CLIP-seq
MIRT795457	hsa-miR-548m	CLIP-seq
MIRT795458	hsa-miR-550a	CLIP-seq
MIRT795459	hsa-miR-567	CLIP-seq
MIRT795460	hsa-miR-568	CLIP-seq
MIRT795461	hsa-miR-577	CLIP-seq
MIRT795462	hsa-miR-587	CLIP-seq
MIRT795463	hsa-miR-596	CLIP-seq
MIRT795464	hsa-miR-619	CLIP-seq
MIRT795465	hsa-miR-646	CLIP-seq
MIRT795466	hsa-miR-654-3p	CLIP-seq
MIRT795467	hsa-miR-659	CLIP-seq
MIRT795468	hsa-miR-875-3p	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT795470	hsa-miR-935	CLIP-seq
MIRT795471	hsa-miR-943	CLIP-seq
MIRT795472	hsa-miR-96	CLIP-seq
MIRT795473	hsa-miR-1255a	CLIP-seq
MIRT795474	hsa-miR-1255b	CLIP-seq
MIRT795364	hsa-miR-1261	CLIP-seq
MIRT795475	hsa-miR-1291	CLIP-seq
MIRT795476	hsa-miR-1294	CLIP-seq
MIRT795477	hsa-miR-142-5p	CLIP-seq
MIRT795478	hsa-miR-151-3p	CLIP-seq
MIRT795479	hsa-miR-3145-3p	CLIP-seq
MIRT795480	hsa-miR-3149	CLIP-seq
MIRT795481	hsa-miR-3173-5p	CLIP-seq
MIRT795482	hsa-miR-3180-5p	CLIP-seq
MIRT795483	hsa-miR-3647-3p	CLIP-seq
MIRT795484	hsa-miR-3942-3p	CLIP-seq
MIRT795485	hsa-miR-4260	CLIP-seq
MIRT795486	hsa-miR-4283	CLIP-seq
MIRT795487	hsa-miR-4316	CLIP-seq
MIRT795488	hsa-miR-4489	CLIP-seq
MIRT795489	hsa-miR-4514	CLIP-seq
MIRT795490	hsa-miR-4639-3p	CLIP-seq
MIRT795491	hsa-miR-4652-3p	CLIP-seq
MIRT795492	hsa-miR-4662a-3p	CLIP-seq
MIRT795431	hsa-miR-4677-3p	CLIP-seq
MIRT795493	hsa-miR-4692	CLIP-seq
MIRT795494	hsa-miR-4694-3p	CLIP-seq
MIRT795495	hsa-miR-4735-5p	CLIP-seq
MIRT795496	hsa-miR-4775	CLIP-seq
MIRT795497	hsa-miR-4777-5p	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT795498	hsa-miR-520a-5p	CLIP-seq
MIRT795454	hsa-miR-520d-5p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT795456	hsa-miR-524-5p	CLIP-seq
MIRT795499	hsa-miR-525-5p	CLIP-seq
MIRT795457	hsa-miR-548m	CLIP-seq
MIRT795500	hsa-miR-561	CLIP-seq
MIRT795501	hsa-miR-590-3p	CLIP-seq
MIRT795502	hsa-miR-635	CLIP-seq
MIRT795471	hsa-miR-943	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT1934819	hsa-miR-103b	CLIP-seq
MIRT1934820	hsa-miR-10a	CLIP-seq
MIRT1934821	hsa-miR-10b	CLIP-seq
MIRT1934822	hsa-miR-1184	CLIP-seq
MIRT795357	hsa-miR-1185	CLIP-seq
MIRT1934823	hsa-miR-1205	CLIP-seq
MIRT795359	hsa-miR-1224-5p	CLIP-seq
MIRT1934824	hsa-miR-1265	CLIP-seq
MIRT1934825	hsa-miR-1266	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT1934826	hsa-miR-142-3p	CLIP-seq
MIRT1934827	hsa-miR-145	CLIP-seq
MIRT1934828	hsa-miR-1909	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT1934829	hsa-miR-3064-5p	CLIP-seq
MIRT1934830	hsa-miR-3074-5p	CLIP-seq
MIRT1934831	hsa-miR-3123	CLIP-seq
MIRT1934832	hsa-miR-3127-5p	CLIP-seq
MIRT1934833	hsa-miR-3158-5p	CLIP-seq
MIRT1934834	hsa-miR-3160-5p	CLIP-seq
MIRT1934835	hsa-miR-3163	CLIP-seq
MIRT1934836	hsa-miR-3176	CLIP-seq
MIRT795482	hsa-miR-3180-5p	CLIP-seq
MIRT1934837	hsa-miR-324-5p	CLIP-seq
MIRT1934838	hsa-miR-325	CLIP-seq
MIRT795389	hsa-miR-337-3p	CLIP-seq
MIRT1934839	hsa-miR-3545-3p	CLIP-seq
MIRT795390	hsa-miR-3605-5p	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT795394	hsa-miR-361-5p	CLIP-seq
MIRT795397	hsa-miR-3662	CLIP-seq
MIRT1934840	hsa-miR-3671	CLIP-seq
MIRT795400	hsa-miR-3679-5p	CLIP-seq
MIRT1934841	hsa-miR-3682-5p	CLIP-seq
MIRT1934842	hsa-miR-3685	CLIP-seq
MIRT1934843	hsa-miR-370	CLIP-seq
MIRT1934844	hsa-miR-376a	CLIP-seq
MIRT1934845	hsa-miR-376b	CLIP-seq
MIRT1934846	hsa-miR-380	CLIP-seq
MIRT1934847	hsa-miR-384	CLIP-seq
MIRT1934848	hsa-miR-3914	CLIP-seq
MIRT795403	hsa-miR-3915	CLIP-seq
MIRT1934849	hsa-miR-3918	CLIP-seq
MIRT1934850	hsa-miR-3920	CLIP-seq
MIRT1934851	hsa-miR-3921	CLIP-seq
MIRT1934852	hsa-miR-3922-3p	CLIP-seq
MIRT1934853	hsa-miR-3925-5p	CLIP-seq
MIRT795405	hsa-miR-3928	CLIP-seq
MIRT795406	hsa-miR-3941	CLIP-seq
MIRT1934854	hsa-miR-4252	CLIP-seq
MIRT1934855	hsa-miR-4256	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT1934856	hsa-miR-4327	CLIP-seq
MIRT1934857	hsa-miR-4328	CLIP-seq
MIRT1934858	hsa-miR-4428	CLIP-seq
MIRT1934859	hsa-miR-4476	CLIP-seq
MIRT1934860	hsa-miR-4477a	CLIP-seq
MIRT1934861	hsa-miR-4502	CLIP-seq
MIRT1934862	hsa-miR-4518	CLIP-seq
MIRT795420	hsa-miR-4520a-3p	CLIP-seq
MIRT1934863	hsa-miR-4539	CLIP-seq
MIRT1934864	hsa-miR-4540	CLIP-seq
MIRT795490	hsa-miR-4639-3p	CLIP-seq
MIRT1934865	hsa-miR-4653-5p	CLIP-seq
MIRT795427	hsa-miR-466	CLIP-seq
MIRT795430	hsa-miR-4672	CLIP-seq
MIRT795431	hsa-miR-4677-3p	CLIP-seq
MIRT795433	hsa-miR-4689	CLIP-seq
MIRT1934866	hsa-miR-4699-3p	CLIP-seq
MIRT1934867	hsa-miR-4710	CLIP-seq
MIRT1934868	hsa-miR-4715-3p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795437	hsa-miR-4731-3p	CLIP-seq
MIRT1934869	hsa-miR-4738-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT1934870	hsa-miR-4753-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934871	hsa-miR-4764-5p	CLIP-seq
MIRT1934872	hsa-miR-4766-5p	CLIP-seq
MIRT1934873	hsa-miR-4768-5p	CLIP-seq
MIRT1934874	hsa-miR-4776-3p	CLIP-seq
MIRT795443	hsa-miR-4781-3p	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT1934875	hsa-miR-4792	CLIP-seq
MIRT1934876	hsa-miR-4795-3p	CLIP-seq
MIRT1934877	hsa-miR-4797-3p	CLIP-seq
MIRT795445	hsa-miR-4801	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT1934878	hsa-miR-494	CLIP-seq
MIRT795448	hsa-miR-498	CLIP-seq
MIRT795498	hsa-miR-520a-5p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT795499	hsa-miR-525-5p	CLIP-seq
MIRT1934879	hsa-miR-539	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT1934881	hsa-miR-548ae	CLIP-seq
MIRT1934882	hsa-miR-548aj	CLIP-seq
MIRT1934883	hsa-miR-548am	CLIP-seq
MIRT1934884	hsa-miR-548c-3p	CLIP-seq
MIRT1934885	hsa-miR-548p	CLIP-seq
MIRT1934886	hsa-miR-548x	CLIP-seq
MIRT795500	hsa-miR-561	CLIP-seq
MIRT795459	hsa-miR-567	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT1934888	hsa-miR-628-3p	CLIP-seq
MIRT1934889	hsa-miR-636	CLIP-seq
MIRT1934890	hsa-miR-640	CLIP-seq
MIRT1934891	hsa-miR-648	CLIP-seq
MIRT1934892	hsa-miR-671-5p	CLIP-seq
MIRT1934893	hsa-miR-767-3p	CLIP-seq
MIRT1934894	hsa-miR-892b	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT1934860	hsa-miR-4477a	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT1934877	hsa-miR-4797-3p	CLIP-seq
MIRT2174608	hsa-miR-513a-5p	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT1934822	hsa-miR-1184	CLIP-seq
MIRT1934823	hsa-miR-1205	CLIP-seq
MIRT2174609	hsa-miR-1237	CLIP-seq
MIRT2174610	hsa-miR-1248	CLIP-seq
MIRT1934824	hsa-miR-1265	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT2174611	hsa-miR-1285	CLIP-seq
MIRT2174612	hsa-miR-1299	CLIP-seq
MIRT2174613	hsa-miR-1302	CLIP-seq
MIRT795371	hsa-miR-1305	CLIP-seq
MIRT795372	hsa-miR-130a	CLIP-seq
MIRT795373	hsa-miR-130b	CLIP-seq
MIRT2174614	hsa-miR-138	CLIP-seq
MIRT795374	hsa-miR-15a	CLIP-seq
MIRT795375	hsa-miR-15b	CLIP-seq
MIRT795376	hsa-miR-16	CLIP-seq
MIRT1934828	hsa-miR-1909	CLIP-seq
MIRT795378	hsa-miR-195	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT2174615	hsa-miR-2114	CLIP-seq
MIRT2174616	hsa-miR-214	CLIP-seq
MIRT2174617	hsa-miR-2278	CLIP-seq
MIRT2174618	hsa-miR-2682	CLIP-seq
MIRT2174619	hsa-miR-27a	CLIP-seq
MIRT2174620	hsa-miR-27b	CLIP-seq
MIRT795385	hsa-miR-301a	CLIP-seq
MIRT795386	hsa-miR-301b	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT2174621	hsa-miR-3122	CLIP-seq
MIRT1934831	hsa-miR-3123	CLIP-seq
MIRT2174622	hsa-miR-3152-5p	CLIP-seq
MIRT2174623	hsa-miR-3156-3p	CLIP-seq
MIRT1934833	hsa-miR-3158-5p	CLIP-seq
MIRT1934835	hsa-miR-3163	CLIP-seq
MIRT2174624	hsa-miR-3185	CLIP-seq
MIRT2174625	hsa-miR-3187-5p	CLIP-seq
MIRT2174626	hsa-miR-3189-3p	CLIP-seq
MIRT2174627	hsa-miR-3192	CLIP-seq
MIRT2174628	hsa-miR-3194-3p	CLIP-seq
MIRT2174629	hsa-miR-3199	CLIP-seq
MIRT1934837	hsa-miR-324-5p	CLIP-seq
MIRT2174630	hsa-miR-326	CLIP-seq
MIRT2174631	hsa-miR-330-5p	CLIP-seq
MIRT2174632	hsa-miR-34a	CLIP-seq
MIRT2174633	hsa-miR-34c-5p	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT2174634	hsa-miR-3619-5p	CLIP-seq
MIRT2174635	hsa-miR-3650	CLIP-seq
MIRT795397	hsa-miR-3662	CLIP-seq
MIRT795398	hsa-miR-3666	CLIP-seq
MIRT1934841	hsa-miR-3682-5p	CLIP-seq
MIRT2174636	hsa-miR-378g	CLIP-seq
MIRT1934846	hsa-miR-380	CLIP-seq
MIRT2174637	hsa-miR-3913-5p	CLIP-seq
MIRT1934853	hsa-miR-3925-5p	CLIP-seq
MIRT795406	hsa-miR-3941	CLIP-seq
MIRT795408	hsa-miR-424	CLIP-seq
MIRT1934854	hsa-miR-4252	CLIP-seq
MIRT2174638	hsa-miR-4257	CLIP-seq
MIRT2174639	hsa-miR-4266	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT2174640	hsa-miR-4277	CLIP-seq
MIRT2174641	hsa-miR-4282	CLIP-seq
MIRT795413	hsa-miR-4295	CLIP-seq
MIRT2174642	hsa-miR-4298	CLIP-seq
MIRT2174643	hsa-miR-4301	CLIP-seq
MIRT2174644	hsa-miR-4314	CLIP-seq
MIRT1934856	hsa-miR-4327	CLIP-seq
MIRT1934857	hsa-miR-4328	CLIP-seq
MIRT2174645	hsa-miR-4468	CLIP-seq
MIRT2174646	hsa-miR-4486	CLIP-seq
MIRT2174647	hsa-miR-4487	CLIP-seq
MIRT2174648	hsa-miR-449a	CLIP-seq
MIRT2174649	hsa-miR-449b	CLIP-seq
MIRT2174650	hsa-miR-449c	CLIP-seq
MIRT2174651	hsa-miR-4511	CLIP-seq
MIRT795489	hsa-miR-4514	CLIP-seq
MIRT795421	hsa-miR-4524	CLIP-seq
MIRT795424	hsa-miR-454	CLIP-seq
MIRT2174652	hsa-miR-4633-3p	CLIP-seq
MIRT795490	hsa-miR-4639-3p	CLIP-seq
MIRT2174653	hsa-miR-4646-5p	CLIP-seq
MIRT795427	hsa-miR-466	CLIP-seq
MIRT2174654	hsa-miR-4671-5p	CLIP-seq
MIRT795430	hsa-miR-4672	CLIP-seq
MIRT2174655	hsa-miR-4690-5p	CLIP-seq
MIRT795493	hsa-miR-4692	CLIP-seq
MIRT2174656	hsa-miR-4695-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT2174657	hsa-miR-4726-3p	CLIP-seq
MIRT795437	hsa-miR-4731-3p	CLIP-seq
MIRT1934869	hsa-miR-4738-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934871	hsa-miR-4764-5p	CLIP-seq
MIRT2174658	hsa-miR-4779	CLIP-seq
MIRT795444	hsa-miR-4782-5p	CLIP-seq
MIRT2174659	hsa-miR-4793-5p	CLIP-seq
MIRT1934877	hsa-miR-4797-3p	CLIP-seq
MIRT795445	hsa-miR-4801	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT795447	hsa-miR-497	CLIP-seq
MIRT795448	hsa-miR-498	CLIP-seq
MIRT795449	hsa-miR-503	CLIP-seq
MIRT2174608	hsa-miR-513a-5p	CLIP-seq
MIRT2174660	hsa-miR-516a-3p	CLIP-seq
MIRT2174661	hsa-miR-516b	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT2174662	hsa-miR-541	CLIP-seq
MIRT2174663	hsa-miR-554	CLIP-seq
MIRT2174664	hsa-miR-558	CLIP-seq
MIRT795462	hsa-miR-587	CLIP-seq
MIRT795463	hsa-miR-596	CLIP-seq
MIRT2174665	hsa-miR-612	CLIP-seq
MIRT795464	hsa-miR-619	CLIP-seq
MIRT795465	hsa-miR-646	CLIP-seq
MIRT2174666	hsa-miR-654-5p	CLIP-seq
MIRT2174667	hsa-miR-664	CLIP-seq
MIRT2174668	hsa-miR-761	CLIP-seq
MIRT795468	hsa-miR-875-3p	CLIP-seq
MIRT2174669	hsa-miR-876-3p	CLIP-seq
MIRT1934894	hsa-miR-892b	CLIP-seq
MIRT795469	hsa-miR-922	CLIP-seq
MIRT795470	hsa-miR-935	CLIP-seq
MIRT795366	hsa-miR-1276	CLIP-seq
MIRT2384431	hsa-miR-203	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2174663	hsa-miR-554	CLIP-seq
MIRT795467	hsa-miR-659	CLIP-seq
MIRT2174611	hsa-miR-1285	CLIP-seq
MIRT2174613	hsa-miR-1302	CLIP-seq
MIRT2174615	hsa-miR-2114	CLIP-seq
MIRT795387	hsa-miR-3064-3p	CLIP-seq
MIRT2174621	hsa-miR-3122	CLIP-seq
MIRT2174623	hsa-miR-3156-3p	CLIP-seq
MIRT2174624	hsa-miR-3185	CLIP-seq
MIRT2174625	hsa-miR-3187-5p	CLIP-seq
MIRT2174626	hsa-miR-3189-3p	CLIP-seq
MIRT2174629	hsa-miR-3199	CLIP-seq
MIRT2174630	hsa-miR-326	CLIP-seq
MIRT2174631	hsa-miR-330-5p	CLIP-seq
MIRT795392	hsa-miR-3611	CLIP-seq
MIRT2174636	hsa-miR-378g	CLIP-seq
MIRT2174637	hsa-miR-3913-5p	CLIP-seq
MIRT2174642	hsa-miR-4298	CLIP-seq
MIRT2174643	hsa-miR-4301	CLIP-seq
MIRT2174646	hsa-miR-4486	CLIP-seq
MIRT2174651	hsa-miR-4511	CLIP-seq
MIRT2174663	hsa-miR-554	CLIP-seq
MIRT2174665	hsa-miR-612	CLIP-seq
MIRT2443938	hsa-miR-1323	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2443939	hsa-miR-548o	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT2478118	hsa-miR-1253	CLIP-seq
MIRT2443938	hsa-miR-1323	CLIP-seq
MIRT2478119	hsa-miR-2115	CLIP-seq
MIRT1934838	hsa-miR-325	CLIP-seq
MIRT795404	hsa-miR-3919	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT2478120	hsa-miR-4436b-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795439	hsa-miR-4756-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2443939	hsa-miR-548o	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT1934888	hsa-miR-628-3p	CLIP-seq
MIRT2174609	hsa-miR-1237	CLIP-seq
MIRT2174610	hsa-miR-1248	CLIP-seq
MIRT2478118	hsa-miR-1253	CLIP-seq
MIRT2443938	hsa-miR-1323	CLIP-seq
MIRT795381	hsa-miR-2110	CLIP-seq
MIRT1934838	hsa-miR-325	CLIP-seq
MIRT1934842	hsa-miR-3685	CLIP-seq
MIRT1934847	hsa-miR-384	CLIP-seq
MIRT795404	hsa-miR-3919	CLIP-seq
MIRT2174639	hsa-miR-4266	CLIP-seq
MIRT795410	hsa-miR-4271	CLIP-seq
MIRT2174656	hsa-miR-4695-5p	CLIP-seq
MIRT795436	hsa-miR-4725-3p	CLIP-seq
MIRT795438	hsa-miR-4747-5p	CLIP-seq
MIRT795439	hsa-miR-4756-3p	CLIP-seq
MIRT795440	hsa-miR-4760-3p	CLIP-seq
MIRT2174658	hsa-miR-4779	CLIP-seq
MIRT795446	hsa-miR-491-5p	CLIP-seq
MIRT2174660	hsa-miR-516a-3p	CLIP-seq
MIRT795455	hsa-miR-522	CLIP-seq
MIRT2174662	hsa-miR-541	CLIP-seq
MIRT1934880	hsa-miR-548aa	CLIP-seq
MIRT2443939	hsa-miR-548o	CLIP-seq
MIRT1934887	hsa-miR-607	CLIP-seq
MIRT795464	hsa-miR-619	CLIP-seq
MIRT1934888	hsa-miR-628-3p	CLIP-seq
MIRT2174666	hsa-miR-654-5p	CLIP-seq
MIRT795468	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001664	Function	G protein-coupled receptor binding	IBA
GO:0001664	Function	G protein-coupled receptor binding	IDA	15755723
GO:0001664	Function	G protein-coupled receptor binding	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	11094164
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	11724822, 15364580, 15755723, 20300064, 20844236, 29467281, 32203420, 33961781, 34591642, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15755723
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	15755723
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007266	Process	Rho protein signal transduction	IDA	26529257
GO:0007266	Process	Rho protein signal transduction	IEA
GO:0007266	Process	Rho protein signal transduction	IMP	23241886, 31570889
GO:0016020	Component	Membrane	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0160221	Process	Rho-activating G protein-coupled receptor signaling pathway	IDA	11094164

Other IDs

• MIM: 604763
• HGNC: 14193
• e!Ensembl: ENSG00000196914

Protein

• UniProt ID: Q9NZN5
• Protein name: Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
• Protein function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and G
• PDB: 1TXD, 1X86, 2OMJ, 2OS6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	73 → 145	PDZ domain	Domain
  PF09128	RGS-like	368 → 558	Regulator of G protein signalling-like domain	Domain
  PF00621	RhoGEF	791 → 975	RhoGEF domain	Domain
  PF17838	PH_16	1004 → 1132	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. Isoform 2 is found in jejunum and testis.
• Sequence:

  MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE
  SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
  LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
  ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
  EAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDAS
  RPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGT
  EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRR
  IFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
  EDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDK
  SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSI
  LGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGY
  LPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ
  VQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
  LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
  LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS
  RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKV
  KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKM
  IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
  KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK
  PIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTS
  GKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLK
  QLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG
  DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEH
  FFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQ
  PMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQ
  SQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS

• Sequence length: 1544

Pathways

KEGG:

Vascular smooth muscle contraction
Axon guidance
Platelet activation
C-type lectin receptor signaling pathway
Regulation of actin cytoskeleton
Pathogenic Escherichia coli infection
Yersinia infection
Tuberculosis
Human cytomegalovirus infection
Pathways in cancer
Proteoglycans in cancer

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BEHCET'S SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glaucoma	Uncertain significance	ClinVar Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	31467124		★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	31467124		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	30385725		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19734946		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	19734946	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	19734946, 26258642		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	19734946, 26258642	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Abnormalities	Congenital abnormalities	Pubtator	33084842	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	30104761		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	16644711, 17766704		★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	25637523		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Glaucoma	Glaucoma	Pubtator	25637523	Associate	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Glaucoma	Glaucoma	GWASCAT_DG	30054594		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Glaucoma Open Angle	Open angle glaucoma	Pubtator	25637523, 38242088	Associate	★☆☆☆☆ Found in Text Mining only
Glaucoma, Open-Angle	Glaucoma	GWASCAT_DG	29891935		★☆☆☆☆ Found in Text Mining only
Glaucoma, Primary Open Angle	Glaucoma	BEFREE	28832686		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	32693062	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	32693062	Associate	★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	33084842	Associate	★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart Diseases	BEFREE	26483157		★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	26483157	Associate	★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	BEFREE	16644711		★☆☆☆☆ Found in Text Mining only
Hypersensitivity Delayed	Hypersensitivity	Pubtator	33084842	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	11373293, 32693062, 33419897	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	15143072		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	10681437, 11094164, 11373293, 19196702, 33419897	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	10681437		★☆☆☆☆ Found in Text Mining only
Low Tension Glaucoma	Low Tension Glaucoma	BEFREE	28832686		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19734946		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26483157		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	17766704		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	32922167	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19734946		★☆☆☆☆ Found in Text Mining only
Pituitary dwarfism 1	Pituitary dwarfism	Pubtator	25485589	Associate	★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	31467124		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21147910	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	34675500	Associate	★☆☆☆☆ Found in Text Mining only
Shwachman syndrome	Shwachman Syndrome	BEFREE	17539775		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	16565089		★☆☆☆☆ Found in Text Mining only