Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23358
Gene name	Ubiquitin specific peptidase 24
Gene symbol	USP24
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p32.3
Summary	Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1557523211	G>A	Likely-pathogenic	Intron variant, genic downstream transcript variant

310

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miRTarBase ID	miRNA	Experiments	Reference
MIRT026075	hsa-miR-196a-5p	Sequencing	20371350
MIRT032176	hsa-let-7d-5p	Sequencing	20371350
MIRT047289	hsa-miR-181b-5p	CLASH	23622248
MIRT041365	hsa-miR-193b-3p	CLASH	23622248
MIRT041365	hsa-miR-193b-3p	CLASH	23622248
MIRT036649	hsa-miR-935	CLASH	23622248
MIRT036516	hsa-miR-1226-3p	CLASH	23622248
MIRT734673	hsa-miR-139-5p	pSILACRNA-seq	33573268
MIRT1478337	hsa-miR-103a	CLIP-seq
MIRT1478338	hsa-miR-107	CLIP-seq
MIRT1478339	hsa-miR-1200	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT1478341	hsa-miR-1234	CLIP-seq
MIRT1478342	hsa-miR-1273f	CLIP-seq
MIRT1478343	hsa-miR-1301	CLIP-seq
MIRT1478344	hsa-miR-143	CLIP-seq
MIRT1478345	hsa-miR-146a	CLIP-seq
MIRT1478346	hsa-miR-146b-5p	CLIP-seq
MIRT1478347	hsa-miR-150	CLIP-seq
MIRT1478348	hsa-miR-1915	CLIP-seq
MIRT1478349	hsa-miR-199a-5p	CLIP-seq
MIRT1478350	hsa-miR-199b-5p	CLIP-seq
MIRT1478351	hsa-miR-2053	CLIP-seq
MIRT1478352	hsa-miR-3124-3p	CLIP-seq
MIRT1478353	hsa-miR-3150b-3p	CLIP-seq
MIRT1478354	hsa-miR-3156-3p	CLIP-seq
MIRT1478355	hsa-miR-3156-5p	CLIP-seq
MIRT1478356	hsa-miR-338-3p	CLIP-seq
MIRT1478357	hsa-miR-338-5p	CLIP-seq
MIRT1478358	hsa-miR-3682-3p	CLIP-seq
MIRT1478359	hsa-miR-3691-5p	CLIP-seq
MIRT1478360	hsa-miR-3911	CLIP-seq
MIRT1478361	hsa-miR-3915	CLIP-seq
MIRT1478362	hsa-miR-4276	CLIP-seq
MIRT1478363	hsa-miR-4300	CLIP-seq
MIRT1478364	hsa-miR-4301	CLIP-seq
MIRT1478365	hsa-miR-4302	CLIP-seq
MIRT1478366	hsa-miR-4310	CLIP-seq
MIRT1478367	hsa-miR-4317	CLIP-seq
MIRT1478368	hsa-miR-4324	CLIP-seq
MIRT1478369	hsa-miR-4461	CLIP-seq
MIRT1478370	hsa-miR-4475	CLIP-seq
MIRT1478371	hsa-miR-4529-5p	CLIP-seq
MIRT1478372	hsa-miR-4689	CLIP-seq
MIRT1478373	hsa-miR-4693-3p	CLIP-seq
MIRT1478374	hsa-miR-4708-5p	CLIP-seq
MIRT1478375	hsa-miR-4713-5p	CLIP-seq
MIRT1478376	hsa-miR-4726-3p	CLIP-seq
MIRT1478377	hsa-miR-4733-5p	CLIP-seq
MIRT1478378	hsa-miR-4752	CLIP-seq
MIRT1478379	hsa-miR-4770	CLIP-seq
MIRT1478380	hsa-miR-4784	CLIP-seq
MIRT1478381	hsa-miR-498	CLIP-seq
MIRT1478382	hsa-miR-5047	CLIP-seq
MIRT1478383	hsa-miR-526b	CLIP-seq
MIRT1478384	hsa-miR-532-3p	CLIP-seq
MIRT1478385	hsa-miR-532-5p	CLIP-seq
MIRT1478386	hsa-miR-544b	CLIP-seq
MIRT1478387	hsa-miR-569	CLIP-seq
MIRT1478388	hsa-miR-580	CLIP-seq
MIRT1478389	hsa-miR-589	CLIP-seq
MIRT1478390	hsa-miR-616	CLIP-seq
MIRT1478391	hsa-miR-920	CLIP-seq
MIRT1478341	hsa-miR-1234	CLIP-seq
MIRT2144081	hsa-miR-145	CLIP-seq
MIRT1478345	hsa-miR-146a	CLIP-seq
MIRT1478346	hsa-miR-146b-5p	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT1478355	hsa-miR-3156-5p	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT1478363	hsa-miR-4300	CLIP-seq
MIRT1478366	hsa-miR-4310	CLIP-seq
MIRT1478369	hsa-miR-4461	CLIP-seq
MIRT2144085	hsa-miR-4663	CLIP-seq
MIRT2144086	hsa-miR-4712-5p	CLIP-seq
MIRT1478383	hsa-miR-526b	CLIP-seq
MIRT2144087	hsa-miR-548ag	CLIP-seq
MIRT2144088	hsa-miR-548ai	CLIP-seq
MIRT1478388	hsa-miR-580	CLIP-seq
MIRT2144089	hsa-miR-582-5p	CLIP-seq
MIRT1478389	hsa-miR-589	CLIP-seq
MIRT2144090	hsa-miR-622	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2144093	hsa-miR-770-5p	CLIP-seq
MIRT1478391	hsa-miR-920	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT1478339	hsa-miR-1200	CLIP-seq
MIRT2364280	hsa-miR-1208	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT2364281	hsa-miR-1228	CLIP-seq
MIRT2364282	hsa-miR-1236	CLIP-seq
MIRT2364283	hsa-miR-140-5p	CLIP-seq
MIRT2364284	hsa-miR-153	CLIP-seq
MIRT2364285	hsa-miR-1587	CLIP-seq
MIRT2364286	hsa-miR-18a	CLIP-seq
MIRT2364287	hsa-miR-18b	CLIP-seq
MIRT2364288	hsa-miR-21	CLIP-seq
MIRT2364289	hsa-miR-224	CLIP-seq
MIRT2364290	hsa-miR-296-3p	CLIP-seq
MIRT2364291	hsa-miR-3155	CLIP-seq
MIRT2364292	hsa-miR-3155b	CLIP-seq
MIRT2364293	hsa-miR-329	CLIP-seq
MIRT1478356	hsa-miR-338-3p	CLIP-seq
MIRT2364294	hsa-miR-362-3p	CLIP-seq
MIRT2364295	hsa-miR-3647-3p	CLIP-seq
MIRT2364296	hsa-miR-3674	CLIP-seq
MIRT1478358	hsa-miR-3682-3p	CLIP-seq
MIRT2364297	hsa-miR-371b-5p	CLIP-seq
MIRT2364298	hsa-miR-3920	CLIP-seq
MIRT2364299	hsa-miR-3925-3p	CLIP-seq
MIRT2364300	hsa-miR-4252	CLIP-seq
MIRT2364301	hsa-miR-4297	CLIP-seq
MIRT1478368	hsa-miR-4324	CLIP-seq
MIRT2364302	hsa-miR-4437	CLIP-seq
MIRT2364303	hsa-miR-4524	CLIP-seq
MIRT2364304	hsa-miR-4530	CLIP-seq
MIRT2364305	hsa-miR-4645-5p	CLIP-seq
MIRT2144085	hsa-miR-4663	CLIP-seq
MIRT2364306	hsa-miR-4673	CLIP-seq
MIRT2364307	hsa-miR-4674	CLIP-seq
MIRT2364308	hsa-miR-4690-5p	CLIP-seq
MIRT1478373	hsa-miR-4693-3p	CLIP-seq
MIRT2364309	hsa-miR-4710	CLIP-seq
MIRT2144086	hsa-miR-4712-5p	CLIP-seq
MIRT1478377	hsa-miR-4733-5p	CLIP-seq
MIRT2364310	hsa-miR-4735-3p	CLIP-seq
MIRT2364311	hsa-miR-4747-5p	CLIP-seq
MIRT2364312	hsa-miR-4762-3p	CLIP-seq
MIRT2364313	hsa-miR-4792	CLIP-seq
MIRT2364314	hsa-miR-483-3p	CLIP-seq
MIRT2364315	hsa-miR-484	CLIP-seq
MIRT2364316	hsa-miR-491-3p	CLIP-seq
MIRT2364317	hsa-miR-499-3p	CLIP-seq
MIRT2364318	hsa-miR-499a-3p	CLIP-seq
MIRT1478385	hsa-miR-532-5p	CLIP-seq
MIRT1478386	hsa-miR-544b	CLIP-seq
MIRT2364319	hsa-miR-545	CLIP-seq
MIRT2144087	hsa-miR-548ag	CLIP-seq
MIRT2144088	hsa-miR-548ai	CLIP-seq
MIRT2364320	hsa-miR-586	CLIP-seq
MIRT2364321	hsa-miR-590-5p	CLIP-seq
MIRT2364322	hsa-miR-640	CLIP-seq
MIRT2364323	hsa-miR-668	CLIP-seq
MIRT2364324	hsa-miR-766	CLIP-seq
MIRT2144093	hsa-miR-770-5p	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT1478337	hsa-miR-103a	CLIP-seq
MIRT1478338	hsa-miR-107	CLIP-seq
MIRT2658056	hsa-miR-1183	CLIP-seq
MIRT2364280	hsa-miR-1208	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT2658057	hsa-miR-1237	CLIP-seq
MIRT2658058	hsa-miR-124	CLIP-seq
MIRT2658059	hsa-miR-1248	CLIP-seq
MIRT2658060	hsa-miR-1257	CLIP-seq
MIRT1478342	hsa-miR-1273f	CLIP-seq
MIRT2658061	hsa-miR-1281	CLIP-seq
MIRT2658062	hsa-miR-1286	CLIP-seq
MIRT1478343	hsa-miR-1301	CLIP-seq
MIRT2364283	hsa-miR-140-5p	CLIP-seq
MIRT1478344	hsa-miR-143	CLIP-seq
MIRT2658063	hsa-miR-1468	CLIP-seq
MIRT2658064	hsa-miR-149	CLIP-seq
MIRT1478351	hsa-miR-2053	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT2658065	hsa-miR-300	CLIP-seq
MIRT2658066	hsa-miR-302a	CLIP-seq
MIRT2658067	hsa-miR-302b	CLIP-seq
MIRT2658068	hsa-miR-302c	CLIP-seq
MIRT2658069	hsa-miR-302d	CLIP-seq
MIRT2658070	hsa-miR-302e	CLIP-seq
MIRT2658071	hsa-miR-3129-3p	CLIP-seq
MIRT2658072	hsa-miR-3136-5p	CLIP-seq
MIRT2658073	hsa-miR-3137	CLIP-seq
MIRT1478353	hsa-miR-3150b-3p	CLIP-seq
MIRT2658074	hsa-miR-3168	CLIP-seq
MIRT2658075	hsa-miR-3177-5p	CLIP-seq
MIRT2658076	hsa-miR-323-3p	CLIP-seq
MIRT1478357	hsa-miR-338-5p	CLIP-seq
MIRT2658077	hsa-miR-3609	CLIP-seq
MIRT2658078	hsa-miR-3613-5p	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2364295	hsa-miR-3647-3p	CLIP-seq
MIRT2658079	hsa-miR-3671	CLIP-seq
MIRT2658080	hsa-miR-3714	CLIP-seq
MIRT2658081	hsa-miR-371-5p	CLIP-seq
MIRT2364297	hsa-miR-371b-5p	CLIP-seq
MIRT2658082	hsa-miR-372	CLIP-seq
MIRT2658083	hsa-miR-373	CLIP-seq
MIRT2658084	hsa-miR-381	CLIP-seq
MIRT2658085	hsa-miR-3910	CLIP-seq
MIRT1478361	hsa-miR-3915	CLIP-seq
MIRT2658086	hsa-miR-409-5p	CLIP-seq
MIRT2364300	hsa-miR-4252	CLIP-seq
MIRT1478362	hsa-miR-4276	CLIP-seq
MIRT2658087	hsa-miR-4277	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT1478365	hsa-miR-4302	CLIP-seq
MIRT1478367	hsa-miR-4317	CLIP-seq
MIRT2658088	hsa-miR-4439	CLIP-seq
MIRT2658089	hsa-miR-4457	CLIP-seq
MIRT2658090	hsa-miR-4484	CLIP-seq
MIRT2658091	hsa-miR-4509	CLIP-seq
MIRT2658092	hsa-miR-4519	CLIP-seq
MIRT2658093	hsa-miR-4521	CLIP-seq
MIRT2658094	hsa-miR-4532	CLIP-seq
MIRT2658095	hsa-miR-4666-3p	CLIP-seq
MIRT2658096	hsa-miR-4684-5p	CLIP-seq
MIRT1478372	hsa-miR-4689	CLIP-seq
MIRT1478374	hsa-miR-4708-5p	CLIP-seq
MIRT2364309	hsa-miR-4710	CLIP-seq
MIRT2658097	hsa-miR-4738-3p	CLIP-seq
MIRT2658098	hsa-miR-4768-5p	CLIP-seq
MIRT1478379	hsa-miR-4770	CLIP-seq
MIRT1478380	hsa-miR-4784	CLIP-seq
MIRT2364313	hsa-miR-4792	CLIP-seq
MIRT2658099	hsa-miR-492	CLIP-seq
MIRT1478382	hsa-miR-5047	CLIP-seq
MIRT2658100	hsa-miR-506	CLIP-seq
MIRT2658101	hsa-miR-513b	CLIP-seq
MIRT2658102	hsa-miR-513c	CLIP-seq
MIRT2658103	hsa-miR-514b-5p	CLIP-seq
MIRT2658104	hsa-miR-519a	CLIP-seq
MIRT2658105	hsa-miR-519b-3p	CLIP-seq
MIRT2658106	hsa-miR-519c-3p	CLIP-seq
MIRT2658107	hsa-miR-520a-3p	CLIP-seq
MIRT2658108	hsa-miR-520b	CLIP-seq
MIRT2658109	hsa-miR-520c-3p	CLIP-seq
MIRT2658110	hsa-miR-520d-3p	CLIP-seq
MIRT2658111	hsa-miR-520e	CLIP-seq
MIRT2658112	hsa-miR-520g	CLIP-seq
MIRT2658113	hsa-miR-520h	CLIP-seq
MIRT2364319	hsa-miR-545	CLIP-seq
MIRT2658114	hsa-miR-548ad	CLIP-seq
MIRT2658115	hsa-miR-548ah	CLIP-seq
MIRT2658116	hsa-miR-548an	CLIP-seq
MIRT1478387	hsa-miR-569	CLIP-seq
MIRT2658117	hsa-miR-570	CLIP-seq
MIRT2144089	hsa-miR-582-5p	CLIP-seq
MIRT1478390	hsa-miR-616	CLIP-seq
MIRT2658118	hsa-miR-634	CLIP-seq
MIRT2364322	hsa-miR-640	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2364323	hsa-miR-668	CLIP-seq
MIRT2658119	hsa-miR-760	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2658120	hsa-miR-767-3p	CLIP-seq
MIRT2658121	hsa-miR-888	CLIP-seq
MIRT2658122	hsa-miR-892b	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT2658123	hsa-miR-940	CLIP-seq
MIRT2658124	hsa-miR-942	CLIP-seq
MIRT2658125	hsa-miR-943	CLIP-seq
MIRT2658056	hsa-miR-1183	CLIP-seq
MIRT2364280	hsa-miR-1208	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT2658057	hsa-miR-1237	CLIP-seq
MIRT2658059	hsa-miR-1248	CLIP-seq
MIRT2658060	hsa-miR-1257	CLIP-seq
MIRT2658064	hsa-miR-149	CLIP-seq
MIRT1478351	hsa-miR-2053	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT2658065	hsa-miR-300	CLIP-seq
MIRT2658072	hsa-miR-3136-5p	CLIP-seq
MIRT2658073	hsa-miR-3137	CLIP-seq
MIRT1478353	hsa-miR-3150b-3p	CLIP-seq
MIRT2658075	hsa-miR-3177-5p	CLIP-seq
MIRT2658076	hsa-miR-323-3p	CLIP-seq
MIRT2694809	hsa-miR-323b-3p	CLIP-seq
MIRT1478357	hsa-miR-338-5p	CLIP-seq
MIRT2658078	hsa-miR-3613-5p	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2658079	hsa-miR-3671	CLIP-seq
MIRT2658081	hsa-miR-371-5p	CLIP-seq
MIRT2364297	hsa-miR-371b-5p	CLIP-seq
MIRT2658084	hsa-miR-381	CLIP-seq
MIRT1478361	hsa-miR-3915	CLIP-seq
MIRT2364300	hsa-miR-4252	CLIP-seq
MIRT1478362	hsa-miR-4276	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT1478365	hsa-miR-4302	CLIP-seq
MIRT2658088	hsa-miR-4439	CLIP-seq
MIRT2658089	hsa-miR-4457	CLIP-seq
MIRT2658092	hsa-miR-4519	CLIP-seq
MIRT2658094	hsa-miR-4532	CLIP-seq
MIRT2658095	hsa-miR-4666-3p	CLIP-seq
MIRT1478372	hsa-miR-4689	CLIP-seq
MIRT1478380	hsa-miR-4784	CLIP-seq
MIRT2658101	hsa-miR-513b	CLIP-seq
MIRT2658102	hsa-miR-513c	CLIP-seq
MIRT2658103	hsa-miR-514b-5p	CLIP-seq
MIRT2364319	hsa-miR-545	CLIP-seq
MIRT1478387	hsa-miR-569	CLIP-seq
MIRT2364322	hsa-miR-640	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2364323	hsa-miR-668	CLIP-seq
MIRT2658119	hsa-miR-760	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2658121	hsa-miR-888	CLIP-seq
MIRT2658122	hsa-miR-892b	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT2658124	hsa-miR-942	CLIP-seq
MIRT2658125	hsa-miR-943	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IBA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0004843	Function	Cysteine-type deubiquitinase activity	TAS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0031647	Process	Regulation of protein stability	IBA

MIM	HGNC	e!Ensembl
610569	12623	ENSG00000162402

Q9UPU5

Protein name

Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)

Protein function

Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in l

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00443	UCH	1689 → 2039	Ubiquitin carboxyl-terminal hydrolase	Family
PF12030	DUF3517	2219 → 2570	Domain of unknown function (DUF3517)	Family

Sequence

MESEEEQHMTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGG
GPSPGPGGGPRGDGGGDGGGGGPSRGGSTGGGGGFDPPPAYHEVVDAEKNDENGNCSGEG
IEFPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENCRRFMDRCM
PEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDN
EYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELGGFAAIQAK
LHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKDLKDKRLVS
IPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTKLIEDSTLS
KSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSLDELTKIWK
IQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKSWETESDRVRQKLLSLIGRIGR
EARFETTSGKVLDVLWELAHLPTLPSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIE
DIKRPGEWSGLEKNKKDGFKSSQLNNPQFVWVVPALRQLHEITRSFIKQTYQKQDKSIIQ
DLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDGRYTYREYLEAHLKFLAFFLQ
EATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQHDLESDVQQQLFKEKILKLE
SYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLELIGMDFIWKIAMESPDEEIAN
EAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAASSALGGPTLTHAVTRATKML
TATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIEDFYSVPRTILPHGASFHGHLL
TLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDNIQIFTNDSLLTVNKDQKLLH
QLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFSSSYAMEQEKSLPGVVMALVC
NVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSK
SPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKS
FCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLLVGQTMPTLLDEDL
TKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQ
TMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSG
SEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIID
ILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGV
NQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSE
ADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFLFRASRIILNSHSPAGSAAIS
QQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALTKEFDYLPPV
DSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFG
HLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKN
TFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCE
KCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGM
ARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRG
CGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQ
RVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVK
KGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKHPYYPC
MAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFISSEGRE
LIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLHQLLEVLLALLDKDVPENCKN
CAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGASRQNNQIRRWSSAQAREFGNL
HNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLPLHEEVEALLFMSEGKPYLLE
VMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEIL
VIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKEN
SHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSG
SSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP

Sequence length

2620

Interactions

View interactions

	Reactome
			Ub-specific processing proteases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Short stature	Likely pathogenic	rs1557523211	RCV000736233	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (17)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	27404287, 39519104	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26568301, 27991932, 30266897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	25514360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	33257797, 40233501	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26568301, 27991932, 30266897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25814533, 26568301, 27991932, 30266897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood disorder	Pubtator	36580462	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	25814533		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	31680297		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	31680297	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	24286619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	15986317, 18854859, 20302855, 22923019, 24156912, 24286619, 30957634		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	15986317, 18854859, 24156912, 30957634	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	LHGDN	16917932		★★★★★ ★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE, LATE-ONSET	Parkinson disease	BEFREE	16917932		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	30911287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37265030	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

USP24 (ubiquitin specific peptidase 24)