Gene Gene information from NCBI Gene database.
Entrez ID 23326
Gene name Ubiquitin specific peptidase 22
Gene symbol USP22
Synonyms (NCBI Gene)
USP3L
Chromosome 17
Chromosome location 17p11.2
miRNA miRNA information provided by mirtarbase database.
1718
miRTarBase ID miRNA Experiments Reference
MIRT052073 hsa-let-7b-5p CLASH 23622248
MIRT047140 hsa-miR-183-5p CLASH 23622248
MIRT044650 hsa-miR-320a CLASH 23622248
MIRT044385 hsa-miR-200c-3p CLASH 23622248
MIRT044092 hsa-miR-361-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 27030811
GO:0000086 Process G2/M transition of mitotic cell cycle NAS 17495531
GO:0000124 Component SAGA complex IDA 18206972, 18206973, 27601583
GO:0000124 Component SAGA complex NAS 19114550
GO:0003713 Function Transcription coactivator activity IDA 18206972
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612116 12621 ENSG00000124422
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UPT9
Protein name Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)
Protein function Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiqu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02148 zf-UBP 63 124 Zn-finger in ubiquitin-hydrolases and other protein Domain
PF00443 UCH 176 517 Ubiquitin carboxyl-terminal hydrolase Family
Tissue specificity TISSUE SPECIFICITY: Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. {ECO:0000269|PubMed:16378762}.
Sequence
Sequence length 525
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Ub-specific processing proteases
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 25907317, 28567015, 29720480, 29981430
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma BEFREE 24466336
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 21337558
★☆☆☆☆
Found in Text Mining only
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 27145278
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 20824490
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 28160502, 31801945
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 21691749 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 21779003, 23979981, 30223389, 30224477, 35449157 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Adenoid Cystic Adenoid cystic carcinoma Pubtator 24466336 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 25909224, 33090397, 35203285, 35449157 Associate
★☆☆☆☆
Found in Text Mining only