Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23324
Gene name	Mannosidase alpha class 2B member 2
Gene symbol	MAN2B2
Synonyms (NCBI Gene)	CDG1EEEpMAN
Chromosome	4
Chromosome location	4p16.1

248

Show/Hide all (248)

miRTarBase ID	miRNA	Experiments	Reference
MIRT695684	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT695683	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT695682	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT695681	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT695680	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT695679	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT695678	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT695677	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT695653	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT695675	hsa-miR-3714	HITS-CLIP	23313552
MIRT695676	hsa-miR-3910	HITS-CLIP	23313552
MIRT695674	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT695673	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT695672	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT695671	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT695670	hsa-miR-302e	HITS-CLIP	23313552
MIRT695669	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT695668	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT695667	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT695666	hsa-miR-520b	HITS-CLIP	23313552
MIRT695665	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT695664	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT695663	hsa-miR-520e	HITS-CLIP	23313552
MIRT695662	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT695661	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT695660	hsa-miR-520h	HITS-CLIP	23313552
MIRT695659	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT695658	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT695657	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT695655	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT695656	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT695654	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT695653	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT695652	hsa-miR-506-3p	HITS-CLIP	23313552
MIRT695651	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT737377	hsa-miR-217	qRT-PCR	32231737
MIRT695684	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT695683	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT695682	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT695681	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT695680	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT695679	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT695678	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT695677	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT695653	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT695675	hsa-miR-3714	HITS-CLIP	23313552
MIRT695676	hsa-miR-3910	HITS-CLIP	23313552
MIRT695674	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT695673	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT695672	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT695671	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT695670	hsa-miR-302e	HITS-CLIP	23313552
MIRT695669	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT695668	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT695667	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT695666	hsa-miR-520b	HITS-CLIP	23313552
MIRT695665	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT695664	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT695663	hsa-miR-520e	HITS-CLIP	23313552
MIRT695662	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT695661	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT695660	hsa-miR-520h	HITS-CLIP	23313552
MIRT695659	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT695658	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT695657	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT695655	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT695656	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT695654	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT695653	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT695652	hsa-miR-506-3p	HITS-CLIP	23313552
MIRT695651	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT1127367	hsa-miR-1193	CLIP-seq
MIRT1127368	hsa-miR-125a-5p	CLIP-seq
MIRT1127369	hsa-miR-125b	CLIP-seq
MIRT1127370	hsa-miR-146b-3p	CLIP-seq
MIRT1127371	hsa-miR-19a	CLIP-seq
MIRT1127372	hsa-miR-19b	CLIP-seq
MIRT1127373	hsa-miR-2054	CLIP-seq
MIRT1127374	hsa-miR-3150b-3p	CLIP-seq
MIRT1127375	hsa-miR-3151	CLIP-seq
MIRT1127376	hsa-miR-3155	CLIP-seq
MIRT1127377	hsa-miR-3155b	CLIP-seq
MIRT1127378	hsa-miR-3173-5p	CLIP-seq
MIRT1127379	hsa-miR-3622b-5p	CLIP-seq
MIRT1127380	hsa-miR-3659	CLIP-seq
MIRT1127381	hsa-miR-3667-3p	CLIP-seq
MIRT1127382	hsa-miR-3688-5p	CLIP-seq
MIRT1127383	hsa-miR-3691-5p	CLIP-seq
MIRT1127384	hsa-miR-382	CLIP-seq
MIRT1127385	hsa-miR-3937	CLIP-seq
MIRT1127386	hsa-miR-3940-5p	CLIP-seq
MIRT1127387	hsa-miR-423-3p	CLIP-seq
MIRT1127388	hsa-miR-4271	CLIP-seq
MIRT1127389	hsa-miR-4319	CLIP-seq
MIRT1127390	hsa-miR-4446-3p	CLIP-seq
MIRT1127391	hsa-miR-4447	CLIP-seq
MIRT1127392	hsa-miR-4472	CLIP-seq
MIRT1127393	hsa-miR-4507	CLIP-seq
MIRT1127394	hsa-miR-4658	CLIP-seq
MIRT1127395	hsa-miR-4719	CLIP-seq
MIRT1127396	hsa-miR-4721	CLIP-seq
MIRT1127397	hsa-miR-4725-3p	CLIP-seq
MIRT1127398	hsa-miR-4746-3p	CLIP-seq
MIRT1127399	hsa-miR-4752	CLIP-seq
MIRT1127400	hsa-miR-4758-5p	CLIP-seq
MIRT1127401	hsa-miR-4784	CLIP-seq
MIRT1127402	hsa-miR-484	CLIP-seq
MIRT1127403	hsa-miR-490-3p	CLIP-seq
MIRT1127404	hsa-miR-491-5p	CLIP-seq
MIRT1127405	hsa-miR-510	CLIP-seq
MIRT1127406	hsa-miR-513b	CLIP-seq
MIRT1127407	hsa-miR-544b	CLIP-seq
MIRT1127408	hsa-miR-548b-3p	CLIP-seq
MIRT1127409	hsa-miR-574-5p	CLIP-seq
MIRT1127410	hsa-miR-619	CLIP-seq
MIRT1127411	hsa-miR-625	CLIP-seq
MIRT1127412	hsa-miR-643	CLIP-seq
MIRT1127413	hsa-miR-767-3p	CLIP-seq
MIRT1127414	hsa-miR-874	CLIP-seq
MIRT2036076	hsa-miR-297	CLIP-seq
MIRT2036077	hsa-miR-3149	CLIP-seq
MIRT2036078	hsa-miR-3926	CLIP-seq
MIRT2036079	hsa-miR-4520a-3p	CLIP-seq
MIRT2036080	hsa-miR-548s	CLIP-seq
MIRT1127368	hsa-miR-125a-5p	CLIP-seq
MIRT1127369	hsa-miR-125b	CLIP-seq
MIRT1127370	hsa-miR-146b-3p	CLIP-seq
MIRT2266406	hsa-miR-155	CLIP-seq
MIRT1127378	hsa-miR-3173-5p	CLIP-seq
MIRT1127385	hsa-miR-3937	CLIP-seq
MIRT1127387	hsa-miR-423-3p	CLIP-seq
MIRT1127389	hsa-miR-4319	CLIP-seq
MIRT1127398	hsa-miR-4746-3p	CLIP-seq
MIRT2266407	hsa-miR-4760-3p	CLIP-seq
MIRT2266408	hsa-miR-509-3p	CLIP-seq
MIRT1127407	hsa-miR-544b	CLIP-seq
MIRT1127413	hsa-miR-767-3p	CLIP-seq
MIRT1127414	hsa-miR-874	CLIP-seq
MIRT2565714	hsa-miR-1227	CLIP-seq
MIRT2565715	hsa-miR-1245b-3p	CLIP-seq
MIRT2565716	hsa-miR-1299	CLIP-seq
MIRT2565717	hsa-miR-23a	CLIP-seq
MIRT2565718	hsa-miR-23b	CLIP-seq
MIRT2565719	hsa-miR-23c	CLIP-seq
MIRT1127374	hsa-miR-3150b-3p	CLIP-seq
MIRT2565720	hsa-miR-3152-5p	CLIP-seq
MIRT1127376	hsa-miR-3155	CLIP-seq
MIRT1127377	hsa-miR-3155b	CLIP-seq
MIRT2565721	hsa-miR-3158-5p	CLIP-seq
MIRT2565722	hsa-miR-3159	CLIP-seq
MIRT1127379	hsa-miR-3622b-5p	CLIP-seq
MIRT2565723	hsa-miR-362-5p	CLIP-seq
MIRT1127380	hsa-miR-3659	CLIP-seq
MIRT1127381	hsa-miR-3667-3p	CLIP-seq
MIRT2565724	hsa-miR-3674	CLIP-seq
MIRT1127382	hsa-miR-3688-5p	CLIP-seq
MIRT2565725	hsa-miR-3692	CLIP-seq
MIRT2565726	hsa-miR-378	CLIP-seq
MIRT2565727	hsa-miR-378b	CLIP-seq
MIRT2565728	hsa-miR-378c	CLIP-seq
MIRT2565729	hsa-miR-378d	CLIP-seq
MIRT2565730	hsa-miR-378e	CLIP-seq
MIRT2565731	hsa-miR-378f	CLIP-seq
MIRT2565732	hsa-miR-378h	CLIP-seq
MIRT2565733	hsa-miR-378i	CLIP-seq
MIRT2036078	hsa-miR-3926	CLIP-seq
MIRT2565734	hsa-miR-422a	CLIP-seq
MIRT2565735	hsa-miR-4293	CLIP-seq
MIRT1127390	hsa-miR-4446-3p	CLIP-seq
MIRT2565736	hsa-miR-4468	CLIP-seq
MIRT2565737	hsa-miR-4636	CLIP-seq
MIRT2565738	hsa-miR-4638-3p	CLIP-seq
MIRT1127394	hsa-miR-4658	CLIP-seq
MIRT2565739	hsa-miR-4672	CLIP-seq
MIRT1127396	hsa-miR-4721	CLIP-seq
MIRT2565740	hsa-miR-4774-3p	CLIP-seq
MIRT2565741	hsa-miR-4778-5p	CLIP-seq
MIRT2565742	hsa-miR-4782-5p	CLIP-seq
MIRT1127401	hsa-miR-4784	CLIP-seq
MIRT1127402	hsa-miR-484	CLIP-seq
MIRT2565743	hsa-miR-500b	CLIP-seq
MIRT2565744	hsa-miR-501-5p	CLIP-seq
MIRT2266408	hsa-miR-509-3p	CLIP-seq
MIRT1127405	hsa-miR-510	CLIP-seq
MIRT2565745	hsa-miR-516b	CLIP-seq
MIRT2565746	hsa-miR-542-3p	CLIP-seq
MIRT2036080	hsa-miR-548s	CLIP-seq
MIRT1127409	hsa-miR-574-5p	CLIP-seq
MIRT2565747	hsa-miR-596	CLIP-seq
MIRT2565748	hsa-miR-646	CLIP-seq
MIRT2565749	hsa-miR-648	CLIP-seq
MIRT2565714	hsa-miR-1227	CLIP-seq
MIRT2565715	hsa-miR-1245b-3p	CLIP-seq
MIRT2565716	hsa-miR-1299	CLIP-seq
MIRT2565717	hsa-miR-23a	CLIP-seq
MIRT2565718	hsa-miR-23b	CLIP-seq
MIRT2565719	hsa-miR-23c	CLIP-seq
MIRT1127374	hsa-miR-3150b-3p	CLIP-seq
MIRT1127375	hsa-miR-3151	CLIP-seq
MIRT2565720	hsa-miR-3152-5p	CLIP-seq
MIRT1127376	hsa-miR-3155	CLIP-seq
MIRT1127377	hsa-miR-3155b	CLIP-seq
MIRT2565721	hsa-miR-3158-5p	CLIP-seq
MIRT2565722	hsa-miR-3159	CLIP-seq
MIRT2565723	hsa-miR-362-5p	CLIP-seq
MIRT1127380	hsa-miR-3659	CLIP-seq
MIRT1127381	hsa-miR-3667-3p	CLIP-seq
MIRT2565724	hsa-miR-3674	CLIP-seq
MIRT1127382	hsa-miR-3688-5p	CLIP-seq
MIRT2565726	hsa-miR-378	CLIP-seq
MIRT2565727	hsa-miR-378b	CLIP-seq
MIRT2565728	hsa-miR-378c	CLIP-seq
MIRT2565729	hsa-miR-378d	CLIP-seq
MIRT2565730	hsa-miR-378e	CLIP-seq
MIRT2565731	hsa-miR-378f	CLIP-seq
MIRT2565732	hsa-miR-378h	CLIP-seq
MIRT2565733	hsa-miR-378i	CLIP-seq
MIRT2565734	hsa-miR-422a	CLIP-seq
MIRT1127388	hsa-miR-4271	CLIP-seq
MIRT2565735	hsa-miR-4293	CLIP-seq
MIRT1127390	hsa-miR-4446-3p	CLIP-seq
MIRT1127391	hsa-miR-4447	CLIP-seq
MIRT2565736	hsa-miR-4468	CLIP-seq
MIRT1127392	hsa-miR-4472	CLIP-seq
MIRT2565737	hsa-miR-4636	CLIP-seq
MIRT2565738	hsa-miR-4638-3p	CLIP-seq
MIRT1127394	hsa-miR-4658	CLIP-seq
MIRT2565739	hsa-miR-4672	CLIP-seq
MIRT1127396	hsa-miR-4721	CLIP-seq
MIRT1127397	hsa-miR-4725-3p	CLIP-seq
MIRT1127400	hsa-miR-4758-5p	CLIP-seq
MIRT2565740	hsa-miR-4774-3p	CLIP-seq
MIRT2565741	hsa-miR-4778-5p	CLIP-seq
MIRT2565742	hsa-miR-4782-5p	CLIP-seq
MIRT1127401	hsa-miR-4784	CLIP-seq
MIRT1127402	hsa-miR-484	CLIP-seq
MIRT1127404	hsa-miR-491-5p	CLIP-seq
MIRT2565743	hsa-miR-500b	CLIP-seq
MIRT2565744	hsa-miR-501-5p	CLIP-seq
MIRT2266408	hsa-miR-509-3p	CLIP-seq
MIRT1127405	hsa-miR-510	CLIP-seq
MIRT2565745	hsa-miR-516b	CLIP-seq
MIRT2565746	hsa-miR-542-3p	CLIP-seq
MIRT1127409	hsa-miR-574-5p	CLIP-seq
MIRT2565747	hsa-miR-596	CLIP-seq
MIRT1127411	hsa-miR-625	CLIP-seq
MIRT2565748	hsa-miR-646	CLIP-seq
MIRT2565749	hsa-miR-648	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004559	Function	Alpha-mannosidase activity	IBA
GO:0004559	Function	Alpha-mannosidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005764	Component	Lysosome	IBA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006013	Process	Mannose metabolic process	IEA
GO:0006516	Process	Glycoprotein catabolic process	IDA	16115860
GO:0009313	Process	Oligosaccharide catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0052767	Function	Mannosyl-oligosaccharide 1,6-alpha-mannosidase activity	IDA	16115860
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
618899	29623	ENSG00000013288

Q9Y2E5

Protein name

Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Alpha-1,6-mannosidase) (Mannosidase alpha class 2B member 2)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01074	Glyco_hydro_38N	28 → 351	Glycosyl hydrolases family 38 N-terminal domain	Domain
PF09261	Alpha-mann_mid	356 → 456	Alpha mannosidase middle domain	Domain
PF07748	Glyco_hydro_38C	583 → 800	Glycosyl hydrolases family 38 C-terminal domain	Domain
PF17677	Glyco_hydro38C2	896 → 1003	Glycosyl hydrolases family 38 C-terminal beta sandwich domain	Domain

Sequence

MGQLCWLPLLAPLLLLRPPGVQSAGPIRAFVVPHSHMDVGWVYTVQESMRAYAANVYTSV
VEELARGQQRRFIAVEQEFFRLWWDGVASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVT
HLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGASATTPTLFALAGFNAHLGSRIDYDL
KAAMQEARGLQFVWRGSPSLSERQEIFTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPK
PPQDGVYPNMSEPVTPANINLYAEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFA
NMDPLLDHINSHAAELGVSVQYATLGDYFRALHALNVTWRVRDHHDFLPYSTEPFQAWTG
FYTSRSSLKGLARRASALLYAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHH
DAITGTESPKVRDMYATHLASGMLGMRKLMASIVLDELQPQAPMAASSDAGPAGHFASVY
NPLAWTVTTIVTLTVGFPGVRVTDEAGHPVPSQIQNSTETPSAYDLLILTTIPGLSYRHY
NIRPTAGAQEGTQEPAATVASTLQFGRRLRRRTSHAGRYLVPVANDCYIVLLDQDTNLMH
SIWERQSNRTVRVTQEFLEYHVNGDVKQGPISDNYLFTPGKAAVPAWEAVEMEIVAGQLV
TEIRQYFYRNMTAQNYTYAIRSRLTHVPQGHDGELLCHRIEQEYQAGPLELNREAVLRTS
TNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVLLSERAHG
ISSQGNGQVEVMLHRRLWNNFDWDLGYNLTLNDTSVVHPVLWLLLGSWSLTTALRQRSAL
ALQHRPVVLFGDLAGTAPKLPGPQQQEAVTLPPNLHLQILSIPGWRYSSNHTEHSQNLRK
GHRGEAQADLRRVLLRLYHLYEVGEDPVLSQPVTVNLEAVLQALGSVVAVEERSLTGTWD
LSMLHRWSWRTGPGRHRGDTTSPSRPPGGPIITVHPKEIRTFFIHFQQQ

Sequence length

1009

Interactions

View interactions

	KEGG		Reactome
	Other glycan degradation		Lysosomal oligosaccharide catabolism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital disorder of glycosylation	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital disorder of glycosylation type 1EE with or without immunodeficiency	Uncertain significance	ClinVar ClinVar, HPO ClinVar, HPO	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
CONGENITAL DISORDERS OF GLYCOSYLATION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAN2B2-related disorder	Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cerebrovascular accident	Stroke	BEFREE	31775018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	32020674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	31775018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32020674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32020674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MAN2B2 (mannosidase alpha class 2B member 2)