Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23348
Gene name	Dedicator of cytokinesis 9
Gene symbol	DOCK9
Synonyms (NCBI Gene)	ZIZ1ZIZIMIN1
Chromosome	13
Chromosome location	13q32.3

142

Show/Hide all (142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017247	hsa-miR-335-5p	Microarray	18185580
MIRT028250	hsa-miR-32-5p	Sequencing	20371350
MIRT051177	hsa-miR-16-5p	CLASH	23622248
MIRT437669	hsa-miR-214-3p	MicroarrayqRT-PCR	22815788
MIRT496323	hsa-miR-1277-5p	PAR-CLIP	22291592
MIRT496322	hsa-miR-1245b-5p	PAR-CLIP	22291592
MIRT496321	hsa-miR-3142	PAR-CLIP	22291592
MIRT496320	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT496319	hsa-miR-889-3p	PAR-CLIP	22291592
MIRT496318	hsa-miR-4477a	PAR-CLIP	22291592
MIRT440786	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440786	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT727862	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727861	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT028250	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT496323	hsa-miR-1277-5p	PAR-CLIP	22291592
MIRT496322	hsa-miR-1245b-5p	PAR-CLIP	22291592
MIRT496321	hsa-miR-3142	PAR-CLIP	22291592
MIRT496320	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT496319	hsa-miR-889-3p	PAR-CLIP	22291592
MIRT496318	hsa-miR-4477a	PAR-CLIP	22291592
MIRT943050	hsa-miR-1279	CLIP-seq
MIRT943051	hsa-miR-133a	CLIP-seq
MIRT943052	hsa-miR-133b	CLIP-seq
MIRT943053	hsa-miR-136	CLIP-seq
MIRT943054	hsa-miR-1914	CLIP-seq
MIRT943055	hsa-miR-25	CLIP-seq
MIRT943056	hsa-miR-32	CLIP-seq
MIRT943057	hsa-miR-339-5p	CLIP-seq
MIRT943058	hsa-miR-363	CLIP-seq
MIRT943059	hsa-miR-367	CLIP-seq
MIRT943060	hsa-miR-374c	CLIP-seq
MIRT943061	hsa-miR-3924	CLIP-seq
MIRT943062	hsa-miR-423-3p	CLIP-seq
MIRT943063	hsa-miR-4536	CLIP-seq
MIRT943064	hsa-miR-576-3p	CLIP-seq
MIRT943065	hsa-miR-655	CLIP-seq
MIRT943066	hsa-miR-92a	CLIP-seq
MIRT943067	hsa-miR-92b	CLIP-seq
MIRT943068	hsa-miR-1183	CLIP-seq
MIRT943069	hsa-miR-145	CLIP-seq
MIRT943070	hsa-miR-190	CLIP-seq
MIRT943071	hsa-miR-190b	CLIP-seq
MIRT943072	hsa-miR-214	CLIP-seq
MIRT943073	hsa-miR-3120-3p	CLIP-seq
MIRT943074	hsa-miR-338-5p	CLIP-seq
MIRT943075	hsa-miR-34a	CLIP-seq
MIRT943076	hsa-miR-34c-5p	CLIP-seq
MIRT943077	hsa-miR-3619-5p	CLIP-seq
MIRT943060	hsa-miR-374c	CLIP-seq
MIRT943078	hsa-miR-3908	CLIP-seq
MIRT943079	hsa-miR-4436b-3p	CLIP-seq
MIRT943080	hsa-miR-449a	CLIP-seq
MIRT943081	hsa-miR-449b	CLIP-seq
MIRT943063	hsa-miR-4536	CLIP-seq
MIRT943082	hsa-miR-511	CLIP-seq
MIRT943083	hsa-miR-545	CLIP-seq
MIRT943064	hsa-miR-576-3p	CLIP-seq
MIRT943065	hsa-miR-655	CLIP-seq
MIRT943084	hsa-miR-761	CLIP-seq
MIRT943060	hsa-miR-374c	CLIP-seq
MIRT1979234	hsa-miR-380	CLIP-seq
MIRT1979235	hsa-miR-509-3p	CLIP-seq
MIRT943065	hsa-miR-655	CLIP-seq
MIRT1979235	hsa-miR-509-3p	CLIP-seq
MIRT943068	hsa-miR-1183	CLIP-seq
MIRT2214347	hsa-miR-1273e	CLIP-seq
MIRT943050	hsa-miR-1279	CLIP-seq
MIRT943053	hsa-miR-136	CLIP-seq
MIRT2214348	hsa-miR-141	CLIP-seq
MIRT2214349	hsa-miR-200a	CLIP-seq
MIRT943072	hsa-miR-214	CLIP-seq
MIRT2214350	hsa-miR-2276	CLIP-seq
MIRT2214351	hsa-miR-2277-3p	CLIP-seq
MIRT943055	hsa-miR-25	CLIP-seq
MIRT943073	hsa-miR-3120-3p	CLIP-seq
MIRT2214352	hsa-miR-3169	CLIP-seq
MIRT943056	hsa-miR-32	CLIP-seq
MIRT943074	hsa-miR-338-5p	CLIP-seq
MIRT943075	hsa-miR-34a	CLIP-seq
MIRT943076	hsa-miR-34c-5p	CLIP-seq
MIRT943077	hsa-miR-3619-5p	CLIP-seq
MIRT943058	hsa-miR-363	CLIP-seq
MIRT2214353	hsa-miR-3664-5p	CLIP-seq
MIRT943059	hsa-miR-367	CLIP-seq
MIRT943061	hsa-miR-3924	CLIP-seq
MIRT2214354	hsa-miR-4291	CLIP-seq
MIRT2214355	hsa-miR-4310	CLIP-seq
MIRT943079	hsa-miR-4436b-3p	CLIP-seq
MIRT943080	hsa-miR-449a	CLIP-seq
MIRT943081	hsa-miR-449b	CLIP-seq
MIRT2214356	hsa-miR-4708-3p	CLIP-seq
MIRT2214357	hsa-miR-4714-5p	CLIP-seq
MIRT2214358	hsa-miR-4719	CLIP-seq
MIRT2214359	hsa-miR-4742-3p	CLIP-seq
MIRT2214360	hsa-miR-4755-3p	CLIP-seq
MIRT2214361	hsa-miR-4772-3p	CLIP-seq
MIRT1979235	hsa-miR-509-3p	CLIP-seq
MIRT2214362	hsa-miR-542-3p	CLIP-seq
MIRT2214363	hsa-miR-548a-5p	CLIP-seq
MIRT2214364	hsa-miR-548ab	CLIP-seq
MIRT2214365	hsa-miR-548ak	CLIP-seq
MIRT2214366	hsa-miR-548b-5p	CLIP-seq
MIRT2214367	hsa-miR-548c-5p	CLIP-seq
MIRT2214368	hsa-miR-548d-5p	CLIP-seq
MIRT2214369	hsa-miR-548g	CLIP-seq
MIRT2214370	hsa-miR-548h	CLIP-seq
MIRT2214371	hsa-miR-548i	CLIP-seq
MIRT2214372	hsa-miR-548j	CLIP-seq
MIRT2214373	hsa-miR-548k	CLIP-seq
MIRT2214374	hsa-miR-548l	CLIP-seq
MIRT2214375	hsa-miR-548w	CLIP-seq
MIRT2214376	hsa-miR-548y	CLIP-seq
MIRT2214377	hsa-miR-559	CLIP-seq
MIRT2214378	hsa-miR-659	CLIP-seq
MIRT943084	hsa-miR-761	CLIP-seq
MIRT2214379	hsa-miR-889	CLIP-seq
MIRT2214380	hsa-miR-9	CLIP-seq
MIRT943066	hsa-miR-92a	CLIP-seq
MIRT943067	hsa-miR-92b	CLIP-seq
MIRT943050	hsa-miR-1279	CLIP-seq
MIRT943051	hsa-miR-133a	CLIP-seq
MIRT943052	hsa-miR-133b	CLIP-seq
MIRT943053	hsa-miR-136	CLIP-seq
MIRT943054	hsa-miR-1914	CLIP-seq
MIRT943072	hsa-miR-214	CLIP-seq
MIRT943055	hsa-miR-25	CLIP-seq
MIRT943073	hsa-miR-3120-3p	CLIP-seq
MIRT943056	hsa-miR-32	CLIP-seq
MIRT943057	hsa-miR-339-5p	CLIP-seq
MIRT943075	hsa-miR-34a	CLIP-seq
MIRT943076	hsa-miR-34c-5p	CLIP-seq
MIRT943077	hsa-miR-3619-5p	CLIP-seq
MIRT943058	hsa-miR-363	CLIP-seq
MIRT943059	hsa-miR-367	CLIP-seq
MIRT943062	hsa-miR-423-3p	CLIP-seq
MIRT943079	hsa-miR-4436b-3p	CLIP-seq
MIRT943080	hsa-miR-449a	CLIP-seq
MIRT943081	hsa-miR-449b	CLIP-seq
MIRT943084	hsa-miR-761	CLIP-seq
MIRT943066	hsa-miR-92a	CLIP-seq
MIRT943067	hsa-miR-92b	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	18729074
GO:0005829	Component	Cytosol	TAS
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0035023	Process	Regulation of Rho protein signal transduction	IBA
GO:0043547	Process	Positive regulation of GTPase activity	ISS
GO:0045296	Function	Cadherin binding	HDA	25468996

MIM	HGNC	e!Ensembl
607325	14132	ENSG00000088387

Q9BZ29

Protein name

Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1)

Protein function

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.

PDB

1WG7 , 2WM9 , 2WMN , 2WMO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11878	DUF3398	46 → 156	Domain of unknown function (DUF3398)	Domain
PF00169	PH	175 → 281	PH domain	Domain
PF14429	DOCK-C2	636 → 827	C2 domain in Dock180 and Zizimin proteins	Domain
PF06920	DHR-2	1506 → 2062	Dock homology region 2	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle. {ECO:0000269|PubMed:12172552}.

Sequence

MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQ
KKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSD
WHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLGSQKGGITKHGW
LYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQ
NNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDD
EQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSF
EEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDL
NHFSVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIE
KVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGNL
DKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYV
NSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAK
ARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPT
QLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSAN
LPSGYLGYQELGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTES
GAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVA
QCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYS
WFFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASK
NANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIP
LNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVL
KNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDES
LALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTD
SGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALF
TYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHSYG
HSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFL
QKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQL
LYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLI
KHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDS
MARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRGGVFRQ
GCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKL
IIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSE
TDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLD
SKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRT
ILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKL
QGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKE
DQLEYQEEMKANYREMAKELSEIMHEQLG

Sequence length

2069

Interactions

View interactions

	Reactome
			Factors involved in megakaryocyte development and platelet production

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNEAL ASTIGMATISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATOCONUS	—	Disgenet, GenCC Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOYAMOYA DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anxiety Disorders	Anxiety disorder	Pubtator	34741163	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	35282771	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	17728666		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	LHGDN	17728666		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	17728666		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	32439797	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Pain	Chronic pain	Pubtator	38104003	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	37501076	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
EDICT syndrome	EDICT Syndrome	BEFREE	23387289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	22399802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	22399802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable bowel syndrome	Pubtator	34741163	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Keratoconus	Keratoconus	BEFREE	22045297, 23387289, 26641546, 28484309		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Keratoconus	Keratoconus	Pubtator	22045297, 28159702, 28484309	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microcephaly	Microcephaly	Pubtator	37501076	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Moyamoya Disease	Moyamoya Disease	GWASCAT_DG	29273593		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moyamoya disease 1	Moyamoya disease	GWASCAT_DG	29273593		★★★★★ ★☆☆☆☆ Found in Text Mining only
Regular astigmatism - corneal	Corneal astigmatism	GWASCAT_DG	30306274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	31856144, 36281116	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DOCK9 (dedicator of cytokinesis 9)